Preventive medicine through inflammation cellular sociology

2020 Fiscal Year Annual Research Report

• Project Area: Preventive medicine through inflammation cellular sociology
• Project/Area Number: 17H06391
• Research Institution: Tokyo University of Science
• Principal Investigator: 松島 綱治 東京理科大学, 研究推進機構生命医科学研究所, 教授 (50222427)
• Co-Investigator(Kenkyū-buntansha): 橋本 真一 和歌山県立医科大学, 先端医学研究所, 教授 (00313099) ; 藤渕 航 京都大学, iPS細胞研究所, 教授 (60273512)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Keywords: 免疫 / 遺伝子 / モデル化 / 情報工学 / 病理学

Outline of Annual Research Achievements

本総括班研究では、包括的single-cell transcriptome、遺伝子発現データ解析、エピゲノム解析、プロテオーム解析、リピドーム解析、マイクロバイオーム解析、遺伝子組換え動物作製を支援する炎症細胞社会解析センターを設置し、領域横断で使用可能な炎症細胞社会の解析プラットフォームを整備し、環境 ストレス、ゲノム社会予防医学、脂質代謝生化学、循環器・肝臓・腎臓臨床医学、分子標的予防医学、計算生物学など多様なバックグランドを持つ研究者の連携を強力に促進することを目的としている。2020年度は、オンラインコラボレーションソフトウェアSLACK、オンラインミーティングシステムZoomを通じて情報解析支援チームと計画研究班、公募研究班の連携を深めた。また、各計画研究班、公募研究班の疾患モデル解析について、解析対象の設定から単細胞懸濁液の調製、調整した細胞サンプルのquality controlを含めた支援を行い、包括的single-cell transcriptomeをすすめた。1細胞のT cell receptor alpha/beta遺伝子の配列決定とtranscriptome解析を同時に行うSingle-cell TCR/RNA seq技術を確立した。Single-cell transcriptomeデータの基本的な解析結果をwetの研究者が簡便に確認するための自動レポート作成プログラムを作成した。COVID19の影響もあり、班会議はZoomを用いたwebミーティング形式とした。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

2020年度は、計画班、公募班のsingle-cell transcriptome解析のニーズが増加し、これに対応するため総括班が中心となって単一細胞懸濁液の調製が困難な臓器の細胞調製指導・支援を積極的に行った。また、凍結保存検体を用いたSCT解析を検討し、臓器ごとに凍結・解凍により頻度が変わる細胞群が存在するものの、実用的なデータが取得出来ることを化確認し、凍結保存検体を用いた支援を開始した。当初の計画を超えて、scTCR/RNA seqの実用化は本領域の推進に大きく貢献するものであり、また自動レポート作成プログラムの作成により総括班支援の省力化が可能になった。

Strategy for Future Research Activity

引き続き、各計画研究、公募研究を支援する。領域の運営方針、研究支援内容は、年2回開催する班会議にて主に策定するが、必要に応じて随時委員会を開催し、領域代表(総括班研究代表者)の承認のもと、柔軟に対応する。1) Single-cell transcriptome: Nx-1マイクロウェルデバイスおよびRhapsodyシステムを用い、固有のバーコードを持つ1細胞由来cDNA libraryを数千個の細胞について作成し、次世代シーケンサーを用いて各細胞の遺伝子発現情報を取得する。2）　Rhapsodyシステムを用いscTCR/RNA seq解析支援を行う。３）細胞核を用いた1細胞遺伝子発現解析支援を行う。５）計画班・公募班の支援ニーズに合わせて臓器からの細胞調製支援をおこなう。５）遺伝子発現データ解析: 発現変動遺伝子抽出、GO解析、クラスター解析、パスウェイ解析、SeqGeqによるWet研究者自身によるSCTデータ解析などを支援する。COVID19が収束しない場合、班会議および国際シンポジウムはWeb開催とする。研究成果はホームページを通じて積極的に発信する。

Research Products

• [Journal Article] D-Serine inhibits the attachment and biofilm formation of methicillin-resistant Staphylococcus aureus. (2021)
  • Author(s): Iwata Y, Sakai N, Yoneda I, Senda Y, Sakai-Takemori Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Furuichi K, Matsushima K, Wada T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 537 Pages: 50-56
  • DOI: 10.1016/j.bbrc.2020.12.078
  • Peer Reviewed / Open Access
• [Journal Article] TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis. (2021)
  • Author(s): Suzuki N, Johmura Y, Wang TW, Migita T, Wu W, Noguchi R, Yamaguchi K, Furukawa Y, Nakamura S, Miyoshi I, Yoshimori T, Ohta T, Nakanishi M.
