2014 Fiscal Year Annual Research Report
Project Area | Machineries of bioactive lipids in homeostasis and diseases |
Project/Area Number |
22116001
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Research Institution | Juntendo University |
Principal Investigator |
横溝 岳彦 順天堂大学, 医学(系)研究科(研究院), 教授 (60302840)
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Co-Investigator(Kenkyū-buntansha) |
青木 淳賢 東北大学, 薬学研究科(研究院), 教授 (20250219)
村上 誠 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 参事研究員 (60276607)
馬嶋 正隆 北里大学, 医学部, 教授 (70181641)
清原 裕 九州大学, 医学(系)研究科(研究院), 教授 (80161602)
杉本 幸彦 熊本大学, 大学院生命科学研究部(薬), 教授 (80243038)
有田 誠 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー (80292952)
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Project Period (FY) |
2010-04-01 – 2015-03-31
|
Keywords | 生理活性脂質 |
Outline of Annual Research Achievements |
計画班員・公募班員の研究を援助するため、以下の活動を行った。1)本領域のホームページ(http://plaza.umin.ac.jp/lipids/)に、研究リソース、遺伝子、抗体のリスト、実験プロトコールの追加を行った。また領域メイリングリストを整備し、班員間の連絡や共同研究にむけてのインフラを整備した。2)研究支援センターの整備と利用:・3つのリピドミクスセンターにおいて、班員の30以上の研究プロジェクトをサポートした。・遺伝子発現解析センターにおいて、班員の5つの研究プロジェクトをサポートした。・SNP解析センターにおいて、班員の7つの研究プロジェクトをサポートした。 3)2014年6月28-29日に公募班員を加えて第2回領域会議を開催した。 4)2015年2月10-12日に、東京で開催されたPLM2015(6th international conference on Phospholipase A2 and Lipid Mediators, 村上誠会長)を協賛した。 5)2015年2月2日に第25領域ニュースレターを発行した。 6)Springer社から出版予定の英文書籍(Bioactive Lipid Mediators: Current Reviews and Protocols, 2015年4月発刊予定)の執筆を行った。
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Research Progress Status |
26年度が最終年度であるため、記入しない。
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Strategy for Future Research Activity |
26年度が最終年度であるため、記入しない。
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Research Products
(210 results)
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[Journal Article] The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury.2015
Author(s)
Asahara, M., Ito, N., Yokomizo, T., Nakamura, M., Shimizu, T., Yamada, Y.
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Journal Title
Mol Pain
Volume: 11
Pages: 11
DOI
Peer Reviewed / Open Access
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[Journal Article] ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration.2015
Author(s)
Zandi, S., Yokomizo, T., Kim, Y. B., Sweetnam, P., Ishibashi, T., Hafezi-Moghadam, A.
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Journal Title
Cell Rep
Volume: 10
Pages: 1173-1186
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic acid in acute coronary syndrome.2015
Author(s)
Kurano M, Suzuki A, Inoue A, Tokuhara Y, Kano K, Matsumoto H, Igarashi K, Ohkawa R, Nakamura K, Dohi T, Miyauchi K, Daida H, Tsukamoto K, Ikeda H, Aoki J, Yatomi Y
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 35
Pages: 463-470
DOI
Peer Reviewed
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[Journal Article] The role of vascular endothelial growth factor receptor-1 signaling in compensatory contralateral lung growth following unilateral pneumonectomy.2015
Author(s)
Matsui Y, Amano H, Ito Y, Eshima K, Tamaki H, Ogawa F, Iyoda A, Shibuya M, Kumagai Y, Satoh Y, Majima M.
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Journal Title
Laboratory Investigation.
Volume: 未定
Pages: 未定
DOI
Peer Reviewed
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[Journal Article] A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40/MEK-ERK pathway.2015
Author(s)
Miyamoto J, Mizukure T, Park S, Kishino S, Kimura I, Hirano K, Bergamo P, Rossi M, Suzuki T, Arita M, Ogawa J, Tanabe S.
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Journal Title
J. Biol. Chem.
Volume: 290
Pages: 2902-2918
DOI
Peer Reviewed
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[Journal Article] 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.2014
Author(s)
Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T
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Journal Title
J Exp Med
Volume: 211
Pages: 1063-1078
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Lysophosphatidylserine analogues differentially activate three LysoPS receptors.2014
Author(s)
Uwamizu A, Inoue A, Suzuki K, Okudaira M, Shuto A, Shinjo Y, Ishiguro J, Makide K, Ikubo M, Nakamura S, Jung S, Sayama M, Otani Y, Ohwada T, Aoki J
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Journal Title
J Biochem
Volume: 157
Pages: 151-160
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.2014
Author(s)
Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, Watanabe M, Baba H, Miyata K, Oike Y, Gelb MH, Murakami M.
