生殖細胞のエピゲノムダイナミクスとその制御

2014 Fiscal Year Annual Research Report

• Project Area: Analyses and regulation of germline epigenome
• Project/Area Number: 25112001
• Research Institution: Kyoto University
• Principal Investigator: 篠原 隆司 京都大学, 医学(系)研究科(研究院), 教授 (30322770)
• Co-Investigator(Kenkyū-buntansha): 伊川 正人 大阪大学, 微生物病研究所, 教授 (20304066)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: 生殖細胞 / エピゲノム

Outline of Annual Research Achievements

平成26年度においては以下の活動を行った。

1) 領域研究の推進体制の構築：各計画班を総括班研究代表者がサイトビジットを行い、個々の研究者が行っている研究の進捗状況や公募班を含めた共同研究状況についての確認を行った。また11月には公募研究班も交えた公開シンポジウムを九州大学で開催した。
2) 研究の広報：領域ホームページにおいて各研究班が発表した特筆すべき業績について別の班員が紹介するという形式で論文発表を行った。またプレスリリースも行っており、その成果は幅広く新聞やテレビにおいて報道された。これに加えて、関連研究分野の研究会の支援も行った。
3) 研究リソース：これまでに予定していた支援（遺伝子改変マウスの共有や作成支援、エピゲノム解析支援、顕微授精・クローン作成支援など）を公募班も含めて行った。支援グループには研究代表者から消耗品についての支援を行った。
4) 若手育成：7月につくばにおいて若手勉強会を二泊三日で行った。口頭発表、ポスター発表を行い、最優秀者２名を参加者全員の投票により決定しベストプレゼンター賞を授与した。昨年度と同様に次回の若手勉強会については、最優秀者が中心となって企画し、その研究者が所属する計画班が準備を行いつつある。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

サイトビジットにより各計画班員が行っている研究の現状を把握し、今後の問題点について議論を行い、その対策について協議を行った。また１１月に九州大学で行われた公開シンポジウムにおいては活発な議論が行われ、実際に公募班も含めた共同研究体制が確立していることも確認できた。若手育成においても夏の若手勉強会で相互の計画班が行っている研究の紹介にとどまらず、実際に班相互において研究者の異動が行われていた。特に複数の研究班から若手研究者の独立があり、若手育成についても順調に進んでいると思われる。

Strategy for Future Research Activity

本年度は昨年度に引き続き若手勉強会を７月に合宿形式で二泊三日で行う予定である。昨年度の勉強会でベストプレゼンター賞を獲得した研究者が勉強会を主催し、そのプログラムを主体的に考えて行うことで進められている。また本年度は２月に京都において総括研究代表者が国際シンポジウムを予定しており、国内外のエピジェネティックス分野において第一線の研究を行っている研究者を招聘する予定である。

Research Products

• [Journal Article] Dppa3 expression is critical for generation of fully-reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting. (2015)
  • Author(s): Xu X, Smorag L, Nakamura T, Kimura T, Dressel R, Fitzner A, Tan X, Linke M, Zechner U, Engel W , Pantakani K.
  • Journal Title: Nat commun Volume: 6 Pages: 6008
  • DOI: 10.1038/ncomms7008.
  • Peer Reviewed / Open Access
• [Journal Article] Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes. (2015)
  • Author(s): Tsuji A, Nakamura T, Shibata K.
  • Journal Title: Biosci Biotechnol Biochem. Volume: 79 Pages: 292-9
  • DOI: 10.1080/09168451.2014.968090
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide screening of aberrant DNA methylation which associated with gene expression in mouse skin cancers. (2015)
  • Author(s): Fujiwara K, Ghosh S, Liang P, Morien E, Soma M, Nagase H.
  • Journal Title: Molecular Carcinogenesis Volume: 54 Pages: 178-88
  • DOI: 10.1002/mc.22085.
  • Peer Reviewed
• [Journal Article] Runt-related transcription factor 2 (RUNX2) attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemo-sensitivity (2015)
  • Author(s): Ozaki T, Sugimoto H, Nakamura M, Hiraoka K, Yoda H, Sang M, Fujiwara K, Nagase H.
  • Journal Title: FEBS Journal Volume: 82 Pages: 114-28
  • DOI: 10.1111/febs.13108.
