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2013 Fiscal Year Final Research Report

Organic Synthesis Based on Reaction Integration. Development of New Methods and Creation of New Substances

Administrative Group

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Project AreaOrganic Synthesis based on Integration of Chemical Reactions. New Methodologies and New Materials
Project/Area Number 21106001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKyoto University

Principal Investigator

YOSHIDA Jun-ichi  京都大学, 工学(系)研究科(研究院), 教授 (30127170)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Shunichi  北海道大学, 大学院薬学研究科, 教授 (80107391)
TOBE Yoshito  大阪大学, 大学院基礎工学研究科, 教授 (60127264)
NAKADA Masahisa  早稲田大学, 大学院理工学術院, 教授 (50198131)
MATSUBARA Seijiro  京都大学, 大学院工学研究科, 教授 (90190496)
Project Period (FY) 2009-07-23 – 2014-03-31
Keywords有機合成化学 / 有機反応 / 生物活性物質 / 機能性材料
Research Abstract

Organic synthesis has been developed mainly based on step-by-step synthesis. This project aims to enhance the power of organic synthesis by introducing an efficient way of combining multiple steps in one-pot or in one-flow. In short, we focused on time and space integration of reactions and its applications to creation of new substances. These were accomplished by the design and study of synthetic transformations that would be impossible without integration, such as the generation of unstable reactive species that are swiftly utilized for a further reaction before they decompose, and the synthesis of biologically interesting molecules and functional materials by taking advantage of reaction integration.
To effect and promote the project we supported individual members to accelerate their individual and joint researches. In addition we also organized symposia periodically to present and share new results and to exchange ideas with extensive discussion.

  • Research Products

    (21 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (16 results) (of which Invited: 9 results) Remarks (1 results)

  • [Journal Article] Flash chemistry: flow chemistry that cannot be done in batch2013

    • Author(s)
      Yoshida, J.; Takahashi, Y.; Nagaki, A
    • Journal Title

      Chem. Commun

      Volume: 49 Pages: 9896-9904

    • DOI

      10.1039/C3CC44709J

    • Peer Reviewed
  • [Journal Article] Space Integration of Reactions: An Approach to Increase the Capability of Organic Synthesis2011

    • Author(s)
      Yoshida, J.; Saito, K.; Nokami, T.; Nagaki, A
    • Journal Title

      Synlett

      Pages: 1189-1194

    • DOI

      10.1055/s-002-22026

    • Peer Reviewed
  • [Journal Article] Green and Sustainable Chemical Synthesis Using Flow Microreactors2011

    • Author(s)
      Yoshida, J.; Kim, H.; Nagaki, A
    • Journal Title

      ChemSusChem

      Volume: 4 Pages: 331-340

    • DOI

      10.1002/cssc.201000271

    • Peer Reviewed
  • [Journal Article] Flash Chemistry: Flow Microreactor Synthesis Based on High-Resolution Reaction Time Control2010

    • Author(s)
      Yoshida, J. Chem
    • Journal Title

      Chem. Rec

      Volume: 10 Pages: 332-341

    • DOI

      10.1002/tcr.201000020

    • Peer Reviewed
  • [Presentation] Strategies and Tactics in Electroorganic Synthesis: Electroauxiliary, Cation Pool, and Flow Microreactor2014

    • Author(s)
      J. Yoshida
    • Organizer
      225^<th> Electrochemical Society Meeting
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      20140511-15
  • [Presentation] Reaction Integration Using Cationic Reactive Intermediates2013

    • Author(s)
      J. Yoshida
    • Organizer
      The 11th International Symposium on Organic Reaction (ISOR 11)
    • Place of Presentation
      Taipei, Taiwan, ROC
    • Year and Date
      20131119-22
    • Invited
  • [Presentation] Organolithium Chemistry in Flow Microreactors Based on High-Resolution Control of Reaction Time by Space2013

    • Author(s)
      J. Yoshida
    • Organizer
      10th International Symposium on Carbanion Chemistry
    • Place of Presentation
      Kyoto Japan
    • Year and Date
      20130923-26
    • Invited
  • [Presentation] Flash Chemistry Using Flow Microreactors. Organic Synthesis That Cannot Be Done in Batch2013

