「脂質マシナリー」領域研究の推進

2011 Fiscal Year Annual Research Report

• Project Area: Machineries of bioactive lipids in homeostasis and diseases
• Project/Area Number: 22116001
• Research Institution: Kyushu University
• Principal Investigator: 横溝 岳彦 九州大学, 大学院・医学研究院, 教授 (60302840)
• Co-Investigator(Kenkyū-buntansha): 杉本 幸彦 熊本大学, 生命科学研究部, 教授 (80243038) ; 青木 淳賢 東北大学, 薬学研究科, 教授 (20250219) ; 村上 誠 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 副参事研究員 (60276607) ; 有田 誠 東京大学, 薬学研究科, 准教授 (80292952) ; 清原 裕 九州大学, 教授 (80161602)
• Keywords: 脂質メディエーター / 生理活性脂質 / 遺伝子欠損マウス / 質量分析計

Research Abstract

計画班員・公募班員の研究を援助するため、以下の活動を行った。
1)本領域のホームページ(http://www.lpid.med.kyushu-u.ac.jp/)に、研究リソース、遺伝子、抗体のリスト、実験プロトコールの追加を行った。また領域メイリングリストを整備し、班員間の連絡や共同研究にむけてのインフラを整備した。
2)研究支援センターの整備と利用:
・3つのリピドミクスセンターにおいて、班員の20以上の研究プロジェクトをサポートした。(マウスコンカナバリンA誘導モデル、EAE脱随モデル、カゼイン誘導腹膜炎モデル、接触性皮膚炎モデル、うつ病モデル、など)
・遺伝子発現解析センターにおいて、班員の5つの研究プロジェクトをサポートした。(マウス脂肪組織、大腸癌組織、マウス好酸球、マウス急性腹膜炎マクロファージ、表皮角化細胞の分化に伴う遺伝子発現プロファイリング)
・SNP解析センターにおいて、班員の7つの研究プロジェクトをサポートした。
・ゼブラフィッシュ解析センターで、リゾリン脂質産生酵素、リゾリン脂質受容体、分泌性PLA2、スフィンゴシン1リン酸受容体の発生胚における遺伝子抑制、強制発現とその表現型解析をサポートした。
3)2011年7月30-31日に公募班員を加えて第2回領域会議を開催した。
4)2012年2月10日に、本領域若手ワークショップを開催した。
5)2012年3月に第2回領域ニュースレターを発行した。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

各研究支援センターの利用に関して、当初想定したよりもはるかに多い数の研究サポートが行われているため。

Strategy for Future Research Activity

現時点では本研究総括班は極めて順調に稼働していると考えているため、大きな問題点はない。今後も積極的な研究のサポートと、活発な班会議、情報発信を心がけてゆきたい。

Research Products

• [Journal Article] Gタンパク質共役型受容体と生理活性脂質 (2012)
  • Author(s): 横溝岳彦
  • Journal Title: 臨床検査 Volume: 63 Pages: 539-587
• [Journal Article] A high-affinity monoclonal antibody against the FLAG tag useful for G-protein coupled receptor study (2012)
  • Author(s): Sasaki F, Okuno T, Saeki K, Liu Min, Onohara N, Kato H, Shimizu T, Yokomizo T
  • Journal Title: Anal.Biochem. Volume: 425 Pages: 157-165
  • DOI: 10.1016/j.ab.2012.03.014
  • Peer Reviewed
• [Journal Article] Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts (2012)
  • Author(s): Takano H, Furuta K, Yamashita K, Sakanaka M, Itano N, Gohda E, Nakayama K, Kimata K, Sugimoto Y, Ichikawa A., Tanaka S.
  • Journal Title: Biol.Pharm.Bull. Volume: 35 Pages: 408-412
  • DOI: 10.1248/bpb.35.408
  • Peer Reviewed
• [Journal Article] Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor (2012)
  • Author(s): Hoshino T, Namba T, Takehara M, Murao N, Matsushima T, Sugimoto Y, Narumiya S, Suzuki T, Mizushima T
  • Journal Title: J.Neurochem. Volume: 120 Pages: 795-805
  • DOI: 10.1111/j.1471-4159.2011.07567.x
  • Peer Reviewed
• [Journal Article] Intracerebral microinjection of interleukin-4/interleukin-13 reduces beta-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young APP23 mice (2012)
  • Author(s): Kawahara K, Suenobu M, Yoshida A, Koga K, Hyodo A, Ohtsuka H, Kuniyasu A, Tamamaki N, Sugimoto Y, Nakayama H
  • Journal Title: Neuroscience Volume: 207 Pages: 243-260
  • DOI: 10.1016/j.neuroscience.2012.01.049
  • Peer Reviewed
• [Journal Article] The prostaglandin E2-EP4 system inherent in the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice (2012)
  • Author(s): Nakagawa N, Yuhki K, Kawabe J, Fujino T, Takahata O, Kabara M, Abe K, Kojima F, Kashiwagi H, Hasebe N, Kikuchi K, Sugimoto Y, Narumiya S, Ushikubi F
  • Journal Title: Kidney Int. Volume: (未定)(印刷中)
  • DOI: doi:10.1038/ki.2012.115
  • Peer Reviewed
• [Journal Article] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice (2012)
  • Author(s): Fukuhara S, et al.