  • Peer Reviewed
• [Journal Article] Generation of cloned mice from adult neurons by direct nuclear transfer. (2015)
  • Author(s): Mizutani E, Oikawa M, Kasai H, Inoue K, Shiura H, Hirasawa R, Kamimura S, Matoba S, Ogonuki N, Nagatomo H, Abe K, Wakayama T, Aiba A, Ogura A
  • Journal Title: Biol. Reprod. Volume: 92 Pages: 1-11
  • Open Access / Acknowledgement Compliant
• [Journal Article] Pluripotent stem cells derived from mouse primordial germ cells by small molecule compounds. (2015)
  • Author(s): Kimura T, Kaga Y, Sekita Y, Fujikawa K, Nakatani T, Odamoto M, Funaki S, Ikawa M, Abe K , Nakano T
  • Journal Title: Stem Cells Volume: 33 Pages: 45-55
  • Acknowledgement Compliant
• [Journal Article] SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice. (2015)
  • Author(s): Wu Q, Fukuda K, Weinstein M, Graff JM, Saga Y.
  • Journal Title: Development. Volume: 142 Pages: 575-86
  • DOI: 10.1242/dev.
  • Acknowledgement Compliant
• [Journal Article] Gene regulation. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. (2015)
  • Author(s): Arner E, Daub CO, Vitting-Seerup K, Andersson R, Lilje B, Drablos F, Lennartsson A, Ronnerblad M, Hrydziuszko O, Vitezic M, Freeman TC, Alhendi AM, Arner P, Axton R, Baillie JK, Beckhouse A, Bodega B, Briggs J, Brombacher F, Davis M, Detmar M, Ehrlund A, Endoh M.
  • Journal Title: Science. Volume: 347 Pages: 1010-4
  • DOI: 10.1126/science.1259418.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Functional crosstalk between Myc and PI3K signaling for supporting unlimited self-renewal of embryonic stem cells. (2015)
  • Author(s): Hishida T, Nakachi Y, Mizuno Y, Katano M, Okazaki Y, Ema M, Takahashi S, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Hishida-Nozaki Y, Vazquez-Ferrer E, Sancho-Martinez I, Izpisua Belmonte JC, Okuda A.
  • Journal Title: Stem Cells Volume: 33 Pages: 713-725
  • Peer Reviewed
• [Journal Article] Induction of DNA Methylation by Artificial piRNA Production in Male Germ Cells. (2015)
  • Author(s): Itou D, Shiromoto Y, Shin-Ya Y, Ishii C, Nishimura T, Ogonuki N, Ogura A, Hasuwa H, Fujihara Y, Kuramochi-Miyagawa S, Nakano T.
  • Journal Title: Curr Biol. Volume: 25 Pages: 901-6
  • DOI: 10.1016/j.cub.2015.01.060.
  • Peer Reviewed
• [Journal Article] Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal. (2015)
  • Author(s): Takashima S, Kanatsu-Shinohara M, Tanaka T, Morimoto H, Inoue K, Ogonuki N, Jijiwa M, Takahashi M, Ogura A, Shinohara T.
  • Journal Title: Stem Cell Reports. Volume: 4 Pages: 489-502
  • DOI: 10.1016/j.stemcr.2015.01.010.
  • Peer Reviewed / Open Access
• [Journal Article] Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9. (2015)
  • Author(s): Honda A, Hirose M, Sankai T, Yasmin L, Yuzawa K, Honsho K, Izu H, Iguchi A, Ikawa M, Ogura A.
  • Journal Title: Exp Anim. Volume: 64 Pages: 31-7
  • DOI: 10.1538/expanim.14-0034.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Naive-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells. (2015)
  • Author(s): Honsho K, Hirose M, Hatori, Yasmin L, Izu H, Matoba S, Togayachi S, Miyoshi H, Sankai T, Ogura A, *Honda A.
  • Journal Title: J Reprod Dev. Volume: 61 Pages: 13-19
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of maintenance DNA methylation by Stella. (2014)
  • Author(s): Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Nakano T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 453 Pages: 455-60
  • DOI: 10.1016/j.bbrc.2014.09.101.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse. (2014)
  • Author(s): Ichiyanagi T, Ichiyanagi K, Ogawa A, Kuramochi-Miyagawa S, Nakano T, Chuma S, Sasaki H , Udono H.
  • Journal Title: Nucl. Acids Res. Volume: 42 Pages: 11903-11911
  • DOI: 10.1093/nar/gku881.
