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2012 Fiscal Year Final Research Report

Management for Molecular Science of Fluctuations toward Biological Functions

Administrative Group

  • PDF
Project AreaMolecular Science of Fluctuations toward Biological Functions
Project/Area Number 20107001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKyoto University

Principal Investigator

TERAZIMA Masahide  京都大学, 大学院・理学研究科, 教授 (00188674)

Co-Investigator(Kenkyū-buntansha) KATAOKA Mikio  奈良先端科学技術大学院大学, 物質創成科学研究科 (30150254)
UEOKA Ryuichi  崇城大学, 生物生命学部, 教授 (70099076)
OKAMOTO Yuko  名古屋大学, 大学院・理学研究科, 教授 (70185487)
KATO Koichi  大学共同利用機関法人自然科学研究機構, 岡崎統合バイオサイエンスセンター, 教授 (20211849)
HOHSAKA Takahiro  北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 教授 (30263619)
HIRATA Fumio  分子科学研究所, 理論・計算分子科学研究領域, 教授 (90218785)
KUWAJIMA Kunihiro  大学共同利用機関法人自然科学研究機構, 岡崎統合バイオサイエンスセンター, 教授 (70091444)
Project Period (FY) 2008-11-13 – 2014-03-31
Keywords揺らぎ / 生体分子 / 反応 / 機能
Research Abstract

To accomplish the project for revealing the relationship between the fluctuation and biological function, we performed following activities. Information on research progress among members were exchanged through the web page and the collaborative researches were encouraged. Advisory meetings were held many times and future direction of the researches was discussed. Many international and domestic symposiums were organized. For educational campaign, review books were edited and published.

  • Research Products

    (23 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (8 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] The molten globule of β(2)-microglobulin accumulated at pH 4 and its role in protein folding2013

    • Author(s)
      A. Mukaiyama, T. Nakamura, K. Makabe, K. Maki, Y. Goto, K. Kuwajima
    • Journal Title

      J. Mol. Biol.

      Volume: 425 Pages: 273-291

    • DOI

      DOI:10.1016/j.jmb.2012.11.002

    • Peer Reviewed
  • [Journal Article] Time-Resolved Tracking of Interprotein Signal Transduction: Synechocystis PixD-PixE complex as a Sensor of Light Intensity2012

    • Author(s)
      K. Tanaka, Y. Nakasone, K. Okajima, M. Ikeuchi, S. Tokutomi, M. Terazima
    • Journal Title

      J.Am.Chem.Soc

      Volume: 134 Pages: 8336-8339

    • DOI

      DOI:10.1021/ja301540r

    • Peer Reviewed
  • [Journal Article] temperature and pressure dependence of complex systems2012

    • Author(s)
      Generalized-ensemble algorithms for studying Y. Mori, Y. Okamoto
    • Journal Title

      Molecular Simulation

      Volume: 38 Pages: 452-457

    • DOI

      DOI:10.1080/08927022.2011.651139

    • Peer Reviewed
  • [Journal Article] Protein encapsulation within synthetic molecular hosts2012

    • Author(s)
      D. Fujita, M. Yagi-Utsumi, Y. Yamaguchi, Takashi Kumasaka, Masaki Takata, M. Noda, S. Uchiyama, K.Kato, M. Fujita et al.
    • Journal Title

      Nature Commun

      Volume: 3 Pages: 1093-

    • DOI

      DOI:10.1038/ncomms2093

    • Peer Reviewed
  • [Journal Article] Watching a signaling protein function in real time via 100-ps time-resolved Laue crystallography2012

    • Author(s)
      F. Schotte, H. Sun Cho, V. R. I. Kaila, H. Kamikubo, N. Dashdorj, E. R. Henry, T. J. Graber, M. Kataoka, P. A. Anfinrud
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Pages: 19256-19261

    • DOI

      DOI:10.1073/pnas.1210938109

    • Peer Reviewed
  • [Journal Article] Selective accumulation and growth inhibition of hybrid liposomes to human hepatocellular carcinoma cells in relation to fluidity of plasma membranes2012

    • Author(s)
      Y. Komizu, H. Ueoka, R. Ueoka, Biochem
    • Journal Title

      Biophys. Res. Commun

      Volume: 418 Pages: 81-86

    • DOI

      DOI:10.1016/j.bbrc.2011.12.134

    • Peer Reviewed
  • [Journal Article] Solvent and Salt Effects on Structural Stability of Human Telomere2011

    • Author(s)
      Y. Maruyama, T. Matsushita, R. Ueoka, F. Hirata
    • Journal Title

