Promotion of the Transcription Cycle Area

2016 Fiscal Year Annual Research Report

• Project Area: Integral understanding of the mechanism of transcription cycle through quantitative, high-resolution approaches
• Project/Area Number: 24118001
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: 山口 雄輝 東京工業大学, 生命理工学院, 教授 (50345360)
• Co-Investigator(Kenkyū-buntansha): 十川 久美子 東京工業大学, 生命理工学院, 准教授 (20291073) ; 中村 春木 大阪大学, たんぱく質研究所, 教授 (80134485) ; 松本 直通 横浜市立大学, 医学研究科, 教授 (80325638) ; 高橋 陽介 広島大学, 理学研究科, 教授 (90183855) ; 緒方 一博 横浜市立大学, 医学研究科, 教授 (90260330) ; 伊藤 敬 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90306275)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: 転写サイクル

Outline of Annual Research Achievements

本領域では、先端的な解析技術の開発・導入、および、ウェットとドライ（情報科学・計算科学）の融合、という2つをドライビングフォースとして、転写制御の全体像を定量的に明らかにすることを目指している。総括班は、開発された技術を領域内外に普及させる活動や、ウェットとドライの融合を促進する場の醸成等を通じて、転写サイクル研究を推進する。今年度は以下の研究支援活動を行った。
（1）先端的技術の領域内共同利用システムの構築と運用。当初計画に従い松本、十川、緒方の各研究室に導入した次世代シーケンサー、1分子蛍光顕微鏡、構造解析用装置を用いて領域内共同利用システムを引き続き運用した。
（2）領域内の研究交流ならびに若手支援。今年度は当初計画に従い、H28年8月に第5回班会議を宮城県で開催した。また、若手中心の研究発表の場として「冬の若手ワークショップ」をH29年1月に千葉県で開催した。
（3）国際シンポジウムの開催。海外からWilliam Lee Kraus（米国）、Laszlo Tora（フランス）、Peter Becker（ドイツ）の3氏を招聘し、H28年12月に第2回転写サイクル国際シンポジウムを東京大学小柴ホールにおいて開催した。
（4）広報活動。領域ホームページを通じて領域の研究成果等を引き続き情報発信する一方、年1回のペースでニュースレターを刊行した。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] 転写反応の生化学 (2017)
  • Author(s): 山口雄輝
  • Journal Title: 生体の科学 Volume: 68(3) Pages: -
• [Journal Article] Autophosphorylation affects substrate-binding affinity of tobacco Ca2+-dependent protein kinase1 (2017)
  • Author(s): Ito, T., Ishida, S., Oe, S., Fukazawa, J. and Takahashi, Y.
  • Journal Title: Plant Physiol. Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] DELLA-GAF1 complex is a main component in gibberellin feedback regulation of GA20ox2 in Arabidopsis (2017)
  • Author(s): Fukazawa, J., Mori, M., Watanabe, S., Miyamoto, C., Ito, T. and Takahashi, Y.
  • Journal Title: Plant Physiol. Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells (2017)
  • Author(s): Kasai S, Kajimoto S, Ito Y, Saito T, Yasumoto K, Tokunaga M, Sakata-Sogawa K, Fukumura H, Sogawa K
  • Journal Title: Journal of Biochemistry Volume: 161 Pages: 291-296
  • DOI: 10.1093/jb/mvw068
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses (2017)
  • Author(s): Shin C, Ito Y, Ichikawa S, Tokunaga M, Sakata-Sogawa K, Tanaka T
  • Journal Title: Scientific Reports Volume: 7 Pages: 46097
  • DOI: 10.1038/srep46097
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A novel GFI1B mutation at the first zinc finger domain causes congenital macrothrombocytopenia (2017)
  • Author(s): Uchiyama Y, Ogawa Y, Kunishima S, Shiina M, Nakashima M, Yanagisawa K, Yokohama A, Imagawa E, Miyatake S, Mizuguchi T, Takata A, Miyake N, Ogata K, Handa H, Matsumoto N
  • Journal Title: British Journal of Haematology Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1111/bjh.14710
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Molecular mechanisms of cooperative binding of transcription factors Runx1-CBFβ-Ets1 on the TCRα gene enhancer (2017)
  • Author(s): Kasahara K, Shiina M, Fukuda I, Ogata K, Nakamura H
  • Journal Title: PloS One Volume: 12 Pages: e0172654
  • DOI: 10.1371/journal.pone.0172654
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing (2017)
  • Author(s): Lardelli RM, Schaffer AE, Eggens VR, ... Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG
  • Journal Title: Nature Genetics Volume: 49 Pages: 457-464
  • DOI: 10.1038/ng.3762
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] PARS2 and NARS2 mutations in infantile-onset neurodegenerative disorder (2017)
  • Author(s): Mizuguchi T, Nakashima M, Kato M, Yamada K, Okanishi T, Ekhilevitch N, Mandel H, Eran A, Toyono M, Sawaishi Y, Motoi H, Shiina M, Ogata K, Miyatake S, Miyake N, Saitsu H, Matsumoto N
  • Journal Title: Journal of Human Genetics Volume: 62 Pages: 525-529
  • DOI: 10.1038/jhg.2016.163
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Biallelic mutations in MYPN, encoding Myopalladin, are associated with childhood-onset, slowly progressive nemaline myopathy (2017)
  • Author(s): Miyatake S, Mitsuhashi S, Hayashi YK, Purevjav E, Nishikawa A, Koshimizu E, Suzuki M, Yatabe K, Tanaka Y, Ogata K, Kuru S, Shiina M, Tsurusaki Y, Nakashima M, Mizuguchi T, Miyake N, Saitsu H, Ogata K, Kawai M, Towbin J, Nonaka I, Nishino I, Matsumoto N
  • Journal Title: American Journal of Human Genetics Volume: 100 Pages: 169-178
  • DOI: 10.1016/j.ajhg.2016.11.017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Distal arthrogryposis with variable clinical expression caused by TNNI2 mutation (2017)
  • Author(s): Culic V, Miyake N, Jankovic S, Petrovic D, Simunovic M, Dapic T, Shiina M, Ogata K, Matsumoto N
  • Journal Title: Human Genome Variation Volume: 3 Pages: 16035
  • DOI: 10.1038/hgv.2016.35
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The first report of Japanese patients with asparagine synthetase deficiency (2017)
  • Author(s): Yamamoto T, Endo W, Ohnishi H, Kubota K, Kawamoto N, Inui T, Imamura A, Takanashi JI, Shiina M, Saitsu H, Ogata K, Matsumoto N, Haginoya K, Fukao T
  • Journal Title: Brain Development Volume: 39 Pages: 236-242
  • DOI: 10.1016/j.braindev.2016.09.010
  • Peer Reviewed
• [Journal Article] Biallelic TBCD mutations cause early-onset neurodegenerative encephalopathy (2017)
  • Author(s): Miyake N, Fukai R, Ohba C, ... Shiina M, Ogata K, Okuno-Yuguchi J, Fueki N, Ogiso Y, Suzumura H, Watabe Y, Imataka G, Leong HY, Fattal-Valevski A, Kramer U, Miyatake S, Kato M, Okamoto N, Sato Y, Mitsuhashi S, Nishino I, Kaneko N, Nishiyama A, Tamura T, Mizuguchi T, Nakashima M, Tanaka F, Saitsu H, Matsumoto N
  • Journal Title: American Journal of Human Genetics Volume: 99 Pages: 950-961
  • DOI: 10.1016/j.ajhg.2016.08.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enhancement of canonical sampling by virtual-state transitions (2017)
  • Author(s): Junichi Higo, Kota Kasahara, Bhaskar Dasgupta, Haruki Nakamura
  • Journal Title: J. Chem. Phys. Volume: 146 Pages: 44104
  • DOI: 10.1063/1.4974087
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ultratra-sensitve droplet digital PCR for detecting a low-prevalence somatic GNAQ mutation in Sturge-Weber syndrome (2016)
  • Author(s): Uchiyama Y, Nakashima M, Watanabe S, Miyajima M, Taguri M, Miyatake S, Miyake N, Saitsu H, Mishima H, Kinoshita A, Arai H, Yoshiura K, Matsumoto N
  • Journal Title: Sci Rep Volume: 6 Pages: 22985
  • DOI: 10.1038/srep22985.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] FDG-PET study of patients with Leigh syndrome (2016)
  • Author(s): Haginoya K, Kaneta T, Togashi N, Hino-Fukuyo N, Kobayashi T, Uematsu M, Kitamura T, Inui T, Okubo Y, Takezawa Y, Anzai M, Endo W, Miyake N, Saitsu H, Matsumoto N, Kure S.