  • Peer Reviewed / Open Access
• [Journal Article] Setdb1 is required for germ line development and silencing of H3K9me3 marked endogenous retroviruses in primordial germ cells. (2014)
  • Author(s): Liu S, Brind’Amour J, Karimi M M, Shirane K, Bogutz A, Lefebvre L, Sasaki H, Shinkai Y ,Lorincz M C.
  • Journal Title: Genes Dev. Volume: 28 Pages: 2041-2055
  • DOI: 28, 2041-2055, 2014. doi: 10.1101/gad.244848.114.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Whole-mount MeFISH: a novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression. (2014)
  • Author(s): Shiura H, Okamoto A, Sasaki H ,Abe K.
  • Journal Title: PLoS One Volume: 9 Pages: e95750
  • DOI: 10.1371/journal.pone.0095750.
  • Peer Reviewed / Open Access
• [Journal Article] DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells. (2014)
  • Author(s): Liao H-F, Chen W S C , Chen Y-H, Kao T-H, Tseng Y-T, Lee C-Y, Chiu Y-C, Lee .-L, Lin Q-J, Ching Y-H, Hata K, Cheng W T K , Tsai M-H, Sasaki H, Ho H-N, Wu S-C , Huang Y-H, Yen P , Lin S-P.
  • Journal Title: Development. Volume: 141 Pages: 2402-2413
  • DOI: 10.1242/dev.105130.
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide analysis of DNA methylation dynamics during early human development (2014)
  • Author(s): Okae H, Chiba H, Hiura H, Hamada H, Sato A, Utsunomiya T, Kikuchi H, Yoshida H, Tanaka A, Suyama M, Arima T.
  • Journal Title: PLoS Genet. Volume: 10 Pages: e1004868
  • DOI: 10.1371/journal.pgen.1004868. eCollection 2014.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Hypoxia-Inducible Epigenetic Regulators Jmjd1a and G9a Provide a Mechanistic Link between Angiogenesis and Tumor Growth. (2014)
  • Author(s): Ueda J, Ho JC2, Lee KL, Kitajima S, Yang H, Sun W, Fukuhara N, Zaiden N, Chan SL, Tachibana M, Shinkai Y, Kato H ,Poellinger L.
  • Journal Title: Mol. Cell. Biol. Volume: 34 Pages: 3702-3720
  • DOI: 10.1128/mcb.00099-14
  • Peer Reviewed
• [Journal Article] Transgenic Expression of Map3k4 Rescues T-associated Sex Reversal (Tas) in Mice (2014)
  • Author(s): Warr N, Siggers P, Carrea GA, Bogani D, Brixey R, Akiyoshi M, Tachibana M, Lydia Teboul L, Wells S, Sanderson J ,Greenfield A
  • Journal Title: Hum. Mol. Genetics, Volume: 23 Pages: 3035-3044
  • DOI: 10.1093/hmg/ddu.020
  • Peer Reviewed / Open Access
• [Journal Article] A novel gene regulator, pyrrole-imidazole polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration. (2014)
  • Author(s): Tsunemi A, Ueno T, Fukuda N, Watanabe T, Tahira K, Haketa A, Hatanaka Y, Tanaka S, Matsumoto T, Matsumoto Y, Nagase H, Soma M.
  • Journal Title: J Mol Med (Berl). Volume: 92 Pages: 509-21
  • DOI: 10.1007/s00109-013-1118-x.
  • Peer Reviewed
• [Journal Article] Inhibition of the human osteosarcoma cell migration and invasion by a gene silencer, Pyrrole-Imidazole polyamide, targeting to the human MMP9 NFkB binding site. (2014)
  • Author(s): Kojima T, Wang X, Fujiwara K, Osakaa S, Yoshida Y, Osaka E, Taniguchi M, Ueno T, Fukuda N, Soma M, Tokuhashi Y ,Nagase H.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 37 Pages: 1460-5
  • Peer Reviewed
• [Journal Article] Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth. (2014)
  • Author(s): Obinata D, Ito A, Fujiwara K, Takayama K, Ashikari D, Murata Y, Yamaguchi K, Urano T, Fujimura T, Fukuda N, Soma M, Watanabe T, Nagase H, Inoue S, Takahashi S.
  • Journal Title: Cancer Science Volume: 105 Pages: 1272-8
  • Peer Reviewed / Open Access
• [Journal Article] Intracellular fragment of NLRR3 (NLRR3-ICD) stimulates ATRA-dependent neuroblastoma differentiation. (2014)
  • Author(s): Akter J, Takatori A, Islam S, Nakazawa A, Ozaki T, Nagase H, Nakagawara A.
