「脂質マシナリー」領域研究の推進

2013 Fiscal Year Annual Research Report

• Project Area: Machineries of bioactive lipids in homeostasis and diseases
• Project/Area Number: 22116001
• Research Institution: Juntendo University
• Principal Investigator: 横溝 岳彦 順天堂大学, 医学(系)研究科(研究院), 教授 (60302840)
• Co-Investigator(Kenkyū-buntansha): 青木 淳賢 東北大学, 薬学研究科(研究院), 教授 (20250219) ; 村上 誠 公益財団法人東京都医学総合研究所, その他部局等, その他 (60276607) ; 馬嶋 正隆 北里大学, 医学部, 教授 (70181641) ; 清原 裕 九州大学, 医学(系)研究科(研究院), 教授 (80161602) ; 杉本 幸彦 熊本大学, その他の研究科, 教授 (80243038) ; 有田 誠 東京大学, 薬学研究科(研究院), 准教授 (80292952)
• Project Period (FY): 2010-06-23 – 2015-03-31
• Keywords: 脂質メディエーター / 生理活性脂質 / 遺伝子欠損マウス / 質量分析機

Research Abstract

1)本領域のホームページ(http://plaza.umin.ac.jp/lipids/)に、研究リソース、遺伝子・抗体リスト、実験プロトコールの追加を行った。また、領域メーリングリストを通じて、班員間の連絡や共同研究を積極的に展開した。
2)研究支援センターの整備と利用：3つのリピドミクスセンターにおいて、班員の20以上の研究プロジェクトの脂質定量解析を行った。遺伝子発現解析センターにおいて、班員の3つの研究プロジェクトの遺伝子発現プロファイリング解析を行った。SNP解析センターにおいて、福岡県久山町の地域住民を対象に班員のプロジェクトの一塩基多型（SNPs）を測定した。
3)班会議・学会関連。2013年7月2-4日にかけて、新学術領域「自然炎症」班(三宅健介領域代表)と合同で、「合同若手ワークショップ」を開催した(徳島県鳴門市)。同年6月6-7日に、研究分担者青木淳賢が学会長として「第55回日本脂質生化学会」を開催し、総括班員の多くが参加し、学会をサポートした(宮城県松島町)。同年8月4-9日に、国内で2回目の開催となるFASEB SRC “Lysophospholipid and other related mediators”が開催され、これを領域としてサポートした(北海道ニセコ町)。同年9月11-13日に、第86回日本生化学会にてシンポジウム「生体膜リン脂質研究の最前線」を、研究分担者の青木・村上がオーガナイズした。同年11月28日に、第3回都医学研シンポジウム「脂質シグナリングの最前線-今、脂質が面白い」を、研究分担者の村上が主宰し、班員の横溝、村上、青木、有田が講演を行った。2014年3月30日に、日本薬学会大129年会において、シンポジウム「疾患標的分子の同定を目指す新しい脂質マシナリー研究」を開催した(熊本)。
4)出版関連。2013年5月に、本領域班員が中心となって、遺伝子医学MOOK「最新生理活性脂質研究とその臨床・創薬応用」を刊行した(横溝監修、青木、杉本、村上編集。)2014年2月に領域ニュースレター第四号を発行した。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

研究支援センターでは、当初想定したよりもはるかに多い数の研究サポートが行えている。領域内のみならず、領域外の研究者に対しても、質量分析機を用いた脂質定量解析を行うことができている。さらに、権威ある国際学会FASEB SRCを日本国内で開催できたことは、日本の脂質研究が世界をリードしていることを顕著に表しているものと思われる。村上班員の研究室を中心に、本領域の多くの研究者が参画した研究が、Nature Immunology誌に掲載されたほか、Journal of Experimental Medicine誌に2報の論文が採択されるなど、世界をリードする研究成果を出しつつある。さらに、国内では20年ほど刊行されることがなかった生理活性脂質研究の実験書「最新生理活性脂質研究とその臨床・創薬応用」を出版し、国内の生理活性脂質研究をサポートできている。

Strategy for Future Research Activity

本研究総括班は極めて順調に稼働しており、平成26年度も同様の研究サポートを行う予定である。班会議に加えて、平成27年2月には東京において脂質メディエーターに関する国際会議を開催する(学会長：村上班員)。また、本領域メンバーが中心になって、英文総説・実験書「Bioactive Lipid Mediators: Current Reviews and Protocols」を、Springer社から発刊予定である。

Research Products

• [Journal Article] 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. (2014)
  • Author(s): Liu M., Saeki K., Matsunobu T., Okuno T., Koga T., Sugimoto Y., Yokoyama C, Nakamizo S., Kabashima K., Narumiya S., Shimizu T., Yokomizo T
  • Journal Title: J. Exp. Med. Volume: in press Pages: -
  • Peer Reviewed
• [Journal Article] International Union of Basic and Clinical Pharmacology. LXXXIV: Update on Leukotriene, Lipoxin and Oxoeicosanoid Receptors. (2014)
  • Author(s): Back M., Dahlen S. E., Drazen J. M., Evans J. F., Serhan C. N., Shimizu T., Yokomizo T., Rovati G. E.
  • Journal Title: Br. J. Pharmacol Volume: in press Pages: -
  • DOI: 10.1111/bph.12665
  • Peer Reviewed
• [Journal Article] ロイコトリエンの生体内における役割 (2014)
  • Author(s): 佐伯和子, 横溝岳彦
  • Journal Title: 医学のあゆみ Volume: 248 Pages: 970-983
• [Journal Article] Autotaxin-lysophosphatidic acid signaling attenuates sphingosine-1-phosphate signaling leading to cardia bifida in zebrafish embryos. (2014)
  • Author(s): Nakanaga K, Hama K, Kano K, Sato T, Yukiura H, Inoue A, Saigusa D, Tokuyama H, Tomioka Y, Nishina H, Kawahara A and Aoki J.
  • Journal Title: J Biochem. Volume: 155 Pages: 235-241
  • DOI: 10.1093/jb/mvt114
  • Peer Reviewed
• [Journal Article] Lack of phospholipase A2 receptor increases susceptibility to cardiac rupture after myocardial infarction. (2014)
  • Author(s): Mishina H, Watanabe K, Tamaru S, Watanabe Y, Fujioka D, Takahashi S, Suzuki K, Nakamura T, Obata JE, Kawabata K, Yokota Y, Inoue O, Murakami M, Hanasaki K, Kugiyama K.
  • Journal Title: Circ Res. Volume: 114 Pages: 493-504
  • DOI: 10.1161/CIRCRESAHA.114.302319
  • Peer Reviewed
• [Journal Article] Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family. (2014)
  • Author(s): Udagawa O, Ito C, Ogonuki N, Sato H, Lee S, Tripvanuntakul P, Ichi I, Uchida Y, Nishimura T, Murakami M, Ogura A, Inoue T, Toshimori K, Arai H.
  • Journal Title: Genes Cells. Volume: 19 Pages: 13-27
  • DOI: 10.1111/gtc.12105
  • Peer Reviewed
• [Journal Article] Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation. (2014)
  • Author(s): Morimoto K, Shirata N, Taketomi Y, Tsuchiya S, Segi-Nishida E, Inazumi T, Kabashima K, Tanaka S, Murakami M, Narumiya S, Sugimoto Y.
  • Journal Title: J Immunol. Volume: 192 Pages: 1130-1137
  • DOI: 10.4049/jimmunol.130029
  • Peer Reviewed
• [Journal Article] Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells. (2014)
  • Author(s): Takahashi R., Amano H., Satoh T., Tabata K., Ikeda M., Kitasato H., Akira S., Iwamura M., Majima M.
  • Journal Title: Biomed Pharmacother. Volume: 28 Pages: 1237-1247
  • DOI: 10.1096/fj.13-238998
  • Peer Reviewed
• [Journal Article] Roles of receptor activity-modifying protein 1 in angiogenesis and lymphangiogenesis during skin wound healing in mice. (2014)
  • Author(s): Kurashige C., Hosono K., Matsuda H., Tsujikawa K., Okamoto H., Majima M.
  • Journal Title: FASEB J. Volume: 28 Pages: 1237-1247
  • DOI: 10.1096/fj.13-238998
  • Peer Reviewed
• [Journal Article] Aspirin reduces lung cancer metastasis to regional lymph nodes. (2014)
  • Author(s): Ogawa F., Amano H., Ito H., Matsui Y., Hosono K., Kitasato H., Satoh Y., Majima M.
  • Journal Title: Biomed Pharmacother. Volume: 68 Pages: 79-86
  • DOI: 10.1016/j.biopha.2013.11.006
  • Peer Reviewed
• [Journal Article] Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study. (2014)
  • Author(s): Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.
  • Journal Title: Cardiovasc Diabetol Volume: 13 Pages: 45-45
  • DOI: 10.1186/1475-2840-13-45
  • Peer Reviewed
• [Journal Article] Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: the Hisayama Study. (2014)
  • Author(s): Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y.
  • Journal Title: J Diabetes Invest Volume: 5 Pages: 162-169
  • DOI: 10.1111/jdi.12136
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling. (2014)
  • Author(s): Yokoyama, U., Minamisawa, S., Shioda, A. Jin, M.-H., Ishiwata, R., Masuda, M., Asou, T., Sugimoto, Y., Aoki, H., Nakamura, T., and Ishikawa, Y.