  • Journal Title: J.Clin.Invest. Volume: 122 Pages: 1416-1426
  • DOI: doi:10.1172/JCI60746
  • Peer Reviewed
• [Journal Article] Surface loops of extracellular phospholipase A1 determine both substrate specificity and preference for lysophospholipids (2012)
  • Author(s): Arima N, et al.
  • Journal Title: J.Lipid Res. Volume: 53 Pages: 513-521
  • DOI: doi:10.1194/jlr.M022400
  • Peer Reviewed
• [Journal Article] PGD_2 induces eotaxin-3 via PPAR□from sebocytes : a possible pathogenesis of eosinophilic pustular folliculitis (2012)
  • Author(s): Nakahigashi, K., Otsuka, A., Doi H., Hirabayashi, T., Murakami, M., Urade, Y., Tanizaki, H., Egawa, G., Miyachi, Y., Kabashima, K.
  • Journal Title: J.Allergy Clin.Immunol. Volume: 129 Pages: 536-543
  • DOI: 10.1016/j.jaci.2011.11.034
  • Peer Reviewed
• [Journal Article] Identification and structure determination of a novel anti-inflammatory mediator resolvin E3 : 17,18-dihydroxy-eicosapentaenoic acid (2012)
  • Author(s): Isobe Y, Arita M, et al.
  • Journal Title: The Journal of Biological Chemistry Volume: (in press)(未定)
  • DOI: 10.1074/jbc.M112.340612
  • Peer Reviewed
• [Journal Article] Leukotriene B_4 receptors : Novel roles in immunological regulations (2011)
  • Author(s): Yokomizo T
  • Journal Title: Adv.Enzyme Regul. Volume: 51 Pages: 59-64
  • DOI: 10.1016/j.advenzreg.2010.08.002
  • Peer Reviewed
• [Journal Article] What is the natural ligand of GPR55? (2011)
  • Author(s): Okuno T, Yokomizo T
  • Journal Title: J.Biochem.(Tokyo) Volume: 149 Pages: 495-497
  • DOI: 10.1093/jb/mvr022
  • Peer Reviewed
• [Journal Article] International Union of Basic and Clinical Pharmacology. LXXXIV : Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions (2011)
  • Author(s): Back M., Dahlen S.E., Drazen J.M., Evans J.F., Serhan C.N., Shimizu T., Yokomizo T., Rovati G.E.
  • Journal Title: Pharmacol.Rev. Volume: 56 Pages: 539-584
  • DOI: 10.1016/j.advenzreg.2010.08.002
  • Peer Reviewed
• [Journal Article] Prostaglandin E_2-EP4 signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanism (2011)
  • Author(s): Inazumi T, Shirata N, Morimoto K, Takano H, Segi-Nishida E, Sugimoto Y
  • Journal Title: J.Lipid Res. Volume: 52 Pages: 1500-1508
  • DOI: 10.1194/jlr.M013615
  • Peer Reviewed
• [Journal Article] Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish (2011)
  • Author(s): Yukiura H, et al.
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 43972-43983
  • DOI: doi:10.1074/jbc.M111.301093
  • Peer Reviewed
• [Journal Article] LPA-producing enzyme PA-PLA1α regulates hair follicle development by modulating EGFR signaling (2011)
  • Author(s): Inoue A, et al.
  • Journal Title: EMBO J. Volume: 30 Pages: 4248-4260
  • DOI: doi:10.1038/emboj.2011.296
  • Peer Reviewed
• [Journal Article] Crystal structure of autotaxin and insight into GPCR activation by lipid mediators (2011)
  • Author(s): Nishimasu H, et al.
  • Journal Title: Nat.Struct.Mol.Biol. Volume: 18 Pages: 205-212
  • DOI: doi:10.1038/nsmb.1998
  • Peer Reviewed
• [Journal Article] Recent progress in phospholipase A_2 research : from cells to animals to humans (2011)
  • Author(s): Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayashi, T., Yamamoto, K.
  • Journal Title: Prog.Lipid Res. Volume: 50 Pages: 152-192
  • DOI: 10.1016/j.plipres.2010.12.001
  • Peer Reviewed
• [Journal Article] Integrated lipidomics in the secreted phospholipase A_2 biology (2011)
  • Author(s): Murakami, M., Taketomi, Y., Sato, H., Yamamoto, K.
  • Journal Title: Int.J.Mol.Sci. Volume: 12 Pages: 1474-1495
  • DOI: 10.3390/ijms12031474
  • Peer Reviewed
• [Journal Article] Secreted phospholipase A_2, lipoprotein hydrolysis, and atherosclerosis : integration with lipidomics (2011)
  • Author(s): Yamamoto, K., Isogai, Y., Sato, H., Taketomi, Y., Murakami, M.