  • Journal Title: Biochemical and Biophysical Research Communications (BBRC) Volume: 453 Pages: 86-93
  • DOI: 10.1016/j.bbrc.2014.09.065.
  • Peer Reviewed
• [Journal Article] Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate. (2014)
  • Author(s): Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H.
  • Journal Title: Nat. Commun. Volume: 6 Pages: 6706
  • DOI: 10.1038/ncomms7706
  • Peer Reviewed / Open Access
• [Journal Article] Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly. (2014)
  • Author(s): Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, Kamatani MK, Saito K, Okano H, Siomi H, Siomi MC.
  • Journal Title: Cell Reports Volume: 8 Pages: 103-113
  • DOI: 10.1016/j.celrep.2014.05.043.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate. (2014)
  • Author(s): Hirano T, Iwasaki YW, Lin ZY, Imamura M, Seki NM, Sasaki E, Saito K, Okano H, Siomi MC, *Siomi H.
  • Journal Title: RNA Volume: 20 Pages: 1223-1237
  • DOI: 10.1261/rna.045310.114
  • Peer Reviewed
• [Journal Article] MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation. (2014)
  • Author(s): Haraguchi H, Saito-Fujita T, Hirota Y, Egashira M, Matsumoto L, Matsuo M, Hiraoka T, Koga K, Yamauchi N, Fukayama M, Bartos A, Cha J, Dey SK, Fujii T, Osuga Y.
  • Journal Title: Mol Endocrinol. Volume: 28 Pages: 1108-17
  • DOI: 10.1210/me.2014-1097.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Application of detergents or high hydrostatic pressure as decellularization processes in uterine tissues and their subsequent effects on in vivo uterine regeneration in murine models. (2014)
  • Author(s): Santoso EG, Yoshida K, Hirota Y, Aizawa M, Yoshino O, Kishida A, Osuga Y, Saito S, Ushida T,Furukawa KS.
  • Journal Title: PLoS One. Volume: 9 Pages: e103201
  • DOI: 10.1371/journal.pone.0103201.
  • Peer Reviewed / Open Access
• [Journal Article] A novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression. (2014)
  • Author(s): Shiura H, Okamoto A, Sasaki H ,Abe K
  • Journal Title: PLoS One. Volume: 9 Pages: e95750
  • DOI: 10.1371/journal.pone.0095750
  • Open Access / Acknowledgement Compliant
• [Journal Article] A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats. (2014)
  • Author(s): Sato A, Abe K, Yuzuriha M, Fujii S, Takahashi N, Teramoto S, Aoyama H.
  • Journal Title: Mutation Research Volume: 762 Pages: 17-23
  • DOI: 10.1016/j.mrfmmm.2014.02.003
• [Journal Article] Genome-wide analysis of the chromatin composition of histone H2A and H3 variants in mouse embryonic stem cells. (2014)
  • Author(s): Yukawa M, Akiyama T, Franke V, Mise N, Isagawa T, Suzuki Y, Suzuki MG, Vlahovicek K, Abe K, Aburatani H, Aoki F
  • Journal Title: PLoS One Volume: 9 Pages: e92689
  • Open Access / Acknowledgement Compliant
• [Journal Article] Prdm9 polymorphism unveils mouse evolutionary tracks (2014)
  • Author(s): Kono H, Tamura M, Osada N, Suzuki H, Abe K, Moriwaki K, Ohta K, Shiroishi T,
  • Journal Title: DNA Research Volume: 21 Pages: 315-326
  • DOI: 10.1093/dnares/dst059.
  • Open Access / Acknowledgement Compliant
• [Journal Article] Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells. (2014)
  • Author(s): Suzuki A, Niimi Y, Saga Y.
  • Journal Title: Biol Open. Volume: 3 Pages: 1207-16
  • DOI: 10.1242/bio.20149308.
  • Open Access / Acknowledgement Compliant
• [Journal Article] FGF8-FGFR1 signaling acts as a niche factor for maintaining undifferentiated spermatogonia in the mouse. (2014)
  • Author(s): Hasegawa K, Saga Y.
  • Journal Title: Biol Reprod. Volume: 91 Pages: 145
  • DOI: 10.1095/biolreprod.114.121012.
