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2012 Fiscal Year Annual Research Report

ATPのエネルギー総括研究

Administrative Group

Project AreaWater plays a key role in ATP hydrolysis and ATP-driven functions of proteins
Project/Area Number 20118001
Research InstitutionTohoku University

Principal Investigator

鈴木 誠  東北大学, 工学(系)研究科(研究院), 教授 (60282109)

Co-Investigator(Kenkyū-buntansha) 松林 伸幸  京都大学, 化学研究所, 准教授 (20281107)
櫻井 実  東京工業大学, 学内共同利用施設等, 教授 (50162342)
木下 正弘  京都大学, エネルギー理工学研究所, 教授 (90195339)
Project Period (FY) 2008-04-01 – 2013-03-31
KeywordsATPエネルギー / タンパク質の水和 / ATP加水分解反応 / ATP駆動タンパク質 / 水和エントロピー / 溶媒和 / 自由エネルギー / ハイパーモバイル水
Outline of Annual Research Achievements

研究の目的:本領域は生命系存続の環境母体である「水」を主役とした新しいエネルギー論の分子的基盤、ATP加水分解にともなう大きな自由エネルギー変化の起源に関する分子論構築を目指し、既存の概念にとらわれない学術的研究領域を新たに開拓する。この為には異なる分野の「融合」による新たな方法論の展開と次世代育成が不可欠である。そこで、総括班としては計画研究のほかに幅広い分野からのユニークな公募研究を糾合して理論的研究と実験的研究とを堅密に組織化して推進する。
研究実績内容:研究領域の研究全体の推進、企画調整、自己評価、研究支援活動等を行ってきた。今年度は最終年度でもあり、①領域研究参画研究者の意識改革の一環として本領域立ち上げ時の問題意識を踏まえた領域シンポジウム「Symposium on ATP and Hydration」)の運営と開催(H25.3.6-8, 秋保仙台)および「揺らぎが機能をを決める生命分子の科学」(領域番号2006)との合同シンポジウム(H24.9.14-15, 大阪)開催;②領域全体をバーチャルラボ体制として進める一環として領域内メンバー間の共同研究を推進;③公募研究の重視として、とくに計画研究メンバーとの連携や共同研究を推進した。計画研究メンバー間、および計画研究メンバーとそれだけでカバー出来ない重要課題、斬新な課題あるいは地味でも重要な研究に取り組む公募研究と連携は、ほとんどの計画メンバーが実施し機動的に作用したといえる。④若手育成として、博士研究員が本領域研究の実施を通して力をつけ助教等のプロモーションを得ている。⑤成果の発信。これらの企画と実施また本領域研究メンバーの成果について、Webを通じて公開発信した。

Research Progress Status

24年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

24年度が最終年度であるため、記入しない。

  • Research Products

    (76 results)

All 2013 2012 Other

All Journal Article (38 results) (of which Peer Reviewed: 38 results) Presentation (37 results) (of which Invited: 8 results) Remarks (1 results)

  • [Journal Article] Hydration state change of horse heart cytochrome c corresponding to trifluoroacetic-acid-induced unfolding2013

    • Author(s)
      Yusuke Miyashita, Tetsuichi Wazawa, George Mogami, Satoshi Takahashi, Yoshihiro Sambongi, and Makoto Suzuki
    • Journal Title

      Biophysical Journal

      Volume: 104 Pages: 163-172

    • DOI

      10.1016/j.bpj.2012.11.3825

    • Peer Reviewed
  • [Journal Article] Entropic Release of a Big Sphere from a Cylindrical Vessel2013

    • Author(s)
      H. Mishima, H. Oshima, S. Yasuda, K. Amano, and M. Kinoshita
    • Journal Title

      Chem. Phys. Left

      Volume: 561-562 Pages: 159-165

    • DOI

      10.1016/j.cplett.2013.01.045

    • Peer Reviewed
  • [Journal Article] A New Theoretical Approach to Biological Self-Assembly2013

    • Author(s)
      M. Kinoshita
    • Journal Title

      Biophys. Rev

      Volume: 5 Pages: 1-11

    • DOI

      10.1007/s12551-013-0100-8

    • Peer Reviewed
  • [Journal Article] The Power Stroke Driven by ATP Binding in CFTR As Studied by by ATP Binding in CFTR As Studied by Molecular Dynamics Simulations2013

