Morphological features and gene expression patterns underlying hub neurons

2022 Fiscal Year Final Research Report

• Project Area: Morphological features and gene expression patterns underlying hub neurons
• Project/Area Number: 20H05774
• Research Category: Grant-in-Aid for Transformative Research Areas (B)
• Allocation Type: Single-year Grants
• Review Section: Transformative Research Areas, Section (III)
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Murayama Masanori 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (30578901)
• Co-Investigator(Kenkyū-buntansha): 竹田 晃人 茨城大学, 理工学研究科(工学野), 准教授 (70397040) ; 高田 篤 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (90643693)
• Project Period (FY): 2020-10-02 – 2023-03-31
• Keywords: 新規分野開拓 / シンポジウム / ハブ細胞 / 大脳新皮質 / ネットワーク

Outline of Final Research Achievements

Hub neurons are believed to be linked to brain function, brain homeostasis, and disease based on their activity patterns. Understanding the causal relationship between these crucial hub neurons and the factors that make them become hub neurons is a challenging and essential task. The aim of this project is to uncover the physio/pathological, gene expression, and morphological characteristics of hub neurons. This group has successfully encouraged researchers both within and outside of this field to participate in symposium and exchange information actively. Consequently, the group has provided an avenue for robust interactions between junior and senior researchers, leading to productive discussions, the initiation of new collaborative research, and the pioneering of the research field related to hub neurons.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

精神・神経疾患などにハブ細胞が関連している可能性があり、本分野に関わる研究者を増やし、開拓することは意義深い。