  • Journal Title: J Neurol Sci Volume: 362 Pages: 309-313
  • DOI: 10.1016/j.njs.2016.02.008.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pathogenic variants in PIGG cause intellectual disability with seizures and hypotonia (2016)
  • Author(s): Makrythanasis P, Kato M, Zaki MS, Saitsu H, Nakamura K, Santoni FA, Miyatake S, Nakashima M, Issa MY, Guipponi M, Letourneau A, Logan CV, Roberts N, Parry DA, Johnson CA, Matsumoto N, Hamamy H, Sheridan E, Kinoshita T, Antonarakis SE, Murakami Y
  • Journal Title: Am J Hum Genet Volume: 98 Pages: 615-626
  • DOI: 10.1016/j.ajhg.2016.02.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mislocalization of syntaxin-1 and impaired neurite growth observed in a human iPSC model for STXBP1-related epileptic encephalopathy (2016)
  • Author(s): Yamashita S, Chiyonobu T, Yoshida M, Maeda H, Zuiki M, Kidowaki S, Isoda K, Morimoto M, Kato M, Saitsu H, Matsumoto N, Nakahata T, Saito MK, Hosoi H.
  • Journal Title: Epilepsia Volume: 57 Pages: e81-86
  • DOI: 10.1111/epi.13338.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Detection of low-prevalence somatic TSC2 mutations in sporadic pulmonary lymphangioleiomyomatosis tissues by deep sequencing (2016)
  • Author(s): Fujita A, Ando K, Kobayashi E, Mitani K, Okudera K, Nakashima N, Miyatake S, Tsurusaki Y, Saitsu H, Seyama K, Miyake N, Matsumoto N
  • Journal Title: Hum Genet Volume: 135 Pages: 61-68
  • DOI: 10.1007/s00439-015-1611-0.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A novel homozygous mutation in HSF4 causing autosomal recessive congenital cataract (2016)
  • Author(s): Behnam M, Imagawa E, Chaleshtori ARS, Ronasian F, Salehi M, Miyake N, Matsumoto N
  • Journal Title: J Hum Genet Volume: 61 Pages: 177-179
  • DOI: 10.1038/jhg.2015.127.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel COL4A1 mutation in an infant with severe dysmorphic syndrome with schizencephaly, periventricular calcifications, and cataract resembling congenital infection. (2016)
  • Author(s): Smigiel R, Cabala M, Jakubiak A, Kodera H, Sasiadek MJ, Matsumoto N, Sasiadek MM, Saitsu H.
  • Journal Title: Birth Defects Res A Clin Mol Teratol Volume: 106 Pages: 304-307
  • DOI: 10.1002/bdra.23488.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Homozygous p.V116* mutation in C12orf65 results in Leigh syndrome (2016)
  • Author(s): Imagawa E, Fattal-Valevski A, Eyal O, Miyatake S, Saada A, Nakashima M, Tsurusaki Y, Saitsu H Miyake N, Matsumoto N
  • Journal Title: Journal of Neurol Neurosurg Psychiatry Volume: 87 Pages: 212-216
  • DOI: 10.1136/jnnp-2014-310084
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] De novo GABRA1 mutations in Ohtahara and West syndromes (2016)
  • Author(s): Kodera H, Ohba C, Kato M, Maeda T, Araki K, Tajima D, Matsuo M, Hino-Fukuyo N, Kohashi K, Ishiyama A, Takeshita S, Motoi H, Kitamura T, Kikuchi A, Tsurusaki Y, Nakashima M, Miyake N, Sasaki M, Kure S, Haginoya K, Saitsu H, Matsumoto N
  • Journal Title: Epilepsia Volume: 57 Pages: 566-573
  • DOI: 10.1111/epi.13344.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Panventriculomegaly with a wide foramen of Magendie and large cisterna magna (2016)
  • Author(s): Kageyama H, Miyajima M, Ogino I, Nakajima M, Shimoji K, Fukai R, Miyake N, Nishiyama K, Matsumoto N, Arai H
  • Journal Title: J Neurosurg Volume: 124 Pages: 1858-1866
  • DOI: 10.3171/2015.6.JNS15162.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] De novo missense mutations in NALCN cause developmental and intellectual impairment with hypotonia (2016)
  • Author(s): Fukai R, Saitsu H, Okamoto N, Sakai Y, Fattal-Valevski A, Masaaki S, Kitai Y, Torio M, Kojima-Ishii K, Ihara K, Nakashima M, Miyatake S, Tanaka F, Miyake N, Matsumoto N
  • Journal Title: J Hum Genet Volume: 61 Pages: 451-455
  • DOI: 10.1038/jhg.2015.163.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dyschromatosis symmetrica hereditaria and Aicardi-Goutieres syndrome 6 are phenotypic variants caused by ADAR1 mutations (2016)
  • Author(s): Kono M, Matsumoto F, Suzuki Y, Suganuma M, Saitsu H, Ito Y, Fujiwara S, Moriwaki S, Matsumoto K, Matsumoto N, Tomita Y, Sugiura K, Akiyama M
  • Journal Title: J Invest Dermatol Volume: 136 Pages: 875-878
  • DOI: 10.1016/J.JID.2015.12.034.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vein of Galen Aneurysmal malformation in monozygotic twin (2016)
  • Author(s): Komiyama M, Miyatake M Watanabe Y, Terada A, Ishiguro T, Ichiba H, Matsumoto M
  • Journal Title: World Neurosurg Volume: 91:672 Pages: e11-15
  • DOI: 10.1016/j.wneu.2016.04.031.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] De novo KCNH1 mutations in four patients with syndromic developmental delay, hypotonia and seizures. (2016)