  • Journal Title: Autophagy. Volume: - Pages: 1-18
  • DOI: 10.1080/15548627.2021.1897961.
  • Peer Reviewed / Open Access
• [Journal Article] Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders. (2021)
  • Author(s): Johmura Y, Yamanaka T, Omori S, Wang TW, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S, Yamaguchi K, Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama KI, Furukawa Y, Imoto S, Nakanishi M.
  • Journal Title: Science. Volume: 371 Pages: 265-270
  • DOI: 10.1126/science.abb5916.
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac macrophages prevent sudden death during heart stress. (2021)
  • Author(s): Sugita J, Fujiu K, Nakayama Y, Matsubara T, Matsuda J, Oshima T, Liu Y, Maru Y, Hasumi E, Kojima T, Seno H, Asano K, Ishijima A, Tomii N, Yamazaki M, Kudo F, Sakuma I, Nagai R, Manabe I, Komuro I.
  • Journal Title: Nat Commun. Volume: 12 Pages: 1910-1910
  • DOI: 10.1038/s41467-021-22178-0.
  • Peer Reviewed / Open Access
• [Journal Article] Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH. (2021)
  • Author(s): Kanamori Y, Tanaka M, Itoh M, Ochi K, Ito A, Hidaka I, Sakaida I, Ogawa Y, Suganami T.
  • Journal Title: iScience. Volume: 24 Pages: 102032-102032
  • DOI: 10.1016/j.isci.2020.102032.
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors. (2021)
  • Author(s): Takashi Sekiya, Shizuko Kagawa, Katsunori Masaki, Koichi Fukunaga, Akihiko Yoshimura, Satoshi Takaki .
  • Journal Title: iScience. Volume: 24 Pages: 102166-102166
  • DOI: 10.1016/j.isci.2021.102166.
  • Peer Reviewed / Open Access
• [Journal Article] LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH. (2021)
  • Author(s): Takata N, Ishii K, Takayama H, Nagashimada M, Kamoshita K, Tanaka T, Kikuchi A, Takeshita Y, Matsumoto Y, Ota T, Yamamoto Y, SYamagoe S, Seki A, Sakai Y, Kaneko S, Takamura T.
  • Journal Title: Sci Rep. Volume: 11 Pages: 555-555
  • DOI: 10.1038/s41598-020-80689-0.
  • Peer Reviewed / Open Access
• [Journal Article] Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double-blind, randomised, two-by-two factorial design trial. (2021)
  • Author(s): Ishikawa H, Mutoh M, Sato Y, Doyama H, Tajika M, Tanaka S, Horimatsu T, Takeuchi Y, Kashida H, Tashiro J, Ezoe Y, Nakajima T, Ikematsu H, Hori S, Suzuki S, Otani T, Takayama T, Ohda Y, Mure K, Wakabayashi K, Sakai T.
  • Journal Title: Lancet Gastroenterol Hepatol. Volume: 6 Pages: 474-481
  • DOI: 10.1016/s2468-1253(21)00018-2.
  • Peer Reviewed
• [Journal Article] Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling (2021)
  • Author(s): Hamoya T, Fujii G, Iizumi Y, Narita T, Komiya M, Matsuzawa Y, Miki K, Kondo T, Kishimoto S, Watanabe K, Wakabayashi K, Sakai T, Toshima J, Mutoh M.
