Lipid machinery

2012 Fiscal Year Annual Research Report

• Project Area: Machineries of bioactive lipids in homeostasis and diseases
• Project/Area Number: 22116001
• Research Institution: Juntendo University
• Principal Investigator: 横溝 岳彦 順天堂大学, 医学(系)研究科(研究院), 教授 (60302840)
• Co-Investigator(Kenkyū-buntansha): 青木 淳賢 東北大学, 薬学研究科(研究院), 教授 (20250219) ; 村上 誠 公益財団法人東京都医学総合研究所, その他部局等, 研究員 (60276607) ; 清原 裕 九州大学, 医学(系)研究科(研究院), 教授 (80161602) ; 杉本 幸彦 熊本大学, 大学院生命科学研究部, 教授 (80243038) ; 有田 誠 東京大学, 薬学研究科(研究院), 准教授 (80292952) ; 馬嶋 正隆 北里大学, 医学部, 教授 (70181641)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 脂質メディエーター / 生理活性脂質 / 遺伝子欠損マウス / 質量分析機

Outline of Annual Research Achievements

計画班員・公募班員の研究を援助するため、以下の活動を行った。
1)本領域のホームページ(http://plaza.umin.ac.jp/lipids/)に、研究リソース、遺伝子、抗体のリスト、実験プロトコールの追加を行った。また領域メイリングリストを通じて、班員間の連絡や共同研究を積極的に展開した。
2)研究支援センターの整備と利用：3つのリピドミクスセンターにおいて、班員の30以上の研究プロジェクトの脂質定量解析を行った。遺伝子発現解析センターにおいて、班員の4つの研究プロジェクトの遺伝子発現プロファイリングを行った。SNP解析センターにおいて、班員の7つの研究プロジェクトをサポートした。ゼブラフィッシュ解析センターで、リゾリン脂質産生酵素、リゾリン脂質受容体、分泌性PLA2、スフィンゴシン1リン酸受容体、ロイコトリエンB4の二つの受容体の発生胚における遺伝子抑制、強制発現とその表現型解析をサポートした。
3)班会議関連。2012年2月1-2日に東京大学薬学部において若手ワークショップを開催した。2012年6月6-7日に、九州大学百年記念講堂で、国際シンポジウム「The first international symposium on lipid mediators」を開催した。2012年11月12-13日に、秋田市において第３回領域会議を開催した。
4)2012年3月に領域ニュースレター第三号を発行した。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

各研究支援センターの利用に関して、当初想定したよりもはるかに多い数の研究サポートが行われている。領域内のみならず、領域外の研究者に対しても、質量分析機を用いた脂質定量解析のサポートが行えているため。

Strategy for Future Research Activity

現時点では本研究総括班は極めて順調に稼働していると考えており、大きな問題点はない。今後も積極的な研究のサポートと、活発な班会議、情報発信を心がけていく。平成25年度は、新学術領域「自然免疫」領域との合同若手ワークショップを開催する予定である。また、本領域のメンバーが中心となって、日本国内では第二回目の開催となるFASEB Summer Research Conferenceを2013年8月に開催する。さらに本領域メンバーが中心となって、脂質分析の実験手法をまとめた単行本を、2013年前半に発行する予定である。

Research Products

• [Journal Article] 脂質由来メディエーターの種類・構造と生体での役割 (2013)
  • Author(s): 横溝岳彦
  • Journal Title: 内分泌・糖尿病・代謝 Volume: 26 Pages: 540-547
• [Journal Article] Ly6C(+) Ly6G(-) Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury. (2013)
  • Author(s): Saiwai H, Kumamaru H, Ohkawa Y, Kubota K, Kobayakawa K, Yamada H, Yokomizo T, Iwamoto Y, Okada S.
  • Journal Title: J. Neurochem. Volume: 125 Pages: 74-88
  • DOI: 10.1111/jnc.12135
  • Peer Reviewed
• [Journal Article] Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. (2013)
  • Author(s): Matsunaga Y., Fukuyama S., Okuno T., Sasaki F., Matsunobu T., Asai Y., Matsumoto K., Saeki K., Oike M., Sadamura Y., Nakanishi Y., Kubo M., Yokomizo T., Inoue H.
  • Journal Title: FASEB J Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] 脂質マシナリー (2013)
  • Author(s): 横溝岳彦
  • Journal Title: 感染 炎症 免疫 Volume: 43 Pages: 43-55
• [Journal Article] Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): metabolically stabilized LPA receptor agonists. (2013)
  • Author(s): Jiang G, Inoue A, Aoki J, Prestwich GD.
  • Journal Title: Bioorg Med Chem Lett. Volume: 23 Pages: 1865-1869
  • DOI: 10.1016/j.bmcl.2013.01.002.
  • Peer Reviewed
• [Journal Article] Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis. (2013)
  • Author(s): Bai Z, Cai L, Umemoto E, Takeda A, Tohya K, Komai Y, Veeraveedu PT, Hata E, Sugiura Y, Kubo A, Suematsu M, Hayasaka H, Okudaira S, Aoki J, Tanaka T, Albers HM, Ovaa H, Miyasaka M.
  • Journal Title: J Immunol. Volume: 190 Pages: 2036-2048
  • DOI: 10.4049/jimmunol.1202025.
  • Peer Reviewed
• [Journal Article] Emerging roles of secreted phospholipase A(2) enzymes: an update. (2013)
  • Author(s): Murakami M, Lambeau G.
  • Journal Title: Biochimie Volume: 95 Pages: 43-50
  • DOI: 10.1016/j.biochi.2012.09.007
  • Peer Reviewed
• [Journal Article] Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing. (2013)
  • Author(s): Ogawa Y, Taketomi Y, Murakami M, Tsujimoto M, Yanoshita R.
  • Journal Title: Biol Pharm Bull. Volume: 36 Pages: 66-75
  • DOI: org/10.1248/bpb.b12-00607
  • Peer Reviewed
• [Journal Article] Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice. (2013)
  • Author(s): Ait-Oufella H, Herbin O, Lahoute C, Coatrieux C, Loyer X, Joffre J, Laurans L, Ramkhelawon B, Blanc-Brude O, Karabina S, Girard CA, Payr#233; C, Yamamoto K, Binder CJ, Murakami M,et.a.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 33 Pages: 466-473
  • DOI: 10.1161/ATVBAHA
  • Peer Reviewed
• [Journal Article] The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer. (2013)
  • Author(s): Hiyoshi M, Kitayama J, Kazama S, Taketomi Y, Murakami M, Tsuno NH, Hongo K, Kaneko M, Sunami E, Watanabe T.
