Management of the research group on logic for biological pattern formation

2015 Fiscal Year Final Research Report

• Project Area: From molecules, cells to organs : trans-hierarchical logic for higher-order pattern and structures
• Project/Area Number: 22127001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: TAKEDA Hiroyuki 東京大学, 理学(系)研究科(研究院), 教授 (80179647)
• Co-Investigator(Renkei-kenkyūsha): KONDO Shigeru 大阪大学, 大学院生命機能研究科, 教授 (10252503) ; OGURA Toshihiko 東北大学, 加齢医学研究所, 教授 (60273851) ; MATSUMOTO Takeo 名古屋工業大学, 大学院工学研究科, 教授 (30209639) ; MATSUNO Kenji 東京理科大学, 基礎工学部, 教授 (60318227) ; SAWA Hitoshi 独立行政法人理化学研究所, 細胞運命研究チーム, チームリーダー (80222024) ; UENO Naoto 基礎生物学研究所, 形態形成研究部門, 教授 (40221105)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: 器官形成 / 体軸形成 / 数理モデル / 力学的パラメータ / パターン形成

Outline of Final Research Achievements

In a multi-cellular organism, groups of cells produce higher-order patterns and structures during development. To explore this order formation, we need logics that explain the processes of trans-hierarchy from the level of molecules and cells to entire organs. In our research group, we examined the logic for organogenesis and pattern formation by introducing mathematical modeling and as-set-unknown parameters relating to physical properties of cells such as force and deformation. To facilitate intimate collaboration among wet biologists, theoretical biologists and engineers specializing in measuring physical properties of cells and tissues, the stirring committee provided various supports such as annual grant meetings, research camps and technical seminars.

Free Research Field

発生遺伝学