  • Journal Title: Carcinogenesis. Volume: 42 Pages: 148-158
  • DOI: 10.1093/carcin/bgaa084.
  • Peer Reviewed / Open Access
• [Journal Article] γ-Glutamylcyclotransferase, a novel regulator of HIF-1α expression, triggers aerobic glycolysis. (2021)
  • Author(s): Taniguchi K, Kageyama S, Moyama C, Ando S, Ii H, Ashihara E, Horinaka M, Sakai T, Kubota S, Kawauchi A, Nakata S.
  • Journal Title: Cancer Gene Ther. Volume: - Pages: -
  • DOI: 10.1038/s41417-020-00287-0.
  • Peer Reviewed
• [Journal Article] Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2 (2021)
  • Author(s): Watanabe M, Yamada Y, Kurumida Y, Kameda T, Sukeno M, Iizuka-Ohashi M, Sowa Y, Iizumi Y, Takakura H, Miyamoto S, Sakai T, Mutoh M.
  • Journal Title: Cancers. Volume: 13 Pages: 982-982
  • DOI: 10.3390/cancers13050982.
  • Peer Reviewed / Open Access
• [Journal Article] Establishment of bioluminescent imaging model using murine T cell lymphoma susceptive to NK cell-dependent immune-surveillance. (2021)
  • Author(s): Fujiwara T, Miyazato K, Takahashi K, Hayakawa Y.
  • Journal Title: J Immunol Methods. Volume: 491 Pages: 112993-112993
  • DOI: 10.1016/j.jim.2021.112993.
  • Peer Reviewed
• [Journal Article] Transient Depletion of CD4 + Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer. (2021)
  • Author(s): Aoki H, Ueha S, Shichino S, Ogiwara H, Shitara K, Shimomura M, Suzuki T, Nakatsura T, Yamashita M, Kitano S, Kuroda S, Wakabayashi M, Kurachi M, Ito S, Doi T, Matsushima K.
  • Journal Title: Cancer Immunol Res. Volume: - Pages: -
  • DOI: 10.1158/2326-6066.CIR-20-0989.
  • Peer Reviewed / Open Access
• [Journal Article] UBC13 is an RNF213-associated E2 ubiquitin-conjugating enzyme, and Lysine 63-linked ubiquitination by the RNF213UBC13 axis is responsible for angiogenic activity. (2021)
  • Author(s): Habu T, Harada K
  • Journal Title: FASEB Bioadv. Volume: 3 Pages: 243-258
  • DOI: 10.1096/fba.2019-00092
  • Peer Reviewed / Open Access
• [Journal Article] RNF213 as a Susceptibility Gene for Moyamoya Disease has Multifunctional Roles in Biological Processes. (2021)
  • Author(s): Hatasu Kobayashi, Kouji H. Harada, Toshiyuki Habu, Yasuhisa Nakamura, Jiyeong Kim, Akio Koizumi.
  • Journal Title: Moyamoya Disease: Current Knowledge and Future Perspectives. Volume: - Pages: 47-60
  • DOI: 10.1007/978-981-33-6404-2_4
  • Peer Reviewed
• [Journal Article] Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo. (2020)
  • Author(s): Omori S, Wang TW, Johmura Y, Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, .…..., Iwasaki K, Miyoshi C, Funato H, Yanagisawa M, Ueno H, Imoto S, Furukawa Y, Yoshida N, Matsushima K, Ueda HR, Miyajima A, Nakanishi M.
  • Journal Title: Cell Metab. Volume: 32 Pages: 814-828
  • DOI: 10.1016/j.cmet.2020.09.006.
  • Peer Reviewed / Open Access
• [Journal Article] A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation. (2020)
  • Author(s): Nakayama Y, Fujiu K, Yuki R, Oishi Y, Morioka MS, Isagawa T, Matsuda J, Oshima T, Matsubara T, Sugita J, Kudo F, Kaneda A, Endo Y, Nakayama T, Nagai R, Komuro I, Manabe I.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 117 Pages: 14365-14375
  • DOI: 10.1073/pnas.2005924117.