  • Journal Title: Oncol Lett. Volume: 5 Pages: 533-538
  • DOI: 10.3892/ol.2012.1067
  • Peer Reviewed
• [Journal Article] The lipid mediator protectin d1 inhibits influenza virus replication and improves severe influenza. (2013)
  • Author(s): Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanebe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, Murakami M, et.al.
  • Journal Title: Cell Volume: 153 Pages: 112-125
  • DOI: 10.1016/j.cell.2013.02.027
  • Peer Reviewed
• [Journal Article] AMPK negatively regulates FceRI-mediated mast cell signaling and anaphylaxis in mice. (2013)
  • Author(s): Hwang, S.L., Li, X., Lu, Y., Jin, Y., Jeong, Y.T., Kim, Y.D., Lee, I.K., Taketomi, Y., Sato, H., Cho, Y.S., Murakami, M., and Chang. H.W.
  • Journal Title: J. Allergy Clin. Immunol. Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression. (2013)
  • Author(s): Morita, Y., Sakaguchi, T., Ikegami, K., Goto-Inoue, N., Hayasaka, T. Hang, V.T., Tanaka, H., Harada, T., Shibasaki, Y., Suzuki, A., Inaba, K., Murakami, M., Setou, M., and Konno, H.
  • Journal Title: J. Hepatol. Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. (2013)
  • Author(s): Taketomi, Y., Ueno, N., Kojima, T., Satom H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M., Nakamura, Nishito, Y., Kawana, M., Kambe, N., Ikeda, K, et. al.
  • Journal Title: Nat. Immunol. Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving anti-inflammatory lipid mediators. (2013)
  • Author(s): Miki, Y., Yamamoto, K., Taketomi, Y., Sato, H., Shimo, K., Kobayashi, T., Ishikawa, Y., Ishii, T., Nakanishi, H., Ikeda, K., Taguchi, R., Kabashima, K., Arita, M、et.al.
  • Journal Title: J Exp. Med. Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] PLA2酵素群 (2013)
  • Author(s): 村上 誠
  • Journal Title: 遺伝子医学MOOK Volume: 印刷中 Pages: 印刷中
• [Journal Article] Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: the Hisayama study (2013)
  • Author(s): Doi Y, Ninomiya T, Hirakawa Y, Takahashi O, Mukai N, Hata J, Iwase M, Kitazono T, Oike Y, Kiyohara Y
  • Journal Title: Diabetes Care Volume: 36 Pages: 98-100
  • DOI: 10.2337/dc12-0166
  • Peer Reviewed
• [Journal Article] Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus. (2013)
  • Author(s): Sakaida, M., Sukeno, M., Imoto, Y., Tsuchiya, S., Sugimoto, Y., Okuno, Y., and Segi-Nishida, E.
  • Journal Title: Neuropharmacol. Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza (2013)
  • Author(s): Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanebe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, et.al.
  • Journal Title: Cell Volume: 153 Pages: 112-125
  • DOI: 10.1016/j.cell.2013.02.027.
  • Peer Reviewed
• [Journal Article] オメガ３脂肪酸の代謝と炎症の制御 (2013)
  • Author(s): 有田誠
  • Journal Title: BIOINDUSTRY（シーエムシー出版） Volume: 347 Pages: 11-17
• [Journal Article] 炎症のメタボローム解析から明らかになった好酸球の新規機能 (2013)
  • Author(s): 有田誠
  • Journal Title: 生化学（日本生化学会） Volume: 85 Pages: 97-102
• [Journal Article] Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells. (2013)
  • Author(s): Amano H, Ito Y, Ogawa F, Eshima K, Suzuki T, Oba K, Matsui Y, Kato S, Fukui T, Nakamura M, Kitasato H, Fukamizu A, Majima M.
  • Journal Title: Am J Pathol. Volume: 182 Pages: 553-564
  • DOI: 10.1016/j.ajpath.2012.10.026.
  • Peer Reviewed
• [Journal Article] Tumor apoptosis in prostate cancer by PGD(2) and its metabolite 15d-PGJ(2) in murine model. (2013)
  • Author(s): Nakamura M, Tsumura H, Satoh T, Matsumoto K, Maruyama H, Majima M, Kitasato H.
  • Journal Title: Biomed Pharmacother. Volume: 67 Pages: 66-71
  • DOI: 10.1016/j.biopha.2012.10.012.
  • Peer Reviewed
• [Journal Article] NSAID, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4+ VEGFR1+ cells to the ulcer granulation tissues. (2013)
  • Author(s): Sato T, Amano H, Ito Y, Eshima K, Minamino T, Ae T, Katada C, Ohno T, Hosono K, Suzuki T, Shibuya M, Koizumi W, Majima M.
  • Journal Title: Biomed Pharmacother. Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment (2013)
  • Author(s): Ohkubo H, Ito Y, Minamino T, Mishima T, Hirata M, Hosono K, Shibuya M, Yokomizo T, Shimizu T, Watanabe M, Majima M.
  • Journal Title: FASEB Journal Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] リンパ管新生：病態時の制御機構 (2013)
  • Author(s): 細野加奈子、馬嶋正隆
  • Journal Title: 日本薬理学会雑誌 Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] Helix 8 of leukotriene B4 receptor 1 inhibits ligand-induced internalization. (2012)
  • Author(s): Aratake Y, Okuno T, Matsunobu T, Saeki K, Takayanagi R, Furuya S, Yokomizo T.
  • Journal Title: FASEB J Volume: 26 Pages: 4068-4078
  • DOI: 10.1096/fj.12-212050
  • Peer Reviewed
• [Journal Article] Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunological memory by enhancing innate and adaptive immune systems. (2012)
  • Author(s): Yokota, Y., Inoue, H., Matsumura, Y., Nabeta, H., Narusawa, M., Watanabe, A., Sakamoto, C., Hijikata, Y., Iga-Murahashi, M., Takayama, K., Sasaki, F., Nakanishi, Y., Yokomizo, T.,Tani, K.
