Preventive medicine through inflammation cellular sociology

2019 Fiscal Year Annual Research Report

• Project Area: Preventive medicine through inflammation cellular sociology
• Project/Area Number: 17H06391
• Research Institution: Tokyo University of Science
• Principal Investigator: 松島 綱治 東京理科大学, 研究推進機構生命医科学研究所, 教授 (50222427)
• Co-Investigator(Kenkyū-buntansha): 橋本 真一 和歌山県立医科大学, 先端医学研究所, 教授 (00313099)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Keywords: 免疫 / 遺伝子 / モデル化 / 情報工学 / 病理学

Outline of Annual Research Achievements

本総括班研究では、包括的single-cell transcriptome、遺伝子発現データ解析、エピゲノム解析、プロテオーム解析、リピドーム解析、マイクロバイオーム解析、遺伝子組換え動物作製を支援する炎症細胞社会解析センターを設置し、領域横断で使用可能な炎症細胞社会の解析プラットフォームを整備し、環境 ストレス、ゲノム社会予防医学、脂質代謝生化学、循環器・肝臓・腎臓臨床医学、分子標的予防医学、計算生物学など多様なバックグランドを持つ研究者の連携を強力に促進することを目的としている。2019度は、オンラインコラボレーションソフトウェアSLACK、オンラインミーティングシステムWebExを通じて情報解析支援チームと計画研究班、公募研究班の連携体制を強化した。また、各計画研究班、公募研究班の疾患モデル解析について、解析対象の設定から単細胞懸濁液の調製、調整した細胞サンプルのquality controlを含めた支援を行い、包括的single-cell transcriptomeをすすめた。これまでに肺、肝臓、腎臓、膵臓、腸管、皮膚などの炎症疾患モデルおよび疾患患者iPS由来細胞などについて包括的single-cell transcriptomeを行い、データを取得している。班会議や共同研究推進委員会などを通じて領域内での情報交換や共同研究を推進するとともに、2019年11月には包括的single-cell transcriptomeを用いた疾患研究を牽引する世界的な研究者を招聘した国際シンポジウムを開催した。また、一般向けの科学コミュニケーション活動「免疫ふしぎ未来」を通じて本学術領域の広報活動を行った。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

2019年度は、計画班、公募班のsingle-cell transcriptome解析のニーズが増加し、これに対応するため総括班が中心となって単一細胞懸濁液の調製が困難な臓器の細胞調製指導・支援を積極的に行った。また、DNAバーコード抗体で細胞サンプルを標識するマルチプレックス解析を実用化しすることで、高額なsingle-cell transcriptome解析のコストのためこれまで困難であった実験群やbiological replicateを増やすことが可能になった。情報解析支援についても、計画班・公募班と、総括班情報解析担当者間で密な連携体制が構築できている。

Strategy for Future Research Activity

引き続き、各計画研究、公募研究を支援する。領域の運営方針、研究支援内容は、年2回開催する班会議にて主に策定するが、必要に応じて随時委員会を開催し、領域代表(総括班研究代表者)の承認のもと、柔軟に対応する。1) Single-cell transcriptome: Nx-1マイクロウェルデバイスおよびRhapsodyシステムを用い、固有のバーコードを持つ1細胞由来cDNA libraryを数千個の細胞について作成し、次世代シーケンサーを用いて各細胞の遺伝子発現情報を取得する。2）　遺伝子発現データ解析: 発現変動遺伝子抽出、GO解析、クラスター解析、パスウェイ解析などを支援する。3） エピゲノム解析: MSD-AFLP法などを用いたDNAメチル化解析、ChIP-seqなどによるヒストン修飾解析を支援する。4) プロテオーム解析: 蛍光標識2次元ディファレンスゲル電気泳動解析システムと質量分析装置(TOF-MS)を用いて標的タンパク質の同定を支援する。 5) リピドーム解析: 液体クロマトグラフィーと三連四重極型質量分析計(TripleQ)を組み合わせたLCMS/MS、ならびに四重極飛行時間型質量分析計(Q-TOF)を用いて、リピドーム解析を支援する。6) マイクロバイオーム解析: 次世代シーケンサーを用いて、細菌叢の16S rRNA遺伝子配列に基づく網羅的解析を行い、腸内 細菌叢遺伝子情報解析を支援する。7) 遺伝子組換え動物作製支援: CRISPR/Cas9などの遺伝子編集技術を用いて、ノックアウトマウス、レポーターマウスの作製を支援する。COVID19が収束しない場合、班会議はオンラインで行い、また公開シンポジウムは実施しない。