  • Journal Title: Anal.Bioanal.Chem. Volume: 400 Pages: 1829-1842
  • DOI: 10.1007/s00216-011-4864-z
  • Peer Reviewed
• [Journal Article] Secreted phospholipase A_2 revisited (2011)
  • Author(s): Murakami, M., Taketomi, Y., Sato, H., Yamamoto, K.
  • Journal Title: J.Biochem.(Tokyo) Volume: 150 Pages: 233-255
  • DOI: 10.1093/jb/mvr088
  • Peer Reviewed
• [Journal Article] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin (2011)
  • Author(s): Yamamoto, K., Taketomi, T., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., Murakami, M.
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 11616-11631
  • DOI: 10.1074/jbc.M110.206714
  • Peer Reviewed
• [Journal Article] Physiological roles of group X secreted phospholipase A_2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function (2011)
  • Author(s): Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., Murakami, M.
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 11632-11648
  • DOI: 10.1074/jbc.M110.206755
  • Peer Reviewed
• [Journal Article] Analysis of two major intracellular phospholipase A_2s in mast cells reveals crucial contribution of cPLA_2□, not iPLA_2□, to lipid mobilization in proximal mast cells and distal fibroblasts (2011)
  • Author(s): Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., Murakami, M.
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 37249-37263
  • DOI: 10.1074/jbc.M111.290312
  • Peer Reviewed
• [Journal Article] m-Calpain is induced in vascular endothelial cells on human atheroma and accelerates atherosclerotic lesion development through proteolytic disorganization of VE-cadherin in hypercholesterolemic mice (2011)
  • Author(s): Miyazaki, T., Taketomi, Y., Takimoto, M., Lei, X., Akita, S., Kim-Kaneyama, J., Arata, S., Ohata, H., Ota, H., Murakami, M., Miyazaki, A.
  • Journal Title: Circulation Volume: 124 Pages: 2522-2532
  • DOI: 10.1161/CIRCULATIONAHA.111.021675
  • Peer Reviewed
• [Journal Article] Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation (2011)
  • Author(s): Lu, Y., Yang, J.H., Li, X., Hwangbo, K., Hwang, S.L., Taketomi, Y., Murakami, M., Chang, Y.C., Kim, C.H., Son, J.K., Chang, H.W.
  • Journal Title: Biochem.Pharmacol. Volume: 82 Pages: 1700-1708
  • DOI: 10.1016/j.bsp.2011.08.022
  • Peer Reviewed
• [Journal Article] N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community : the Hisayama Study (2011)
  • Author(s): Doi, Y., et.al.
  • Journal Title: Arterioscler Thromb Vase Biol Volume: 31(12) Pages: 2997-3003
  • DOI: ATVBAHA.111.223669[pii] 10.1161/ATVBAHA.111.223669
  • Peer Reviewed
• [Journal Article] Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese : the Hisayama Study (2011)
  • Author(s): Hata, J., et.al.
  • Journal Title: Cerebrovasc Dis Volume: 31(5) Pages: 477-84
  • DOI: 000324392[pii] 10.1159/000324392
  • Peer Reviewed
• [Journal Article] Association of Alzheimer disease pathology with abnormal lipid metabolism : the Hisayama Study (2011)
  • Author(s): Matsuzaki, T., et.al.
  • Journal Title: Neurology Volume: 77(11) Pages: 1068-75
  • DOI: 77/11/1068[pii] 10.1212/WNL.0b013e31822e145d
  • Peer Reviewed
• [Journal Article] Glucose tolerance status and risk of dementia in the community : the Hisayama Study (2011)
  • Author(s): Ohara, T., et.al.
  • Journal Title: Neurology Volume: 77(12) Pages: 1126-34
  • DOI: 77/12/1126[pii] 10.1212/WNL.0b013e31822f0435
  • Peer Reviewed
• [Journal Article] Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese : the Hisayama Study (2011)
  • Author(s): Ohara, T., et.al.
  • Journal Title: J Am Geriatr Soc Volume: 59(6) Pages: 1074-9
  • DOI: 10.1111/j.1532-5415.2011.03405.x
  • Peer Reviewed
• [Journal Article] Albuminuria as a risk factor for peripheral arterial disease in a general population : the Hisayama Study (2011)
  • Author(s): Usui, T., et.al.
  • Journal Title: J Atheroscler Thromb Volume: 18(8) Pages: 705-12
  • DOI: JST.JSTAGE/jat/7682[pii]
  • Peer Reviewed
• [Journal Article] White blood cell count and risk of gastric cancer incidence in a general Japanese population : the Hisayama Study (2011)
  • Author(s): Iida, M., et.al.
