Generation of Neural Diversity and Neocortex

2015 Fiscal Year Final Research Report

• Project Area: Neural Diversity and Neocortical Organization
• Project/Area Number: 22123001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Institute of Physical and Chemical Research (2014-2015); National Institute for Basic Biology (2010-2013)
• Principal Investigator: Yamamori Tetsuo 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (80260206)
• Co-Investigator(Kenkyū-buntansha): 影山 龍一郎 京都大学, ウイルス研究所, 教授 (80224369) ; 後藤 由季子 東京大学, 薬学研究科, 教授 (70252525) ; 島崎 琢也 慶應義塾大学, 医学部, 准教授 (00324749) ; 野田 亮 京都大学, 医学研究科, 教授 (30146708) ; 桝 正幸 筑波大学, 医学医療系, 教授 (20243032) ; 大隅 典子 東北大学, 医学研究科, 教授 (00220343) ; 三品 昌美 立命館大学, 総合科学技術研究機構, 教授 (80144351) ; 森 郁恵 名古屋大学, 理学研究科, 教授 (90219999)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: 大脳新皮質 / 領野 / 層 / 神経幹細胞 / 神経投射

Outline of Final Research Achievements

The neocortex is formed as the six layers that are sequentially generated in the order so that newly synthesized layer neurons get over the older layer cells (in-side-out fashion). The neocortical cells also are formed as so called "areas" that are divided into some of 50 different parts of the neocortex. Each area is defined as a functional unit which is originally distinguished by cytoarchetechnotic differences. It is thought that understanding the formation of the layers and areas can contribute to understanding the basic principle underlying the function of the neocortex. We therefore organized a group grant that is specifically focused on the formation and the functional organization of the neocortex. This group started in 2010 for five years and achieved a significant contribution to the field not only in Japan but also internationally.

Free Research Field

分子脳科学