  • Acknowledgement Compliant
• [Journal Article] Establishment of a novel model for chondrogenesis using murine embryonic stem cells carrying mutant ALK2 associated with fibrodysplasia ossificans progressive. (2014)
  • Author(s): Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Miyamoto A, Tsukamoto S, Mizuta T, Kokabu S, Machiya A, Okuda A, Suda N, Katagiri T.
  • Journal Title: Biochem Biophys Res Commun Volume: 455 Pages: 347-352
  • Peer Reviewed
• [Journal Article] Genomic Aspects of Common Diseases. (2014)
  • Author(s): Muramatsu M, Okuda A, Okazaki Y.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 452 Pages: 211-212
  • Peer Reviewed
• [Journal Article] Identification of Ccr4-Not complex components as regulators of transition from partial to genuine induced pluripotent stem cells. (2014)
  • Author(s): Kamon M, Katano M, Hiraki K, Hishida T, Nakachi Y, Mizuno Y, Okazaki Y, Suzuki A, Hirasaki M, Ueda A, Nishimoto M, Kato H, Okuda A.
  • Journal Title: Stem Cells Dev Volume: 23 Pages: 2170-2179
  • Peer Reviewed
• [Journal Article] Induction of the G2/M transition stabilizes haploid embryonic stem cells. (2014)
  • Author(s): Takahashi S, Lee J, Kohda T, Matsuzawa A, Kawasumi M, Kanai-Azuma M, Kaneko-Ishino T, Ishino F.
  • Journal Title: Development. Volume: 141 Pages: 3842-7
  • Peer Reviewed / Open Access
• [Journal Article] Establishment of paternal genomic imprinting in mouse prospermatogonia analyzed by nuclear transfer. (2014)
  • Author(s): Kamimura S, Hatanaka Y, Hirasawa R, Matsumoto K, Oikawa M, Lee J, Matoba S, Mizutani E, Ogonuki N, Inoue K, Kohda T, Ishino F, Ogura A.
  • Journal Title: Biol Reprod. Volume: 91 Pages: 120
  • Peer Reviewed / Open Access
• [Journal Article] LINE-1 of evidence for fetal oocyte attrition by retrotransposon. (2014)
  • Author(s): Chuma, S.
  • Journal Title: Dev Cell. Volume: 29 Pages: 501-2
  • DOI: 10.1016/j.devcel.2014.05.017.
  • Peer Reviewed
• [Journal Article] The Trp53-Trp53inp1-Tnfrsf10b pathway regulates the radiation response of mouse spermatogonial stem cells. (2014)
  • Author(s): Ishii K, Ishiai M, Morimoto H, Kanatsu-Shinohara M, Niwa O, Takata M, Shinohara T.
  • Journal Title: Stem Cell Reports. Volume: 3 Pages: 676-89
  • DOI: 10.1016/j.stemcr.2014.08.006.
  • Peer Reviewed / Open Access
• [Journal Article] Improved serum- and feeder-free culture of mouse germline stem cells. (2014)
  • Author(s): Kanatsu-Shinohara M, Ogonuki N, Matoba S, Morimoto H, Ogura A, Shinohara T.
  • Journal Title: Biol Reprod. Volume: 91 Pages: 88
  • DOI: 10.1095/biolreprod.114.122317.
  • Peer Reviewed
• [Journal Article] Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal. (2014)
  • Author(s): Kanatsu-Shinohara M, Onoyama I, Nakayama KI, Shinohara T.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 111 Pages: 8826-31
  • DOI: 10.1073/pnas.1401837111.
  • Peer Reviewed
• [Journal Article] Induction of primordial germ cell-like cells from mouse embryonic stem cells by EKR signal inhibition. (2014)
  • Author(s): Kimura T, Kaga Y, Ohta H, Odamoto M, Sekita Y, Li K, Yamano N, Fujikawa K, Isotani A, Sasaki N, Toyoda M, Hayashi K, Okabe M, Shinohara T, Saitou M, Nakano, T.
  • Journal Title: Stem Cells. Volume: 32 Pages: 2668-78
  • DOI: 10.1002/stem.1781.
  • Peer Reviewed
• [Journal Article] NUCKS Is a Positive Transcriptional Regulator of Insulin Signaling. (2014)
  • Author(s): Qiu B, Shi X, Wong ET, Lim J, Bezzi M, Low D, Zhou Q, Akincilar SC, Lakshmanan M, Swa HL, Tham JM, Gunaratne J, Cheng KK, Hong W, Lam KS, Ikawa M, Guccione E, Xu A, Han W, Tergaonkar V.