  • Journal Title: Am J Epidemiol Volume: 175(6) Pages: 504-10
  • DOI: kwr345[pii] 10.1093/aje/kwr345
  • Peer Reviewed
• [Journal Article] Effectiveness of the salivary occult blood test as a screening method for periodontal status (2011)
  • Author(s): Shimazaki, Y., et.al.
  • Journal Title: J Periodontol Volume: 82(4) Pages: 581-7
  • DOI: 10.1902/jop.2010.100304
  • Peer Reviewed
• [Journal Article] Nine-year incidence and risk factors for retinal vein occlusion in a general Japanese population : the Hisayama Study (2011)
  • Author(s): Arakawa, S., et.al.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52(8) Pages: 5905-9
  • DOI: iovs.11-7775[pii] 10.1167/iovs.11-7775
  • Peer Reviewed
• [Journal Article] High serum bilirubin levels and diabetic retinopathy : the Hisayama Study (2011)
  • Author(s): Yasuda, M., et.al.
  • Journal Title: Ophthalmology Volume: 118(7) Pages: 1423-8
  • DOI: S0161-6420(10)01302-3[pii] 10.1016/j.ophtha.2010.12.009
  • Peer Reviewed
• [Journal Article] Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis (2011)
  • Author(s): Umeno, J., et.al.
  • Journal Title: Inflamm Bowel Dis Volume: 17(12) Pages: 2407-15
  • DOI: 10.1002/ibd.21651
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population
  • Author(s): Arakawa, S., et.al.
  • Journal Title: Nat Genet Volume: 43(10) Pages: 1001-4
  • DOI: ng.938[pii] 10.1038/ng.938
  • Peer Reviewed
• [Presentation] Generation of a novel anti-FLAG monoclonal antibody (2012)
  • Author(s): Yokomizo, T
  • Organizer: The 7th Korea-Japan Conference on Cellular Signaling for Young Scientists
  • Place of Presentation: 韓国(Ulsan)(招待講演)
  • Year and Date: 20120217-20120218
• [Presentation] プロスタグランジンEP2受容体によるGs/□-arrestin活性化の相関 (2012)
  • Author(s): 松永拓子、岩崎亮、告恭史郎、稲住知明、森本和志、成宮周、杉本幸彦
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-29
• [Presentation] プロスタグランジンE2はマスト細胞のEP3受容体に作用して脱顆粒を引き起こし皮膚炎症を惹起する (2012)
  • Author(s): 森本和志、白田成俊、武富芳隆、瀬木-西田恵里、田中智之、村上誠、成宮周、杉本幸彦
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-29
• [Presentation] Two distinct leukotriene B4 receptors : BLT1 and BLT2 (2011)
  • Author(s): Yokomizo, T, Liu, M, Saeki, K, Okuno, T
  • Organizer: The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 20111114-20111116
• [Presentation] BLT1 as a potential marker of mouse dendritic cell subsets (2011)
  • Author(s): Koga T., Sasaki F., Saeki K., Okuno T., Yokomizo T.
  • Organizer: The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
  • Place of Presentation: Fukuoka
  • Year and Date: 20111114-20111116
• [Presentation] Two distinct pathway for biosynthesis of 12-HHT, a ligand for BLT2 (2011)
  • Author(s): Matsunobu T., Okuno T., Yokomizo T.
  • Organizer: The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
  • Place of Presentation: Fukuoka
  • Year and Date: 20111114-20111116
• [Presentation] 12-HHT is a natural ligand for BLT2 (2011)
  • Author(s): Okuno T., Yokomizo T.
  • Organizer: The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
  • Place of Presentation: Fukuoka
  • Year and Date: 20111114-20111116
• [Presentation] Leukotriene B4 augments and restores FcgRs-dependent phagocytosis in macrophages (2011)
  • Author(s): Saeki K., Okamoto R., Yokomizo T.
  • Organizer: The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
  • Place of Presentation: Fukuoka
  • Year and Date: 20111114-20111116
• [Presentation] Expression of an LTB4 receptor BLT1 in M2 macrophages (2011)
  • Author(s): Sasaki F., Koga T., Saeki K., Okuno T., Yokomizo T.