Research Products

• [Journal Article] Analyzing Leukocyte Migration Trajectories by Deformable Image Matching (2019)
  • Author(s): Shigeta Hironori、Seno Shigeto、Nishizawa Shino、Uchida Yutaka、Kikuta Junichi、Ishii Masaru、Matsuda Hideo
  • Journal Title: IEEE Xplore Volume: 19243594 Pages: 94-98
  • DOI: 10.1109/BIBE.2019.00025
  • Peer Reviewed / Open Access
• [Journal Article] Single-cell transcriptome analysis of mouse leukocytes in inflammatory stimulation. (2019)
  • Author(s): Osato N, Shigeta H, Seno S, Uchida Y, Kikuta J, Ishii M, Matsuda H.
  • Journal Title: IEEE Xplore Volume: 19351527 Pages: 1229-1231
  • DOI: 10.1109/BIBM47256.2019.8983394
  • Peer Reviewed / Open Access
• [Journal Article] Lipopolysaccharide-induced expansion of histidine decarboxylase-expressing Ly6G+ myeloid cells identified by exploiting histidine decarboxylase BAC-GFP transgenic mice. (2019)
  • Author(s): Takai J, Ohtsu H, Sato A, Uemura S, Fujimura T, Yamamoto M, Moriguchi T.
  • Journal Title: Sci Rep. Volume: 9 Pages: 15603
  • DOI: 10.1038/s41598-019-51716-6
  • Peer Reviewed / Open Access
• [Journal Article] Epidermal loss of phospholipase Cδ1 attenuates irritant contact dermatitis. (2019)
  • Author(s): Shiratori, K., Kanemaru, K., Ogura, T., Nakajima, A., Sugizaki, Y., Fukuyama, T., Iwakura, Y., Nakamura, Y., and Fukami, K.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 511 Pages: 330-335
  • DOI: 10.1016/j.bbrc.2019.02.046
  • Peer Reviewed / Open Access
• [Journal Article] IL-1β plays an important role in pressure overoad-induced atrial fibrillation in mice. (2019)
  • Author(s): Matsushita, N., Ishida, N., Ibi, M., Saito, M., Takahashi, M., Taniguchi, S., Iwakura, Y., Morino, Y., Taira, E., Sawa, Y., and Hirose, M.
  • Journal Title: Biol. Pharm. Bull. Volume: 42 Pages: 543-546
  • DOI: 10.1248/bpb.b18-00363
  • Peer Reviewed / Open Access
• [Journal Article] Spontaneous atopic dermataitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. (2019)
  • Author(s): Schwartz, C., Moran, T., Saunders, S. P., Kaszlikowska, A., Floudas, A., Bom, J., Nunez, G., Iwakura, Y., O’Neill, L., Irvine, A. D., McKenzie, A. N. J., Ogg, G., Walsh, P. T., Demengeot, J., and Fallon, P. G.
  • Journal Title: Allergy Volume: 74 Pages: 1920-1933
  • DOI: 10.1111/all.13801.
  • Peer Reviewed / Open Access
• [Journal Article] Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors. (2019)
  • Author(s): Tang, C., Makusheva, Y., Sun, H., Han, W., and Iwakura, Y.
  • Journal Title: J. Leukoc. Biol. Volume: 106 Pages: 903-917
  • DOI: 10.1002/JLB.2RI0119-031R
  • Peer Reviewed / Open Access
• [Journal Article] Uncoupling the senescence-associated secretory phenotype from cell cycle exit via IL-1 inactivation unveils its pro-tumorigenic role. (2019)
  • Author(s): Lau, L., Porciuncula, A., Yu, A., Iwakura, Y., and David, G.
  • Journal Title: Mol. Cell Biol. Volume: 39 Pages: e00586-18
  • DOI: 10.1128/MCB.00586-18
  • Peer Reviewed / Open Access
• [Journal Article] arge scale cacium imaging of the cerebellar vermis during sensory stimulus unravels two response’s components that differ in their spatiotemporal properties. (2019)
  • Author(s): Byk, H., Huang, G. J., Iwakura, Y., and Yarom, Y.
  • Journal Title: Front. Syst. Neurosci. Volume: 13 Pages: 18
  • DOI: 10.3389/fnsys.2019.00018
  • Peer Reviewed / Open Access
• [Journal Article] CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment. (2019)
  • Author(s): Drummond, R. A., Swamydas, M., Oikonomou, V., Zhai, B., Dambuza, I. M., Schaefer, B. C., Bohrer, A. C., Mayer-Barber, K. D., Lira, S. A., Iwakura, Y., Filler, S. G., Brown, G. D., Hube, B., Naglik, J. R., Hohl, T. M., and Lionakis, M. S.
