2024 Fiscal Year Final Research Report

Establishment of interstitial literacy based on complex systems crosstalk

Administrative Group

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Project Area	Interstitial literacy: Integrated understanding of disease pathogenesis based on interstitial cell diversity.
Project/Area Number	22H05060
Research Category	Grant-in-Aid for Transformative Research Areas (B)
Allocation Type	Single-year Grants
Review Section	Transformative Research Areas, Section (III)
Research Institution	Institute of Science Tokyo (2024) Tokyo Medical and Dental University (2022-2023)
Principal Investigator	Satoh Takashi 東京科学大学, 大学院医歯学総合研究科, 教授 (60619716)
Co-Investigator(Kenkyū-buntansha)	内藤尚道金沢大学, 医学系, 教授 (30570676) 石亀晴道関西医科大学, 附属光免疫医学研究所, 准教授 (70729227) 伊藤美菜子九州大学, 生体防御医学研究所, 准教授 (70793115) 七野成之東京理科大学, 研究推進機構生命医科学研究所, 講師 (70822435) 尾松芳樹大阪大学, 大学院生命機能研究科, 准教授 (80437277) 増田隆博九州大学, 薬学研究院, 准教授 (80615287) 田井育江慶應義塾大学, 医学部(信濃町), 講師 (90749508)
Project Period (FY)	2022-05-20 – 2025-03-31
Keywords	間質リテラシー / 細胞間クロストーク / シングルセルRNA-seq / ノックアウトマウス作製
Outline of Final Research Achievements	The administrative group promoted the elucidation of the structure and function of multicellular stromal crosstalk by establishing analytical support systems and strengthening cross-project collaboration. Through integrated analysis of scRNA-seq, spatial transcriptomics, and in vivo imaging, the group enabled high-resolution visualization of the spatiotemporal reorganization of stromal architecture during disease progression. It also supported the identification of novel cell populations and disease-related molecules via the generation and analysis of knockout mice, contributing to the discovery of potential therapeutic targets. The findings offer a new perspective that positions the stroma as an active regulator of disease and provide a foundation for the future construction and international deployment of a “Stromal Cell Atlas.”
Free Research Field	免疫学
Academic Significance and Societal Importance of the Research Achievements	本総括班の成果は、「間質」を単なる支持構造ではなく疾患進展の調整因子と捉え直す革新的視座を提供した点で学術的意義が大きい。特に、空間情報を持つ単一細胞解析の技術支援とデータ統合を通じて、間質クロストークの構造的理解が飛躍的に進んだ。さらに、若手研究者の育成や国内外への成果発信を通じて、間質研究の社会的認知度を高めるとともに、難治性疾患への新たな介入戦略の基盤形成に貢献した。