Facilitation and development of parametric biology based on translation rate regulatory mechanism

2022 Fiscal Year Final Research Report

• Project Area: Parametric biology based on translation rate regulatory mechanism
• Project/Area Number: 20H05782
• Research Category: Grant-in-Aid for Transformative Research Areas (B)
• Allocation Type: Single-year Grants
• Review Section: Transformative Research Areas, Section (III)
• Research Institution: Kyoto University
• Principal Investigator: Doi Masao 京都大学, 薬学研究科, 教授 (20432578)
• Project Period (FY): 2020-10-02 – 2023-03-31
• Keywords: 翻訳

Outline of Final Research Achievements

We aimed to facilitate the development of parametric biology based on translation rate regulatory mechanism. To achieve this goal, it is necessary for research groups with hierarchical diversity, ranging from physical chemistry to physiology, to collaborate organically, so we helped facilitate this joint research. In addition, we (1) planned and held symposiums at related conferences, (2) organized a Parametric Translation Club to share information and techniques with researchers outside the field, (3) publicized the project through our website, (4) held open lectures for citizens and classes for high school students, (5) held training camps to share specialized skills, and (6) as part of efforts to nurture young trainees, held international symposiums to promote exchanges with world-leading overseas researchers. Through these activities and efforts, we contributed to raising the level of our field.

Free Research Field

翻訳

Academic Significance and Societal Importance of the Research Achievements

以下の目的を達成したことが学術的意義であり、その成果をHPや公開シンポジウム等の様々な方法で社会に発信し続けたことが社会的意義である。１）柔軟な神経らしさを作り出すパラメトリック翻訳制御を明らかにする。２）細胞内局所パラメトリック翻訳における物理化学的調節機構を明らかにする。３）Disome-Seq法の開発および本法を用いたリボソーム渋滞の網羅的探索を行うことによってパラメトリック翻訳制御を明らかにする。４）翻訳速度制御を介した睡眠・代謝・体内時計のパラメトリック制御のメカニズムを明らかにする。５）１）-４）を統合し、翻訳速度調節機構を基盤としたパラメトリック生物学の創成に貢献する。