  • Journal Title: Nat Immunol. Volume: 20 Pages: 559-570
  • DOI: 10.1038/s41590-019-0377-2
  • Peer Reviewed / Open Access
• [Journal Article] Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis. (2019)
  • Author(s): Miyabe, C., Miyabe, Y., Moreno, L., Lian, J., Rahimi, R. A., Miura, N. N., Ohno, N., Iwakura, Y., Kawakami, T., and Luster, A. D.
  • Journal Title: J. Clin. Invest Volume: 130 Pages: 3610-3624
  • DOI: 10.1172/JCI123778
  • Peer Reviewed / Open Access
• [Journal Article] CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis. (2019)
  • Author(s): Blanco-Perez, F., Kato, Y., Gonzalez-Menendez, I., Laino, J., Ohbayashi, M., Burggraf, M., Krause, M., Kirberg, J., Iwakura, Y., Martella, M., Quintanilla-Martinez, L., Shibata, N., Vieths, S., Scheurer, S., and Toda, M.
  • Journal Title: Sci. Rep. Volume: 9 Pages: 9608
  • DOI: 10.1038/s41598-019-45653-7
  • Peer Reviewed / Open Access
• [Journal Article] AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice. (2019)
  • Author(s): Hupa, K. J., Stein, K., Schneider, R., Lysson, M., Schneiker, B., Hornung, V., Latz, E., Iwakura, Y., Kalff, J. C., and Wehner, S.
  • Journal Title: Sci. Rep. Volume: 9 Pages: 10602
  • DOI: 10.1038/s41598-019-46968-1
  • Peer Reviewed / Open Access
• [Journal Article] Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis. (2019)
  • Author(s): Sakurai, K., Dainichi, T., Garcet, S., Tsuchiya, S., Yamamoto, Y., Kitoh, A., Honda, T., Nomura, T., Egawa, G., Otsuka, A., Nakajima, S., Matsumoto, R., Nakano, Y., Otsuka, M., Iwakura, Y., Grinberg-Bleyer, Y., Ghosh, S., Sugimoto, Y., Guttman-Yassky, E., Krueger, J. G., and Kabashima, K.
  • Journal Title: J. Allergy Clin. Immunol. Volume: 144 Pages: 1036-1049
  • DOI: 10.1016/j.jaci.2019.06.019
  • Peer Reviewed / Open Access
• [Journal Article] Defect of interferon γ leads to impaired wound healing through prolonged neutrophilic inflammatory response and enhanced MMP-2 activation. (2019)
  • Author(s): Kanno, E., Tanno, H., Masaki, A., Sasaki, A., Sato, N., Goto, M., Shisai, M., Yamaguchi, K., Takagi, N., Shoji, M., Kitai, Y., Sato, K., Kasamatsu, J., Ishii, K., Miyasaka, T., Kawakami, K., Imai, Y., Iwakura, Y., Maruyama, R., Tachi, M., and Kawakami, K.
  • Journal Title: nt. J. Mol. Sci. Volume: 20 Pages: 5657
  • DOI: 10.3390/ijms20225657
  • Peer Reviewed / Open Access
• [Journal Article] Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, is a potent inhibitor of hepatitis B virus. (2019)
  • Author(s): Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Seimiya T, Suzuki T, Tanaka E, Ishibashi R, Funato K, and Koike K.
  • Journal Title: Hepatology Volume: － Pages: －
  • DOI: 10.1002/hep.30491
  • Peer Reviewed / Open Access
• [Journal Article] Liver stiffness measurements in chronic hepatitis C: treatment evaluation and risk assessment. (2019)
  • Author(s): Nakagomi R, Tateishi R, Masuzaki R, Soroida Y, Iwai T, Kondo M, Fujiwara N, Sato M, Minami T, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Tanaka Y, Otsuka M, Kato N, Moriya K, Ikeda H, Koike K.
  • Journal Title: Gastroenterol Hepatol. Volume: 34 Pages: 921-928
  • DOI: 10.1111/jgh.14530
  • Peer Reviewed / Open Access
• [Journal Article] Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase. (2019)
  • Author(s): Nishimura K(co-first authors), Johmura Y (co-first authors), Deguchi K, Jiang Z, Uchida K, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura S, Kono K, Nakanishi M.
  • Journal Title: Nature Communications. Volume: － Pages: －