  • Journal Title: Circulation Volume: 129 Pages: 487-496
  • DOI: 10.1161/​CIRCULATIONAHA.113.004726
  • Peer Reviewed
• [Journal Article] Histamine synthesis is required for granule maturation in murine mast cells. (2014)
  • Author(s): Nakazawa, S., Sakanaka, M., Furuta, K., Natsuhara, M., Takano, H., Tsuchiya, S., Okuno, Y., Ohtsu, H., Nishibori, M., Thurmond, R.L., Hirasawa, N., Nakayama, K., Ichikawa, A., Sugimoto, Y., and Tanaka, S.
  • Journal Title: Eur. J. Immunol. Volume: 44 Pages: 204-214
  • DOI: 10.1002/eji.201343838
  • Peer Reviewed
• [Journal Article] プロスタグランジンＥ２による炎症惹起の分子機構 (2014)
  • Author(s): 北條寬典、杉本幸彦
  • Journal Title: 医学のあゆみ Volume: 248 Pages: 977-983
• [Journal Article] Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyusaturated fatty acids in vitro and in vivo. (2014)
  • Author(s): Taguchi A, Kawana K, Tomio K, Yamashita A, Isobe Y, Nagasaka K, Koga K, Inoue T, Nishida H, kojima S, Adachi K, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, kang JX, Arai H, Arita M, Osuga Y, Fujii T.
  • Journal Title: PLoS One Volume: 27 Pages: e89605
  • DOI: 10.1371/journal.pone.0089605.
  • Peer Reviewed
• [Journal Article] Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Leprcp/NDmcr rats, a metabolic syndrome model. (2014)
  • Author(s): Katakura M, Hashimoto M, Inoue T, Al Mamun A, Tanabe Y, Iwamoto R, Arita M, Tsuchikura S, Shido O.
  • Journal Title: Molecules Volume: 15 Pages: 3247-3263
  • DOI: 10.3390/molecules19033247.
  • Peer Reviewed
• [Journal Article] Combination therapy of 15-epi-lipoxin A4 with antibiotics protects mice from Escherichia coli-induced sepsis. (2014)
  • Author(s): Ueda T, Fukunaga K, Seki H, Miyata J, Arita M, Miyasho T, Obata T, Asano K, Betsuyaku T, Takeda J.
  • Journal Title: Crit Care Med Volume: 42 Pages: e288-295
  • DOI: 10.1097/CCM.0000000000000162.
  • Peer Reviewed
• [Journal Article] 炎症を制御する脂肪酸代謝物の包括的メタボロミクス (2014)
  • Author(s): 有田誠
  • Journal Title: 医学のあゆみ Volume: 248 Pages: 1199-1204
• [Journal Article] ω３脂肪酸の抗炎症作用とメタボロミクス (2014)
  • Author(s): 磯部洋輔、有田誠
  • Journal Title: 医学のあゆみ Volume: 248 Pages: 984-987
• [Journal Article] 炎症の収束に関わる脂質メディエーター (2014)
  • Author(s): 有田誠
  • Journal Title: 炎症と免疫 Volume: 22 Pages: 79-84
• [Journal Article] Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. (2013)
  • Author(s): Matsunaga Y., Fukuyama S., Okuno T., Sasaki F., Matsunobu T., Asai Y., Matsumoto K., Saeki K., Oike M., Sadamura Y., Machida K., Nakanishi Y., Kubo M., Yokomizo T., Inoue H.
  • Journal Title: FASEB J. Volume: 27 Pages: 3306-3314
  • DOI: 10.1096/fj.12-217000
  • Peer Reviewed
• [Journal Article] Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment. (2013)
  • Author(s): Ohkubo H., Ito Y., Minamino T., Mishima T., Hirata M., Hosono K., Shibuya M., Yokomizo T., Shimizu T., Watanabe M., Majima M.
  • Journal Title: FASEB J. Volume: 27 Pages: 3132-3143
  • DOI: 10.1096/fj.13-227421
  • Peer Reviewed
• [Journal Article] Ly6C+ Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury. (2013)
  • Author(s): Saiwai H, Kumamaru H, Ohkawa Y, Kubota K, Kobayakawa K, Yamada H, Yokomizo T, Iwamoto Y, Okada S.
  • Journal Title: J Neurochem. Volume: 125 Pages: 74-88
  • DOI: doi: 10.1111/jnc.12135
  • Peer Reviewed
• [Journal Article] Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. (2013)
  • Author(s): Taketomi Y., Ueno N., Kojima T., Sakanaka M., Kambe N., Ikeda K., Taguchi R., Nakamizo S., Kabashima K., Gelb M. H., Arita M., Yokomizo T., Nakamura M., Watanabe K., Hirai H., Nakamura M., Okayama Y., Ra C., Aritake K., Urade Y., Morimoto K., Sugimoto Y., Shimizu T., Narumiya S., Hara S., Murakami M.他5名
  • Journal Title: Nat. Immunol Volume: 14 Pages: 554-563
  • DOI: 10.1038/ni.2586
  • Peer Reviewed
• [Journal Article] Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand. (2013)
  • Author(s): Matsunobu T., Okuno T., Yokoyama C., Yokomizo T.
  • Journal Title: J. Lipid Res. Volume: 54 Pages: 2979-2987
  • DOI: 10.1194/jlr.M037754
  • Peer Reviewed
• [Journal Article] Synthesis of (S,5Z,8E,10E)-12-Hydroxyheptadeca-5,8,10-trienoic Acid (12S-HHT) and its Analogues (2013)
  • Author(s): Tojo, T. Wang, Q. Okuno, T. Yokomizo, T. Kobayashi, Y.
  • Journal Title: Synlett Volume: 24 Pages: 1545-1548
  • DOI: 10.1055/S-0033-1338961
  • Peer Reviewed
• [Journal Article] Neuronatin is related to keratinocyte differentiation by up-regulating involucrin. (2013)
  • Author(s): Dugu L., Nakahara T., Wu Z., Uchi H., Liu M., Hirano K., Yokomizo T., Furue M.
  • Journal Title: J. Dermatol. Sci. Volume: 73 Pages: 225-231
  • DOI: 10.1016/j.jdermsci.2013.10.008
  • Peer Reviewed
• [Journal Article] 脂質由来メディエーターの種類・構造と生体での役割 (2013)
  • Author(s): 横溝岳彦
  • Journal Title: 内分泌・糖尿病・代謝 Volume: 26 Pages: 540-547
• [Journal Article] エイコサノイド：臨床検査項目としての可能性 (2013)
  • Author(s): 横溝岳彦
  • Journal Title: 臨床化学 Volume: 42 Pages: 221-228
• [Journal Article] Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. (2013)
  • Author(s): Nakamura A, Ebina-Shibuya R, Itoh-Nakadai A, Muto A, Shima H, Saigusa D, Aoki J, Ebina M, Nukiwa T, Igarashi K.
  • Journal Title: J Exp Med. Volume: 210 Pages: 2191-2204
  • DOI: 110.1084/jem.20130028
  • Peer Reviewed
• [Journal Article] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators. (2013)
  • Author(s): Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M.
  • Journal Title: J Exp Med. Volume: 210 Pages: 1217-1234
  • DOI: 10.1084/jem.20121887
  • Peer Reviewed
• [Journal Article] Anti-inflammatory activity of hexane extracts from bones and internal organs of Anguilla japonica suppresses cyclooxygenase-2-dependent prostaglandin D₂ generation in mast cells and anaphylaxis in mice. (2013)
  • Author(s): Lu Y, Na MK, Suh SJ, Li X, Kim GJ, Chao GH, Jeong YT, Kim DS, Chang YC, Murakami M, Kang W, Kim CH, Chang HW.
  • Journal Title: Food Chem Toxicol Volume: 57 Pages: 307-313
  • DOI: 10.1016/j.fct.2013.03.029
  • Peer Reviewed
• [Journal Article] Deficiency of phospholipase A2 receptor exacerbates ovalbumin-induced lung inflammation. (2013)
  • Author(s): Tamaru S, Mishina H, Watanabe Y, Watanabe K, Fujioka D, Takahashi S, Suzuki K, Nakamura T, Obata JE, Kawabata K, Yokota Y, Murakami M, Hanasaki K, Kugiyama K.
  • Journal Title: J Immunol. Volume: 191 Pages: 1021-1028
  • DOI: 10.4049/jimmunol.1300738
  • Peer Reviewed
• [Journal Article] Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression. (2013)
  • Author(s): Morita Y, Sakaguchi T, Ikegami K, Goto-Inoue N, Hayasaka T, Hang VT, Tanaka H, Harada T, Shibasaki Y, Suzuki A, Fukumoto K, Inaba K, Murakami M, Setou M, Konno H.
  • Journal Title: J Hepatol. Volume: 29 Pages: 292-299
  • DOI: 10.1016/j.jhep.2013.02.030
  • Peer Reviewed
• [Journal Article] AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice. (2013)
  • Author(s): Hwang SL, Li X, Lu Y, Jin Y, Jeong YT, Kim YD, Lee IK, Taketomi Y, Sato H, Cho YS, Murakami M, Chang HW.