  • Author(s): Fukai R, Saitsu H, Tsurusaki Y, Sakai Y, Haginoya K, Takahashi K, Hubshman MW, Okamoto N, Nakashima M, Tanaka F, Miyake N, Matsumoto N
  • Journal Title: J Hum Genet Volume: 61 Pages: 381-387
  • DOI: 10.1038/jhg.2016.1.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Two cases of early-onset myoclonic seizures with continuous parietal delta activity caused by EEF1A2 mutations (2016)
  • Author(s): Inui T, Kobayashi S, Ashikari Y, Sato R, Endo W, Uematsu M, Oba H, Saitsu H, Matsumoto N, Kure S, Haginoya K
  • Journal Title: Brain Dev Volume: 38 Pages: 520-524
  • DOI: 10.1016/j.braindev.2015.11.003.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay (2016)
  • Author(s): Saitsu H, Watanabe M, Akita T, Ohba C, Sugai K, Ong WP, Shiraishi H, Yuasa S, Matsumoto H, Beng KT, Saitoh S, Miyatake S, Nakashima M, Miyake N, Kato M, Fukuda A, Matsumoto N
  • Journal Title: Sci Rep Volume: 6 Pages: 30072
  • DOI: 10.1038/srep30072.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] De novo truncating mutation of TRIM8 causes early-onset epileptic encephalopathy (2016)
  • Author(s): Sakai Y#, Fukai R# (# denotes equal contribution), Matsushita Y, Miyake N, Saitsu H, Akamine S, Torio M, Sasazaki M, Ishizaki Y, Sanefuji M, Torisu H, Shaw CA, Matsumoto N, Hara T
  • Journal Title: Ann Hum Genet Volume: 80 Pages: 235-240
  • DOI: 10.1111/ahg.12157.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] SMARCE1, a rare cause of Coffin-Siris Syndrome: Clinical description of three additional cases (2016)
  • Author(s): Zarate YA, Bhoj E, Kaylor J, Li D, Tsurusaki Y, Miyake N, Matsumoto N, Phadke S, Escobar L, Irani A, Hakonarson H, Schrier Vergano SA
  • Journal Title: Am J Med Genet A Volume: 170 Pages: 1967-1973
  • DOI: 10.1002/ajmg.a.37722.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7 (2016)
  • Author(s): Narumi S*, et al., Matsumoto N, et al.
  • Journal Title: Nat Genet Volume: 48 Pages: 792-797
  • DOI: 10.1038/ng.3569.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] De novo p.Arg756Cys mutation of ATP1A3 causes an atypical form of alternating hemiplegia of childhood with prolonged paralysis and choreoathetosis (2016)
  • Author(s): Kanemasa H, Fukai R, Sakai Y, Torio M, Miyake N, Lee S, Ono H, Akamine S, Nishiyama K, Sanefuji M, Ishizaki Y, Torisu H, Saitsu H, Matsumoto N, Hara T
  • Journal Title: BMC Neurol Volume: 16 Pages: 174
  • DOI: 10.1186/s12883-016-0680-6.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The first genetically confirmed Japanese patient with mucolipidosis type IV (2016)
  • Author(s): Saijo H, Hayashi M, Ezoe T, Ohba C, Saitsu H, Kurata K, Matsumoto N
  • Journal Title: Clin Case Rep Volume: 4 Pages: 509-512
  • DOI: 10.1002/ccr3.540.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The first Japanese case of leukodystrophy with ovarian failure arising from novel compound heterozygous AARS2 mutations (2016)
  • Author(s): Hamatani M, Jingami N, Tsurusaki Y, Shimada S, Shimojima K, Asada-Utsugi M, Yoshinaga K, Uemura N, Yamashita H, Uemura K, Takahashi R, Matsumoto N, Yamamoto T
  • Journal Title: J Hum Genet Volume: 61 Pages: 899-902
  • DOI: 10.1038/jhg.2016.64.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Molecular genetic analysis of 30 families with Joubert syndrome (2016)
  • Author(s): Suzuki T, et al., Matsumoto N
  • Journal Title: Clin Genet Volume: 90 Pages: 526-535
  • DOI: 10.1111/cge.12836.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Distinct but milder phenotypes with choreiform movements in siblings with compound heterozygous mutations in the transcription preinitiation mediator complex subunit 17 (MED17) (2016)
  • Author(s): Hirabayashi S, Saitsu H, Matsumoto N
  • Journal Title: Brain Dev Volume: 38 Pages: 118-123
  • DOI: 10.1016/j.braindev.2015.05.004.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Diagnosis of pancreatic lesions collected by endoscopic ultrasound-guided fine-needle aspiration using next-generation sequencing (2016)
  • Author(s): Kameta E, Sugimori K, Kaneko T, Ishii T, Miwa H, Sato T, Ishii Y, Sue S, Sasaki T, Yamashita Y, Shibata W, Matsumoto N, Maeda S
  • Journal Title: Oncol Lett Volume: 12 Pages: 3875-3881
  • DOI: 10.3892/ol.2016.5168
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Autosomal-recessive mutations in AP3B2, adaptor-related protein complex 3 beta 2 subunit, cause an early-onset epileptic encephalopathy with optic atrophy (2016)
  • Author(s): Assoum M, Philippe C, et al., Matsumoto N, et al.
  • Journal Title: Am J Hum Genet Volume: 99 Pages: 1368-1376
  • DOI: 10.1016/j.ajhg.2016.10.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The molecular and phenotypic spectrum of IQSEC2-related epilepsy (2016)
  • Author(s): Zerem A, et al., Matsumoto N, et al.