    • Author(s)
      T. Furukawa-Hagiya
    • Journal Title

      J. Phys. Chem. B

      Volume: 117 Pages: 83-93

    • DOI

      10.1021/jp308315w

    • Peer Reviewed
  • [Journal Article] High-Energy X-ray Diffraction Study on the Intramolecular Structure of 2-Aminoethanol in the Liquid State2013

    • Author(s)
      Y. Kameda, H. Deguchi, Y. Kubota, H. Furukawa, Y. Yagi, Y. Imai, M. Tatsumi, N. Yamazaki, N. Watari, T. Hirata, N. Matubayasi
    • Journal Title

      Bull. Chem. Soc. Japan

      Volume: 86 Pages: 99-103

    • DOI

      10.1246/bcsj.20120222

    • Peer Reviewed
  • [Journal Article] Free-energy analysis of lysozyme–triNAG binding modes with all-atom molecular dynamics simulation combined with the solution theory in the energy representation2013

    • Author(s)
      K. Takemura, R. R. Burri, T. Ishikawa, T. Ishikura, S. Sakuraba, N. Matubayasi, K. Kuwata, and A. Kitao
    • Journal Title

      Chem. Phys. Lett.

      Volume: 559 Pages: 94-98

    • DOI

      10.1016/j.cplett.2012.12.063

    • Peer Reviewed
  • [Journal Article] A theoretical study of the two binding modes between lysozyme and tri-NAG with an explicit solvent model based on the fragment molecular orbital method2013

    • Author(s)
      T. Ishikawa, R. R. Burri, Y. O. Kamatari, S. Sakuraba, N. Matubayasi, A. Kitao, and K. Kuwata
    • Journal Title

      Phys. Chem. Chem. Phys.

      Volume: 559 Pages: 3646-3654

    • DOI

      10.1039/C3CP42761G

    • Peer Reviewed
  • [Journal Article] Interaction-component analysis of the urea effect on amino acid analogs2013

    • Author(s)
      Y. Karino and N. Matubayasi
    • Journal Title

      Phys. Chem. Chem. Phys.

      Volume: 15 Pages: 4377-4391

    • DOI

      10.1039/C3CP43346C

    • Peer Reviewed
  • [Journal Article] Solvent Effect on Pathways and Mechanisms for D-Fructose Conversion to 5-Hydroxymethyl-2-furaldehyde: In Situ 13C NMR Study2013

    • Author(s)
      H. Kimura, M. Nakahara, and N. Matubayasi
    • Journal Title

      J. Phys.Chem. A

      Volume: 117 Pages: 2102-2113

    • DOI

      10.1021/jp312002h

    • Peer Reviewed
  • [Journal Article] Effect of heavy hydrogen isotopes on the vibrational line shape for supercritical water through rotational couplings2013

    • Author(s)
      K. Yoshida, N. Matubayasi, Y. Uosaki, and M. Nakahara
    • Journal Title

      J. Chem. Phys.

      Volume: 138 Pages: 134508(1-12)

    • DOI

      10.1063/1.4798933

    • Peer Reviewed
  • [Journal Article] Electrochemical Deposition of Platinum within Nanopores on Silicon: Drastic Acceleration Originating from Surface-Induced Phase Transition2013

    • Author(s)
      K. Fukami, R. Koda, T. Sakka, Y. Ogata, and M. Kinoshita
    • Journal Title

      Journal of Chemical Physics

      Volume: 138 Pages: 194702(1-10)

    • DOI

      10.1063/1.4793526

    • Peer Reviewed
  • [Journal Article] Molecular Dinamics Simulation of Yeast F1-ATPase before and after 16-Degree Ritation of the Gamma Subunit2013

    • Author(s)
      Y. Ito, T. Yoshidome, N. Matubayasi, M. Kinoshita, and M. Ikeguchi
    • Journal Title

      Journal of Physical Chemistry B

      Volume: 117 Pages: 3298-3307

    • DOI

      10.1021/jp312499u

    • Peer Reviewed
  • [Journal Article] Dynamics and structural changes induced by ATP and/or substrate binding in the inward-facing conformation state of P-glycoprotein2013

    • Author(s)
      Y. Watanabe
    • Journal Title

      Chem. Phys. Lett.