  • Journal Title: J Allergy Clin Immunol. Volume: 132 Pages: 729-736
  • DOI: 10.1016/j.jaci.2013.02.018
  • Peer Reviewed
• [Journal Article] 分泌性ホスホリパーゼA2による免疫制御 (2013)
  • Author(s): 村上誠
  • Journal Title: 細胞工学 Volume: 32 Pages: 1265-1271
• [Journal Article] 脂質ネットワークとアナフィラキシー (2013)
  • Author(s): 武富芳隆、村上誠
  • Journal Title: アレルギー・免疫 Volume: 20 Pages: 38-48
• [Journal Article] 分泌性ホスホリパーゼA2. (2013)
  • Author(s): 武富芳隆、村上誠
  • Journal Title: The Lipids Volume: 24 Pages: 70-78
• [Journal Article] 脂質メディエーターによるアレルギー制御 (2013)
  • Author(s): 武富芳隆、村上誠
  • Journal Title: 実験医学増刊―病態の理解に向かうアレルギー疾患研究 Volume: 31 Pages: 118-127
• [Journal Article] 疾病における脂質代謝ネットワークの機能 (2013)
  • Author(s): 三木寿美、山本圭、村上誠
  • Journal Title: オレオサイエンス Volume: 13 Pages: 23-29
• [Journal Article] PLA2酵素群 (2013)
  • Author(s): 村上誠
  • Journal Title: 遺伝子医学MOOK：最新生理活性脂質研究―実験手法、基礎知識とその応用― Volume: 24 Pages: 138-145
• [Journal Article] NSAID, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4+ VEGFR1+ cells to theulcer granulation tissues. (2013)
  • Author(s): Sato T., Amano H., Ito Y., Eshima K., Minamino .T, Ae T., Katada C., Ohno T., Hosono K., Suzuki T., Shibuya M., Koizumi W., Majima M.
  • Journal Title: Biomed Pharmacother Volume: 67 Pages: 607-613
  • DOI: 10.1016/j.biopha.2013.01.009
  • Peer Reviewed
• [Journal Article] Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the up regulation of epidermal growth factor expression on VEGFR1+ CXCR4+ cells recruited from bone marrow. (2013)
  • Author(s): Sato T., Amano H., Ito Y., Eshima K., Minamino T., Ae T., Katada C., Ohno T., Hosono K., Suzuki T., Shibuya M., Koizumi W., Majima M.
  • Journal Title: J Gastroenterol. Volume: 49 Pages: 455-469
  • DOI: 10.1007/s00535-013-0869-z
  • Peer Reviewed
• [Journal Article] A common polymorphism in the tissue kallikrein gene is associated with increased urinary excretions of calcium and sodium in Japanese volunteers. (2013)
  • Author(s): Fujita T., Yasuda S., Kamata T., Kamata K., Kumagai Y., Majima M.
  • Journal Title: J Hum Genet. Volume: 58 Pages: 758-761
  • DOI: 10.1038/jhg.2013.93
  • Peer Reviewed
• [Journal Article] リンパ管新生 (2013)
  • Author(s): 細野加奈子、馬嶋正隆
  • Journal Title: 日本薬理学雑誌 Volume: 141 Pages: 290-291
  • DOI: 10.1254/fpj.141.290
• [Journal Article] Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study. (2013)
  • Author(s): Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M, Kitazono T, Kiyohara Y.
  • Journal Title: Atherosclerosis Volume: 231 Pages: 261-267
  • DOI: 10.1016/j.atherosclerosis.2013.09.023
  • Peer Reviewed
• [Journal Article] Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study. (2013)
  • Author(s): Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y.
  • Journal Title: Kidney Int Volume: 84 Pages: 373-380
  • DOI: 10.1038/ki.2013.111
  • Peer Reviewed
• [Journal Article] Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: the Hisayama Study. (2013)
  • Author(s): Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, Fukuhara M, Kitazono T, Oike Y, Kiyohara Y.
  • Journal Title: Circ J Volume: 77 Pages: 2311-2317
  • DOI: 10.1253/circj.CJ-12-1548
  • Peer Reviewed
• [Journal Article] Temporal trends in sudden unexpected death in a general population: the Hisayama Study. (2013)
  • Author(s): Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y.
  • Journal Title: Am Heart J Volume: 165 Pages: 932-938
  • DOI: 10.1016/j.ahj.2013.02.028
  • Peer Reviewed
• [Journal Article] Magnesium intake decreases ｔype 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study. (2013)
  • Author(s): Hata A, Doi Y, Ninomiya T, Mukai N, Hirakawa Y, Hata J, Ozawa M, Uchida K, Shirota T, Kitazono T, Kiyohara Y.
  • Journal Title: Diabet Med Volume: 30 Pages: 1487-1494
  • DOI: 10.1111/dme.12250
  • Peer Reviewed
• [Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009). (2013)
  • Author(s): Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y.
  • Journal Title: Circulation Volume: 128 Pages: 1198-1205
  • DOI: 10.1161/CIRCULATIONAHA.113.002424
  • Peer Reviewed
• [Journal Article] Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study. (2013)
  • Author(s): Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y.
  • Journal Title: Cardiovasc Diabetol Volume: 12 Pages: 164-164
  • DOI: 10.1186/1475-2840-12-164
  • Peer Reviewed
• [Journal Article] Birth regulates the initiation of sensory map formation through serotonin signaling. (2013)
  • Author(s): Toda, T., Homma, D., Tokuoka, H., Hayakawa, I., Sugimoto, Y., Ichinose, H., and Kawasaki, H.
  • Journal Title: Dev. Cell Volume: 27 Pages: 32-46
  • DOI: 10.1016/j.devcel.2013.09.002
  • Peer Reviewed
• [Journal Article] Electroconvulsive seizure-induced changes in gene expression in the mouse hypothalamic paraventricular nucleus. (2013)
  • Author(s): Segi-Nishida, E., Sakaida, M., Sukeno, M., Imoto, Y., Kira, T., Tsuchiya, S., Sugimoto, Y., Okuno, Y.
  • Journal Title: J. Psychopharmacol. Volume: 27 Pages: 1058-1069
  • DOI: 10.1177/0269881113497612
  • Peer Reviewed
• [Journal Article] Molecular and pharmacological characterization of zebrafish 'contractile' and 'inhibitory' prostanoid receptors. (2013)
  • Author(s): Iwasaki, R., Tsuge, K., Morimoto, K., Inazumi, T., Kawahara, O., Kawahara, A., Tsuchiya, S., Sugimoto, Y.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 438 Pages: 353-358
  • DOI: 10.1016/j.bbrc.2013.07.075
  • Peer Reviewed
• [Journal Article] Molecular and pharmacological characterization of zebrafish ‘relaxant’ prostanoid receptors. (2013)
  • Author(s): Tsuge, K., Iwasaki, R., Morimoto, K., Inazumi, T., Kawahara, O., Kawahara, A., Tsuchiya, S., and Sugimoto, Y.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 436 Pages: 685-690
  • DOI: 10.1016/j.bbrc.2013.06.017
  • Peer Reviewed
• [Journal Article] Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus. (2013)
  • Author(s): Segi-Nishida, E., Sukeno, M., Imoto, Y., Kira, T., Sakaida, M., Tsuchiya, S., Sugimoto, Y., and Okuno, Y.
  • Journal Title: Neuropharmacol. Volume: 71 Pages: 164-173
  • DOI: 10.1016/j.neuropharm.2013.03.033
  • Peer Reviewed
• [Journal Article] プロスタノイド受容体の作用機序と中枢における意義・役割 (2013)
  • Author(s): 稲住知明、土屋創健、杉本幸彦
  • Journal Title: 遺伝子医学MOOK Volume: 24 Pages: 187-192
• [Journal Article] 抗原非依存性急性炎症におけるプロスタグランジンの役割 (2013)
  • Author(s): 杉本幸彦、森本和志、土屋創健
  • Journal Title: 血栓と循環 Volume: 21 Pages: 178-182
• [Journal Article] Eicosapentaenoic acid is converted via omega-3 epoxygenation to anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid. (2013)
  • Author(s): Kubota T, Arita M, Isobe Y, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H
  • Journal Title: FASEB J. Volume: 28 Pages: 586-593
  • DOI: 10.1096/fj.13-236224.
  • Peer Reviewed
• [Journal Article] Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3 (2013)
  • Author(s): Isobe Y, Arita M, Iwamoto R, Urabe D, Todoroki H, Masuda K, Inoue M, Arai H.
  • Journal Title: J Biochem Volume: 153 Pages: 355-360
  • DOI: 10.1093/jb/mvs151.
  • Peer Reviewed
• [Journal Article] Omega-3 polyunsaturated fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models. (2013)
  • Author(s): Tomio K, Kawana K, Taguchi A, Isobe Y, Iwamoto R, Yamashita A, Kojima S, Mori M, Nagamatsu T, Arimoto T, Oda K, Osuga Y, Taketani Y, Kang JX, Arai H, Arita M, Kozuma S, Fujii T.
  • Journal Title: PLoS One Volume: 8 Pages: e73085
  • DOI: 10.1371/journal.pone.0073085.
  • Peer Reviewed
• [Journal Article] Increased tissue level of omega-3 polyunsaturated fatty acids prevents pathological preterm birth. (2013)
  • Author(s): Yamashita A, Kawana K, Tomio K, Taguchi A, Isobe Y, Iwamoto R, Masuda K, Furuya H, Nagamatsu T, Nagasaka K, Oda K, Wada-Hiraike O, Yamashita T, Taketani Y, Kang JX, Arai H, Arita M, Kozuma S, Fujii T.