  • Organizer: The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
  • Place of Presentation: Fukuoka
  • Year and Date: 20111114-20111116
• [Presentation] 二つのロイコトリエンB4受容体(BLT1,BLT2)のシグナルと病態生理機能 (2011)
  • Author(s): 佐伯和子, 劉〓, 岡元冬樹, 奥野利明, 横溝岳彦
  • Organizer: 第84回日本生化学会大会シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 20110921-20110924
• [Presentation] Crucial role of the leukotriene B4 receptor BLT2 in epidermal wound healing (2011)
  • Author(s): Liu M., 佐伯和子, 奥野利明, 横溝岳彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 20110921-20110924
• [Presentation] GPCRの免疫沈降に有用な新規抗FLAG抗体の樹立と本抗体を用いた新規GPCR結合タンパク質の探索 (2011)
  • Author(s): 佐々木文之, 奥野利明, 佐伯和子, 横溝岳彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 20110921-20110924
• [Presentation] 結晶化のためのロイコトリエンB4受容体(BLT1)の熱安定化と抗BLT1モノクローナル抗体の作製 (2011)
  • Author(s): 堀哲哉, 菅原光明, 中村元直, 横溝岳彦, 清水孝雄, 宮野雅司
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 20110921-20110924
• [Presentation] Helix 8 of the leukotriene B4 receptor type 1 inhibits ligand-induced internalization (2011)
  • Author(s): 荒武良総, 奥野利明, 横溝岳彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 20110921-20110924
• [Presentation] ゼブラフィッシュのロイコトリエンB4/12-HHT受容体の同定 (2011)
  • Author(s): 奥野利明, 石谷太, 横溝岳彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 20110921-20110924
• [Presentation] Two distinct pathways for biosynthesis of 12-HHT, a ligand for BLT2 (2011)
  • Author(s): 松延武彦, 奥野利明, 横溝岳彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 20110921-20110924
• [Presentation] ロイコトリエンB4第二受容体BLT2の新しいリガンド12-HHTの生合成機構の解明 (2011)
  • Author(s): 松延武彦, 奥野利明, 横溝岳彦
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 20110512-20110513
• [Presentation] Crucial role of the leukotriene B4 receptor BLT2 in epidermal wound healing (2011)
  • Author(s): Liu M., Saeki K., Abe Y., Yokomizo T.
  • Organizer: Experimental Biology (Annual Meeting of American Society for Biochemistry and Molecular Biology)
  • Place of Presentation: Washington DC
  • Year and Date: 20110409-20110413
• [Presentation] Roles of 12-HHT/LTB4 receptor, BLT2 in murine inflammatory colitis (2011)
  • Author(s): Okuno T., Iizuka Y., Saeki K., Yokomizo T.
  • Organizer: Experimental Biology (Annual Meeting of American Society for Biochemistry and Molecular Biology)
  • Place of Presentation: Washington DC
  • Year and Date: 20110409-20110413
• [Presentation] Leukotriene B4 augments and restores FcgRs-dependent phagocytosis in macrophages (2011)
  • Author(s): Saeki K., Okamoto F., Yamasaki S., Yokomizo T.
  • Organizer: Experimental Biology (Annual Meeting of American Society for Biochemistry and Molecular Biology)
  • Place of Presentation: Washington DC
  • Year and Date: 20110409-20110413
• [Presentation] Generation of monoclonal antibodies specific for mouse leukotriene B4 receptor 1 and N-terminal FLAG sequence (2011)
  • Author(s): Sasaki F., Saeki K., Okuno T., Yokomizo T.
  • Organizer: Experimental Biology (Annual Meeting of American Society for Biochemistry and Molecular Biology)
  • Place of Presentation: Washington DC
  • Year and Date: 20110409-20110413
• [Presentation] 生理活性脂質受容体の同定と生体内機能の解析・高親和性FLAG抗体の樹立と応用 (2011)
  • Author(s): 横溝岳彦
  • Organizer: 第2回九州エリア薬理・生理学若手研究会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-12-26
• [Presentation] Mediator Lipidomics in Inflammation Research (2011)
  • Author(s): 有田誠
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-12-10
• [Presentation] 炎症の収束に関わる脂質メディエーターの代謝と網羅的解析 (2011)
  • Author(s): 有田誠
  • Organizer: 第50回日本鼻科学会総会
  • Place of Presentation: 岡山(招待講演)
  • Year and Date: 2011-12-02
• [Presentation] Immunosuppressive roles of lysophosphatidylserine in mice (2011)
  • Author(s): Kumiko Makide, Junken Aoki
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-27
• [Presentation] BLT1は樹状細胞の新規マーカー分子となりうるか? (2011)
  • Author(s): 古賀友紹, 佐伯和子, 佐々木文之, 奥野利明, 横溝岳彦
  • Organizer: 第8回東京呼吸器リサーチフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2011-11-19
• [Presentation] 生活習慣病の危険因子:久山町研究 (2011)
  • Author(s): 清原裕
  • Organizer: 第18回日本未病システム学会学術総会
  • Place of Presentation: 名古屋市(招待講演)
  • Year and Date: 2011-11-19
• [Presentation] Arachidonic acid metabolites are regulatory signals for neural stem cell proliferation and differentiation (2011)
  • Author(s): Makoto Arita
  • Organizer: 5th Congress of the International Society of Nutrigenetics/Nutrigenomics
  • Place of Presentation: Beijing, China(招待講演)
  • Year and Date: 2011-11-17
• [Presentation] Secreted phospholipase A_2s in reproduction (2011)
  • Author(s): Ushida, A., Sato, H., Yamamoto, K., Kobayashi, T., Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-15
• [Presentation] Secreted phospholipase A_2s in skin homeostasis (2011)
  • Author(s): Yamamoto, K., Shimo, K., Miki, Y, Sato, M., Taketomi, Y, Ikeda, K., Nakanishi, H., Taguchi, R., Gelb, M.H., Lambeau, G., Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-15
• [Presentation] Secreted phospholipase A_2s in anaphylaxis (2011)
  • Author(s): Taketomi, Y., Kojima, T., Ueno, N., Sato, H., Yamamoto, K., Aritake, K., Urade, Y, Sugimoto, Y., Narumiya, S., Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-15
• [Presentation] Secreted phospholipase A_2s in metabolic syndrome (2011)
  • Author(s): Sato, H., Taketomi, Y., Yamamoto, K., Ikeda, K., Arm, J.P., Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-15
• [Presentation] Secreted phospholipase A_2s in atopic dermatitis (2011)
  • Author(s): Shimo, K., Taketomi, Y., Miki, Y., Kojima, T., Kobayashi, T., Yamamoto, K., Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-15
• [Presentation] Searching the secrets of secreted phospholipase A_2s (2011)
  • Author(s): Murakami, M.
