2022 Fiscal Year Final Research Report

Interplay of developmental clock and extracellular environment in brain formation

International Activities Supporting Group

PDF

Project Area	Interplay of developmental clock and extracellular environment in brain formation
Project/Area Number	16K21729
Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Allocation Type	Multi-year Fund
Review Section	Biological Sciences
Research Institution	Institute of Physical and Chemical Research (2022) Kyoto University (2016-2021)
Principal Investigator	Kageyama Ryoichiro 国立研究開発法人理化学研究所, 脳神経科学研究センター, センター長 (80224369)
Co-Investigator(Kenkyū-buntansha)	仲嶋一範慶應義塾大学, 医学部(信濃町), 教授 (90280734) 見学美根子京都大学, 高等研究院, 教授 (10303801)
Project Period (FY)	2016-06-30 – 2023-03-31
Keywords	発生時計 / 神経発生 / 脳構築 / 神経幹細胞 / 数理モデル / 分節時計
Outline of Final Research Achievements	We supported mainly young researchers’ travel expenses for collaboration research with foreign laboratories and presentation of their results overseas. In addition, an international workshop was held in Kyoto from March 19 to 23, 2018, in order to deepen exchanges between young domestic researchers and top-class young researchers from overseas. Ten young top researchers from overseas were invited, and many young researchers from Japan participated. A total of 88 people participated, including senior researchers, and there were lively question-and-answer sessions, discussions, and joint research meetings. An international symposium was held at Kyoto University on March 15-17, 2023. We invited eight well-known researchers from abroad, and many researchers from within the field participated, making for meaningful research exchanges.
Free Research Field	発生生物学
Academic Significance and Societal Importance of the Research Achievements	発生時計について多くの点が不明であったが、分節時計について研究が大いに進んだ。マウスの分節周期は約２時間なのに対してヒトは約５時間であることを発見し、その種差の分子機構を明らかにするとともに、神経発生過程の進行速度の種差も同じ機構によることを示した。これら一連の成果は、一般にも大きなインパクトを与え、Nature誌等で解説されるとともに、国内外の多くのマスコミでも報道された。発生過程はドミノ式に進行すると考えられていたが、上記のように厳密に時間を測る発生時計の実体が示され、さらに発生時計が場と連携する過程が明らかになった。神経科学や発生生物学に「革新的・創造的な学術研究の発展」をもたらした。