  • Journal Title: Blood Volume: 120 Pages: 3444-3454
  • DOI: 10.1182/blood-2011-10-383240
  • Peer Reviewed
• [Journal Article] Gタンパク質共役型受容体と生理活性脂質 (2012)
  • Author(s): 横溝岳彦
  • Journal Title: 臨床検査 Volume: 63 Pages: 539-587
• [Journal Article] クローズアップ実験法：新規抗FLAG抗体2H8の活用法 (2012)
  • Author(s): 佐々木文之、横溝岳彦
  • Journal Title: 実験医学 Volume: 30 Pages: 2987-2992
• [Journal Article] TGFα shedding assay: an accurate and versatile method for detecting GPCR activation. (2012)
  • Author(s): Inoue A, Ishiguro J, Kitamura H, Arima N, Okutani M, Shuto A, Higashiyama S, Ohwada T, Arai H, Makide K, Aoki J.
  • Journal Title: Nat Methods. Volume: 9 Pages: 1021-1029
  • DOI: 10.1038/nmeth.2172.
  • Peer Reviewed
• [Journal Article] A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis. (2012)
  • Author(s): Fujimoto A, Farooq M, Fujikawa H, Inoue A, Ohyama M, Ehama R, Nakanishi J, Hagihara M, Iwabuchi T, Aoki J, Ito M, Shimomura Y.
  • Journal Title: J Invest Dermatol. Volume: 132 Pages: 2342-2349
  • DOI: 10.1038/jid.2012.154
  • Peer Reviewed
• [Journal Article] Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry. (2012)
  • Author(s): Saigusa D, Shiba K, Inoue A, Hama K, Okutani M, Iida N, Saito M, Suzuki K, Kaneko T, Suzuki N, Yamaguchi H, Mano N, Goto J, Hishinuma T, Aoki J, Tomioka Y.
  • Journal Title: Anal Bioanal Chem. Volume: 403 Pages: 1897-1905
  • DOI: 10.1007/s00216-012-6004-9
  • Peer Reviewed
• [Journal Article] The β9 loop domain of PA-PLA1α has a crucial role in autosomal recessive woolly hair/hypotrichosis. (2012)
  • Author(s): Shinkuma S, Inoue A, Aoki J, Nishie W, Natsuga K, Ujiie H, Nomura T, Abe R, Akiyama M, Shimizu H.
  • Journal Title: J Invest Dermatol. Volume: 132 Pages: 2093-2095
  • DOI: 10.1038/jid.2012.96
  • Peer Reviewed
• [Journal Article] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. (2012)
  • Author(s): Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, et.al.
  • Journal Title: J Clin Invest. Volume: 122 Pages: 1416-1426
  • DOI: 10.1172/JCI60746.
  • Peer Reviewed
• [Journal Article] PGD2 induces eotaxin-3 via PPARg#61472;from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis. (2012)
  • Author(s): Nakahigashi K, Doi H, Otsuka A, Hirabayashi T, Murakami M, Urade Y, Tanizaki H, Egawa G, Miyachi Y, Kabashima K.
  • Journal Title: J. Allergy Clin. Immunol. Volume: 129 Pages: 536-543
  • DOI: 10.1016/j.jaci.2011.11.034
  • Peer Reviewed
• [Journal Article] Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis. (2012)
  • Author(s): Sasaki Y, Kamei D, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Hara S.
  • Journal Title: Oncogene Volume: 31 Pages: 2943-2952
  • DOI: 10.1038/onc.2011.472
  • Peer Reviewed
• [Journal Article] Citreorosein inhibits production of proinflammatory cytokines by blocking mitogen activated protein kinases, nuclear factor-κB and activator protein-1 activation in mouse bone marrow-derived mast cells. (2012)
  • Author(s): Lu Y, Suh SJ, Li X, Liang JL, Chi M, Hwangbo K, Kwon O, Chung TW, Kwak CH, Kwon KM, Murakami M, Jahng Y, Kim CH, Son JK, Chang HW.
  • Journal Title: Biol Pharm Bull. Volume: 35 Pages: 938-945
  • DOI: org/10.1248/bpb.35.938
  • Peer Reviewed
• [Journal Article] Saucerneol D inhibits eicosanoid generation and degranulation through suppression of Syk kinase in mast cells. (2012)
  • Author(s): Lu Y, Li Y, Seo CS, Murakami M, Son JK, Chang HW.
  • Journal Title: Food Chem Toxicol. Volume: 50 Pages: 4382-4388
  • DOI: 10.1016/j.fct.2012.08.053
  • Peer Reviewed
• [Journal Article] Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells. (2012)
  • Author(s): Lu Y, Suh SJ, Li X, Hwang SL, Li Y, Hwangbo K, Park SJ, Murakami M, Lee SH, Jahng Y, Son JK, Kim CH, Chang HW.
  • Journal Title: Food Chem Toxicol. Volume: 50 Pages: 913-919
  • DOI: 10.1016/j.fct.2011.11.046
  • Peer Reviewed
• [Journal Article] アナフィラキシーを制御する脂質ネットワーク (2012)
  • Author(s): 武富芳隆、村上 誠
  • Journal Title: 臨床免疫・アレルギー科 Volume: 58 Pages: 550-559
• [Journal Article] Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population: the Hisayama Study (2012)
  • Author(s): Miyazaki M, Doi Y, Ikeda F, Ninomiya T, Hata J, Uchida K, Shirota T, Matsumoto T, Iida M, Kiyohara Y
  • Journal Title: Gastric Cancer Volume: 15 Pages: 162-169
  • DOI: 10.1007/s10120-011-0092-7
  • Peer Reviewed
• [Journal Article] Impact of lower range of prehypertension on cardiovascular events in a general population: the Hisayama Study (2012)
  • Author(s): Fukuhara M, Arima H, Ninomiya T, Hata J, Yonemoto K, Doi Y, Hirakawa Y, Matsumura K, Kitazono T, Kiyohara Y
  • Journal Title: J Hypertens Volume: 30 Pages: 893-900
  • DOI: 10.1097/HJH.0b013e328351d380
  • Peer Reviewed
• [Journal Article] Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: the Hisayama study (2012)
  • Author(s): Ozawa M, Ninomiya T, Ohara T, Hirakawa Y, Doi Y, Hata J, Uchida K, Shirota T, Kitazono T, Kiyohara Y
  • Journal Title: J Am Geriatr Soc Volume: 60 Pages: 1515-1520
  • DOI: 10.1111/j.1532-5415.2012.04061.x
  • Peer Reviewed
• [Journal Article] Association between glucose tolerance level and cancer death in a general Japanese population: the Hisayama Study (2012)
  • Author(s): Hirakawa Y, Ninomiya T, Mukai N, Doi Y, Hata J, Fukuhara M, Iwase M, Kitazono T, Kiyohara Y
  • Journal Title: Am J Epidemiol Volume: 176 Pages: 856-864
  • DOI: 10.1093/aje/kws178
  • Peer Reviewed
• [Journal Article] Association study of susceptibility genes for late-onset Alzheimer's disease in the Japanese population (2012)
  • Author(s): Ohara T, Ninomiya T, Hirakawa Y, Ashikawa K, Monji A, Kiyohara Y, Kanba S, Kubo M
  • Journal Title: Psychiatr Genet Volume: 22 Pages: 290-293
  • DOI: 10.1097/YPG.0b013e3283586215
  • Peer Reviewed
• [Journal Article] The prostaglandin E2-EP4 system inherent in the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice. (2012)
  • Author(s): Nakagawa, N., Yuhki, K., Kawabe, J., Fujino, T., Takahata, O., Kabara, M., Abe, K., Kojima, F., Kashiwagi, H., Hasebe, N., Kikuchi, K., Sugimoto, Y., Narumiya, S., and Ushikubi, F.