  • Organizer: The 10^<th> JBS Biofrontier International Symposium-New Aspect of Phospholipid Biology and Medicine 2011
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-11-15
• [Presentation] アレルギー応答を制御する新しい脂質ネットワーク (2011)
  • Author(s): 村上誠、武富芳隆
  • Organizer: 第61回日本アレルギー学会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-11-12
• [Presentation] 糖尿病と認知症の疫学:久山町研究 (2011)
  • Author(s): 清原裕
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] Secreted Phospholipase A_2 in epidermal differentiation, acidification, and barrier function (2011)
  • Author(s): Murakami, M., Lambeau, G., Gelb, M.H., Yamamoto, K.
  • Organizer: The 8^<th> GERLI Lipidomics meeting
  • Place of Presentation: Lyon, France
  • Year and Date: 2011-10-28
• [Presentation] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin (2011)
  • Author(s): Yamamoto, K., Taketomi, Y., Miki, Y., Sato, H., Ikeda, K., Nakanishi, H., Taguchi, R., Murakami, M.
  • Organizer: The 8^<th> GERLI Lipidomics meeting
  • Place of Presentation: Lyon, France
  • Year and Date: 2011-10-27
• [Presentation] 高血圧とメタボリックシンドロームの疫学 (2011)
  • Author(s): 清原裕
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 宇都宮市(招待講演)
  • Year and Date: 2011-10-21
• [Presentation] 脂質メタボロミクスによる炎症の制御機構の解析 (2011)
  • Author(s): 有田誠
  • Organizer: 第6回メタボロームシンポジウム
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-10-13
• [Presentation] sPLA_2-IIDは抗炎症性脂質の産生を制御して炎症応答の寛解に関与する (2011)
  • Author(s): 三木寿美、山本圭、下華奈子、武富芳隆、中西広樹、田口良、原俊太郎、村上誠
  • Organizer: ファーマ・バイオフォーラム2011
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-09
• [Presentation] 細胞内II型PAFアセチルハイドロラーゼマスト細胞における機能解析 (2011)
  • Author(s): 嶋中雄太、河野望、武富芳隆、向井康治朗、村上誠、新井洋由
  • Organizer: ファーマ・バイオフォーラム2011
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-08
• [Presentation] 変貌する日本人の生活習慣病の現状と課題:久山町研究 (2011)
  • Author(s): 清原裕
  • Organizer: 第61回日本体質医学会総会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-10-08
• [Presentation] 皮脂腺に特異的に発現する新規脂質代謝酵素の機能解析 (2011)
  • Author(s): 平林哲也、横山浩平、堀山正雄、島村透、片桐千仭、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-24
• [Presentation] PGE_2-EP3受容体シグナルはマスト細胞の活性化を介して炎症を惹起する (2011)
  • Author(s): 森本和志、白田成俊、武富芳隆、瀬木-西田恵里、田中智之、村上誠、成宮周、杉本幸彦
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] 好酸球性膿疱性毛包炎におけるPGD_2の役割の解明 (2011)
  • Author(s): 中東恭子、大塚篤志、平林哲也、村上誠、椛島健次
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] 皮膚病態生理における分泌性ホスホリパーゼA_2の機能 (2011)
  • Author(s): 山本圭、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-09-23
• [Presentation] プロスタグランジンE2-EP3受容体シグナルはマスト細胞の活性化を介して炎症を惹起する (2011)
  • Author(s): 森本和志、白田成俊、武富芳隆、瀬木-西田恵里、田中智之、村上誠、成宮周、杉本幸彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] 脂肪細胞への分化における内因性プロスタグランジンの役割 (2011)
  • Author(s): 稲住知明、白田成俊、瀬木-西田恵里、杉本幸彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] ゼブラフィッシュ プロスタノイド受容体のクローニングと性状解析 (2011)
  • Author(s): 告恭史郎, 岩崎亮, 川原敦雄, 井上飛鳥, 青木淳賢, 杉本幸彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] プロスタグランジンEP4受容体による視索前野ニューロンの細胞骨格制御の分子機構 (2011)
  • Author(s): 北條寛典、吉岡美樹、川原浩一、三隅将吾、瀬木-西田恵里、成宮周、杉本幸彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] アトピー性皮膚炎モデルにおける分泌性ホスホリパーゼA_2分子群の機能解析 (2011)
  • Author(s): 下華奈子、山本圭、三木寿美、武富芳隆、小林哲幸、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] X型分泌性ホスホリパーゼA_2の消化、神経機能、体毛形成における新規機能 (2011)
  • Author(s): 佐藤弘泰、武富芳隆、池田和貴、田口良、山本登志子、山本圭、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] X型分泌性ホスホリパーゼA_2の生殖における新規機能 (2011)
  • Author(s): 牛田絢子、佐藤弘泰、山本圭、池田和貴、小林哲幸、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] ホスファチジルエタノールアミンは破骨細胞融合に関与する (2011)
  • Author(s): 入江敦、山本圭、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] 細胞内II型PAFアセチルヒドラーゼのマスト細胞における機能解析 (2011)
  • Author(s): 嶋中雄太、河野望、武富芳隆、向野康二朗、村上誠、新井洋由
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] Getting new insights into the functions of sPLA_2s (2011)
  • Author(s): Murakami, M., Sato, H., Taketomi, Y., Yamamoto, K.