  • Journal Title: Cell Rep. Volume: 7 Pages: 1876-86
  • DOI: 10.1016/j.celrep.2014.05.030.
  • Peer Reviewed / Open Access
• [Journal Article] Effect of isolated AMP deaminase deficiency on skeletal muscle function. (2014)
  • Author(s): Chenga j, Morisaki H, Sugimoto N, Dohi A, Shintani T, Kimura E, Toyama K, Ikawa M, Okabe M, Higuchi I, Matsuo S, Kawai Y, Hisatome I, Sugama T, Holmes E. W. , *Morisaki T.
  • Journal Title: Molecular Genetics and Metabolism Reports Volume: 1 Pages: 51-9
  • DOI: 10.1016/j.ymgmr.2013.12.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system. (2014)
  • Author(s): Mizuno S, Dinh TT, Kato K, Mizuno-Iijima S, Tanimoto Y, Daitoku Y, Hoshino Y, Ikawa M, Takahashi S, Sugiyama F, Yagami KI.
  • Journal Title: Mamm Genome. Volume: 25 Pages: 327-34
  • DOI: 10.1007/s00335-014-9524-0.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury. (2014)
  • Author(s): Takarada-Iemata M, Kezuka D, Takeichi T, Ikawa M, Hattori T, Kitao Y, Hori O.
  • Journal Title: J Neurochem. Volume: 130 Pages: 374-87
  • DOI: 10.1111/jnc.12729.
  • Peer Reviewed
• [Journal Article] Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus. (2014)
  • Author(s): Mochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi M, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A.
  • Journal Title: PLoS One Volume: 9 Pages: e114305
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A novel AMH-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads. (2014)
  • Author(s): Shinomura M, Kishi K, Tomita A, Kawasumi M, Kanezashi H, Kuroda Y, Tsunekawa N, Ozawa A, Aiyama Y, Yoneda A, Suzuki H, Saito M, Picard JY, Kohno K, Kurohmaru M, Kanai-Azuma M, Kanai Y.
  • Journal Title: Reproduction. Volume: 148 Pages: H1-9
  • Peer Reviewed
• [Presentation] Mechanism of Sex determination of mouse germ cells (2015)
  • Author(s): Yumiko Saga.
  • Organizer: Vertebrate Sex determination meeting ,2015.4.17
  • Place of Presentation: Kona, Hawaii,
  • Year and Date: 2015-04-17
  • Invited
• [Presentation] A role for postfertilization, allele-specific DNA methylation activity in maintaining the imprinted H19 ICR methylation (2015)
  • Author(s): H. Matsuzaki, E. Okamura, A. Ushiki, T. Takahashi and K. Tanimoto
  • Organizer: Keystone Symposia (DNA methylation)
  • Place of Presentation: Keystone, CO, USA
  • Year and Date: 2015-03-29 – 2015-04-03
• [Presentation] CRISPR/Casシステムが開く遺伝子改変マウスの未来 (2015)
  • Author(s): 伊川正人
  • Organizer: 第86回東海実験動物研究会
  • Place of Presentation: 岐阜県岐阜市
  • Year and Date: 2015-03-28
  • Invited
• [Presentation] Skewed X chromosome inactivation in human placental tissue (2015)
  • Author(s): Hamada H, Okae H, Arima T, Yaegashi N
  • Organizer: Society for Reproductive Investigation 62nd Annual Scientific Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-03-26
• [Presentation] Epigenetic regulation of mouse retrotransposons during male germ cell development. (2015)
  • Author(s): Ichiyanagi, K.
  • Organizer: 2nd international symposium on mobile genetic elements and genome evolution
  • Place of Presentation: 熊本県熊本市
  • Year and Date: 2015-03-26
  • Invited
• [Presentation] 卵子形成過程および初期胚発生におけるUhrf1の機能解析 (2015)
  • Author(s): 前之原章司，鵜木元香，小倉淳郎，井上貴美子，山縣一夫，堀真由子，藤英博，大石裕晃，Jafar Sharif，古関明彦，植田幸嗣，佐々木裕之
  • Organizer: 第10回日本生殖再生医学会・学術集会
  • Place of Presentation: 京都府京都市
  • Year and Date: 2015-03-22
• [Presentation] ADAM3と精子受精能力 (2015)
  • Author(s): 伊川正人
  • Organizer: 第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-03-21
  • Invited
• [Presentation] 卵が先か精子が先か？ マウス生殖細胞の性分化機構 (2015)
  • Author(s): 相賀裕美子
  • Organizer: 阪大コロキウム
  • Place of Presentation: 大阪大学
  • Year and Date: 2015-03-13
  • Invited
• [Presentation] CRISPR/Cas Mediated Genome Editing in Mice and its Application for the Study of Reproduction (2015)
  • Author(s): 伊川正人
  • Organizer: BRI International Symposium 2015
  • Place of Presentation: 新潟県新潟市
  • Year and Date: 2015-03-05
  • Invited
• [Presentation] Sex determination of mouse germ cells (2015)
  • Author(s): Yumiko Saga.