      Volume: 557 Pages: 145-149

    • DOI

      10.1016/j.cplett.2012.12.040

    • Peer Reviewed
  • [Journal Article] A Scoring function based on salvation thermodynamics for protein structure prediction2012

    • Author(s)
      S. Du
    • Journal Title

      biophysics

      Volume: 8 Pages: 127-138

    • DOI

      10.2142/biophysics.8.127

    • Peer Reviewed
  • [Journal Article] Full-Quantum chemical calculation of the absorption maximum of bacteriorhodopsin: a comprehensive2012

    • Author(s)
      T. Hayashi
    • Journal Title

      Biophysics

      Volume: 8 Pages: 115-125

    • DOI

      10.2142/biophysics.8.115

    • Peer Reviewed
  • [Journal Article] Application of Hydration Thermodynanlics to the Evaluation of Protein Structures and Protein-Ligand Binding2012

    • Author(s)
      Y. Harano
    • Journal Title

      Entropy

      Volume: 14 Pages: 1443-1468

    • DOI

      10.3390/e14081443

    • Peer Reviewed
  • [Journal Article] Characterization of Experimentally Determined Native-Structure Models of a Protein Using Energetic and Entropic Components of Free-Energy Function2012

    • Author(s)
      H. Mishima, S. Yasuda, T. Yoshidome, H. Oshima, Y. Harano, M. Ikeguchi, and M. Kinoshita
    • Journal Title

      J. Phys. Chem. B

      Volume: 116 Pages: 7776-7786

    • DOI

      10.1021/jp301541z

    • Peer Reviewed
  • [Journal Article] Scoring Function Based on Solvation Thermodynamics for Protein Structure Prediction2012

    • Author(s)
      D. Shiqiao, Y. Harano, M. Kinoshita, and M. Sakurai
    • Journal Title

      Biophysics

      Volume: 8 Pages: 127-138

    • DOI

      10.2142/biophysics.8.127

    • Peer Reviewed
  • [Journal Article] Structural Stability of Proteins in Aqueous and Nonpolar Environments2012

    • Author(s)
      S. Yasuda, H. Oshima, and M. Kinoshita
    • Journal Title

      J. Chem. Phys

      Volume: 137 Pages: 135103(1-14)

    • DOI

      10.1063/1.4755755

    • Peer Reviewed
  • [Journal Article] Physical Origin of Hydrophobicity Studied in terms of Cold Denaturation of Proteins: Comparison between Water and Simple Fluids2012

    • Author(s)
      T. Yoshidome and M. Kinoshita
    • Journal Title

      Phys. Chem. Chem. l Phys

      Volume: 14 Pages: 14554-14566

    • DOI

      10.1039/c2cp41738c

    • Peer Reviewed
  • [Journal Article] Molecular Dynamics Study of Fast Dielectric Relaxation of Water2012

    • Author(s)
      Yoji Kubota, Akira Yoshimori, Nobuyuki Matubayasi, Makoto Suzuki, and Ryo Akiyama
    • Journal Title

      J. Chem. Phys

      Volume: 137 Pages: 224502(1-4)

    • DOI

      10.1063/1.4769972

    • Peer Reviewed
  • [Journal Article] Role of Water in Actin-Myosin Binding and Actin Polymerization: Rotational and translational Mobility of water Molecules2012

    • Author(s)
      Makoto Suzuki, Teysuichi Wazawa, George Mogami, Takao Kodama
    • Journal Title

      J. Phys. Soc. jpn.

      Volume: 81 Pages: SA003(1-14)

    • Peer Reviewed
  • [Journal Article] Rotational dynamics of benzene and water in an ionic liquid explored via molecular dynamics simulations and NMR T1 measurements2012

    • Author(s)
      Y. Yasaka, M. L. Klein, M. Nakahara, and N. Matubayasi
    • Journal Title

      J. Chem. Phys.

      Volume: 136 Pages: 074508(1-12)

    • DOI

      10.1063/1.3685100

    • Peer Reviewed
  • [Journal Article] The effect of pressure on halothane binding to hydrated DMPC bilayers2012

    • Author(s)
      P.-L. Chau, K. M. Tu, K. K. Liang, I. T. Todorov, S. J. Roser, R. Barker,, N. Matubayasi
    • Journal Title

      Molecular Physics

      Volume: 110 Pages: 1461-1467

    • DOI

      10.1080/00268976.2012.659682

    • Peer Reviewed
  • [Journal Article] -Energy and Structural Analysis of Ion Solvation and Contact Ion-Pair Formation of Li+ with BF4− and PF6− in Water and Carbonate Solvents2012