    • Author(s)
      J. Yoshida
    • Organizer
      Microwave and Flow Chemistry Conference 2013
    • Place of Presentation
      Napa Valley, California, USA
    • Year and Date
      20130720-23
  • [Presentation] Flash Chemistry Using Flow Microreactors. The Principle and Applications2013

    • Author(s)
      J. Yoshida
    • Organizer
      Eight International Congress for Innovation in Chemistry (PERCH-CIC Congress VIII)
    • Place of Presentation
      Pattaya, Thailand
    • Year and Date
      20130505-08
  • [Presentation] Flash Chemistry: organic chemistry that cannot be done in batch2013

    • Author(s)
      J. Yoshida
    • Organizer
      Bürgenstock Conference 2013
    • Place of Presentation
      Brunnen, Switzerland
    • Year and Date
      20130428-0503
    • Invited
  • [Presentation] Flash Chemistry Using Flow Microreactors. The Principle and Applications2013

    • Author(s)
      J. Yoshida
    • Organizer
      The Ta-shue Chou Lectureship Award Symposium. Outstanding Achievements in Organic Synthesis
    • Place of Presentation
      Academia Sinica, Taipei, Taiwan
    • Year and Date
      2013-03-08
  • [Presentation] Hot Reagents in High-tech Reactors2012

    • Author(s)
      J. Yoshida
    • Organizer
      GRIGNARD: 100 ans de modernite d'un Prix Nobel (100 year anniversary of Nobel Prize)
    • Place of Presentation
      Lyon, France
    • Year and Date
      20120621-22
    • Invited
  • [Presentation] Flash Chemistry Using Flow Microreactors. Principle and Applications2012

    • Author(s)
      J. Yoshida
    • Organizer
      5th Siegfried Symposium
    • Place of Presentation
      Zurich, Switzerland
    • Year and Date
      2012-10-05
    • Invited
  • [Presentation] Organic Electrochemistry, Microreactors, and Their Synergy2011

    • Author(s)
      J. Yoshida
    • Organizer
      10th International Symposium Organic Reactions (ISOR-10)
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      20111121-24
  • [Presentation] Flash Chemistry: Fast Chemical Synthesis Using Flow Microreactors2011

    • Author(s)
      J. Yoshida
    • Organizer
      2ndAsia-Pacific Chemical and Biological Microfluidics Conference
    • Place of Presentation
      Nanjing, China
    • Year and Date
      20110525-27
  • [Presentation] Flash Chemistry Fast Chemical Synthesis in Flow Microreactors2010

    • Author(s)
      J. Yoshida
    • Organizer
      The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Groningen, The Netherlands
    • Year and Date
      20101003-07
  • [Presentation] Flash Chemistry Fast Chemical Synthesis in Flow Microreactors2010

    • Author(s)
      J. Yoshida
    • Organizer
      Ischia Advanced School of Organic Chemistry
    • Place of Presentation
      Ischia Porto, Napoli, Italy
    • Year and Date
      20100925-29
    • Invited
  • [Presentation] Synergy between Organic Electrochemistry and Flow Microreactor Chemistry2010

    • Author(s)
      J. Yoshida
    • Organizer
      PacifiChem 2010, Green Electrochemistry
    • Place of Presentation
      Hawaii, U.S.A.
    • Year and Date
      2010-12-17
    • Invited
  • [Presentation] Flash chemistry using flow microreactors2010

    • Author(s)
      J. Yoshida
    • Organizer
      PacifiChem2010. Achieving Efficiency in Organic Reactions via Greener Processes and Practices
    • Place of Presentation
      Hawaii, U.S.A.
    • Year and Date
      2010-12-17
    • Invited
  • [Presentation] Iterative Molecular Assembly Based on the Cation-Pool Method.Convergent Synthesis of Dendritic Molecules2010

    • Author(s)
      J. Yoshida
    • Organizer
      First German-Japanese Symposium on Electrosynthesis
    • Place of Presentation
      Bonn, Germany
    • Year and Date
      2010-10-02
    • Invited
  • [Remarks]

    • URL

      http://www.sbchem.kyoto-u.ac.jp/syuuseki/

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Published: 2015-06-25  

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