  • Journal Title: Kidney Int. Volume: 82 Pages: 158-171
  • DOI: 10.1038/ki.2012.115.
  • Peer Reviewed
• [Journal Article] Inhibition of EP4 signaling attenuates aortic aneurysm formation. (2012)
  • Author(s): Yokoyama, U., Ishiwata, R., Jin, M., Kato, Y., Suzuki, O., Jin, H., Ichikawa, Y., Kumagaya, S., Katayama, Y., Fujita, T., Okumura, S., Sato, M., Sugimoto, Y, et. al.
  • Journal Title: PLOS ONE Volume: 7 Pages: e36724
  • DOI: 10.1371/journal.pone.0036724
  • Peer Reviewed
• [Journal Article] Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor. (2012)
  • Author(s): Hoshino, T., Namba, T., Takehara, M., Murao, N., Matsushima, T., Sugimoto, Y., Narumiya, S., Suzuki, T., Mizushima, T.
  • Journal Title: J. Neurochem. Volume: 120 Pages: 795-805
  • DOI: 10.1111/j.1471-4159.2011.07567.x
  • Peer Reviewed
• [Journal Article] Intracerebral microinjection of interleukin-4/interleukin-13 reduces beta-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young APP23 mice. (2012)
  • Author(s): Kawahara, K. Suenobu, M., Yoshida, A., Koga, K., Hyodo, A., Ohtsuka, H., Kuniyasu, A., Tamamaki, N., Sugimoto, Y., and Nakayama, H.
  • Journal Title: Neuroscience. Volume: 207 Pages: 243-260
  • DOI: 10.1016/j.neuroscience.2012.01.049
  • Peer Reviewed
• [Journal Article] Functions of prostaglandin receptors in contact dermatitis and application to drug discovery (2012)
  • Author(s): Morimoto K, Tsuchiya S, Sugimoto Y.
  • Journal Title: Yakugaku Zasshi. Volume: 132 Pages: 1217-1223
  • DOI: 10.1248/yakushi.12-00232-2
  • Peer Reviewed
• [Journal Article] CCL7 (2012)
  • Author(s): 杉本幸彦、森本和志
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57(Suppl.21) Pages: 386-390
• [Journal Article] Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acid. (2012)
  • Author(s): Isobe Y, Arita M, Matsueda S, Iwamoto R, Fujihara T, Nakanishi H, Taguchi R, Masuda K, Sasaki K, Urabe D, Inoue M, Arai H.
  • Journal Title: J Biol Chem Volume: 287 Pages: 10525-10534
  • DOI: 10.1074/jbc.M112.340612.
  • Peer Reviewed
• [Journal Article] Mediator lipidomics in acute inflammation and resolution (2012)
  • Author(s): Arita M
  • Journal Title: J Biochem Volume: 152 Pages: 313-319
  • DOI: 10.1093/jb/mvs092
  • Peer Reviewed
• [Journal Article] Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of inflammation (2012)
  • Author(s): Isobe Y, Kato T, Arita M
  • Journal Title: Front Immunol Volume: 3 Pages: Article 270
  • DOI: 10.3389/fimmu.2012.00270.
  • Peer Reviewed
• [Journal Article] 炎症の収束に関わる脂質メディエーターの新規機能 (2012)
  • Author(s): 有田誠
  • Journal Title: バイオサイエンスとインダストリー（バイオインダストリー協会） Volume: 71 Pages: 14-17
• [Journal Article] ω３/ω６脂肪酸バランスと炎症の制御 (2012)
  • Author(s): 有田誠
  • Journal Title: Surgery Frontier（メディカルレビュー社） Volume: 19 Pages: 428-430
• [Journal Article] In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats. (2012)
  • Author(s): Fujita T, Ishihara K, Yasuda S, Nakamura T, Maeda M, Kobayashi M, Sahashi K, Ikeda Y, Kumagai Y, Majima M.
  • Journal Title: J Pharmacol Exp Ther. Volume: 341 Pages: 626-633
  • DOI: 10.1124/jpet.111.187732.
  • Peer Reviewed
• [Journal Article] Thromboxane A#8322; receptor signaling facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells. (2012)
  • Author(s): Matsui Y, Amano H, Ito Y, Eshima K, Suzuki T, Ogawa F, Iyoda A, Satoh Y, Kato S, Nakamura M, Kitasato H, Narumiya S, Majima M.
  • Journal Title: Cancer Sci. Volume: 103 Pages: 700-707
  • DOI: 10.1111/j.1349-7006.2012.02200.x.
  • Peer Reviewed
• [Journal Article] Thromboxane A#8322; receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment. (2012)
  • Author(s): Minamino T, Ito Y, Ohkubo H, Hosono K, Suzuki T, Sato T, Ae T, Shibuya A, Sakagami H, Narumiya S, Koizumi W, Majima M.
  • Journal Title: Toxicol Appl Pharmacol. Volume: 259 Pages: 104-114
  • DOI: 10.1016/j.taap.2011.12.013.