  • Peer Reviewed / Open Access
• [Journal Article] Organ System Crosstalk in Cardiometabolic Disease in the Age of Multimorbidity. (2020)
  • Author(s): Oishi Y, Manabe I.
  • Journal Title: Front Cardiovasc Med. Volume: 7 Pages: 64-64
  • DOI: 10.3389/fcvm.2020.00064.
  • Peer Reviewed / Open Access
• [Journal Article] Human Cell Atlas and cell-type authentication for regenerative medicine. (2020)
  • Author(s): Yulia Panina, Peter Karagiannis, Andreas Kurtz, Glyn N. Stacey, Wataru Fujibuchi.
  • Journal Title: Exp Mol Med. Volume: 52 Pages: 1443-1451
  • DOI: 10.1038/s12276-020-0421-1.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Proteomic analysis of liver proteins of mice exposed to 1,2-dichloropropane. (2020)
  • Author(s): Zhang X, Morikawa K, Mori Y, Zong C, Zhang L, Garner E, Huang C, Wu W, Chang J, Nagashima D, Sakurai T, Ichihara S, Oikawa S, Ichihara G.
  • Journal Title: Arch Toxicol. Volume: 94 Pages: 2691-2705
  • DOI: 10.1007/s00204-020-02785-4.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury. (2020)
  • Author(s): Tanaka M, Saka-Tanaka M, Ochi K, Fujieda K, Sugiura Y, Miyamoto T, Kohda H, Ito A, Miyazawa T, Matsumoto A, Aoe S, Miyamoto Y, Tsuboi N, Maruyama S, Suematsu M, Yamasaki S, Ogawa Y, Suganami T.
  • Journal Title: J Exp Med. Volume: 217 Pages: e20192230
  • DOI: 10.1084/jem.20192230.
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine. (2020)
  • Author(s): Sato T, Sase M, Ishikawa S, Kajita M, Asano J, Sato T, Mori Y, Ohteki T.
  • Journal Title: Sci Rep. Volume: 10 Pages: 8308
  • DOI: 10.1038/s41598-020-64987-1.
  • Peer Reviewed / Open Access
• [Journal Article] Pathogenicity Characterization of Prevalent-Type Streptococcus dysgalactiae subsp. equisimilis Strains. (2020)
  • Author(s): Matsue M, Ogura K, Sugiyama H, Miyoshi-Akiyama T, Takemori-Sakai Y, Iwata Y, Wada T, Okamoto S.
  • Journal Title: Front Microbiol. Volume: 11 Pages: 97
  • DOI: 10.3389/fmicb.2020.00097.
  • Peer Reviewed / Open Access
• [Journal Article] The increased frequency of methicillin-resistant Staphylococcus aureus with low MIC of beta-lactam antibiotics isolated from hospitalized patients. (2020)
  • Author(s): Iwata Y, Sakai N, Yoneda I, Satou K, Furuichi K, Senda Y, Sakai-Takemori Y, Wada T, Fujita S, Ogura H, ......, Miyagawa T, Hara A, Shimizu M, Sakai Y, Ikeo K, Shichino S, Ueha S, Nakajima T, Matsushima K, Wada T.
  • Journal Title: J Infect Chemother. Volume: 26 Pages: 604-610
  • DOI: 10.1016/j.jiac.2020.01.016.
  • Peer Reviewed / Open Access
• [Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice. (2020)
  • Author(s): Matsuzaka T, Kuba M, Koyasu S, Yamamoto Y, Motomura K, Arulmozhiraja S, Ohno H, Sharma R, Shimura T, Okajima Y, Han SI, ....., Suzuki H, Sone H, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H.
  • Journal Title: Hepatology. Volume: 71 Pages: 1609-1625
  • DOI: 10.1002/hep.30953.
  • Peer Reviewed / Open Access
• [Journal Article] Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition. (2020)
  • Author(s): Nakagawa Y, Wang Y, Han SI, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano H.