    • Author(s)
      M. Takeuchi, N. Matubayasi, Y. Kameda, B. Minofar, S. Ishiguro, and Y. UmebayashiFree
    • Journal Title

      J. Phys. Chem. B

      Volume: 116 Pages: 6476-6487

    • DOI

      10.1021/jp3011487

    • Peer Reviewed
  • [Journal Article] Simple and exact approach to the electronic polarization effect on the solvation free energy: Formulation for quantum-mechanical/molecular-mechanical system and its applications to aqueous solutions2012

    • Author(s)
      H. Takahashi, A. Omi, A. Morita, and N. Matubayasi
    • Journal Title

      J. Chem. Phys.

      Volume: 136 Pages: 214503(1-12)

    • DOI

      10.1063/1.4722347

    • Peer Reviewed
  • [Journal Article] A possible molecular mechanism for the pressure reversal of general anaesthetics: aggregation of halothane in POPC bilayers at high pressure2012

    • Author(s)
      K. M. Tu, N. Matubayasi, K. K. Liang, I. T. Todorov, S. L. Chan, and P.-L. Chau
    • Journal Title

      Chem. Phys. Lett.

      Volume: 543 Pages: 148-154

    • DOI

      10.1016/j.cplett.2012.06.044

    • Peer Reviewed
  • [Journal Article] Interaction of naphthalene derivatives with lipid in membrane studied by 1H-nuclear Overhauser effect and molecular dynamics simulation2012

    • Author(s)
      M. Shintani, Y. Matsuo, S. Sakuraba, and N. Matubayasi
    • Journal Title

      Phys. Chem. Chem. Phys.

      Volume: 14 Pages: 14049-14060

    • DOI

      10.1039/C2CP41984J

    • Peer Reviewed
  • [Journal Article] Nuclear magnetic resonance study on rotational dynamics of water and benzene in a series of ionic liquids: Anion and cation effects2012

    • Author(s)
      H. Kimura, Y. Yasaka, M. Nakahara, and N. Matubayasi
    • Journal Title

      J. Chem. Phys.

      Volume: 137 Pages: 194503(1-10)

    • DOI

      10.1063/1.4766258

    • Peer Reviewed
  • [Journal Article] Density effect on infrared spectrum for supercritical water in the low-and medium-density region studied by molecular dynamics simulation2012

    • Author(s)
      K. Yoshida, N. Matubayasi, Y. Uosaki, and M. Nakahara
    • Journal Title

      J. Chem. Phys.

      Volume: 137 Pages: 194506(1-10)

    • DOI

      10.1063/1.4767352

    • Peer Reviewed
  • [Journal Article] Evaluation of protein-protein docking model structures using all-atom molecular dynamics simulations combined with the solution theory in the energy representation2012

    • Author(s)
      K. Takemura, H. Guo, S. Sakuraba, N. Matubayasi, and A. Kitao
    • Journal Title

      J. Chem. Phys.

      Volume: 137 Pages: 215105(1-10)

    • DOI

      10.1063/1.4768901

    • Peer Reviewed
  • [Journal Article] Noncatalytic Hydrothermal Elimination of the Terminal D-Glucose Unit from Malto- and Cello-Oligosaccharides through Transformation to D-Fructose2012

    • Author(s)
      H. Kimura, M. Nakahara, and N. Matubayasi
    • Journal Title

      J. Phys. Chem. A

      Volume: 116 Pages: 11039-11049

    • DOI

      10.1021/jp3034165

    • Peer Reviewed
  • [Journal Article] Free-energy analysis of water affinity in polymer studied by atomistic molecular simulation combined with the theory of solutions in the energy representation2012

    • Author(s)
      T. Kawakami, I. Shigemoto, and N. Matubayasi
    • Journal Title

      J. Chem. Phys.

      Volume: 137 Pages: 234903(1-9)

    • DOI

      10.1063/1.4770334

    • Peer Reviewed
  • [Journal Article] Platinum Electrodeposition in Porous Silicon: The Influence of Surface Solvation Effects on a Chemical Reaction in s Nanospace2012

    • Author(s)
      K. Fukami, R. Koda, T. Sakka, T. Urata, K. Amano, H. Takaya, M. Nakamura, Y. Ogata and M. Kinoshita
    • Journal Title