  • Peer Reviewed
• [Journal Article] 病態時のリンパ管新生を制御するプロスタノイドの役割 (2012)
  • Author(s): 馬嶋正隆
  • Journal Title: 生体の科学 Volume: 63 Pages: 564-571
• [Presentation] 全身性代謝応答を制御するリゾホスホリパーゼ (2013)
  • Author(s): 村上誠
  • Organizer: 第133会日本薬学会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-30 – 2013-03-30
  • Invited
• [Presentation] TGFα切断を用いたGPCRと三量体Gタンパク質の共役活性の評価系の確立 (2013)
  • Author(s): 井上 飛鳥、青木 淳賢
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-28 – 2013-03-30
• [Presentation] 自己免疫性肝炎モデルにおけるリゾホスファチジルセリンの薬理作用 (2013)
  • Author(s): 巻出久美子、鈴木健介、井上飛鳥、青木淳賢
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-28 – 2013-03-30
• [Presentation] Lipid phophate phosphatase 3 による血管形成制御 (2013)
  • Author(s): 雪浦弘志、濱弘太郎、中永景太、井上飛鳥、奥平真一、青木淳賢
  • Organizer: 日本薬学会第133年会 シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-28 – 2013-03-30
• [Presentation] ゼブラフィッシュGs共役型プロスタグランジン受容体の基盤解析 (2013)
  • Author(s): 告恭史郎、岩崎亮、川原敦雄、土屋創健、杉本幸彦
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-28 – 2013-03-30
• [Presentation] プロスタグランジンの新たな生理機能 (2013)
  • Author(s): 杉本幸彦
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-28 – 2013-03-30
  • Invited
• [Presentation] ゼブラフィッシュCa2+動員型プロスタノイド受容体の薬理学的解析 (2013)
  • Author(s): 岩崎亮、川原敦雄、井上飛鳥、青木淳賢、土屋創健、杉本幸彦
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21 – 2013-03-23
• [Presentation] Roles of prostanoid receptor signaling in enhancement of tumor metastasis (2013)
  • Author(s): Ogawa F. Amano H. Majima M.
  • Organizer: 86th Jap Pharmacological Society Annual Meeting
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21 – 2013-03-21
  • Invited
• [Presentation] RAMP-1シグナルによる創傷治癒および血管新生の増強 (2013)
  • Author(s): 藏重千絵、細野加奈子、松田弘美、馬嶋正隆
  • Organizer: 86th Jap Pharmacological Society Annual Meeting
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21 – 2013-03-21
• [Presentation] A high-affinity monoclonal antibody against the FLAG tag useful for G-protein coupled receptor study (2013)
  • Author(s): F. Sasaki,, T. YokomizoF.
  • Organizer: 5th Annual International Congress of Antibodies
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2013-03-18 – 2013-03-20
  • Invited
• [Presentation] Generation of a high-affinity anti-FLAG monoclonal antibody 2H8 (2013)
  • Author(s): T. Yokomizo
  • Organizer: 5th Annual International Congress of Antibodies
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2013-03-18 – 2013-03-20
• [Presentation] Emerging roles of eosinophil-derived lipid mediators in controlling inflammation and resolution. (2013)
  • Author(s): Makoto Arita
  • Organizer: JST-CREST International Symposium, Frontiers in Immunology and Inflammation
  • Place of Presentation: 東京
  • Year and Date: 2013-02-12 – 2013-02-12
• [Presentation] Lipid phosphate phosphatase 3 regulates blood vessel formation by negatively controlling autotaxin - lysophosphatidic acid signaling (2013)
  • Author(s): Hiroshi Yukiura、 Kotaro Hama、 Shinichi Okudaira、 Asuka Inoue、 Junken Aok
  • Organizer: Gordon Research Conference Vascular Cell Biology
  • Place of Presentation: California, USA
  • Year and Date: 2013-01-27 – 2013-02-01
• [Presentation] 新規リゾホスホリパーゼによるGPC産生経路の生理的意義 (2012)
  • Author(s): 平林哲也、村上誠
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15 – 2012-12-15
  • Invited
• [Presentation] マスト細胞を制御するホスホリパーゼA2分子群の網羅的解析 (2012)
  • Author(s): 武富芳隆、上野紀子、小島卓巳、田中智之、依田恵美子、佐藤弘泰、平林哲也、山本圭、原俊太郎、村上誠.
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15 – 2012-12-15
• [Presentation] IIF型分泌性ホスホリパーゼA2の欠損は皮膚癌形成を抑制する (2012)
  • Author(s): 佐藤真利子、山本圭、下華奈子、三木寿美、村上誠
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15 – 2012-12-15
• [Presentation] sPLA2-IIDの欠損は接触性皮膚炎の感作相後期においてリンパ節の炎症を増悪する (2012)
  • Author(s): 三木寿美、山本圭、村上誠
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15 – 2012-12-15
• [Presentation] 遺伝子欠損マウスを用いた新規細胞内リゾホスホリパーゼの機能解析 (2012)
  • Author(s): 利美紗、平林哲也、島村透、安城樹、小林哲幸、村上誠.