      J. Phys. Chem. B

      Volume: 115 Pages: 2408-2416

    • DOI

      DOI:10.1021/jp1096019

    • Peer Reviewed
  • [Journal Article] Position-specific incorporation of fluorescent non-natural amino acids into maltose-binding protein for detection of ligand binding by FRET and fluorescence quenching2009

    • Author(s)
      I. Iijima, T. Hohsaka
    • Journal Title

      Chem Bio Chem

      Volume: 10 Pages: 999-1006

    • DOI

      DOI:10.1002/cbic.200800703

    • Peer Reviewed
  • [Presentation] Molecular mechanisms of cytotoxicity of HAMLET and other protein-oleic acid complexes2012

    • Author(s)
      K. Kuwajima
    • Organizer
      12th KIAS Conference on Protein Structure
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20121011-13
  • [Presentation] Ligand Binding by Protein Probed with the 3D-RISM Microscope2012

    • Author(s)
      F. Hirata
    • Organizer
      The ACS Symposium on "Continuum Solvation Modeling in Biological Systems
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      20120819-23
  • [Presentation] Membrane-Targeted Nanotherapy with Hybrid Liposomes for Cancer Cells Leading to Apoptosis2012

    • Author(s)
      Y. Matsumoto, R. Ueoka
    • Organizer
      The International Conference on Statistical Mechanics of Liquids: From Water to Biomolecules
    • Place of Presentation
      岡崎,日本
    • Year and Date
      20120212-14
  • [Presentation] Generalized-ensemble algorithms for classical and quantum simulations2012

    • Author(s)
      Y. Okamoto
    • Organizer
      International Workshop on Recent Advances in Computational and Theoretical Chemistry
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2012-11-09
  • [Presentation] Protein dynamics and hydration water2012

    • Author(s)
      M. Kataoka
    • Organizer
      10th International Conference on Quasielastic Neutron Scattering
    • Place of Presentation
      Nikko, Japan
    • Year and Date
      2012-10-04
  • [Presentation] 非天然アミノ酸の導入によるタンパク質の部位特異的PEG化2012

    • Author(s)
      渡邉 貴嘉・山口 純・芳坂 貴弘
    • Organizer
      第6回バイオ関連化学シンポジウム
    • Place of Presentation
      札幌, 日本
    • Year and Date
      2012-09-06
  • [Presentation] NMR analysis of specific carbohydrate-carbohydrate interaction between gangliosides2012

    • Author(s)
      Y. Uekusa, S. Sonnino, K. Kato
    • Organizer
      26 International Carbohydrate Symposium
    • Place of Presentation
      Madrid, スペイン
    • Year and Date
      2012-07-25
  • [Presentation] A strange reaction of a photosensor protein: PixD2011

    • Author(s)
      M.Terazima
    • Organizer
      Third Korea-Japan Seminars on Biomolecular Sciences
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      20110226-0301
  • [Book] アミロイド蓄積開始機構の解明と治療薬開発への展開2012

    • Author(s)
      柳澤勝彦, 松崎勝巳, 加藤晃一
    • Total Pages
      138-158
    • Publisher
      最新医学, 67
  • [Book] Protein dynamics studied by neutron incoherent scattering2011

    • Author(s)
      M. Kataoka, H.Nakagawa
    • Total Pages
      517-538
    • Publisher
      Neutrons in Soft Matter
  • [Book] 揺らぎと生体機能総論, メディカルバイオ別冊2010

    • Author(s)
      寺嶋正秀、揺らぎと生体機能、寺嶋正秀監修
    • Total Pages
      6-9
    • Publisher
      オーム社
  • [Book] 人工タンパク質の合成と応用, 超分子サイエンス&テクノロジー2009

    • Author(s)
      芳坂貴弘
    • Total Pages
      890-895
    • Publisher
      エヌティーエス
  • [Remarks]

    • URL

      http://kuchem.kyoto-u.ac.jp/hikari/yuragi/

  • [Patent(Industrial Property Rights)] 焼酎蒸留粕からのエタノール抽出残さ、エタノール抽出物及びそれらの製造方法2012

    • Inventor(s)
      上岡龍一、家藤治幸、廣瀬茂
    • Industrial Property Rights Holder
      上岡龍一、家藤治幸、廣瀬茂
    • Industrial Property Number
      特許、特許4071062
    • Acquisition Date
      2012-06-29
  • [Patent(Industrial Property Rights)] 残余双極子相互作用の解析法及び残余双極子相互作用解析用試薬2009

    • Inventor(s)
      藤田誠、佐藤宗太、諸原理、加藤晃一、山口芳樹
    • Industrial Property Rights Holder
      藤田誠、佐藤宗太、諸原理、加藤晃一、山口芳樹
    • Industrial Property Number
      特許、特願2009-057080
    • Filing Date
      2009-03-10

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Published: 2014-08-29   Modified: 2014-09-05  

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