  • Journal Title: Epilepsia Volume: 57 Pages: 1858-1869
  • DOI: 10.1111/epi.13560.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between invisible basal ganglia and ZNF335 mutations: a case report (2016)
  • Author(s): Sato R, Takanashi J, Tsuyusaki Y, Kato M, Saitsu H, Matsumoto N, Takahashi T
  • Journal Title: Pediatrics Volume: 138 Pages: e20160897
  • DOI: 10.1542/peds.2016-0897.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Megalencephaly, polymicrogyria and ribbon-like band heterotopia: A new cortical malformation (2016)
  • Author(s): Kobayashi Y, Magara S, Okazaki K, Komatsubara T, Saitsu H, Matsumoto N, Kato M, Tohyama J
  • Journal Title: Brain Dev Volume: 38 Pages: 950-953
  • DOI: 10.1016/j.braindev.2016.06.004.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A female case of aromatic l-amino acid decarboxylase deficiency responsive to MAO-B inhibition (2016)
  • Author(s): Kojima K, Anzai R, Ohba C, Goto T, Miyauchi A, Thony B, Saitsu H, Matsumoto N, Osaka H, Yamagata T
  • Journal Title: Brain Dev Volume: 38 Pages: 959-963
  • DOI: 10.1016/j.braindev.2016.06.002.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical features of SMARCA2 duplication overlap with Coffin-Siris syndrome (2016)
  • Author(s): Miyake N, Abdel-Salam G, Yamagata T, Eid MM, Osaka H, Okamoto N, Mohamed AM, Ikeda T, Afifi HH, Piard J, van Maldergem L, Mizuguchi T, Miyatake S, Tsurusaki Y, Matsumoto N
  • Journal Title: Am J Med Genet A Volume: 170 Pages: 2662-2670
  • DOI: 10.1002/ajmg.a.37778.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux (2016)
  • Author(s): Fujita A, Isidor B, Piloquet H, Corre P, Okamoto N, Nakashima M, Tsurusaki Y, Saitsu H, Miyake N, Matsumoto N
  • Journal Title: J Hum Genet Volume: 61 Pages: 835-838
  • DOI: 10.1038/jhg.2016.54.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] First Japanese variant of late infantile neuronal ceroid lipofuscinosis caused by novel CLN6 mutations (2016)
  • Author(s): Sato R, Inui T, Endo W, Okubo Y, Takezawa Y, Anzai M, Morita H, Saitsu H, Matsumoto N, Haginoya K
  • Journal Title: Brain Dev Volume: 38 Pages: 852-826
  • DOI: 10.1016/j.braindev.2016.04.007.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of biallelic LRRK1 mutations in osteosclerotic metaphyseal dysplasia and evidence for locus heterogeneity (2016)
  • Author(s): Iida A, Xing W, Docx MK, Nakashima T, Wang Z, Kimizuka M, Van Hul W, Rating D, Spranger J, Ohashi H, Miyake N, Matsumoto N, Mohan S, Nishimura G, Mortier G, Ikegawa S
  • Journal Title: J Med Genet Volume: 53 Pages: 568-574
  • DOI: 10.1136/jmedgenet-2016-103756.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] WDR45 mutations in three male patients with West syndrome (2016)
  • Author(s): Nakashima M, Takano K, Tsuyusaki Y, Yoshitomi S, Shimono M, Aoki Y, Kato M, Aida N, Mizuguchi T, Miyatake S, Miyake N, Osaka H, Saitsu H, Matsumoto N
  • Journal Title: J Hum Genet Volume: 61 Pages: 653-661
  • DOI: 10.1038/jhg.2016.27.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Milder progressive cerebellar atrophy caused by biallelic SEPSECS mutations (2016)
  • Author(s): Iwama K, Sasaki M, Hirabayashi S, Ohba C, Iwabuchi E, Miyatake S, Nakashima M, Miyake N, Ito S, Saitsu H, Matsumoto N
  • Journal Title: J Hum Genet Volume: 61 Pages: 527-531
  • DOI: 10.1038/jhg.2016.9.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dermatan 4-O-sulfotransferase 1-deficient Ehlers-Danlos syndrome complicated by a large subcutaneous hematoma on the back (2016)
  • Author(s): Mochida K, Amano M, Miyake N, Matsumoto N, Hatamochi A, Kosho T
  • Journal Title: J Dermatol Volume: 43 Pages: 832-833
  • DOI: 10.1111/1346-8138.13273.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] mDCC_tools: Characterizing Multi-modal Atomic Motions in Molecular Dynamics Trajectories (2016)
  • Author(s): Kota Kasahara, Neetha Mohan, Ikuo Fukuda, Haruki Nakamura
  • Journal Title: Bioinformatics Volume: 32 Pages: 2531-2533
  • DOI: 10.1093/bioinformatics/btw129
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Elastic properties of dynein motor domain obtained from all-atom molecular dynamics simulations (2016)
  • Author(s): Narutoshi Kamiya, Tadaaki Mashimo, Yu Takano, Takahide Kon, Genji Kurisu, Haruki Nakamura
  • Journal Title: Protein Engineering, Design and Selection Volume: 29 Pages: 317-325
  • DOI: 10.1093/protein/gzw022
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Rapid and efficient analysis of gene function using CRISPR-Cas9 in Xenopus tropicalis founders (2016)
  • Author(s): Mitsuki Shigeta, Yuto Sakan, Midori Iida, Miyuki Suzuki, Keiko Kashiwagi, Akihiko Kashiwagi, Satoshi Fujii, Takashi Yamamoto, Ken-ichi T. Suzuki