  • Journal Title: Cell Mol Gastroenterol Hepatol. Volume: 11 Pages: 949-971
  • DOI: 10.1016/j.jcmgh.2020.11.004.
  • Peer Reviewed / Open Access
• [Journal Article] CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms. (2020)
  • Author(s): Satoh A, Han SI, Araki M, Nakagawa Y, Ohno H, Mizunoe Y, Kumagai K, Murayama Y, Osaki Y, Iwasaki H, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Sone H, Shimano H.
  • Journal Title: iScience. Volume: 23 Pages: 100930-100930
  • DOI: 10.1016/j.isci.2020.100930.
  • Peer Reviewed / Open Access
• [Journal Article] Deactivation of Glutaminolysis Sensitizes PIK3CA-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition. (2020)
  • Author(s): Boku S, Watanabe M, Sukeno M, Yaoi T, Hirota K, Iizuka-Ohashi M, Itoh K, Sakai T.
  • Journal Title: Cancers. Volume: 12 Pages: 1097-1097
  • DOI: 10.3390/cancers12051097.
  • Peer Reviewed / Open Access
• [Journal Article] The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA. (2020)
  • Author(s): Sugimoto Y, Katsumi Y, Iehara T, Kaneda D, Tomoyasu C, Ouchi K, Yoshida H, Miyachi M, Yagyu S, Kikuchi K, Tsuchiya K, Kuwahara Y, Sakai T, Hosoi H.
  • Journal Title: Mol Cancer Ther. Volume: 19 Pages: 1992-2000
  • DOI: 10.1158/1535-7163.MCT-20-0243.
  • Peer Reviewed
• [Journal Article] Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS-mutated ovarian cancer cells with high AXL expression. (2020)
  • Author(s): Umemura S, Sowa Y, Iizumi Y, Kitawaki J, Sakai T.
  • Journal Title: Cancer Sci. Volume: 111 Pages: 2052-2061
  • DOI: 10.1111/cas.14414.
  • Peer Reviewed / Open Access
• [Journal Article] Very Long-Term Treatment with a Lactobacillus Probiotic Preparation, Lactobacillus casei Strain Shirota, Suppresses Weight Loss in the Elderly. (2020)
  • Author(s): Mutoh M, Yoshimura K, Fujii G, Nakamura T, Takeshita T, Wakabayashi K, Sakai T, Ishikawa H.
  • Journal Title: Nutrients. Volume: 12 Pages: 1599-1599
  • DOI: 10.3390/nu12061599.
  • Peer Reviewed / Open Access
• [Journal Article] Anti-Metastatic Effects of Curcumin Analogues in a Mouse Breast Cancer Model. (2020)
  • Author(s): Ucche S, Murwanti R, Ritmaleni, Hayakawa Y.
  • Journal Title: BPB Reports. Volume: 3 Pages: 76-79
  • DOI: 10.1248/bpbreports.3.2_76.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pharmacological targeting of natural killer cells for cancer immunotherapy. (2020)
  • Author(s): Miyazato K, Hayakawa Y.
  • Journal Title: Cancer Sci. Volume: 111 Pages: 1869-1875
  • DOI: 10.1111/cas.14418.
  • Peer Reviewed / Open Access
• [Journal Article] Antimetastatic effects of thalidomide by inducing the functional maturation of peripheral natural killer cells (2020)
  • Author(s): Miyazato K, Tahara H, Hayakawa Y.
  • Journal Title: Cancer Sci. Volume: 111 Pages: 2770-2778
  • DOI: 10.1111/cas.14538.
  • Peer Reviewed / Open Access
• [Journal Article] Anti‑inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. (2020)
  • Author(s): Hardianti B, Umeyama L, Li F, Yokoyama S, Hayakawa Y.
  • Journal Title: Mol Med Rep. Volume: 22 Pages: 5385-5391
  • DOI: 10.3892/mmr.2020.11615.