  • DOI: 10.1038/s41467-019-08957-w
  • Peer Reviewed / Open Access
• [Journal Article] Identification and isolation of splenic tissue resident macrophage subpopulations by flow cytometry. (2019)
  • Author(s): Fujiyama S, Nakahashi-Oda C, Abe F, Wang Y, Sato K, Shibuya A.
  • Journal Title: Int Immunol. Volume: 31 Pages: 51-56
  • DOI: 10.1093/intimm/dxy064
  • Peer Reviewed / Open Access
• [Journal Article] Serum aldo-keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis. (2019)
  • Author(s): Kanno M, Kawaguchi K, Honda M, Horii R, Takatori H, Shimakami T, Kitamura K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
  • Journal Title: J Gastroenterol. Volume: 54 Pages: 549-557
  • DOI: 10.1007/s00535-019-01551-3
  • Peer Reviewed / Open Access
• [Journal Article] The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study (2019)
  • Author(s): Muller CP, Chu C, Qin L, Liu C, Xu B, Gao H, Ruggeri B, Hieber S, Schneider J, Jia T, Tay N, Akira S, Satoh T, Banaschewski T, Bokde ALW, Bromberg U, Buchel C, Quinlan EB, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Artiges E, Lemaitre H, Nees F, ..., Schumann G.
  • Journal Title: Cerebral Cortex Volume: 29 Pages: 1736-1751
  • DOI: 10.1093/cercor/bhy341
  • Peer Reviewed / Open Access
• [Journal Article] TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity. (2019)
  • Author(s): Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N.
  • Journal Title: Dev Cell. Volume: 48 Pages: 151-166.e7
  • DOI: 10.1016/j.devcel.2018.12.002
  • Peer Reviewed / Open Access
• [Journal Article] Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. (2019)
  • Author(s): Brenner D, Sieverding K, Bruno C, Luningschror P, Buck E, Mungwa S, Fischer L, Brockmann SJ, Ulmer J, Bliederhauser C, Philibert CE, Satoh T, Akira S, Boillee S, Mayer B, Sendtner M, Ludolph AC, Danzer KM, Lobsiger CS, Freischmidt A, Weishaupt JH.
  • Journal Title: J Exp Med. Volume: 216 Pages: 267-278
  • DOI: 10.1084/jem.20180729
  • Peer Reviewed / Open Access
• [Journal Article] USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation. (2019)
  • Author(s): Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, He Z, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T, Matsuura Y.
  • Journal Title: J Virol. Volume: 93 Pages: e01708-18
  • DOI: 10.1128/JVI.01708-18
  • Peer Reviewed / Open Access
• [Journal Article] Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma. (2019)
  • Author(s): Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
  • Journal Title: Exp Mol Pathol. Volume: 106 Pages: 78-88
  • DOI: 10.1016/j.yexmp.2018.11.013
  • Peer Reviewed / Open Access
• [Journal Article] Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema. (2019)
  • Author(s): Kazushige Shiraishi, Shigeyuki Shichino, Tatsuya Tsukui, Shinichi Hashimoto, Satoshi Ueha, and Kouji Matsushima.
  • Journal Title: Sci Rep. Volume: 9 Pages: 3657
  • DOI: 10.1038/s41598-019-40237-x
  • Peer Reviewed / Open Access
• [Journal Article] Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice. (2019)
  • Author(s): Chen CY, Ueha S, Ishiwata Y, Yokochi S, Yang D, Oppenheim JJ, Ogiwara H, Shichino S, Deshimaru S, Shand FH, Shibayama S, Matsushima K.
  • Journal Title: J Immunother. Volume: 7 Pages: 21
  • DOI: 10.1186/s40425-019-0503-6
  • Peer Reviewed / Open Access
• [Journal Article] A dendritic cell-based systemic vaccine induces long-lived lung-resident memory Th17 cells and ameliorates pulmonary mycosis. (2019)