  • Journal Title: Genes to Cells Volume: 21 Pages: 755-771
  • DOI: 10.1111/gtc.12379
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Revisiting Antibody Modeling Assessment for CDR-H3 loop (2016)
  • Author(s): Hiroshi Nishigami, Narutoshi Kamiya, Haruki Nakamura
  • Journal Title: Protein Engineering, Design and Selection Volume: 29 Pages: 477-484
  • DOI: 10.1093/protein/gzw028
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of aryl hydrocarbon receptor signaling pathways altered in TCDD- treated red seabream embryos by transcriptome analysis (2016)
  • Author(s): Midori Iida, Satoshi Fujii, Masaya Uchida, , Hiroshi Nakamura, Yoshihiro Kagami, Tetsuro Agusa, Masashi Hirano, Su-Min Bak, Eun-Young Kim, Hisato Iwata
  • Journal Title: Aquatic Toxicology Volume: 177 Pages: 156-170
  • DOI: 10.1016/j.aquatox.2016.05.014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] myPresto/omegagene: a GPU-accelerated molecular dynamics simulator tailored for enhanced conformational sampling methods with a non-Ewald electrostatic scheme (2016)
  • Author(s): Kota Kasahara, Benson Ma, Kota Goto, Bhaskar Dasgupta, Junichi Higo, Ikuo Fukuda, Tadaaki Mashimo, Yutaka Akiyama, Haruki Nakamura
  • Journal Title: Biophys. PhysicoBiol. Volume: 13 Pages: 209-216
  • DOI: 10.2142/biophysico.13.0_209
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Variation of Free-Energy Landscape of the p53 C-terminal Domain Induced by Acetylation: Enhanced Conformational Sampling (2016)
  • Author(s): Shinji Iida, Tadaaki Mashimo, Takashi Kurosawa, Hironobu Hojo, Hiroya Muta, Yuji Goto, Yoshifumi Fukunishi, Haruki Nakamura, Junichi Higo
  • Journal Title: J. Comput. Chem. Volume: 37 Pages: 2687-2700
  • DOI: 10.1002/jcc.24494
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] GAF1 とその相互作用因子によるジベレリン生合成酵素遺伝転写制御（優秀発表賞受賞） (2017)
  • Author(s): 勝部隆義，伊藤岳，深澤壽太郎，高橋陽介
  • Organizer: 第74回中国四国植物学会
  • Place of Presentation: 高知大学（高知県高知市）
  • Year and Date: 2017-05-14
• [Presentation] ホメオドメインタンパク質によるジベレリン生合成遺伝子の転写制御機構の解析 (2017)
  • Author(s): 中村駿志，深澤壽太郎，高橋陽介
  • Organizer: 第74回中国四国植物学会
  • Place of Presentation: 高知大学（高知県高知市）
  • Year and Date: 2017-05-13
• [Presentation] ジベレリンによるシロイヌナズナの花成制御（優秀発表賞受賞） (2017)
  • Author(s): 大橋由紀，髙橋竜平，伊藤岳，深澤壽太郎，高橋陽介
  • Organizer: 第74回中国四国植物学会
  • Place of Presentation: 高知大学（高知県高知市）
  • Year and Date: 2017-05-13
• [Presentation] DELLA を介したジベレリンとジャスモン酸のクロストーク制御 (2017)
  • Author(s): 森 亮太，藤井麻耶，伊藤 岳，深澤壽太郎，高橋陽介
  • Organizer: 第74回中国四国植物学会
  • Place of Presentation: 高知大学（高知県高知市）
  • Year and Date: 2017-05-13
• [Presentation] Search for anti-leukemic drugs targeting the transcription factor Runx1 by INTENDD (2017)
  • Author(s): Shiina M, Baba S, Uchiyama A, Okada C, Tanaka T, Ikeda K, Kawakita S, Matsuzaki T, Komatsu H, Hosoda M, Ogata K
  • Organizer: The 137th Annual Meeting of the Pharmaceutical Society of Japan, 3rd International Symposium for Medicinal Sciences
  • Place of Presentation: 仙台国際センター・東北大学川内北キャンパス(宮城県仙台市)
  • Year and Date: 2017-03-24 – 2017-03-25
  • Int'l Joint Research / Invited
• [Presentation] 細胞分化における核内アクチンの機能解析 (2017)
  • Author(s): 横山吟司, 山本浩志, 山崎祥他, 十川久美子, 徳永万喜洋, 原田昌彦
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-17 – 2017-03-20
• [Presentation] ジベレリン信号伝達におけるDELLA-GAF1複合体による新たな標的遺伝子の制御 (2017)
  • Author(s): 深澤壽太郎、大橋由紀、森亮太、高橋陽介
  • Organizer: 日本植物生理学会 第58回年会
  • Place of Presentation: 鹿児島大学（鹿児島県鹿児島市）
  • Year and Date: 2017-03-17
• [Presentation] 抗炎症薬サリチル酸が示す生体内作用メカニズムの解析 (2017)
  • Author(s): 坂本 聡、Gupta Vipul、劉 舒捷、安藤秀樹、舘野峻平、金子裕生、湯上真人、石井亮平、濡木 理、山口雄輝、半田 宏
  • Organizer: 日本化学会第97春季年会
  • Place of Presentation: 慶應義塾大学（神奈川県横浜市）
  • Year and Date: 2017-03-16 – 2017-03-19
• [Presentation] 天然変性領域による転写制御の分子機構 (2017)
  • Author(s): 笠原 浩太
  • Organizer: 第5回 関西4私大 生命科学シンポジウム
  • Place of Presentation: 関西学院会館光の間(兵庫県西宮市)
  • Year and Date: 2017-03-07 – 2017-03-07
• [Presentation] Multi-modal Dynamic Cross Correlation (mDCC) 法の開発と転写因子- DNA 複合体におけ る動的相関ネットワークの解析 (2017)
  • Author(s): 笠原 浩太
  • Organizer: 名古屋大学 IGER セミナー
  • Place of Presentation: 名古屋大学(愛知県名古屋市)
  • Year and Date: 2017-02-28 – 2017-02-28
• [Presentation] ＲＮＡポリメラーゼⅡ転写産物の長さを決める３’末端プロセシングの制御メカニズムの解明 (2017)
  • Author(s): 瑞慶覧 安里、舘野 峻平、山本 淳一、山口 雄輝
  • Organizer: 新学術領域研究「転写サイクル」冬の若手ワークショップ2017
  • Place of Presentation: 一宮シーサイドオーツカ(千葉県一宮町)
  • Year and Date: 2017-01-30 – 2017-02-02
• [Presentation] マウスES細胞における2細胞期特異的な遺伝子の発現制御メカニズムの解析 (2017)
  • Author(s): 鈴木 翔子、柴田 紘孝、山口 雄輝
  • Organizer: 新学術領域研究「転写サイクル」冬の若手ワークショップ2017
  • Place of Presentation: 一宮シーサイドオーツカ(千葉県一宮町)
  • Year and Date: 2017-01-30 – 2017-02-02
• [Presentation] E3ユビキチンリガーゼCRBNの細胞内局在が免疫調整薬IMiDsの薬効に及ぼす影響 (2017)