  • Peer Reviewed / Open Access
• [Journal Article] Anti-inflammatory effect of fermented brown rice and rice bran with Aspergillus oryzae on mice. (2020)
  • Author(s): Umeyama L, Kasahara S, Sugawara M, Yokoyama S, Saiki I, Hayakawa Y.
  • Journal Title: Traditional & Kampo Medicine. Volume: 8 Pages: 60-65
  • DOI: 10.1002/tkm2.1270.
  • Peer Reviewed / Open Access
• [Journal Article] Anti-metastatic Effects of Baicalein by Targeting STAT3 Activity in Breast Cancer Cells. (2020)
  • Author(s): Susmitha Gorrepotu D, Miyazato K, Ogura K, Yokoyama S, Hayakawa Y.
  • Journal Title: Biol Pharm Bull. Volume: 43 Pages: 1899-1905
  • DOI: 10.1248/bpb.b20-00571.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus. (2020)
  • Author(s): Y. Iwata, K. Satou, K. Furuichi, I. Yoneda T. Matsumura, ....., S. Ueha, T. Nakajima, K. Matsushima, S. Kaneko, T. Wada.
  • Journal Title: Int J Infect Dis. Volume: 91 Pages: 22-31
  • DOI: 10.1016/j.ijid.2019.11.003.
  • Peer Reviewed / Open Access
• [Journal Article] Tracking and Analysis of FUCCI-Labeled Cells Based on Particle Filters and Time-to-Event Analysis. (2020)
  • Author(s): Fujimoto, K., Seno, S., Shigeta, H., Mashita, T., Ishii, M., Matsuda, H.
  • Journal Title: Int J Biosci Biochem Bioinforma. Volume: 10 Pages: 94-109
  • DOI: 10.17706/ijbbb.2020.10.2.94-109.
  • Peer Reviewed / Open Access
• [Journal Article] Glycolysis and subsequent mevalonate biosynthesis play an important role in Th2 cell differentiation. (2020)
  • Author(s): Yagi Y, Kuwahara M, Suzuki J, Imai Y and Yamashita M.
  • Journal Title: Biochem Biophys Res Commun. Volume: 530 Pages: 355-361
  • DOI: 10.1016/j.bbrc.2020.08.009.
  • Peer Reviewed / Open Access
• [Journal Article] T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. (2020)
  • Author(s): Toriyama K, Kuwahara M, Kondoh H, Mikawa T, Takemori N, Konishi A, Yorozuya T, Yamada T, Soga T, Shiraishi A, Yamashita M.
  • Journal Title: Commun Biol. Volume: 3 Pages: 394-394
  • DOI: 10.1038/s42003-020-01122-w.
  • Peer Reviewed / Open Access
• [Journal Article] Composition Proposal Generation for Manga Creation Support. (2020)
  • Author(s): Hironori Ito, Yasuhito Asano.
  • Journal Title: IEICE Trans. Inf. Syst. Volume: 103-D Pages: 949-957
  • Peer Reviewed / Open Access
• [Book] 脂質メディエーターによるマスト細胞とアレルギー炎症の制御, アレルギーの臨床, 41 (2) (2021)
  • Author(s): 村上誠
  • Total Pages: 13-16
  • Publisher: 北隆館
• [Book] ＴＨＥ創薬 -少資源国家にっぽんの生きる道- (2021)
  • Author(s): 酒井敏行
  • Total Pages: 63-77
  • Publisher: 薬事日報社
• [Book] 脂質とアレルギー疾患, アレルギー, 69 (4) (2020)
  • Author(s): 村上誠
  • Total Pages: 250-255
  • Publisher: 一般社団法人 日本アレルギー学会
• [Book] 腸内細菌代謝産物による腎臓病の治療薬開発, ヒトマイクロバイオーム, Vol.2 (2020)
  • Author(s): 岩田恭宜・中出祐介・和田隆志
  • Total Pages: 361-365
  • Publisher: エヌ・ティー・エス
• [Remarks] 予防を科学する炎症細胞社会学ホームページ
  • URL: http://inflammationcellularsociology.org/