      Chemical Physics Letters

      Volume: 542 Pages: 99-105

    • DOI

      10.1016/j.cplett.2012.05.078

    • Peer Reviewed
  • [Journal Article] Structural Characteristics of Yeast F1-ATPase before and after 16-Degree Rotation of the Gamma Subunit: Theoretical Analysis Focused on the Water-Entropy Effect2012

    • Author(s)
      T. Yoshidome, Y. Ito, N. Matubayasi, M. Ikeguchi, and M. Kinoshita
    • Journal Title

      Journal of Chemical Physics

      Volume: 137 Pages: 035102(1-8)

    • DOI

      10.1063/1.4734298

    • Peer Reviewed
  • [Journal Article] タンパク質水和理論の新機軸Ⅰ.朝倉-大沢理論を越えて2012

    • Author(s)
      木下正弘,永山國昭
    • Journal Title

      生物物理

      Volume: 52 Pages: 203-205

    • Peer Reviewed
  • [Journal Article] タンパク質水和理論の新機軸Ⅱ.新理論の応用展開2012

    • Author(s)
      木下正弘,永山國昭
    • Journal Title

      生物物理

      Volume: 52 Pages: 250-253

    • Peer Reviewed
  • [Journal Article] タンパク質水和理論の新機軸Ⅲ。理論的考察2012

    • Author(s)
      木下正弘,永山國昭
    • Journal Title

      生物物理

      Volume: 52 Pages: 300-303

    • Peer Reviewed
  • [Presentation] Effects of Sugars on the Thermal Stability of a Protein2013

    • Author(s)
      H. Oshima and M. Kinoshita
    • Organizer
      Biophysical Society 57th Annual Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      20130202-06
  • [Presentation] Hydration and ATP energetic on Actomyosin2013

    • Author(s)
      鈴木 誠
    • Organizer
      Alpbach Workshop on Molecular Motors 2013
    • Place of Presentation
      Alpbach, Austria
    • Year and Date
      2013-03-16 – 2013-03-22
  • [Presentation] Effects of nucleotide and cosolvents on the hydration state of myosin subfragment-12013

    • Author(s)
      鈴木 誠
    • Organizer
      新学術領域研究「水を主役としたATPエネルギー変換」国際シンポジウム
    • Place of Presentation
      仙台秋保 岩沼屋
    • Year and Date
      2013-03-06 – 2013-03-08
    • Invited
  • [Presentation] Effects of halide ions on the hydration properties of F-actin,2013

    • Author(s)
      鈴木 誠
    • Organizer
      新学術領域研究「水を主役としたATPエネルギー変換」国際シンポジウム
    • Place of Presentation
      仙台秋保 岩沼屋
    • Year and Date
      2013-03-06 – 2013-03-08
    • Invited
  • [Presentation] Hypermobile water observed in sulfonates, phosphates solutions and its volume change in protein interactions2013

    • Author(s)
      鈴木 誠
    • Organizer
      新学術領域研究「水を主役としたATPエネルギー変換」国際シンポジウム
    • Place of Presentation
      仙台秋保 岩沼屋
    • Year and Date
      2013-03-06 – 2013-03-08
    • Invited
  • [Presentation] Anion-dependence of hypermobile water in Na-, K-halide solutions at low concentrations measured by high-resolution microwave dielectric spectroscopy2013

    • Author(s)
      鈴木 誠
    • Organizer
      新学術領域研究「水を主役としたATPエネルギー変換」国際シンポジウム
    • Place of Presentation
      仙台秋保 岩沼屋
    • Year and Date
      2013-03-06 – 2013-03-08
    • Invited
  • [Presentation] Effects of Sugars on the Thermal Stability of a Protein2013

    • Author(s)
      H. Oshima and M. Kinoshita
    • Organizer
      International Symposium on Hydration and ATP Energy 2013
    • Place of Presentation
      Hotel Iwanumaya, Miyagi, Japan
    • Year and Date
      2013-03-06 – 2013-03-08
  • [Presentation] Structural Stability of Proteins in Aqueous and Ninpolar Environments2013

    • Author(s)
      S. Yasuda, H. Oshima, and M. Kinoshita
    • Organizer
      International Symposium on Hydration and ATP Energy 2013
    • Place of Presentation
      Hotel Iwanumaya, Miyagi, Japan
    • Year and Date
      2013-03-06 – 2013-03-08
  • [Presentation] Physics of Multidrug Efflux of a Biomolecular Complex2013