  • Author(s): 徳山 遥香、片山 美樹、山口 雄輝
  • Organizer: 新学術領域研究「転写サイクル」冬の若手ワークショップ2017
  • Place of Presentation: 一宮シーサイドオーツカ(千葉県一宮町)
  • Year and Date: 2017-01-30 – 2017-02-02
• [Presentation] ターゲット因子の解析を基盤とする生物活性物質が示す作用機構の解明 (2017)
  • Author(s): 坂本 聡、山口 雄輝、半田 宏
  • Organizer: 新学術領域研究「転写サイクル」冬の若手ワークショップ2017
  • Place of Presentation: 一宮シーサイドオーツカ(千葉県一宮町)
  • Year and Date: 2017-01-30 – 2017-02-02
• [Presentation] DNA損傷時に誘導される転写制御の生理的意義とTLPの役割 (2017)
  • Author(s): 鈴木 秀文、前田 亮、木村 宏、浦 聖恵、山口 雄輝、田村 隆明
  • Organizer: 新学術領域研究「転写サイクル」冬の若手ワークショップ2017
  • Place of Presentation: 一宮シーサイドオーツカ(千葉県一宮町)
  • Year and Date: 2017-01-30 – 2017-02-02
• [Presentation] 多発性骨髄腫における Pomalidomide 標的因子の網羅的探索 (2017)
  • Author(s): 舘野 峻平 、飯田 緑 、藤井 聡 、佐倉 絵里、山口 雄輝
  • Organizer: 新学術領域研究「転写サイクル」冬の若手ワークショップ2017
  • Place of Presentation: 一宮シーサイドオーツカ(千葉県一宮町)
  • Year and Date: 2017-01-30 – 2017-02-02
• [Presentation] ウェットとドライの真の融合を目指して (2017)
  • Author(s): 藤井 聡
  • Organizer: 冬の若手ワークショップ2017
  • Place of Presentation: 一宮シーサイドオーツカ（千葉県長生郡）
  • Year and Date: 2017-01-30 – 2017-02-02
• [Presentation] 転写因子とヒストン修飾の関連性を提示するためのデータベース構築 (2017)
  • Author(s): 飯田 緑、藤井 聡
  • Organizer: 冬の若手ワークショップ2017
  • Place of Presentation: 一宮シーサイドオーツカ（千葉県長生郡）
  • Year and Date: 2017-01-30 – 2017-02-02
• [Presentation] １分子イメージングとFRAPによるINO80クロマチン再構成複合体の核内動態解析 (2016)
  • Author(s): 伊藤由馬, 原田昌彦, 木村宏, 十川久美子, 徳永万喜洋
  • Organizer: 第8回「光塾」
  • Place of Presentation: 東京工業大学すずかけ台キャンパス（神奈川県横浜市）
  • Year and Date: 2016-12-17 – 2016-12-18
• [Presentation] How Pol II termination and 3' processing sites are precisely determined in higher eukaryotes.高等真核生物においてPol IIの転写終結と3'プロセシングの部位はいかにして正確に決定されるのか (2016)
  • Author(s): Ari Zukeran, Junichi Yamamoto, and Yuki Yamaguchi
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30 – 2016-12-02
  • Invited
• [Presentation] NELFを中心としたポリ(A)付加部位選択のメカニズム (2016)
  • Author(s): 瑞慶覧 安里、山本 淳一、山口 雄輝
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30 – 2016-12-02
• [Presentation] パートナー因子によるEts1のコンフォーメーション分布の変化と活性制御機構の解析 (2016)
  • Author(s): 内山晃子，椎名政昭，浜田恵輔，馬場しほ，岡田千佳子，鈴木香絵，佐藤 光，緒方一博
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜 (神奈川県横浜市)
  • Year and Date: 2016-11-30 – 2016-12-02
• [Presentation] 転写因子Ets1の天然変性領域のリン酸化によるDNA結合制御機構の速度論的解析 (2016)
  • Author(s): 椎名政昭，笠原浩太，肥後順一，馬場しほ，内山晃子，岡田千佳子，浜田恵輔，佐藤 光，中村春木，緒方一博
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜 (神奈川県横浜市)
  • Year and Date: 2016-11-30 – 2016-12-02
• [Presentation] Single-molecule imaging of the INO80 chromatin remodeling complex in the living cell nucleus (2016)
  • Author(s): 伊藤 由馬, 原田 昌彦, 十川久美子, 徳永万喜洋
  • Organizer: 第54回日本生物物理学会年会
  • Place of Presentation: つくば国際会議場（ 茨城県つくば市）
  • Year and Date: 2016-11-25 – 2016-11-27
• [Presentation] CLIP-170 phosphorylation mediates repositioning of microtubule-organizing center during T cell activation (2016)
  • Author(s): 林 偉銘, 伊藤 由馬, 徳永万喜洋, 十川久美子
  • Organizer: 第54回日本生物物理学会年会
  • Place of Presentation: つくば国際会議場（ 茨城県つくば市）
  • Year and Date: 2016-11-25 – 2016-11-27
• [Presentation] Single molecule imaging and quantitative analysis of nucleolar-localized protein dynamics (2016)
  • Author(s): 松本 大輝, 伊藤 由馬, 斉藤 典子，徳永万喜洋, 十川久美子
  • Organizer: 第54回日本生物物理学会年会
  • Place of Presentation: つくば国際会議場（ 茨城県つくば市）
  • Year and Date: 2016-11-25 – 2016-11-27
• [Presentation] Super-resolution analysis of microtubule dynamics on T cell activation (2016)
  • Author(s): 史 恒宇, 伊藤 由馬, 林 偉銘， 十川久美子, 徳永万喜洋
  • Organizer: 第54回日本生物物理学会年会
  • Place of Presentation: つくば国際会議場（ 茨城県つくば市）
  • Year and Date: 2016-11-25 – 2016-11-27
• [Presentation] Fluorescence recovery after photobleaching(FRAP) analysis of INO80 chromatin remodeling complex (2016)
  • Author(s): 磯垣 翼, 伊藤 由馬, 市川 翔太, 木村 宏, 原田 昌彦, 十川久美子, 徳永万喜洋
  • Organizer: 第54回日本生物物理学会年会
  • Place of Presentation: つくば国際会議場（ 茨城県つくば市）
  • Year and Date: 2016-11-25 – 2016-11-27
• [Presentation] PDLIM2-interacting protein MKRN2 functions as a novel E3 ligase for p65 subunit of NF-κB (2016)
  • Author(s): 申 纂暎, 伊藤 由馬, 徳永万喜洋, 田中 貴志, 十川久美子
  • Organizer: 第54回日本生物物理学会年会
  • Place of Presentation: つくば国際会議場（ 茨城県つくば市）
  • Year and Date: 2016-11-25 – 2016-11-27
• [Presentation] Live cell imaging and quantitative analysis of anti-inflammatory protein PDLIM2 activation upon LPS stimulation (2016)
  • Author(s): 市川 翔太, 伊藤 由馬, 田中 貴志, 徳永万喜洋, 十川久美子
  • Organizer: 第54回日本生物物理学会年会
  • Place of Presentation: つくば国際会議場（ 茨城県つくば市）
  • Year and Date: 2016-11-25 – 2016-11-27
• [Presentation] Quantitative image analysis of dynamics of promoter-proximal pausing related proteins (2016)
  • Author(s): 國見 慎之介, 伊藤 由馬, 山口 雄輝, 十川久美子, 徳永万喜洋
  • Organizer: 第54回日本生物物理学会年会
  • Place of Presentation: つくば国際会議場（ 茨城県つくば市）