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Journal Title
Cell Metab.
Volume: 20
Pages: 119-132
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Prostanoid induces premetastatic niche in regional lymph nodes.2014
Author(s)
Ogawa F, Amano H, Eshima Y, Ito Y, Matsui Y, Hosono K, Kitasato H, Iyoda A, Iwabuchi K, Kumagai Y, Satoh Y, Narumiiya S, Majima M.
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Journal Title
J. Clin. Invest.
Volume: 124
Pages: 4882-4894
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community: the Hisayama Study.2014
Author(s)
Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
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Journal Title
Circ J
Volume: 78
Pages: 403-409
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Serum 1,25-dihydroxyvitamin D and the development of kidney dysfunction in a Japanese community: the Hisayama Study.2014
Author(s)
Izumaru K, Ninomiya T, Nagata M, Usui T, Yoshida D, Yonemoto K, Fukuhara M, Tsuruya K, Kitazono T, Kiyohara Y
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Journal Title
Circ J
Volume: 78
Pages: 732-737
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study.2014
Author(s)
Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
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Journal Title
Atherosclerosis
Volume: 233
Pages: 343-348
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study.2014
Author(s)
Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y
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Journal Title
J Am Geriatr Soc
Volume: 62
Pages: 1224-1230
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Dermal Vγ4+ γδ T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8+ T-Cell Activity through TNF-α Production.2014
Author(s)
Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K
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Journal Title
J Invest Dermatol
Volume: 135
Pages: 1007-1015
DOI
Peer Reviewed
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[Journal Article] Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.2014
Author(s)
Natsuaki Y, Egawa G, Nakamizo S, Ono S, Hanakawa S, Okada T, Kusuba N, Otsuka A, Kitoh A, Honda T, Nakajima S, Tsuchiya S, Sugimoto Y, Ishii K, Tsutsui H, Yagita H, Iwakura Y, Kubo M, Ng L G, Hashimoto T, Fuentes J, Guttman-Yassky E, Miyachi Y, Kabashima K
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Journal Title
Nature Immunol
Volume: 15
Pages: 1064-1069
DOI
Peer Reviewed
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[Journal Article] Identification of 14,20-dihydroxy-docosahexaenoic acid as a novel anti-inflammatory metabolite.2014
Author(s)
Yokokura Y, Isobe Y, Matsueda S, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H, Arita M.
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Journal Title
J. Biochem.
Volume: 156
Pages: 315-321
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Immunomodulation with eicosapentaenoic acid supports the treatment of autoimmune small-vessel vasculitis.2014
Author(s)
Hirahashi J, Kawahata K, Arita M, Iwamoto R, Hishikawa K, Honda M, Hamasaki Y, Tanaka M, Okubo K, Kurosawa M, Takase O, Nakakuki M, Saiga K, Suzuki K, Kawachi S, Tojo A, Seki G, Marumo T, Hayashi M, Fujita T.
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Journal Title
Sci. Rep
Volume: 4
Pages: 6406
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The arachidonic acid metabolome as conserved regulator of cholesterol metabolism.2014
Author(s)
Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Lener D, Stanzl U, Seifert M, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Li X, Pallweber P, Scharnagl H, Stojakovic T, Marz W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Kuba K, Imai Y, Arita M, Tancevski I.
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Journal Title
Cell Metab.
Volume: 20
Pages: 787-798
DOI
Peer Reviewed
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[Presentation] 糖化抑制酵素GLO1は加齢に伴う内皮機能障害を軽減する.2014
Author(s)
城(渡辺)愛理, 大瀬貴元, 西松寛明, 高橋政夫, 池田洋一郎, 和田健彦, 白河潤一, 永井竜児, 宮田敏男, 長野哲雄, 横溝岳彦, 平田恭信, 稲城玲子, 南学正臣
Organizer
第87回日本生化学会大会
Place of Presentation
京都
Year and Date
2014-10-15 – 2014-10-18
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[Presentation] プロスタノイド受容体の構造解析へのアプローチ2014
Author(s)
豊田洋輔, 関口雄介, 浅田秀基, 寿野良二, 中根崇根, 椎村裕樹, 中北智哉, 森本和志, 稲住知明, 告恭史郎, 杉本幸彦, 岩田想, 成宮周, 小林拓也
Organizer
第11回GPCR研究会
Place of Presentation
東京
Year and Date
2014-05-09 – 2014-05-10
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