  • Journal Title: Sci Rep Volume: 3 Pages: 3113
  • DOI: 10.1038/srep03113.
  • Peer Reviewed
• [Journal Article] Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. (2013)
  • Author(s): Kishino S, Takeuchi M, Park S, Hirata A, Kitamura N, Kunisawa J, Kiyono H, Iwamoto R, Isobe Y, Arita M, Arai H, Ueda K, Shima J, Takahashi S, Yokozeki K, Shimizu S, Ogawa J.
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 Pages: 17808-17813
  • DOI: 10.1073/pnas.1312937110.
  • Peer Reviewed
• [Journal Article] Inflammation and resolution are associated with upregulation of fatty acid beta-oxidation in zymosan-induced peritonitis. (2013)
  • Author(s): Fujieda Y, Manno A, Hayashi Y, Rhodes N, Guo L, Arita M, Bamba T, Fukusaki E.
  • Journal Title: PLoS One Volume: 8 Pages: e66270
  • DOI: 10.1371/journal.pone.0066270.
  • Peer Reviewed
• [Journal Article] Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy. (2013)
  • Author(s): Maekawa K, Hirayama A, Iwata Y, Tajima Y, Nishimaki-Mogami T, Sugawara S, Ueno N, Abe H, Ishikawa M, Murayama M, Matsuzawa Y, Nakanishi H, Ikeda K, Arita M, Taguchi R, Minamino N, Wakabayashi S, Soga T, Saito Y.
  • Journal Title: J Mol Cell Cardiol Volume: 59 Pages: 76-85
  • DOI: 10.1016/j.yjmcc.2013.02.008.
  • Peer Reviewed
• [Journal Article] Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease. (2013)
  • Author(s): Tajima Y, Ishikawa M, Maekawa K, Murayama M, Senoo Y, Nishimaki-Mogami T, Nakanishi H, Ikeda K, Arita M, Taguchi R, Okuno A, Mikawa R, Niida S, Takikawa O, Saito Y.
  • Journal Title: Lipids Health Dis Volume: 12 Pages: 68
  • DOI: 10.1186/1476-511X-12-68.
  • Peer Reviewed
• [Journal Article] Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. (2013)
  • Author(s): Juman S, Hashimoto M, Katakura M, Inoue T, Tanabe Y, Arita M, Miki T, Shido O.
  • Journal Title: Nutrients Volume: 5 Pages: 1949-1961
  • DOI: 10.3390/nu5061949.
  • Peer Reviewed
• [Journal Article] ω３脂肪酸代謝産物のメタボローム解析と抗炎症作用 (2013)
  • Author(s): 久保田唯史、磯部洋輔、有田誠
  • Journal Title: 血栓と循環 Volume: 21 Pages: 195-199
• [Journal Article] オメガ３系多価不飽和脂肪酸の代謝と抗炎症作用 (2013)
  • Author(s): 有田誠
  • Journal Title: Cardiovascular Contemporary Volume: 2 Pages: 32-37
• [Journal Article] リピドミクス解析のアレルギー研究への応用 (2013)
  • Author(s): 宮田純、有田誠
  • Journal Title: 実験医学増刊「病態の理解に向かうアレルギー疾患研究」 Volume: 31 Pages: 2852-2858
• [Journal Article] 好酸球による炎症とホメオスタシスの制御 (2013)
  • Author(s): 松枝進之介、磯部洋輔、有田誠
  • Journal Title: 炎症と免疫 Volume: 21 Pages: 450-454
• [Journal Article] 組織炎症の制御におけるn-3/n-6系脂肪酸バランスの重要性 (2013)
  • Author(s): 松枝進之介、有田誠
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 36 Pages: 485-489
• [Journal Article] 脂肪酸バランスと炎症の制御 (2013)
  • Author(s): 有田誠
  • Journal Title: 静脈経腸栄養 Volume: 28 Pages: 929-932
• [Presentation] Highly efficient immunoprecipitation using high-affinity FLAG antibody and magnetic beads (2014)
  • Author(s): Ichiki, T., Sasaki, F.,Yokomizo, T.
  • Organizer: Keystone Symposium
  • Place of Presentation: Snowbird
  • Year and Date: 20140330-20140405
• [Presentation] 脂肪組織におけるプロスタグランジンの生理機能 (2014)
  • Author(s): 杉本幸彦
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本
  • Year and Date: 20140328-20140330
  • Invited
• [Presentation] 炎症の収束に関わる細胞と脂質マシナリー (2014)
  • Author(s): 有田誠、谷友香子、磯部洋輔、新井洋由
  • Organizer: 第134回日本薬学会
  • Place of Presentation: 熊本
  • Year and Date: 20140328-20140330
  • Invited
• [Presentation] ω３系脂肪酸の代謝と抗炎症作用のメタボローム解析 (2014)
  • Author(s): 有田誠、磯部洋輔、遠藤仁、新井洋由
  • Organizer: 第134回日本薬学会
  • Place of Presentation: 熊本
  • Year and Date: 20140328-20140330
  • Invited
• [Presentation] 新規樹状細胞サブセットマーカー分子としてのロイコトリエンB4受容体 (2014)
  • Author(s): 古賀友紹, 佐々木文之, 佐伯和子, 奥野利明,横溝岳彦
  • Organizer: 第134回日本薬学会
  • Place of Presentation: 熊本
  • Year and Date: 20140327-20140330
• [Presentation] 12-HHT受容体BLT2の上皮保護作用 (2014)
  • Author(s): 奥野利明, 劉珉, 佐伯和子, 松延武彦,横溝岳彦
  • Organizer: 第134回日本薬学会
  • Place of Presentation: 熊本
  • Year and Date: 20140327-20140330
  • Invited
• [Presentation] 免疫系を制御する新たな脂質メディエーターリゾホスファチジルセリン (2014)
  • Author(s): 青木 淳賢、巻出 久美子、井上 飛鳥
  • Organizer: 第134回日本薬学会
  • Place of Presentation: 熊本
  • Year and Date: 20140327-20140330
  • Invited
• [Presentation] sPLA2と免疫抑制 (2014)
  • Author(s): 村上誠
  • Organizer: 第134会日本薬学会
  • Place of Presentation: 熊本
  • Year and Date: 20140327-20140330
  • Invited
• [Presentation] オメガ3脂肪酸由来の活性代謝物の構造と機能 (2014)
  • Author(s): 磯部洋輔、有田誠
  • Organizer: 日本農芸化学会2014年度大会
  • Place of Presentation: 東京
  • Year and Date: 20140327-20140330
  • Invited
• [Presentation] ω3系脂肪酸の代謝と抗炎症作用 (2014)
  • Author(s): 有田誠
  • Organizer: 第35回Osaka Diabetes Forum
  • Place of Presentation: 大坂
  • Year and Date: 20140327-20140327
  • Invited
• [Presentation] 我が国の循環器疾患とリスク因子の時代変遷． (2014)
  • Author(s): 清原 裕
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20140321-20140323
• [Presentation] リン脂質代謝酵素ホスホリパーゼA2による生命応答制御の新基軸 (2014)
  • Author(s): 村上誠
  • Organizer: 順天堂大学アトピー疾患研究センターセミナー
  • Place of Presentation: 東京
  • Year and Date: 20140320-20140320
  • Invited
• [Presentation] Role of Dendritic Cells via COX-2 Derived PGE2-EP3 Signaling for Pre-metastatic Niche Formation in Lymph Node Metastasis on Lung Cancer （肺癌リンパ節転移でのPre-metastastatic nicheにおけるCOX-2誘導性PGE2-EP3シグナリングを介した樹状細胞の役割） (2014)
  • Author(s): 小川 史洋、天野 英樹、江島 耕二、細野 加奈子、佐藤 之俊、成宮 周、熊谷 雄二、馬嶋 正隆
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
  • Year and Date: 20140319-20140321
• [Presentation] Role of VEGFR1 in diabetic wound healing （糖尿病創傷治癒における血管内皮増殖因子(VEGF)受容体1の役割） (2014)
  • Author(s): 沖崎 進一郎、伊藤 義也、大久保 博世、古城 憲、大庭 和人、七里 眞義、馬嶋 正隆
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
  • Year and Date: 20140319-20140321
• [Presentation] Role of VEGFR1 in liver repair after hepatic ischemia/reperfusion (肝臓虚血再潅流障害後の肝修復におけるVEGFR1の役割) (2014)
  • Author(s): 大久保 博世、伊藤 義也、南野 勉、古城 憲、細野 加奈子、渡邊 昌彦、馬嶋 正隆
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
  • Year and Date: 20140319-20140321
• [Presentation] Role of COX-2 and TP signaling in lenhancement of lymph angiogenesis in diaphragm in endotoxins -induced peritonitis (2014)
  • Author(s): 松田 弘美、細野 加奈子、藏重 千絵、成宮 周、馬嶋 正隆
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
  • Year and Date: 20140319-20140321
• [Presentation] Microsomal prostaglandin E synthase-1 facilitates angiogenesis and lung metastasis formation in prostate cancer cells (2014)
  • Author(s): 高橋 亮、天野 英樹、佐藤 威史、岩村 正嗣、馬嶋 正隆
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
  • Year and Date: 20140319-20140321
• [Presentation] 炎症を制御する脂肪酸代謝のメタボロミクス (2014)
  • Author(s): 有田誠
  • Organizer: 腸内細菌脂質代謝研究会
  • Place of Presentation: 京都
  • Year and Date: 20140317-20140317
  • Invited
• [Presentation] Prostanoids as Regulators of Pathological Lymphangiogenesis (2014)
  • Author(s): Majima M., Hosono K., Amano H., Ogawa F., Park K.