  • Year and Date: 2016-11-25 – 2016-11-27
• [Presentation] Flexible docking between cyclin-dependent kinase 2 and its inhibitor using multicanonical MD (2016)
  • Author(s): Gert-Jan Bekker, Narutoshi Kamiya, Mitsugu Araki, Yasushi Okuno, Haruki Nakamura
  • Organizer: 第54回日本生物物理学会年会
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2016-11-25 – 2016-11-27
• [Presentation] 分子シミュレーションにおける静電相互作用計算法:零多重極子法の理論と実際 (2016)
  • Author(s): 福田 育夫, Wang Han, 神谷 成敏, 笠原 浩太, 寺田 透, 櫻庭 俊, 中村 春木
  • Organizer: 第54回日本生物物理学会年会
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2016-11-25 – 2016-11-27
• [Presentation] Oct4の2つのDNA結合サブドメインを結ぶ柔軟なlinker領域の自由エネルギー地形 (2016)
  • Author(s): 速水 智教、高田 彰二、中村 春木、肥後 順一
  • Organizer: 第54回日本生物物理学会年会
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2016-11-25 – 2016-11-27
• [Presentation] Rare variants in human diseases (2016)
  • Author(s): Naomichi Matsumoto
  • Organizer: The 2016 Annual Meeting of the Chinese Society of Medical Genetics (CSMG)
  • Place of Presentation: 中国杭州市
  • Year and Date: 2016-11-06 – 2016-11-06
  • Int'l Joint Research / Invited
• [Presentation] Mendelian Exome in Japan (2016)
  • Author(s): Naomichi Matsumoto
  • Organizer: LMCE2016, Symposium 13
  • Place of Presentation: The-K Hotel（韓国ソウル市）
  • Year and Date: 2016-10-28 – 2016-10-28
  • Int'l Joint Research / Invited
• [Presentation] 巨大生体分子の長時間 MD シミュレーションの開発と生体分子の構造機能相関の解明 (2016)
  • Author(s): 鷹野 優、Neetha Mohan、草鹿 あゆみ、川端 猛、笠原 浩太、真下 忠彰、神谷 成敏、中村 春木
  • Organizer: 第8回「学際計算科学による新たな知の発展・統合・創出」 シンポジウム
  • Place of Presentation: 筑波大学計算科学研究センター(茨城県つくば市)
  • Year and Date: 2016-10-17 – 2016-10-18
• [Presentation] 高等真核生物においてPOL Ⅱの転写終結と3'プロセシングの部位はいかにして正確に決定されるのか (2016)
  • Author(s): 瑞慶覧 安里、長谷川 冴妃子、館野 峻平、山本 淳一、山口 雄輝
  • Organizer: 新学術領域研究「転写サイクル」班会議2016
  • Place of Presentation: 松島一の坊（宮城県宮城郡）
  • Year and Date: 2016-09-05 – 2016-09-07
• [Presentation] ＴＢＰ類似因子ＴＬＰによるＤＮＡ損傷応答時の転写抑制と細胞死誘導機構の解析 (2016)
  • Author(s): 鈴木 秀文、前田 亮、浦 聖恵、木村 宏、山口 雄輝、田村 隆明
  • Organizer: 新学術領域研究「転写サイクル」班会議2016
  • Place of Presentation: 松島一の坊（宮城県宮城郡）
  • Year and Date: 2016-09-05 – 2016-09-07
• [Presentation] NELFを中心としたポリ(A)付加部位選択のメカニズム (2016)
  • Author(s): 瑞慶覧 安里、館野 峻平、山本 淳一、山口 雄輝
  • Organizer: 新学術領域研究「転写サイクル」班会議2016
  • Place of Presentation: 松島一の坊（宮城県宮城郡）
  • Year and Date: 2016-09-05 – 2016-09-07
• [Presentation] 公共ChIP-Seqデータの統合解析による転写制御の解析 (2016)
  • Author(s): 藤井 聡
  • Organizer: 転写サイクル合同班会議2016
  • Place of Presentation: 松島一の坊(宮城県宮城郡)
  • Year and Date: 2016-09-05 – 2016-09-07
• [Presentation] 転写産物とPolIIエンリッチメントプロファイリングによるDecapping exoribonuclease (Dom3z) の機能解析 (2016)
  • Author(s): 飯田 緑、磯部 智康、山口 雄輝、藤井 聡
  • Organizer: 転写サイクル合同班会議2016
  • Place of Presentation: 松島一の坊(宮城県宮城郡)
  • Year and Date: 2016-09-05 – 2016-09-07
• [Presentation] 計算・情報科学による 転写サイクルにおける情報変換機構の解明 (2016)
  • Author(s): 笠原 浩太、Neetha Mohan、中村 春木
  • Organizer: 転写サイクル合同班会議2016
  • Place of Presentation: 松島一の坊(宮城県宮城郡)
  • Year and Date: 2016-09-05 – 2016-09-07
• [Presentation] Molecular behavior of a higher-order complex of multiple transcription factors on enhancer site upon phosphorylation (2016)
  • Author(s): Ogata K, Shiina M, Kasahara K, Higo J, Hamada K, Nakamura H
  • Organizer: 6th International Conference on Structural Biology (Structural Biology 2016)
  • Place of Presentation: Hilton New Orleans Airport Hotel (米国ルイジアナ州)
  • Year and Date: 2016-08-22 – 2016-08-23
  • Int'l Joint Research / Invited
• [Presentation] Computational Approaches to Protein Interactions (2016)
  • Author(s): Haruki Nakamura
  • Organizer: Japan-Slovenia JSPS Bilateral scientific exchange
  • Place of Presentation: Koper（スロベニア）
  • Year and Date: 2016-08-17 – 2016-08-17
  • Int'l Joint Research / Invited
• [Presentation] Computational Approaches to Coupled Folding and Binding in Protein-Protein Interactions (2016)
  • Author(s): Haruki Nakamura
  • Organizer: The 11th International Symposium of the Protein Society of Thailand
  • Place of Presentation: Bangkok (タイ)
  • Year and Date: 2016-08-03 – 2016-08-03
  • Int'l Joint Research / Invited
• [Presentation] バイオインフォマティクスの世界へようこそ (2016)
  • Author(s): 飯田 緑
  • Organizer: 第3回LaMer 特別講演会
  • Place of Presentation: 愛媛大学(愛媛県松山市)
  • Year and Date: 2016-07-09 – 2016-07-09
• [Presentation] Rare variants in human diseases (2016)
  • Author(s): Naomichi Matsumoto
  • Organizer: International Symposium on Genomic Medicine 2016
  • Place of Presentation: Samsung Medical Center（韓国ソウル市）
  • Year and Date: 2016-06-24 – 2016-06-24
  • Int'l Joint Research / Invited
• [Presentation] DELLA-GAF1/IDD2 complex regulates gibberellin homeostasis and signaling (2016)
  • Author(s): Fukazawa, J., Ito, T., Takahashi, Y.