  • Organizer: The 12^<th> International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
  • Place of Presentation: Seattle, USA(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] マスト細胞を制御する新しい脂質マシナリー (2011)
  • Author(s): 武富芳隆、村上誠
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] ゼブラフィッシュ体節間血管形成におけるリゾホスファチジン酸シグナルの作用機序 (2011)
  • Author(s): 濱弘太郎、青木淳賢
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] 生理活性リゾリン脂質の定量系の開発と産生機構の解析 (2011)
  • Author(s): 井上飛鳥、青木淳賢
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] リゾホスファチジルセリンの細胞接着抑制作用 (2011)
  • Author(s): 北村一、青木淳賢
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] Novel role of eosinophils in controlling the resolution of acute inflammation by producing pro-resolving lipid mediators (2011)
  • Author(s): Makoto Arita
  • Organizer: 12th International Conference of bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Place of Presentation: Seattle, USA
  • Year and Date: 2011-09-21
• [Presentation] An adipokine-like phospholipase A_2 from hypertrophied adipocytes controls lipid metabolism and obesity (2011)
  • Author(s): Sato, H., Taketomi, T., Ikeda, K., Arm, J.P., Murakami, M.
  • Organizer: The 12^<th> International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
  • Place of Presentation: Seattle, USA
  • Year and Date: 2011-09-19
• [Presentation] Group IIF phospholipase A_2 maintains epidermal homeostasis (2011)
  • Author(s): Yamamoto, K., Shimo, K., Miki, Y., Taketomi, Y., Ikeda, K., Nakanishi, H., Taguchi, R., Gelb, M.H., Lambeau, G., Murakami, M.
  • Organizer: The 12^<th> International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
  • Place of Presentation: Seattle, USA
  • Year and Date: 2011-09-19
• [Presentation] 日本人におけるエビデンス構築の意義:Hisayama Studyを通して (2011)
  • Author(s): 清原裕
  • Organizer: 第54回日本歯周病学会秋季学術大会
  • Place of Presentation: 下関市(招待講演)
  • Year and Date: 2011-09-15
• [Presentation] Autaxin regulates vascular development via multiple LPA receptors in zebrafish (2011)
  • Author(s): Aoki J
  • Organizer: FASEB Summer Research Conference
  • Place of Presentation: Lucca, Italy(招待講演)
  • Year and Date: 2011-08-15
• [Presentation] The characterization of ATX and LPA receptors in zebrafish (2011)
  • Author(s): Kotaro Hama, 他
  • Organizer: 2011 FASEB Summer Research Conference
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-08-14
• [Presentation] TGF-alpha ectodomain shedding underlies LPA-induced hair formation (2011)
  • Author(s): Asuka Inoue, Junken Aoki
  • Organizer: 2011 FASEB Summer Research Conference
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-08-14
• [Presentation] Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful mammalian fertilization (2011)
  • Author(s): Yukihiko Sugimoto
  • Organizer: Gordon Research Conferences
  • Place of Presentation: Holderness, NH, USA(招待講演)
  • Year and Date: 2011-07-19
• [Presentation] Secular trends in hypertension and risk of stroke : the Hisayama Study (2011)
  • Author(s): Kiyohara Y
  • Organizer: 第43回日本動脈硬化学会総会
  • Place of Presentation: 札幌市(招待講演)
  • Year and Date: 2011-07-15
• [Presentation] Phospholipase A_2s in adiposity and metabolic syndrome (2011)
  • Author(s): Murakami, M.