  • Organizer: GRC Molecular Mechanisms in Lymphatic Function & Disease
  • Place of Presentation: Lucca (Barga), Italy
  • Year and Date: 20140309-20140314
  • Invited
• [Presentation] A new era of secreted phospholipase A2 (sPLA2). (2014)
  • Author(s): Murakami M.
  • Organizer: The 15th International Winter Eicosanoid Conference
  • Place of Presentation: Baltimore, USA
  • Year and Date: 20140309-20140312
  • Invited
• [Presentation] n-3系脂肪酸の代謝と抗炎症作用についてのメタボローム解析 (2014)
  • Author(s): 有田誠
  • Organizer: JSPEN2014
  • Place of Presentation: 横浜
  • Year and Date: 20140228-20140228
  • Invited
• [Presentation] 脂質メディエーターによるアレルギー制御 (2014)
  • Author(s): 武富芳隆, 村上誠
  • Organizer: 第77回日本皮膚科学会東京支部学術大会
  • Place of Presentation: 東京
  • Year and Date: 20140215-20140216
  • Invited
• [Presentation] 脂質メディエーターの新機軸 (2014)
  • Author(s): 村上誠, 武富芳隆
  • Organizer: 第25回鹿児島呼吸器内科セミナー
  • Place of Presentation: 鹿児島
  • Year and Date: 20140215-20140215
  • Invited
• [Presentation] VEGFR1signaling facilitates diabetic skin wound healing in mice (2014)
  • Author(s): Okizaki S., Ito Y., Okubo H., Kojyou K., Ohba K., Shichiri M., Majima M.
  • Organizer: 第39回日本微小循環学会総会
  • Place of Presentation: 東京
  • Year and Date: 20140207-20140208
• [Presentation] Role of leukotriene B4 receptor1 (BLT1) signaling in liverrepair hepatic ischemia reperfusion injury (2014)
  • Author(s): Ohkubo H., Ito Y., Watanabe M., Majima M.
  • Organizer: 第39回日本微小循環学会総会
  • Place of Presentation: 東京
  • Year and Date: 20140207-20140208
• [Presentation] Roles of Prostanoids in Regulation of Angiogenesis and Lymphatic Tissue Remodeling (2014)
  • Author(s): Majima M.
  • Organizer: 第39回日本微小循環学会総会
  • Place of Presentation: 東京
  • Year and Date: 20140207-20140208
  • Invited
• [Presentation] Emerging roles of lipid mediators in controlling inflammation and resolution (2014)
  • Author(s): Makoto Arita
  • Organizer: Symposium of Lipid Biology Division, Korea Society of Molecular and Cellular Biology
  • Place of Presentation: Busan, Korea
  • Year and Date: 20140207-20140207
  • Invited
• [Presentation] 脂肪酸メタボロミクスと病態・バイオロジー（量から質へ） (2014)
  • Author(s): 有田誠
  • Organizer: 第１回JFAS
  • Place of Presentation: 東京
  • Year and Date: 20140111-20140111
  • Invited
• [Presentation] リン脂質代謝異常とメタボリックシンドローム (2013)
  • Author(s): 村上誠
  • Organizer: 第3回Metabolism Scientific Forum
  • Place of Presentation: 東京
  • Year and Date: 20131221-20131221
  • Invited
• [Presentation] BLT1 defines a DC1 subset that induces Th1 differentiation by releasing IL-12p35 (2013)
  • Author(s): Koga, T., Sasaki, F., Saeki, K., Ichiki, T., Okuno, T.,Yokomizo, T.
  • Organizer: 第42回日本免疫学会
  • Place of Presentation: 千葉
  • Year and Date: 20131211-20131213
• [Presentation] Physiological and pathological roles of leukotriene B4 receptor 1 in M2 macrophages (2013)
  • Author(s): Sasaki, F., Koga, T., Saeki, K., Okuno, T.,Yokomizo, T.
  • Organizer: 第42回日本免疫学会
  • Place of Presentation: 千葉
  • Year and Date: 20131211-20131213
• [Presentation] 食道扁平上皮癌の遊走におけるmicroRNAの機能解明 (2013)
  • Author(s): 濵田ひかり、土屋創健、杉本幸彦
  • Organizer: 第29回日本薬学会九州支部大会
  • Place of Presentation: 長崎
  • Year and Date: 20131207-20131208
• [Presentation] miR-210による食道扁平上皮癌細胞増殖抑制機構の解明 (2013)
  • Author(s): 土屋創健、嶋田 裕、清水一治、杉本幸彦
  • Organizer: 第29回日本薬学会九州支部大会
  • Place of Presentation: 長崎
  • Year and Date: 20131207-20131208
• [Presentation] プロスタグランジンF受容体FPの可視化系の構築 (2013)
  • Author(s): 平井友貴、北條寛典、杉本聡子、野中夏姫、高宗暢暁、三隅将吾、土屋創健、杉本幸彦
  • Organizer: 第29回日本薬学会九州支部大会
  • Place of Presentation: 長崎
  • Year and Date: 20131207-20131208
• [Presentation] 炎症収束の制御における脂肪酸代謝系の役割 (2013)
  • Author(s): 有田誠
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 20131203-20131206
  • Invited
• [Presentation] 新しいGPCR活性化測定法TGFα切断アッセイ (2013)
  • Author(s): 青木淳賢
  • Organizer: CBI学会年会
  • Place of Presentation: 東京
  • Year and Date: 20131129-20131129
  • Invited
• [Presentation] 第一世代の脂質メディエーター：エイコサノイドと疾患 (2013)
  • Author(s): 横溝岳彦
  • Organizer: 第３回都医学研シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20131128-20131128
  • Invited
• [Presentation] 第三世代の脂質メディエーター：ω３脂肪酸と炎症抑制 (2013)
  • Author(s): 有田誠
  • Organizer: 第３回都医学研シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20131128-20131128
  • Invited
• [Presentation] ホスホリパーゼA2分子ファミリーの機能 (2013)
  • Author(s): 村上誠
  • Organizer: 第11回心血管先端医療フォーラム
  • Place of Presentation: 甲府
  • Year and Date: 20131126-20131126
  • Invited
• [Presentation] PLA2を起点とした脂質ネットワークによるアレルギー制御 (2013)
  • Author(s): 武富良隆, 村上誠
  • Organizer: 第12回ホスファチジルセリン研究会
  • Place of Presentation: 東京
  • Year and Date: 20131118-20131118
  • Invited
• [Presentation] Novel insights into sPLA2s in health and disease (2013)
  • Author(s): Murakami M.
  • Organizer: The 16th GEM-10th GERLI meeting: from membranes to pathologies
  • Place of Presentation: Saint-Jean Cap Ferrat, France
  • Year and Date: 20131111-20131114
  • Invited
• [Presentation] A new era of secreted phospholipase A2 (sPLA2). (2013)
  • Author(s): Murakami M.
  • Organizer: The 15th International Winter Eicosanoid Conference
  • Place of Presentation: Saint-Jean Cap Ferrat, France
  • Year and Date: 20131111-20131114
  • Invited
• [Presentation] Roles Of Vascular Endothelial Growth Factor Receptor -1 Signaling In Compensatory Contralateral Lung Growth After Unilateral Pneumonectomy (2013)
  • Author(s): Amano H.,Mastui Y.,Ito Y,Ogawa F.,Fujita T.,Shibuya M., Kumagai Y., Majima M.
  • Organizer: 18thCongress of the Asian Pacific Society of Respirology
  • Place of Presentation: Yokohama
  • Year and Date: 20131111-20131114
• [Presentation] Pge2-Ep3 Signaling Induces Pre-Metastatic Niche Formation In Mediastinal Lymph Node By Cxcr4/Sdf-1 Axis (2013)
  • Author(s): Ogawa F., Amano H., Hosono K., Satoh Y., Kumaga Y., Majima M.
  • Organizer: 18th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Yokohama
  • Year and Date: 20131111-20131114
• [Presentation] Novel insights into sPLA2s in health and disease. (2013)
  • Author(s): Majima M., Hosono K., Suzuki T., Amano H.
  • Organizer: The 16th GEM-10th GERLI meeting: from membranes to path ologies.
  • Place of Presentation: Saint-Jean Cap Ferrat, France
  • Year and Date: 20131111-20131114
  • Invited
• [Presentation] Prostaglandins, Masct Cells, and Acute Inflammation (2013)
  • Author(s): Sugimoto, Y., Morimoto, K., Tsuchiya, S., Taketomi, Y., Murakami, M., and Shuh Narumiya.
  • Organizer: 16th GEM-10th GERLI lipidomics meeting
  • Place of Presentation: France
  • Year and Date: 20131110-20131114
• [Presentation] Regulation of embryo implantation and spacing by multiple prostanoid receptors. (2013)
  • Author(s): Tsuchiya, S., Ma, X.-Y., Inazumi, T., Sugimoto, T., Takeo, T., Nakagata, N., Narumiya, S., and Sugimoto, Y.