  • Author(s): Ueno, K., Urai, M., Sadamoto, S., Shinozaki, M., Takatsuka, S., Abe, M., Otani, Y., Yanagihara, N., Shimizu, K., Iwakura, Y., Shibuya, K., Miyazaki, Y., and Kinjo, Y.
  • Journal Title: Mucosal Immunol. Volume: 12 Pages: 265-276
  • DOI: 10.1371/journal.pone.0220989
  • Peer Reviewed / Open Access
• [Journal Article] Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells. (2019)
  • Author(s): Yamada T, Nabe S, Toriyama K, Inoue K, Imai Y, Shiraishi A, Takenaka K, Yasukawa M, Yamashita M.
  • Journal Title: J. Immunol. Volume: 202 Pages: 1088-1098
  • DOI: 10.4049/jimmunol.1801083
  • Peer Reviewed / Open Access
• [Journal Article] Toxicological Evaluation of SiO2 Nanoparticles by Zebrafish Embryo Toxicity Test. (2019)
  • Author(s): Vranic S, Shimada Y, Ichihara S, Kimata M, Wu W, Tanaka T, Boland S, Tran L, Ichihara G.
  • Journal Title: Int J Mol Sci. Volume: 20 Pages: 882
  • DOI: 10.3390/ijms20040882
  • Peer Reviewed / Open Access
• [Journal Article] Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation. (2019)
  • Author(s): Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, Miura K, …, Takashima S.
  • Journal Title: Circulation Volume: 139 Pages: 2157-2169
  • DOI: 10.1161/CIRCULATIONAHA.118.036761
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics of Japanese Patients with Nonvalvular Atrial Fibrillation on Anticoagulant Treatment: A Descriptive Analysis of J-dabigatran Surveillance and JAPAF Study. (2019)
  • Author(s): Koretsune Y, Kusakawa K, Harada KH, Koizumi A, Uchiyama S, Atarashi H, Okumura K, Yasaka M, Yamashita T, Taniguchi A, Fukaya T, Inoue H; for J-dabigatran surveillance and JAPAF study investigators.
  • Journal Title: Cardiol Ther. Volume: 8 Pages: 43-54
  • DOI: 10.1007/s40119-019-0129-2
  • Peer Reviewed / Open Access
• [Journal Article] Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis. (2019)
  • Author(s): Okazaki S, Morimoto T, Kamatani Y, Kamimura T, Kobayashi H, Harada K, Tomita T, Higashiyama A, Takahashi JC, Nakagawara J, Koga M, Toyoda K, Washida K, Saito S, Takahashi A, Hirata M, Matsuda K, Mochizuki H, Chong M, Pare G, O’Donnell M, Ago T, Hata J, Ninomiya T, Dichgans M, …, Kubo M, Koizumi A, Ihara M.
  • Journal Title: Circulation. Volume: 139 Pages: 295-298
  • DOI: 10.1161/CIRCULATIONAHA.118.038439
  • Peer Reviewed / Open Access
• [Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex. (2019)
  • Author(s): Murayama Y, Yahagi N, Takeuchi Y, Aita Y, Mehrazad Saber Z, Wada N, Li E, Piao X, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Miyamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.
  • Journal Title: FEBS Lett. Volume: 593 Pages: 423-432
  • DOI: 10.1002/1873-3468.13328
  • Peer Reviewed / Open Access
• [Journal Article] Role of eosinophils in a murine model of inflammatory bowel disease. (2019)
  • Author(s): Wang Z, Adachi S, Kong L, Watanabe D, Nakanishi Y, Ohteki T, Hoshi N, Kodama Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 511 Pages: 99-104
  • DOI: 10.1016/j.bbrc.2019.02.056
  • Peer Reviewed / Open Access
• [Journal Article] Transcriptome network analysis identifies protective role of the LXR-SREBP-1c axis in murine pulmonary fibrosis. (2019)
  • Author(s): Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, Kosugi-Kanaya M, Shand FH, Inagaki Y, Shimano H, Matsushima K.
  • Journal Title: JCI Insight. Volume: 4 Pages: e122163
  • DOI: 10.1172/jci.insight.122163.
  • Peer Reviewed / Open Access
• [Remarks] 予防を科学する炎症細胞社会学ホームページ
  • URL: http://inflammationcellularsociology.org/
• [Funded Workshop] 文部科学省新学術領域研究 予防を科学する炎症細胞社会学 1st International Symposium on Inflammation Cellular Sociology（第1回国際シンポジウム） (2019)