2014 Fiscal Year Final Research Report
Infection/inflammation-assisted acceleration of the carcinogenic spiral and its alteration though vector conversion of the host response to tumors
| Project Area | Conversion of tumor-regulation vector to intercept oncogenic spiral accelerated by infection and inflammation |
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| Project/Area Number |
22114001
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TANIGUCHI Tadatsugu 東京大学, 生産技術研究所, 特任教授 (50133616)
SEYA Tsukasa 北海道大学, 大学院医学研究科, 教授 (10301805)
OSHIMA Masanobu 金沢大学, がん進展制御研究所, 教授 (40324610)
MATSUOKA Masao 京都大学, ウイルス研究所, 教授 (10244138)
SHIMOTOHNO Kunitada 国立国際医療研究センター, 肝炎・免疫研究センター, 特任部長 (10000259)
AZUMA Takeshi 神戸大学, 医学研究科, 教授 (60221040)
AKIYOSHI Kazunari 京都大学, 工学研究科, 教授 (90201285)
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| Project Period (FY) |
2010-04-01 – 2016-03-31
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| Keywords | がん / 感染症 / 感染がん / 炎症 / 免疫 / ドラッグデリバリー |
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| Outline of Final Research Achievements |
The program "Infection/inflammation-assisted acceleration of the carcinogenic spiral and its alteration though vector conversion of the host response to tumors (carcinogenic Spiral)" elucidated the roles of innate and acquired immunity and inflammation in the initiation and development of infection-associated cancer (cancer caused by a specific oncogenic microbes) at every possible level from molecular to whole-body. The program also succeeded in developing new drug delivery systems (DDS) as well as innovative innate immune adjuvants, providing preventive and therapeutic principles that can be promptly translated into clinical practice in controlling carcinogenic spiral. The head office of the program held annual international symposiums with great success, issued annual news letters, and promoted scientific collaborations among participating researchers.
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| Free Research Field |
感染腫瘍学、分子腫瘍学
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