  • Organizer: 16th GEM-10th GERLI lipidomics meeting
  • Place of Presentation: France
  • Year and Date: 20131110-20131114
• [Presentation] 循環器疾患発症リスクと検査値の未病域：久山町研究． (2013)
  • Author(s): 清原 裕
  • Organizer: 第20回日本未病システム学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 20131109-20131110
  • Invited
• [Presentation] Leukotriene B4 receptor 1 is a potential marker of mouse dendritic cells (2013)
  • Author(s): Koga, T., Sasaki, F., Saeki, K., Ichiki, T., Okuno, T.,Yokomizo, T.
  • Organizer: The 8th Korea-Japan Conference on Cellular Signaling for Young Scientists
  • Place of Presentation: Fukuoka
  • Year and Date: 20131107-20131108
• [Presentation] Physiological and pathological roles of leukotriene B4 receptor 1 in M2 macrophages (2013)
  • Author(s): Sasaki, F., Koga, T., Saeki, K., Okuno, T.,Yokomizo, T.
  • Organizer: The 8th Korea-Japan Conference on Cellular Signaling for Young Scientists
  • Place of Presentation: Fukuoka
  • Year and Date: 20131107-20131108
• [Presentation] Biosynthetic pathway of 12-hydroxyeicosatetraenoic acid, a BLT2 ligand (2013)
  • Author(s): Okuno, T., Matunobu, T., Yokoyama, C.,Yokomizo, T.
  • Organizer: 13th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Place of Presentation: San Juan, Puerto Rico
  • Year and Date: 20131103-20131106
• [Presentation] DEFining the biological functions of DEF of group II sPLA2s (2013)
  • Author(s): Murakami M.
  • Organizer: The 13th International Conference on Bioactive Lipids in Inflammation, Cancer and Related Diseases
  • Place of Presentation: San Juan, Puerto Rico
  • Year and Date: 20131103-20131106
  • Invited
• [Presentation] Emerging roles of eosinophils and eosinophil-derived lipid mediators in controlling inflammation and resolution (2013)
  • Author(s): Makoto Arita
  • Organizer: 13th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Place of Presentation: San Juan, Puerto Rico
  • Year and Date: 20131103-20131106
  • Invited
• [Presentation] Dendritic Cells Promoted the SDF-1-expressing Premetastatic Niche Formation in Mediastinal Lymph Node Metastasis for Lung Cancer via COX-2-derived PGE2-EP3 Signaling (2013)
  • Author(s): Ogawa F., Amano H., Satoh Y., Kumaga Y., Majima M.
  • Organizer: 15th World Conference on Lung Cancer
  • Place of Presentation: Sydney, Aus
  • Year and Date: 20131027-20131030
• [Presentation] 日本人の生活習慣病の時代的変遷～半世紀に及ぶ久山町からのメッセージ～ (2013)
  • Author(s): 清原 裕
  • Organizer: 第9回日本食品免疫学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 20131017-20131018
  • Invited
• [Presentation] 脂質メディエーターの観点から捉えた慢性炎症と肥満症. (2013)
  • Author(s): 村上誠, 佐藤弘泰, 武富良隆
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京
  • Year and Date: 20131011-20131012
  • Invited
• [Presentation] The mechanism of Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation (2013)
  • Author(s): Amano H., Ito Y., Ogawa F., Kumagai Y., Majima M.
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20131003-20131005
• [Presentation] The roles of PGE2-EP3 signaling, SDF-1/CXCR4 axis for premetastatic niche formation in lymph node with dendritic cells. (2013)
  • Author(s): Ogawa F., Amano H., Iyoda A., Satoh Y., Narumiya S., Kumaga Y., Majima M.
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20131003-20131005
• [Presentation] Role of Microsomal prostaglandin E synthase-1 in the facilitation ofangiogenesis and lung metastasis formation (2013)
  • Author(s): Takahashi R., Amano H., Satoh T., Iwamura M, Majima M.
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20131003-20131005
• [Presentation] Mediator Lipidomics: 炎症を制御する細胞と脂質メディエーターのメタボロミクス (2013)
  • Author(s): 有田誠
  • Organizer: 第８回メタボロームシンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 20131003-20131004
  • Invited
• [Presentation] 脂質メタボロミクスによる炎症の制御機構の解明 (2013)
  • Author(s): 有田誠
  • Organizer: ERATO/さきがけ共催シンポジウム 『先端メタボロミクスを駆使して展開する新しい代謝生物学』
  • Place of Presentation: 東京
  • Year and Date: 20130918-20130918
  • Invited
• [Presentation] プロスタグランジンEP4受容体による視索前野ニューロンの細胞骨格制御 (2013)
  • Author(s): 北條寛典、吉岡美樹、土屋裕義、土屋創健、川原浩一、三隅将吾、瀬木-西田恵里、杉本幸彦
  • Organizer: 第12回次世代を担う若手ファーマ・バイオフォーラム2013
  • Place of Presentation: 東京
  • Year and Date: 20130914-20130915
• [Presentation] Mediator Lipidomics: 炎症の制御と疾患に関わる脂肪酸代謝のメタボロミクス (2013)
  • Author(s): 有田誠
  • Organizer: 第２回代謝と脳心血管疾患研究会
  • Place of Presentation: 京都
  • Year and Date: 20130914-20130914
  • Invited
• [Presentation] リン脂質代謝異常と生活習慣病 (2013)
  • Author(s): 村上誠
  • Organizer: フォーラム2013衛生薬学環境トキシコロジー
  • Place of Presentation: 福岡
  • Year and Date: 20130913-20130914
  • Invited
• [Presentation] プロスタグランディンと雌性生殖生理(シンポジウム：健康維持における脂質の役割) (2013)
  • Author(s): 杉本幸彦
  • Organizer: フォーラム2013：衛生薬学・環境トキシコロジー
  • Place of Presentation: 福岡
  • Year and Date: 20130913-20130914
  • Invited
• [Presentation] マウスBLT1およびDYKDDDDK配列に対して高親和性を有するヒト化単クローン抗体の樹立 (2013)
  • Author(s): 佐々木文之, 池田恒基, 上野あゆみ, 佐伯和子, 奥野利明, 古賀友紹,横溝岳彦
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20130911-20130913
• [Presentation] トロンボキサン合成酵素非依存的な12-HHT産生機構 (2013)
  • Author(s): 奥野利明, 松延武彦,横溝岳彦
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20130911-20130913
• [Presentation] ロイコトリエンB4第二受容体(BLT2)の細胞接着形成における役割 (2013)
  • Author(s): 石井由美子, 佐伯和子, Min, L., 奥野利明, 横溝岳彦
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20130911-20130913
• [Presentation] 急性肺損傷モデルにおけるBLT2)の肺保護作用 (2013)
  • Author(s): 重松美沙子, 古賀友紹, 佐伯和子,横溝岳彦
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20130911-20130913
• [Presentation] Identification and analysis of GPCRs that recognize oxidized phospholipids (2013)
  • Author(s): Asuka Inoue, Jun Ishiguro, Junken Aoki
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20130911-20130913
  • Invited
• [Presentation] New function of LPA3 receptor that regulates vagal afferent nerves activation (2013)
  • Author(s): 可野 邦行、青木淳賢
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20130911-20130913
  • Invited
• [Presentation] sPLA2の新しいパラダイム (2013)
  • Author(s): 村上誠, 武富芳隆, 佐藤弘泰, 三木寿美, 山本圭
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20130911-20130913
  • Invited
• [Presentation] プロスタグランジン受容体との相互作用因子の探索 (2013)
  • Author(s): 島津佑太朗, 森本和志, 土屋創健, 杉本幸彦
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20130911-20130913
• [Presentation] IL-33誘導性マスト細胞応答におけるプロスタサイクリン受容体IPの役割 (2013)
  • Author(s): 鈴木佑治, 渡辺真由帆, 森本和志, 土屋創健, 成宮 周, 杉本幸彦
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20130911-20130913
• [Presentation] Emerging roles of eosinophils in the resolution of inflammation (2013)
  • Author(s): Makoto Arita
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20130911-20130913
  • Invited
• [Presentation] プロスタグランジンによる炎症惹起の分子機構 (2013)
  • Author(s): 杉本幸彦
  • Organizer: 生体機能と創薬シンポジウム2013
  • Place of Presentation: 福岡
  • Year and Date: 20130829-20130830
  • Invited
• [Presentation] Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of acute inflammation (2013)
  • Author(s): Makoto Arita
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
  • Year and Date: 20130825-20130825
• [Presentation] Roles of Prostanoids in Pathological Lymphangiogenesis (2013)
  • Author(s): 馬嶋正隆
  • Organizer: 第3回リンパ学に関する松本カンファランス
  • Place of Presentation: 松本
  • Year and Date: 20130823-20130824
  • Invited
• [Presentation] Generation, characterization and humanization of high-affinity monoclonal antibody against leukotriene B4 receptor 1 (BLT1) (2013)
  • Author(s): Ikeda, K., Sasaki, F., Ueno, A., Okuno, T., Koga, T.,Yokomizo, T.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
  • Year and Date: 20130804-20130809
• [Presentation] Role of leukotriene B4 receptor BLT1 in dendritic cells (2013)
  • Author(s): Koga, T., Sasaki, F., Saeki, K., Ichiki, T., Okuno, T.,Yokomizo, T.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
  • Year and Date: 20130804-20130809
• [Presentation] Crucial role of the 12-HHT receptor BLT2 in epidermal wound healing (2013)
  • Author(s): Liu, M., Saeki, K.,Yokomizo, T.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
  • Year and Date: 20130804-20130809
• [Presentation] The physiological function of a leukotriene B4 receptor 1 in M2 macrophages (2013)
  • Author(s): Sasaki, F., Koga, T., Saeki, K., Okuno, T.,Yokomizo, T.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
  • Year and Date: 20130804-20130809
• [Presentation] Leukotriene B4 receptors: BLT1 and BLT2 (2013)
  • Author(s): Yokomizo, T.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
  • Year and Date: 20130804-20130809
  • Invited
• [Presentation] Lysophosphatidic acid in blood regulates vagal afferent nerves through LPA3 receptor (2013)
  • Author(s): Junken Aoki & Kuniyuki Kano
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
  • Year and Date: 20130804-20130809
  • Invited
• [Presentation] Emerging roles of secreted phospholipase A2s (2013)
  • Author(s): Murakami M, Taketomi Y, Miki Y, Sato H, Yamamoto K.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
  • Year and Date: 20130804-20130809
  • Invited
• [Presentation] Microsomal prostaglandin E synthase-1 as a regulator of angiogenesis (2013)
  • Author(s): Majima M., Hosono K., Suzuki T., Amano H.