    • Author(s)
      H. Mishima, H. Oshima, S. Yasuda, K. Amano
    • Organizer
      International Symposium on Hydration and ATP Energy 2013
    • Place of Presentation
      Hotel Iwanumaya, Miyagi, Japan
    • Year and Date
      2013-03-06 – 2013-03-08
  • [Presentation] Molecular Dynamics Simulations of Yeast F1-ATPase before and after 16-degree Rotation of Gamma2013

    • Author(s)
      Y. Ito, T. Yoshidome, N. Matsubayashi, M. Kinoshita, and M. Ikeguchi
    • Organizer
      Biophysical Society 57th Annual Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2013-02-02 – 2013-02-06
  • [Presentation] エントロピー力による円筒状容器からの大珠の放出2013

    • Author(s)
      三嶋浩和、尾嶋拓、安田賢司、天野健一、木下正弘
    • Organizer
      GCOE年次報告会
    • Place of Presentation
      京都大学時計台記念館
    • Year and Date
      2013-01-16
  • [Presentation] 溶質が狭い空間に入るダイナミクスにおける溶媒のエントロピー効果2012

    • Author(s)
      原諒平、天野健一、木下正弘、吉森明
    • Organizer
      第35回溶液化学シンポジウム
    • Place of Presentation
      早稲田大学西早稲田キャンパス
    • Year and Date
      20121112-14
  • [Presentation] Full-quantum chemical calculations of the absorption maxima of retinal proteins2012

    • Author(s)
      櫻井実
    • Organizer
      第50回生物物理学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      20120922-24
  • [Presentation] The chrolide ion uptake mechanism in pharaonis halorhodopsin as studied by the energy representation method2012

    • Author(s)
      櫻井実
    • Organizer
      第50回生物物理学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      20120922-24
  • [Presentation] Calculation of the binding free energy of ATP to the nucleotide binding domain of an ABC Transporter2012

    • Author(s)
      櫻井実
    • Organizer
      第50回生物物理学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      20120922-24
  • [Presentation] Entropic Release of a Big Sphere from a Cylindrical Vessel2012

    • Author(s)
      H. Mishima, H. Oshima, S. Yasuda, K. Amano, and M. Kinoshita
    • Organizer
      日本生物物理学会第50回年会
    • Place of Presentation
      名古屋大学
    • Year and Date
      20120922-24
  • [Presentation] Effects of Sugars on the Thermal Stability of Proteins2012

    • Author(s)
      H. Oshima, K. Amano, M. Kinoshita
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学
    • Year and Date
      20120922-24
  • [Presentation] 分子動力学シミュレーションによるABCトランスポーターMsbAにおけるカップリング・ヘリックス変異の構造的影響2012

    • Author(s)
      櫻井実
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      20120620-22
  • [Presentation] ABCトランスポーターCFTRチャネルのATP加水分解駆動ゲーティング機構の解析2012

    • Author(s)
      櫻井実
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      20120620-22
  • [Presentation] MM-PB/SA法によるタンパク質リガンド間結合自由エネルギー計算の再現性向上を目指して2012

    • Author(s)
      櫻井実
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      20120620-22
  • [Presentation] MDシミュレーションによるCFTRタンパク質のATP結合誘導NBD二量体化の解析2012

    • Author(s)
      櫻井実
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      20120620-22
  • [Presentation] シャペロニンの中央になぜ蛋白質が入るのか2012

    • Author(s)
      原諒平、天野健一、木下正弘、吉森明
    • Organizer
      第118回日本物理学会九州支部例会
    • Place of Presentation
      琉球大学
    • Year and Date
      2012-12-08
  • [Presentation] 溶媒の効果を含めた溶質のダイナミクス:シャペロニンへの蛋白質の挿入過程2012

    • Author(s)
      原諒平、天野健一、木下正弘、吉森明
    • Organizer
      第24回分子シュミレーション研究会
    • Place of Presentation
      九州大学西新プラザ
    • Year and Date
      2012-11-26 – 2012-11-28
  • [Presentation] マイクロ波誘電緩和分光法による有機・無機イオンおよびタンパク質の水和特性2012

