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2014 Fiscal Year Final Research Report

Systematic understanding of genome adaptation

Administrative Group

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Project AreaSystematic study of chromosome adaptation
Project/Area Number 22125001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University

Principal Investigator

SHINOHARA Akira  大阪大学, たんぱく質研究所, 教授 (00252578)

Project Period (FY) 2010-04-01 – 2016-03-31
Keywords染色体適応 / 染色体 / 環境ストレス / ゲノム / 減数分裂 / 組換え
Outline of Final Research Achievements

Genome adaptation promotes the formation of new traits in next generation such as heterogeneity irrespective of homogenous genome. In this study, we revealed a new mechanism which facilitates genomic variation through chromosome structure or epi-genetic information. Moreover, we showed environmental stress such as heat shock or infection by pathogen as well as mind stress promotes a new trait in a few generation through the propagation and maintenance of specific chromosomal structures without change of DNA information. To promote more efficient analysis for data from chromatin-immunoprecipitation DNA sequence (ChIP-Seq) and genetic variation using next-generation sequencers (NGS) , we have developed a new platform for annotation of the information. To facilitate the interaction with society, we carried out classes to high school students and public in 48 cases in past 5 years.

Free Research Field

分子生物学

URL: 

Published: 2016-06-03  

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