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15 – 2012-12-15
• [Presentation] 皮膚病態生理機能におけるIIE型分泌性ホスホリパーゼA2の役割 (2012)
  • Author(s): 山本圭、佐藤弘泰、佐藤真利子、三木寿美、武富芳隆、村上誠
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15 – 2012-12-15
• [Presentation] Crucial role of the 12-HHT receptor BLT2 in epidermal wound healing (2012)
  • Author(s): L. Min, K. Saeki, T. Matsunobu, T. Okuno, T. Yokomizo
  • Organizer: 第85回日本生化学会大会シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
  • Invited
• [Presentation] Gタンパク質シグナルと受容体内在化を制御するGPCRヘリックス8の役割 (2012)
  • Author(s): 奥野利明, 荒武良総, 横溝岳彦
  • Organizer: 第85回日本生化学会大会シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
  • Invited
• [Presentation] The roles of leukotriene B4 receptor BLT2 in the cell-cell junction formation (2012)
  • Author(s): 石井由美子, 佐伯和子, L. Min, 奥野利明, 横溝岳彦
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
• [Presentation] LPAはLPA3受容体を介し着床期子宮の血管新生を亢進させる (2012)
  • Author(s): 藍川志津、濱弘太郎、可野邦行、青木淳賢
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
• [Presentation] セリンリゾリン脂質を認識する新規GPCRとその機能 (2012)
  • Author(s): 青木淳賢、 井上飛鳥、 巻出久美子
  • Organizer: 第85回日本生化学会大会 シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
  • Invited
• [Presentation] 毛髪形成メカニズムから派生したGタンパク質共役型受容体（GPCR）の新規検出系の開発とその応用 (2012)
  • Author(s): 井上 飛鳥、石黒 純、巻出 久美子、青木 淳賢
  • Organizer: 第85回日本生化学会大会 シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
  • Invited
• [Presentation] リゾホスファチジン酸受容体LPA3の活性化は迷走神経刺激の感受性を亢進させる (2012)
  • Author(s): 可野邦行、 遠藤智子、 濱弘太郎、 新井洋由、 Jerold Chun、 青木淳賢
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
• [Presentation] Lipid phosphate phosphatase 3 (LPP3) による血管形成制御機構の解析 (2012)
  • Author(s): 雪浦 弘志、濱 弘太郎、奥平 真一、井上 飛鳥、青木淳賢
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
• [Presentation] 抗原非依存性炎症におけるプロスタグランジンの役割 (2012)
  • Author(s): 森本和志、白田成俊、武富芳隆、土屋創健、瀬木-西田恵里、田中智之、椛島健治、村上誠、成宮周、杉本幸彦
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
  • Invited
• [Presentation] プロスタグランジンEP4受容体は脂肪細胞のインスリン応答を抑制する (2012)
  • Author(s): 稲住知明、白田成俊、瀬木-西田恵里、土屋創健、杉本幸彦
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
• [Presentation] IL-33誘導性マスト細胞応答におけるプロスタグランジンI2受容体IPの役割 (2012)
  • Author(s): 渡辺真由帆、森本和志、土屋創健、成宮周、杉本幸彦
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
• [Presentation] ゼブラフィッシュGs共役型プロスタグランジン受容体の基盤解析 (2012)
  • Author(s): 告恭史郎、岩崎亮、川原敦雄、土屋創健、杉本幸彦
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-16
• [Presentation] Emerging role of eosinophils and eosinophil-derived lipid mediators in controlling inflammation and resolution. (2012)
  • Author(s): Makoto Arita
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14 – 2012-12-14
  • Invited
• [Presentation] ミクログリアのIL-33遺伝子発現に対するプロスタグランジンE2の効果 (2012)
  • Author(s): 鈴木佑治、稲住知明、土屋創健、川原浩一、杉本幸彦
  • Organizer: 第28回日本薬学会九州支部大会
  • Place of Presentation: 熊本
  • Year and Date: 2012-12-08 – 2012-12-09
• [Presentation] Emerging roles of lipid mediators in the resolution of inflmmation (2012)
  • Author(s): Makoto Arita
  • Organizer: 日本免疫学会2012
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-06 – 2012-12-06
  • Invited
• [Presentation] Expression and Function of a Leukotriene B4 receptor 1 in M2-type macrophage (2012)
  • Author(s): 佐々木文之, 古賀友紹, 佐伯和子, 奥野利明, 横溝岳彦
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05 – 2012-12-07
• [Presentation] BLT1 as a potential marker of mouse dendritic cell subsets (2012)
  • Author(s): 古賀友紹, 佐々木文之, 佐伯和子, 奥野利明, 横溝岳彦
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05 – 2012-12-07
• [Presentation] Mediator lipidomics in inflammation research (2012)
  • Author(s): Makoto Arita
  • Organizer: JAFoS
  • Place of Presentation: USA
  • Year and Date: 2012-12-01 – 2012-12-01
  • Invited
• [Presentation] BLT1発現が規定するマクロファージサブセットの解析 (2012)
  • Author(s): 佐々木文之, 古賀友紹, 佐伯和子, 奥野利明, 横溝岳彦
  • Organizer: 第９回東京呼吸器リサーチフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2012-11-17 – 2012-11-17
• [Presentation] sPLA2群のバイオロジー (2012)
  • Author(s): 村上誠
  • Organizer: 第23回フォーラム・イン・ドージン
  • Place of Presentation: 熊本
  • Year and Date: 2012-11-16 – 2012-11-16
  • Invited
• [Presentation] ロイコトリエン受容体と新規生理活性脂質12-HHT (2012)
  • Author(s): 横溝岳彦
  • Organizer: 千里ライフサイエンスセミナー D5 脂質メディエーターと疾患
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-15 – 2012-11-15
  • Invited
• [Presentation] 細胞外リン脂質環境を制御するsPLA2群のバイオロジー (2012)
  • Author(s): 村上誠
  • Organizer: 千里ライフサイエンスセミナー
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-15 – 2012-11-15
  • Invited
• [Presentation] 病態時の脈管新生を制御する脂質メディエーターの役割 (2012)
  • Author(s): Majima M.
  • Organizer: 千里ライフサイエンスセミナー D5 脂質メディエーターと疾患
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-15 – 2012-11-15
  • Invited
• [Presentation] PLA2G5, a secreted phospholipase A2 induced in hypertrophic adipocytes, regulates lipid metabolism and obesity. (2012)
  • Author(s): Sato, H., Taketomi, Y., Kojima, T., Ushida, A., Yamamoto, K., Ikeda, K., Hara, S., Miyata, K., Oike, Y., and Murakami, M.
  • Organizer: The Annual IEIIS Meeting 2012
  • Place of Presentation: 東京
  • Year and Date: 2012-10-24 – 2012-10-24
• [Presentation] PLA2G2D, a Lymphoid tissue-associated secreted phospholipase A2, resolves inflammation by driving an anti-inflammatory lipid program. (2012)
  • Author(s): Miki, Y., Yamamoto, K., Taketomi, Y., and Murakami, M.
  • Organizer: The Annual IEIIS Meeting 2012
  • Place of Presentation: 東京
  • Year and Date: 2012-10-24 – 2012-10-24
• [Presentation] A novel dendritic cell subset that promotes Th17 differentiation (2012)
  • Author(s): T. Koga, F. Sasaki, K. Saeki, T. Okuno, T. Yokomizo
  • Organizer: 12th Biennial International Endotoxin Innate Immunity Society (IEIIS) Meeting
  • Place of Presentation: 東京
  • Year and Date: 2012-10-23 – 2012-10-26
• [Presentation] Two distinct pathways for biosynthesis of 12-HHT, a ligand for BLT2 receptor (2012)
  • Author(s): T. Okuno, T. Natsunobu, T. Yokomizo
  • Organizer: 12th Biennial International Endotoxin Innate Immunity Society (IEIIS) Meeting
  • Place of Presentation: 東京
  • Year and Date: 2012-10-23 – 2012-10-26
• [Presentation] Leukotriene B4 auguments and restores FcgRs-dependent phagocytosis in macrophages (2012)
  • Author(s): K. Saeki, F. Okamoto, T. Yokomizo
  • Organizer: 5th Annual International Congress of Antibodies
  • Place of Presentation: 東京
  • Year and Date: 2012-10-23 – 2012-10-26
• [Presentation] Roles of leukotriene B4 receptors in inflammation and immunity (2012)
  • Author(s): T. Yokomizo
  • Organizer: 12th Biennial International Endotoxin Innate Immunity Society (IEIIS) Meeting
  • Place of Presentation: 東京
  • Year and Date: 2012-10-23 – 2012-10-26
• [Presentation] Novel roles of phospholipase A2 enzymes and lipid machineries in allergic inflammation. (2012)
  • Author(s): Murakami, M., Taketomi, Y., and Yamamoto, K.