  • Organizer: GRC Angiogenesis
  • Place of Presentation: New Port
  • Year and Date: 20130804-20130809
  • Invited
• [Presentation] Prostaglandins, mast cells and acute inflammation (2013)
  • Author(s): Sugimoto.Y.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
  • Year and Date: 20130804-20130809
• [Presentation] Role of prostaglandin EP4 receptor in adipocyte differentiation and maturation. (2013)
  • Author(s): Inazumi, T., Tsuchiya, S., Narumiya, S., and Sugimoto, Y.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
  • Year and Date: 20130804-20130809
• [Presentation] Regulation of embryo implantation and spacing by multiple prostanoid receptors. (2013)
  • Author(s): Tsuchiya, S., Ma, X.-Y., Inazumi, T., Sugimoto, T., Takeo, T., Nakagata, N., Narumiya, S., and Sugimoto, Y.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
  • Year and Date: 20130804-20130809
• [Presentation] Identification of 17,18-diHEPE as a novel EPA-derived anti-inflammatory lipid mediator (2013)
  • Author(s): Yosuke Isobe, Makoto Arita, Shinnosuke Matsueda, Hiroki Nakanishi, Ryo Taguchi, Daisuke Urabe, Masayuki Inoue, Hiroyuki Arai
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: ニセコ
  • Year and Date: 20130804-20130809
• [Presentation] Mediator Lipidomics: 炎症を制御する細胞と脂質メディエーターのメタボロミクスv (2013)
  • Author(s): 有田誠
  • Organizer: 第26回バイオメディカル分析科学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20130802-20130803
  • Invited
• [Presentation] EOSINOPHILS CONTROL THE RESOLUTION OF INFLAMMATION THROUTH THE 12/15-LIPOXYGENASE PATHWAY (2013)
  • Author(s): Makoto Arita
  • Organizer: 9th Biennial Symposium of International Eosinophil Society
  • Place of Presentation: Oxford, UK
  • Year and Date: 20130716-20130716
• [Presentation] Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. (2013)
  • Author(s): Jun Miyata, Koichi Fukunaga, Koichiro Asano, Makoto Arita
  • Organizer: 9th Biennial Symposium of International Eosinophil Society
  • Place of Presentation: Oxford, UK
  • Year and Date: 20130716-20130716
• [Presentation] マウス前立腺癌の血行性肺転移モデルにおけるPGE2の転移抑制効果メカニズムの解析 (2013)
  • Author(s): 高橋亮、天野英樹、馬嶋正隆
  • Organizer: 第 128回日本薬理学会関東部会
  • Place of Presentation: 東京
  • Year and Date: 20130714-20130714
• [Presentation] 糖尿病創傷治癒における血管内皮増殖因子(VEGF)受容体-1の関与 (2013)
  • Author(s): 沖崎進一郎，伊藤 義也，大久保博世，大庭 和人，七里 眞義，馬嶋 正隆
  • Organizer: 第34回日本炎症・再生医学会
  • Place of Presentation: 京都
  • Year and Date: 20130702-20130703
• [Presentation] 受容体活性調節蛋白1(RAMP1)シグナルによる創傷治癒および脈管新生の増強 (2013)
  • Author(s): 藏重 千絵，細野加奈子，松田 弘美，馬嶋 正隆
  • Organizer: 第34回日本炎症・再生医学会
  • Place of Presentation: 京都
  • Year and Date: 20130702-20130703
• [Presentation] 創傷治癒時のリンパ管新生を制御するプロスタグランジンE2受容体シグナリングの役割 (2013)
  • Author(s): 細野加奈子，成宮 周，馬嶋 正隆
  • Organizer: 第34回日本炎症・再生医学会
  • Place of Presentation: 京都
  • Year and Date: 20130702-20130703
• [Presentation] Premetastatic niche形成における樹状細胞-PGE2-EP3 signaling,SDF-1/CXCR4の役割 (2013)
  • Author(s): 小川 史洋，天野 英樹，佐藤 之俊，熊谷 雄治，馬嶋 正隆
  • Organizer: 第34回日本炎症・再生医学会
  • Place of Presentation: 京都
  • Year and Date: 20130702-20130703
• [Presentation] マウストロンボキサン生合成酵素遺伝子導入細胞によるアポトーシスの検討 (2013)
  • Author(s): 香川 理紗，高橋 諒多，中村 正樹，天野 英樹，馬嶋 正隆，北里 英郎
  • Organizer: 第34回日本炎症・再生医学会
  • Place of Presentation: 京都
  • Year and Date: 20130702-20130703
• [Presentation] エンドトキシン誘発性腹膜炎マウスの横隔膜リンパ管新生におけるCOX-2の役割 (2013)
  • Author(s): 松田 弘美，細野加奈子，藏重 千絵，馬嶋 正隆
  • Organizer: 第34回日本炎症・再生医学会
  • Place of Presentation: 京都
  • Year and Date: 20130702-20130703
• [Presentation] インターフェロン産生細胞を用いたマウス悪性黒色腫モデルに対する細胞療法 (2013)
  • Author(s): 中村 正樹，馬嶋 正隆，北里 英郎
  • Organizer: 第34回日本炎症・再生医学会
  • Place of Presentation: 京都
  • Year and Date: 20130702-20130703
• [Presentation] 魚類における性行動発現の嗅覚メカニズム：性フェロモン・プロスタグランジンF2aが活性化するゼブラフィッシュ嗅覚受容体および神経回路素子の同定 (2013)
  • Author(s): 矢吹陽一、小出哲也、宮坂信彦、脇阪紀子、増田美和、告恭史郎、杉本幸彦、渡邉和忠、吉原良浩
  • Organizer: Neuro2013 第36回日本神経科学大会、第56回日本神経化学会大会、第23回日本神経回路学会大会
  • Place of Presentation: 京都
  • Year and Date: 20130620-20130623
• [Presentation] 病態時のリンパ管新生とリンパ流を制御するプロスタグランジンの役割 (2013)
  • Author(s): 馬嶋正隆
  • Organizer: 第３７回日本リンパ学会総会
  • Place of Presentation: 福岡
  • Year and Date: 20130614-20130615
  • Invited
• [Presentation] ロイコトリエンB4第二受容体(BLT2)の皮膚創傷治癒における促進的役割 (2013)
  • Author(s): Liu, M., 佐伯和子, 松延武彦, 奥野利明, 中溝聡, 椛島健治,横溝岳彦
  • Organizer: 第55回日本脂質生化学会
  • Place of Presentation: 宮城県松島町
  • Year and Date: 20130606-20130607
• [Presentation] 新規樹状細胞サブセットマーカーとしてのBLT1受容体 (2013)
  • Author(s): 古賀友紹, 佐々木文之, 佐伯和子, 奥野利明,横溝岳彦
  • Organizer: 第55回日本脂質生化学会
  • Place of Presentation: 宮城県松島町
  • Year and Date: 20130606-20130607
• [Presentation] 酸化リン脂質を認識するタンパク質共役型受容体 (2013)
  • Author(s): 井上飛鳥、石黒純、青木淳賢
  • Organizer: 第55回日本脂質生化学会
  • Place of Presentation: 松島
  • Year and Date: 20130606-20130607
  • Invited
• [Presentation] 脂肪細胞におけるプロスタグランジンEP4受容体の機能解析 (2013)
  • Author(s): 稲住知明、土屋創健、成宮 周、杉本幸彦
  • Organizer: 第55回日本脂質生化学会
  • Place of Presentation: 松島
  • Year and Date: 20130606-20130607
• [Presentation] 炎症を制御する細胞と脂質メディエーターのメタボローム解析 (2013)
  • Author(s): 有田誠
  • Organizer: 第55回日本脂質生化学会
  • Place of Presentation: 松島
  • Year and Date: 20130606-20130607
  • Invited
• [Presentation] エイコサペンタエン酸の抗炎症作用についての包括的メタボローム解析 (2013)
  • Author(s): 磯部 洋輔, 久保田 唯史, 岩本 涼, 有田 誠, 新井 洋由
  • Organizer: 第55回日本脂質生化学会
  • Place of Presentation: 松島
  • Year and Date: 20130606-20130607
• [Presentation] Prostanoids regulate tumor stromal profiles via specific G-protein coupled receptors (2013)
  • Author(s): Majima M., Hosono K., Suzuki T., Amano H., Kato H., Ogawa F., Park K.