  • Organizer: The 30^<th> Naito Conference on Membrane Dynamics and Lipid Biology
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2011-06-30
• [Presentation] Roles of multiple sPLA_2 enzymes in obesity, hepatic steatosis, insulin tolerance, lipoprotein metabolism and adipose inflammation (2011)
  • Author(s): Sato, H., Taketomi, T., Yamamoto, K., Murakami, M.
  • Organizer: The 30^<th> Naito Conference on Membrane Dynamics and Lipid Biology
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-30
• [Presentation] Metabolic pathways regulating formation and composition of lipid droplets in sebocytes (2011)
  • Author(s): Hirabayashi, T., Yokoyama, K., Ueno, N., Yamamoto, K., Katagiri, C., Murakami, M.
  • Organizer: The 30^<th> Naito Conference on Membrane Dynamics and Lipid Biology
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-30
• [Presentation] Eosinophils contribute to the resolution of acute peritonitis through the 12/15-lipoxygenase pathway (2011)
  • Author(s): Makoto Arita
  • Organizer: 10th World Congress on Inflammation
  • Place of Presentation: Paris, France
  • Year and Date: 2011-06-28
• [Presentation] Eosinophils promote resolution of acute peritonitis by producing 12/15-lipoxygenase-derived lipid mediators in mice (2011)
  • Author(s): Makoto Arita
  • Organizer: 7th Symposium for the International Eosinophil Society
  • Place of Presentation: Quebec, Canada
  • Year and Date: 2011-06-24
• [Presentation] 高齢者における脳血管疾患を考慮した脂質管理 (2011)
  • Author(s): 清原裕
  • Organizer: 第27回日本老年学会総会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-06-16
• [Presentation] 変貌する心血管病の現状と課題:久山町研究 (2011)
  • Author(s): 清原裕
  • Organizer: 第47回日本循環器病予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 福岡市(招待講演)
  • Year and Date: 2011-06-03
• [Presentation] 認知症のコホート研究:久山町研究 (2011)
  • Author(s): 清原裕
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋市(招待講演)
  • Year and Date: 2011-05-19
• [Presentation] 炎症を制御する脂肪酸代謝物の包括的メタボローム解析 (2011)
  • Author(s): 有田誠
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] Eosinophils contribute to the resolution of acute peritonitis by producing pro-resolving lipid mediators (2011)
  • Author(s): Makoto Arita
  • Organizer: LIPID MAPS Annual Meeting 2011
  • Place of Presentation: La Jolla, USA
  • Year and Date: 2011-05-02
• [Presentation] プロスタグランジン-ケモカイン相互作用の受精における役割 (2011)
  • Author(s): 杉本幸彦
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2011-04-22
• [Presentation] コホート研究の実践:久山町研究 (2011)
  • Author(s): 清原裕
  • Organizer: 第39回日本血管外科学会学術総会
  • Place of Presentation: 沖縄県宜野湾市(招待講演)
  • Year and Date: 2011-04-21
• [Presentation] 日本人の心血管病のリスクを考える:久山町研究 (2011)
  • Author(s): 清原裕
  • Organizer: 第39回日本血管外科学会学術総会
  • Place of Presentation: 沖縄県宜野湾市(招待講演)
  • Year and Date: 2011-04-21
• [Book] 実験医学2月号 (2012)
  • Author(s): 有田誠編
  • Total Pages: 129
  • Publisher: 羊土社
• [Book] 生化学実践問題基礎と臨床をつなぐ420題 (2011)
  • Author(s): 横溝岳彦
  • Total Pages: 214
  • Publisher: 南江堂
• [Book] 試料分析講座:脂質分析 (2011)
  • Author(s): 有田誠, ら・日本分析化学会編
  • Total Pages: 223
  • Publisher: 丸善出版株式会社
• [Book] Visual糖尿病臨床のすべて (2011)
  • Author(s): 平川洋一郎, 他
  • Total Pages: 133-140
  • Publisher: 中山書店
• [Book] 糖尿病学2011 (2011)
  • Author(s): 向井直子, 他
  • Total Pages: 128-133
  • Publisher: 診断と治療社
• [Book] 高血圧ナビゲーター (2011)
  • Author(s): 清原裕, 他
  • Total Pages: 50-51
  • Publisher: メディカルレビュー社
• [Book] すべてがわかる最新糖尿病 (2011)
  • Author(s): 清原裕, 他
  • Total Pages: 254-258
  • Publisher: 照林社
• [Remarks]
  • URL: http://www.lipid.med.kyushu-u.ac.jp/
• [Patent(Industrial Property Rights)] P2Y10またはGPR174を使用して、リゾホスファチジルセリン受容体への被検化合物のアゴニスト活性またはアンタゴニスト活性を評価することを含む、自己免疫疾患の治療剤または予防剤のスクリーニング方法 (2011)
  • Inventor(s): 青木淳賢, 他
  • Industrial Property Rights Holder: 青木淳賢, 他
  • Industrial Property Number: 特願2011-112881
  • Filing Date: 2011-05-19