    • Author(s)
      鈴木 誠
    • Organizer
      日本分光学会テラヘルツ分光部会シンポジウム「テラヘルツ分光法の最先端Ⅵ~ここまできたテラヘルツ時間領域分光~」
    • Place of Presentation
      筑波
    • Year and Date
      2012-10-26
    • Invited
  • [Presentation] シャぺロニンに対する蛋白質挿入のダイナミクス2012

    • Author(s)
      原諒平、天野健一、木下正弘、吉森明
    • Organizer
      第2回ソフトマター研究会
    • Place of Presentation
      九州大学西新プラザ
    • Year and Date
      2012-09-24 – 2012-09-26
  • [Presentation] Molecular Dynamics Simulations on Structural Characteristics of Yeast F1-ATPase before and after2012

    • Author(s)
      Y. Ito, T. Yoshidome, N. Matsubayashi, M. Kinoshita, and M. Ikeguchi
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2012-09-23 – 2012-09-24
  • [Presentation] Structual Stability of Proteins in Aqueous and Nonpolar Environments2012

    • Author(s)
      S. Yasuda, H. Oshima and M. Kinoshita,
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2012-09-22 – 2012-09-24
  • [Presentation] Dynamics and structural changes of ABCB1 transporter induced by binding of substrates and inhibitors2012

    • Author(s)
      櫻井実
    • Organizer
      第50回生物物理学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2012-09-22 – 2012-09-24
  • [Presentation] ATP-binding induced conformational change in CFTR as studied by MD simulation2012

    • Author(s)
      櫻井実
    • Organizer
      第50回生物物理学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2012-09-22
  • [Presentation] 溶液中で狭い空間に溶質が入るときの経路2012

    • Author(s)
      原諒平、天野健一、木下正弘、吉森明
    • Organizer
      2012年度日本物理学会秋季大会
    • Place of Presentation
      、横浜国立大学
    • Year and Date
      2012-09-18 – 2012-09-21
  • [Presentation] 蛋白質複合体におけるホットスポットの理論的予測2012

    • Author(s)
      尾嶋拓、安田賢司 吉留崇、池口満徳、木下正弘
    • Organizer
      合同公開シンポジウム「ゆらぎと水-生命のエネルギーと機能の
    • Place of Presentation
      大阪ガーデンパレス
    • Year and Date
      2012-09-14 – 2012-09-15
  • [Presentation] 分子機械の機能発現機構に対する横断的描像2012

    • Author(s)
      木下正弘
    • Organizer
      合同公開シンポジウム「ゆらぎと水-生命のエネルギーと機能の分子機構を探る」(招待講演)
    • Place of Presentation
      、大阪ガーデンパレス
    • Year and Date
      2012-09-14 – 2012-09-15
    • Invited
  • [Presentation] 水及び非水環境におけるタンパク質の立体構造安定性2012

    • Author(s)
      安田賢司、尾嶋拓、木下正弘
    • Organizer
      第52回生物物理若手の会 夏の学校
    • Place of Presentation
      支笏湖温泉
    • Year and Date
      2012-08-31 – 2012-09-03
  • [Presentation] A Solvent Effect on Insertion Path of a Solute Particle into a Cylindrical Vessel2012

    • Author(s)
      R. Hara, K. Amano, M. Kinoshita, A. Yoshimori
    • Organizer
      6-th Mini-Symposium on Liquid
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-06-23 – 2012-06-23
    • Invited
  • [Presentation] ABCトランスポーターのヌクレオチド結合ドメインへのATPの結合エネルギーの計算2012

    • Author(s)
      櫻井実
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-06-20 – 2012-06-22
  • [Presentation] ER法によるハロロドプシンの塩素イオン取り込み機構の解明2012

    • Author(s)
      櫻井実
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-06-20 – 2012-06-22
  • [Presentation] Extended Concept of Solvation toward Unified Understandings of Molecular Binding in weakly Ordered Systems2012

    • Author(s)
      Nobuyuki Matubayasi
    • Organizer
      JST International Symposium on Multi-scale Simulation of Condensed-phase Reacting Systems
    • Place of Presentation
      名古屋大学 東山キャンパスESホール
    • Year and Date
      2012-05-10
    • Invited
  • [Remarks] 水を主役としたATPエネルギー変換

    • URL

      www.material.tohoku.ac.jp/atpwater/

URL: 

Published: 2018-02-02  

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