  • Organizer: 22nd International Plant Growth Substances Association Conference
  • Place of Presentation: トロント（カナダ）
  • Year and Date: 2016-06-21 – 2016-06-25
  • Int'l Joint Research
• [Presentation] CRBNに対するサリドマイド光学異性体の結合基盤解析 (2016)
  • Author(s): 坂本 聡、伊藤 拓水、森 智行、安藤 秀樹、山口 雄輝、箱嶋 敏雄、半田 宏
  • Organizer: 日本ケミカルバイオロジー学会第11回年会
  • Place of Presentation: 京都テルサ（京都府京都市）
  • Year and Date: 2016-06-15 – 2016-06-17
• [Presentation] リガンド依存的ユビキチンリガーゼＣＲＢＮの制御機構 (2016)
  • Author(s): 伊藤 拓水、朝妻 知子、山本 淳一 安藤 秀樹、佐藤 智美、山口 雄輝、半田 宏
  • Organizer: 日本ケミカルバイオロジー学会第11回年会
  • Place of Presentation: 京都テルサ（京都府京都市）
  • Year and Date: 2016-06-15 – 2016-06-17
• [Presentation] p53 C末端ドメインのアセチル化およびヒスチジンの荷電状態の変化がその立体構造集団に及ぼす影響 (2016)
  • Author(s): 飯田 慎仁, 牟田 寛弥, 後藤 祐児, 北條 裕信, 中村 春木, 肥後 順一
  • Organizer: 第16回日本蛋白質科学会年会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
  • Year and Date: 2016-06-07 – 2016-06-09
• [Presentation] 天然変性領域の過渡的な相互作用による転写制御の分子機構 (2016)
  • Author(s): 笠原 浩太、椎名 政昭、肥後 順一、緒方 一博、中村 春木
  • Organizer: 第16回日本蛋白質科学会年会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
  • Year and Date: 2016-06-07 – 2016-06-09
• [Presentation] Insights Derived from Molecular Dynamics Simulations into the Subunit Assembly and Clamp Motions of Thermococcus kodakarensis RNA Polymerase (2016)
  • Author(s): Neetha Mohan, Kota Kasahara, Akira Hirata, Haruki Nakamura
  • Organizer: 第16回日本蛋白質科学会年会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
  • Year and Date: 2016-06-07 – 2016-06-09
• [Presentation] An efficient new methodology for path elucidation and binding free energy calculation (2016)
  • Author(s): Gert-Jan Bekker, Narutoshi Kamiya, Haruki Nakamura
  • Organizer: 第16回日本蛋白質科学会年会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
  • Year and Date: 2016-06-07 – 2016-06-09
• [Presentation] Computational analysis on electrostatic properties of protein and Protein-Protein Interactions (2016)
  • Author(s): Haruki Nakamura
  • Organizer: Asia Pacific Protein Association (APPA), IPR International Seminar
  • Place of Presentation: 大阪大学蛋白質研究所(大阪府吹田市)
  • Year and Date: 2016-06-06 – 2016-06-06
  • Int'l Joint Research / Invited
• [Presentation] Computational Approaches to Coupled Folding and Binding in Protein-Protein Interactions (2016)
  • Author(s): Haruki Nakamura
  • Organizer: 21st Biophysics Conference
  • Place of Presentation: Hsinchu (台湾)
  • Year and Date: 2016-05-21 – 2016-05-21
  • Int'l Joint Research / Invited
• [Presentation] New Methods for Structure Guided Drug Development (2016)
  • Author(s): Haruki Nakamura
  • Organizer: JCUP VII
  • Place of Presentation: 大手町サンスカイルーム朝日生命大手町ビル(東京都千代田区)
  • Year and Date: 2016-05-20 – 2016-05-20
  • Int'l Joint Research / Invited
• [Presentation] Molecular mechanism for modulation of a multiple transcription factor complex formed on enhancer site up on phosphorylation (2016)
  • Author(s): Ogata K, Shiina M, Kasahara K, Higo J, Hamada K, Nakamura H
  • Organizer: 5th International Conference and Exhibition on Metabolomics
  • Place of Presentation: ハイアットリージェンシー大阪（大阪府大阪市）
  • Year and Date: 2016-05-16 – 2016-05-18
  • Int'l Joint Research / Invited
• [Presentation] Somatic mutation in Sturge Weber syndrome (2016)
  • Author(s): Naomichi Matsumoto
  • Organizer: The 11th Asisan & Oceanian Epilepsy Congress(AOEC)
  • Place of Presentation: Hong Kong Convention & Exhibition Centre（香港）
  • Year and Date: 2016-05-16 – 2016-05-16
  • Int'l Joint Research / Invited
• [Presentation] GAF1複合体によるGA生合成酵素遺伝子の転写抑制機構の解析（優秀発表賞受賞） (2016)
  • Author(s): 勝部隆義, 伊藤岳, 深澤壽太郎, 高橋陽介
  • Organizer: 第73回 中国四国植物学会
  • Place of Presentation: 米子コンベンションセンター（島根県）
  • Year and Date: 2016-05-15
• [Presentation] ジベレリンとオーキシンによる茎部の伸長制御機構の解析（優秀発表賞受賞） (2016)
  • Author(s): 伊東裕太, 伊藤岳, 高橋陽介
  • Organizer: 第73回 中国四国植物学会
  • Place of Presentation: 米子コンベンションセンター（島根県）
  • Year and Date: 2016-05-15
• [Presentation] DELLA-GAF1複合体によるジベレリン信号伝達の制御機構 (2016)
  • Author(s): 深澤壽太郎、高橋竜平、藤井麻弥、高橋陽介
  • Organizer: 第73回 中国四国植物学会
  • Place of Presentation: 米子コンベンションセンター（島根県）
  • Year and Date: 2016-05-15
• [Book] 遺伝子発現制御機構 クロマチン，転写制御，エピジェネティクス (2017)
  • Author(s): 田村隆明、浦清恵、山口雄輝ほか
  • Total Pages: 264
  • Publisher: 東京化学同人
• [Book] 植物生理学概論第二版 (2017)
  • Author(s): 桜井英博、柴岡弘郎、高橋陽介、小関良宏、藤田知道
  • Total Pages: 印刷中
  • Publisher: 培風館
• [Remarks] 新学術領域研究「転写サイクル」ウェブサイト
  • URL: http://transcriptioncycle.org