  • Organizer: International Symposium “Allergy and Inflammation”
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-10-13 – 2012-10-13
  • Invited
• [Presentation] Lipid mediator metabolism in the resolution of inflammation and potential drug development. (2012)
  • Author(s): Makoto Arita
  • Organizer: KSAP2012
  • Place of Presentation: Korea
  • Year and Date: 2012-10-05 – 2012-10-05
  • Invited
• [Presentation] PLA2G3, a mammalian homolog of anaphylactic phospholipase A2 in bee venom, facilitates proper maturation of mast cells through the paracrine PGD2 loop. (2012)
  • Author(s): Taketomi, Y., Kojima, T., Ueno, N., Sato, H., Urade, Y., Tanaka, S., Sugimoto, Y., and Murakami, M.
  • Organizer: CREST symposium
  • Place of Presentation: 東京
  • Year and Date: 2012-09-27 – 2012-09-27
• [Presentation] Emerging role of eosinophils and eosinophil-derived lipid mediators in acute inflammation and resolution. (2012)
  • Author(s): Makoto Arita
  • Organizer: 4th European Workshop on Lipid Mediators
  • Place of Presentation: France
  • Year and Date: 2012-09-27 – 2012-09-27
• [Presentation] Characterization of gene expression profiles for different types of mast cells pooled from mouse stomach sub-regions by an RNA amplification method (2012)
  • Author(s): Yukihiko Sugimoto and Soken Tsuchiya
  • Organizer: Single Cell Analysis Summit
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-09-25 – 2012-09-26
• [Presentation] 疫学的エビデンスに基づいた提言 (2012)
  • Author(s): 清原 裕
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20 – 2012-09-20
  • Invited
• [Presentation] リゾホスファチジン酸のマスト細胞における機能解明 (2012)
  • Author(s): 近藤 朋恵、可野 邦行、奥平 真一、Jerold Chun、青木 淳賢
  • Organizer: 第11回次世代を担う若手ファーマバイオフォーラム2012
  • Place of Presentation: 福岡
  • Year and Date: 2012-09-15 – 2012-09-16
• [Presentation] 血管形成におけるLPAシグナル調節機構の解析 (2012)
  • Author(s): 雪浦 弘志、濱 弘太郎、奥平 真一、井上 飛鳥、青木淳賢
  • Organizer: 第11回次世代を担う若手ファーマバイオフォーラム2012
  • Place of Presentation: 福岡
  • Year and Date: 2012-09-15 – 2012-09-16
• [Presentation] プロスタグランジンEP4受容体は脂肪細胞のインスリン応答を抑制する (2012)
  • Author(s): 稲住知明、白田成俊、土屋創健、瀬木-西田恵里、成宮周、杉本幸彦
  • Organizer: 第11回次世代を担う若手ファーマ・バイオフォーラム2012
  • Place of Presentation: 福岡
  • Year and Date: 2012-09-15 – 2012-09-16
• [Presentation] 脂肪酸代謝と炎症のメタボロミクス (2012)
  • Author(s): 有田誠
  • Organizer: 第３回Molecular Cardiovascular Conference
  • Place of Presentation: 北海道
  • Year and Date: 2012-09-07 – 2012-09-07
  • Invited
• [Presentation] リゾホスファチジン酸受容体LPA3選択的アゴニストは着床痕を劇的に増加させる (2012)
  • Author(s): 藍川志津、濱弘太郎、可野邦行、青木淳賢
  • Organizer: 第30回日本受精着床学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2012-08-30 – 2012-08-31
• [Presentation] 脂質メタボロミクスによる炎症の制御機構の解析 (2012)
  • Author(s): 有田誠
  • Organizer: レドックスライフイノベーション
  • Place of Presentation: 栃木
  • Year and Date: 2012-08-29 – 2012-08-29
  • Invited
• [Presentation] 炎症の収束における好酸球の新規機能 (2012)
  • Author(s): 有田誠
  • Organizer: 千里ライフサイエンスセミナー
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-27 – 2012-07-27
  • Invited
• [Presentation] sPLA2とメタボリックシンドローム. (2012)
  • Author(s): 村上誠
  • Organizer: 第33回日本炎症再生医学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-06 – 2012-07-06
  • Invited
• [Presentation] 胃潰瘍治癒過程におけるVEGF １型受容体シグナリングの役割 (2012)
  • Author(s): 佐東 丈仁、天野 英樹、馬嶋 正隆
  • Organizer: 第33回日本炎症・再生学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-06 – 2012-07-06
• [Presentation] 虚血筋組織におけるトロンボキサンA ２シグナルによる虚血改善メカニズムの解析 (2012)
  • Author(s): 天野 英樹、伊藤 義也、大庭 和人、江島 耕二、成宮 周、馬嶋 正隆
  • Organizer: 第33回日本炎症・再生学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-06 – 2012-07-06
• [Presentation] 肺再生におけるVEGFR1TK シグナルの役割 (2012)
  • Author(s): 天野 英樹、松井 啓夫、小川 史洋、渋谷 正史、馬嶋 正隆
  • Organizer: 第33回日本炎症・再生学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-06 – 2012-07-06
• [Presentation] 新規生理活性脂質12-HHTの同定と生体内における役割の解明 (2012)
  • Author(s): 横溝岳彦
  • Organizer: 第33回日本炎症・再生学会(シンポジウム)
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-05 – 2012-07-06
  • Invited
• [Presentation] マスト細胞を制御する新しい脂質マシナリー (2012)
  • Author(s): 武富芳隆、上野紀子、小島卓巳、田中智之、佐藤弘泰、西藤泰昌、山本圭、有竹浩介、裏出良博、杉本幸彦、成宮周、原俊太郎、村上誠
  • Organizer: 第33回日本炎症再生医学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-05 – 2012-07-05
• [Presentation] 油はなぜ体に必要か？脂質代謝酵素のノックアウトマウスから脂質シグナリングの重要性を考える (2012)
  • Author(s): 村上誠
  • Organizer: 第26回モロシヌス研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-06-15 – 2012-06-15
  • Invited
• [Presentation] マスト細胞を制御する新しい脂質マシナリー (2012)
  • Author(s): 武富芳隆、上野紀子、小島卓巳、田中智之、佐藤弘泰、西藤泰昌、山本圭、有竹浩介、裏出良博、杉本幸彦、成宮周、原俊太郎、村上誠
