2023 Fiscal Year Final Research Report
Integrated elucidation of inflammatory tissue-resilience and tissue damage-entropy;Creation of innovative science for resolution of inflammation
| Project Area | Integrated elucidation of inflammatory tissue-resilience and tissue damage-entropy;Creation of innovative science for resolution of inflammation |
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| Project/Area Number |
21H05120
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| Research Category |
Grant-in-Aid for Transformative Research Areas (B)
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| Allocation Type | Single-year Grants |
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| Review Section |
Transformative Research Areas, Section (III)
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
新井 郷子 一般社団法人AIM医学研究所, 研究部門, 副所長 (60422276)
三上 洋平 慶應義塾大学, 医学部(信濃町), 准教授 (80528662)
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| Project Period (FY) |
2021-08-23 – 2024-03-31
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| Keywords | 炎症収束 / 炎症記憶 / 炎症性組織レジリエンス / 組織障害エントロピー |
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| Outline of Final Research Achievements |
Aiming to understand "Inflammation Resolution”, this area has developed a research support system (Dr. Hirahara, in charge of research support), enhanced its website (Dr. Mikami, in charge of public relations), and held regular area meetings and symposia (Dr. Arai, in charge of meetings; 4 international symposia, 3 research meetings, monthly online meetings). Professor Yoichi Nabeshima (Kyoto University), Professor Yutaka Kawakami (International University of Health and Welfare, School of Medicine), and Professor Atsushi Iwama (Institute of Medical Science, University of Tokyo), who are conducting advanced research in the field of inflammation, evaluated and provided advice on the entire field.
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| Free Research Field |
免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
これまで世界的に炎症の誘導機構については研究が盛んに行われている一方、炎症の収束機構に関する研究は注目されていなかった。本領域では、臓器や学問の従来の垣根を取り払い「炎症性組織レジリエンスと炎症の収束」に着目して統合的に研究を推進し、各班員が国際的な学術誌へ複数報告するだけでなく、「炎症収束」についての新たな概念を提示することでより大規模な新興・融合領域の形成への基盤形成を行うことができた。
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