  • Organizer: 4th International conference on tumor-host interaction and Angiogenesis
  • Place of Presentation: Ascona, Switzerland
  • Year and Date: 20130602-20130605
  • Invited
• [Presentation] 生理活性脂質産生を介した血小板の新しい機能 (2013)
  • Author(s): 横溝岳彦
  • Organizer: 第14回Pharmaco-Hematologyシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20130601-20130601
  • Invited
• [Presentation] 急性肺傷害におけるBLT2の肺保護作用 (2013)
  • Author(s): 重松美沙子, 外須美夫,横溝岳彦
  • Organizer: 日本麻酔科学会第60回学術集会
  • Place of Presentation: 札幌
  • Year and Date: 20130523-20130525
• [Presentation] Deciphering the physiological functions of sPLA2s (2013)
  • Author(s): Murakami M, Taketomi Y, Miki Y, Sato H, Yamamoto K.
  • Organizer: The 5th International Conference of Phospholipase A2 Mediated Signaling in Translational Medicine
  • Place of Presentation: New Orleans, LU, USA
  • Year and Date: 20130521-20130521
  • Invited
• [Presentation] Angiotensin Type 1a Signaling Facilitates Tumor Metastasis Formation Through P-Selectin-Mediated Interaction Of Tumor Cells With Platelets And Endothelial Cells (2013)
  • Author(s): Amano H., Ito Y., Ogawa F., Kumagai Y., Majima M.
  • Organizer: American Thoracic Society 2013
  • Place of Presentation: Philadelphia, USA.
  • Year and Date: 20130517-20130522
• [Presentation] COX-2-Derived PGE2 Forms SDF-1-Expressing Premetastatic Niche Via EP3 Signaling In Mediastinal Lymph Node With Accumulation Of Immature Dendritic Cells (2013)
  • Author(s): Ogawa F., Amano H., Iyoda A., Satoh Y., Kumaga Y., Majima M.
  • Organizer: American Thoracic Society 2013
  • Place of Presentation: Philadelphia, USA.
  • Year and Date: 20130517-20130522
• [Presentation] 肝虚血再灌流後肝修復過程に果たすロイコトリエンB4受容体 (BLT1) の役割 (2013)
  • Author(s): 大久保 博世, 伊藤 義也, 渡邊 昌彦, 馬嶋 正隆
  • Organizer: 第28回日本Shock学会総会
  • Place of Presentation: 東京
  • Year and Date: 20130517-20130518
• [Presentation] マウス心肺停止蘇生モデルにおける肝虚血再灌流障害のロイコトリエンB4の役割 (2013)
  • Author(s): 小坂 康晴, 馬嶋 正隆
  • Organizer: 第28回日本Shock学会総会
  • Place of Presentation: 東京
  • Year and Date: 20130517-20130518
• [Presentation] 糖尿病と癌－久山町研究から (2013)
  • Author(s): 清原 裕
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本
  • Year and Date: 20130516-20130518
  • Invited
• [Presentation] エイコサペンタエン酸由来の抗炎症性代謝物Resolvin E3の新規同定 (2013)
  • Author(s): 磯部 洋輔, 有田 誠, 中西 広樹, 田口 良, 占部 大介, 井上 将行, 新井 洋由
  • Organizer: 日本ビタミン学会第65回大会
  • Place of Presentation: 東京
  • Year and Date: 20130516-20130518
• [Presentation] Protective role of BLT2 receptor in mouse acute lung injury (2013)
  • Author(s): Shigematsu, M., Koga, T., Saeki, K.,Yokomizo, T.
  • Organizer: Experimental Biology 2013
  • Place of Presentation: Boston
  • Year and Date: 20130420-20130424
• [Presentation] Aspirin delays skin wound healing by reducing the production of 12-hydroxyheptadecatrienoic acid, a ligand for BLT2 receptor (2013)
  • Author(s): Yokomizo, T.
  • Organizer: Experimental Biology 2013
  • Place of Presentation: Boston
  • Year and Date: 20130420-20130424
• [Presentation] 縦隔リンパ節内premetastatic niche形成における樹状細胞-PGE2-EP3シグナリングの役割 (2013)
  • Author(s): 小川 史洋,天野 英樹, 松井 啓夫,中島 裕康,伊豫田 明,佐藤 之俊,熊谷 雄治,馬嶋 正隆
  • Organizer: 第113回日本外科学会
  • Place of Presentation: 福岡
  • Year and Date: 20130411-20130413
• [Book] 臨床研究のススメ．５．コホート研究─久山町スタディの最近の成果─ (2014)
  • Author(s): 清原 裕
  • Total Pages: 6
  • Publisher: 最新医学社
• [Book] 脳神経外科診療プラクティス １ 脳血管障害の急性期マネジメント (2014)
  • Author(s): 清原 裕
  • Total Pages: 5
  • Publisher: 光文堂
• [Book] 医用質量分析ガイドブック (2014)
  • Author(s): 有田誠、池田和貴
  • Total Pages: 6
  • Publisher: 診断と治療社
• [Book] 人体の構造と機能及び疾病の成り立ち 改訂第2版 (2013)
  • Author(s): 横溝岳彦
  • Total Pages: 4
  • Publisher: 南江堂
• [Book] 「最新生理活性脂質研究-実験手法、基礎的知識とその応用-」遺伝子医学MOOK 24号 (2013)
  • Author(s): 馬嶋正隆
  • Total Pages: 7
  • Publisher: メディカル ドゥ社
• [Book] 高血圧診療のすべて．I 疫学，遺伝． (2013)
  • Author(s): 清原 裕
  • Total Pages: 4
  • Publisher: 診断と治療社
• [Book] 脳とこころのプライマリケア (2013)
  • Author(s): 清原 裕
  • Total Pages: 13
  • Publisher: シナジー
• [Book] 「最新生理活性脂質研究-実験手法、基礎的知識とその応用-」遺伝子医学MOOK 24号 (2013)
  • Author(s): 磯部洋輔、岩本涼、有田誠
  • Total Pages: 5
  • Publisher: メディカル ドゥ社
• [Book] そうだったんだ脂肪酸（循環器疾患との深い関係） (2013)
  • Author(s): 遠藤仁、有田誠
  • Total Pages: 7
  • Publisher: 文光堂
• [Remarks] 新学術領域脂質マシナリー
  • URL: http://plazaumin.ac.jp/lipids/
• [Remarks] 順天堂大学生化学第一講座
  • URL: http://plaza.umin.ac.jp/j_bio/Biochem1/Top.html
• [Remarks] 東京都医学総合研究所脂質代謝プロジェクト村上研究室（マスト細胞の成熟経路の発見）
  • URL: http://www.igakuken.or.jp/lipid/reseacch8.html
• [Remarks] 東京都医学総合研究所村上研究室（体に優しい脂質を働かせ、炎症にブレーキをかける酵素の同定）
  • URL: http://www.igakuken.or.jp/lipid/research9.htm
• [Remarks] 北里大学医学部薬理学講座
  • URL: http://www.med.kitasato-u.ac.jp/pharm/index.html
• [Patent(Industrial Property Rights)] ホスホリパーゼA2G3を指標としたスクリーニング方法 (2014)
  • Inventor(s): 村上誠、武富芳隆
  • Industrial Property Rights Holder: 村上誠、武富芳隆、東京都医学研
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2013-073775
  • Filing Date: 2014-03-29
• [Patent(Industrial Property Rights)] Gタンパク質共役型受容体シグナルの伝達の検出方法 (2014)
  • Inventor(s): 井上飛鳥、青木淳賢
  • Industrial Property Rights Holder: 東北大学、東ソー
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願２０１４－５１３３８３
  • Filing Date: 2014-03-18
• [Patent(Industrial Property Rights)] アレルギー性疾患の予防または治療のための医薬組成物 (2013)
  • Inventor(s): 國澤純、清野宏、有田誠
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2013-081548
  • Filing Date: 2013-04-09
• [Patent(Industrial Property Rights)] PLA2G2Fを指標とした表皮角化細胞の過増殖性疾患に対する薬剤のスクリーニング方法 (2013)
  • Inventor(s): 村上誠、山本圭
  • Industrial Property Rights Holder: 村上誠、山本圭、東京都医学研
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2013-240871
  • Filing Date: 2013-11-21
• [Patent(Industrial Property Rights)] オートタキシンアイソフォームα、β及びγの測定による疾患等の検出方法 (2013)
  • Inventor(s): 青木淳賢、島本怜史、五十嵐 浩二
  • Industrial Property Rights Holder: 東北大学、東ソー
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願２０１３－２０８０４９
  • Filing Date: 2013-10-03
• [Patent(Industrial Property Rights)] オートタキシンアイソフォームδ及びεの測定による疾患等の検出方法 (2013)
  • Inventor(s): 青木淳賢、島本怜史、五十嵐 浩二
  • Industrial Property Rights Holder: 東北大学、東ソー
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願２０１３－２０８０５０
  • Filing Date: 2013-10-02