  • Organizer: 第54回日本脂質生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-08 – 2012-06-08
• [Presentation] マスト細胞のcPLA2aにより遊離されるアラキドン酸は局所環境でmPGES-1によりPGE2へ変換され抗アレルギーに関わる (2012)
  • Author(s): 上野紀子、武富芳隆、山本圭、平林哲也、亀井大輔、北芳博、清水孝雄、新沢康英、辻本賀英、池田和貴、田口良、村上誠
  • Organizer: 第54回日本脂質生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-08 – 2012-06-08
• [Presentation] BLT2の内在性リガンド12-HHTの生合成機構の解明 (2012)
  • Author(s): 松延武彦, 奥野利明, 横溝岳彦
  • Organizer: 第54回日本脂質生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-07 – 2012-06-08
• [Presentation] TGFα 切断を用いた脂質メディエーター受容体の検出法の開発 (2012)
  • Author(s): 井上 飛鳥、石黒 純、巻出 久美子、青木 淳賢
  • Organizer: 第54回日本脂質生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-07 – 2012-06-08
• [Presentation] 血管形成におけるLPAシグナルの解析 (2012)
  • Author(s): 雪浦弘志、濱弘太郎、奥平真一、中永景太、青木淳賢
  • Organizer: 第54回日本脂質生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-07 – 2012-06-08
• [Presentation] Roles of prostaglandins in enhancement of angiogenesis and lymphangiogenesis (2012)
  • Author(s): Majima M.
  • Organizer: 国際シンポジウム「1st International Symposium on Lipid Mediators」
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-07 – 2012-06-07
  • Invited
• [Presentation] sPLA2s in skin biology (2012)
  • Author(s): Murakami, M
  • Organizer: The 1st International Conference of Lipid Mediators
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-06 – 2012-06-06
  • Invited
• [Presentation] Mediator lipidomics in inflammation research. (2012)
  • Author(s): Makoto Arita
  • Organizer: The 1st International Symposium in Lipid Mediators
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-06 – 2012-06-06
• [Presentation] Roles of thromboxane receptor signaling in enhancement of angiogenesis. (2012)
  • Author(s): Majima M.
  • Organizer: 17th International Vascular Biology Meeting (IVBM) 2012
  • Place of Presentation: Wiesbaden
  • Year and Date: 2012-06-03 – 2012-06-03
  • Invited
• [Presentation] Roles of prostaglandins in enhancement of angiogenesis and lymphangiogenesis during the developments of cancers and inflammation. (2012)
  • Author(s): Majima M.
  • Organizer: Keystone Symposium: Inflammation during Carcinogenesis
  • Place of Presentation: Dublin
  • Year and Date: 2012-05-23 – 2012-05-23
  • Invited
• [Presentation] Development of a versatile GPCR assay and its application for ligand identification of orphan GPCRs (2012)
  • Author(s): Asuka Inoue、 Jun Ishiguro、 Kumiko Makide and Junken Aoki
  • Organizer: LIPID MAPS Annual Meeting 2012
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-05-07 – 2012-05-08
• [Presentation] Phospholipid metabolism and Autophagy (2012)
  • Author(s): Keita Nakanaga、 Asuka Inoue、 Junken Aoki
  • Organizer: LIPID MAPS Annual Meeting 2012
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-05-07 – 2012-05-08
• [Presentation] Calcitonin Gene-related Peptide; A neuronal cue for angiogenesis (2012)
  • Author(s): Majima M.
  • Organizer: Pacific Symposium on Vascular Biology in KAIST
  • Place of Presentation: Daejeon
  • Year and Date: 2012-04-26 – 2012-04-26
  • Invited
• [Book] 「最新生理活性脂質研究-実験手法、基礎的知識とその応用-」遺伝子医学MOOK 24号 (2013)
  • Author(s): 馬嶋正隆
  • Total Pages: 7
  • Publisher: メディカル ドゥ社
• [Book] 「最新生理活性脂質研究-実験手法、基礎的知識とその応用-」遺伝子医学MOOK 24号 (2013)
  • Author(s): 横溝岳彦(編)
  • Total Pages: 360
  • Publisher: メディカル ドゥ社
• [Book] 標準薬理学 第７版 (2013)
  • Author(s): 馬嶋正隆
  • Total Pages: 印刷中
  • Publisher: 医学書院
• [Book] Lipidomics (2012)
  • Author(s): Arita M, Iwamoto R, Isobe Y
  • Total Pages: 336
  • Publisher: WILEY-VCH
• [Remarks] 生命応答を制御する脂質マシーナリー
  • URL: http://plaza.umin.ac.jp/lipids/
• [Remarks] 順天堂大学医学部生化学第一講座
  • URL: http://plaza.umin.ac.jp/j_bio/
• [Patent(Industrial Property Rights)] ホスホリパーゼA2G3を指標としたスクリーニング方法 (2014)
  • Inventor(s): 村上誠、武富芳隆
  • Industrial Property Rights Holder: 村上誠、武富芳隆、東京都医学研
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2013-073775
  • Filing Date: 2014-03-29
• [Patent(Industrial Property Rights)] インフルエンザウイルス感染症の治療におけるプロテクチンD1の有効性 (2013)
  • Inventor(s): 今井由美子、久場敬司、有田誠、Josef Penninger
  • Industrial Property Rights Holder: 秋田大学、東京大学、IMBA
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2013-044813
  • Filing Date: 2013-03-06
• [Patent(Industrial Property Rights)] PLA2G2Fを指標とした抗皮膚癌薬のスクリーニング方法 (2012)
  • Inventor(s): 村上誠、山本圭
  • Industrial Property Rights Holder: 村上誠、山本圭、東京都医学研
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2012-25531
  • Filing Date: 2012-11-21