  • Organizer: Finnish-Japanese joint symposium
  • Place of Presentation: Helsinki
  • Year and Date: 2015-03-03
  • Invited
• [Presentation] Alkylating agents targeting oncogenic driver mutationsドライバー遺伝子変異を標的としたアルキル化剤 (2015)
  • Author(s): 永瀬浩喜
  • Organizer: 私立大学戦略的研究基盤形成支援事業｢ゲノム化学に基づく先進医療開発研究拠点｣平成26年度報告会
  • Place of Presentation: 東京都
  • Year and Date: 2015-02-28
• [Presentation] Genome-wide survey of imprinted genes in the human placenta (2015)
  • Author(s): Okae H, Hamada H, Chiba H, Hiura H, Arima T
  • Organizer: CREST「エピゲノム研究に基づく診断・治療へ向けた新技術の創出」第４回領域会議
  • Place of Presentation: 大阪・千里ライフサイエンスセンター
  • Year and Date: 2015-02-21
• [Presentation] ドライバー遺伝子変異を標的としたアルキル化剤による治療法の開発 (2015)
  • Author(s): 永瀬 浩喜
  • Organizer: 第37回近畿小児血液・がん研究会 ランチョンセミナー
  • Place of Presentation: 京都
  • Year and Date: 2015-02-14
• [Presentation] 武装PIポリアミド（PIポリアミド薬物複合体）の臨床応用に向けた取り組み (2015)
  • Author(s): 永瀬 浩喜
  • Organizer: PI polyamide-drug-conjugates(PDC) towards clinical application
  • Place of Presentation: 京都
  • Year and Date: 2015-02-13
  • Invited
• [Presentation] マウス受精卵における能動的DNA脱メチル化機構の解明 (2015)
  • Author(s): 畑中勇輝，清水なつみ，守田昂太郎，佐藤学，本多新，廣瀬美智子，井上貴美子，細井美彦，松本和也，小倉淳郎
  • Organizer: RIKEN EPIGENETICS in Kobe
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-02-13
• [Presentation] 生殖系列の成立に必要な因子PRDM14の分子進化及び複合体解析 (2015)
  • Author(s): 関由行
  • Organizer: 第245回発生研セミナー
  • Place of Presentation: 熊本県熊本市
  • Year and Date: 2015-01-26
  • Invited
• [Presentation] RASコドン12変異を標的とした分子標的アルキル化剤 (2014)
  • Author(s): 永瀬 浩喜
  • Organizer: 革新的がん医療シーズ育成領域 革新的シーズ育成分野7 「転写機能をターゲットとした創薬」会議
  • Place of Presentation: 癌研究会癌研究所 東京
  • Year and Date: 2014-12-23
• [Presentation] メチル化DNA酸化の役割と制御機構. (2014)
  • Author(s): 束田裕一
  • Organizer: 第2回さきがけ「エピジェネティクスの制御と生命機能」領域会議
  • Place of Presentation: 沖縄.
  • Year and Date: 2014-12-15 – 2014-12-17
• [Presentation] 千葉県がんセンターにおけるClinical Genomics の視点に基づく治療法開発の取り組み (2014)
  • Author(s): 永瀬 浩喜
  • Organizer: 千葉がんシンポジウム 臨床研究総合センターシンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 2014-12-13
• [Presentation] 黄体ホルモンによる子宮内膜の機能調節と着床 (2014)
  • Author(s): 廣田泰
  • Organizer: 第29回日本生殖免疫学会
  • Place of Presentation: 東京都文京区
  • Year and Date: 2014-12-12
  • Invited
• [Presentation] マウスにおけるビオチン欠乏は卵子の質を劣化させる (2014)
  • Author(s): 辻 愛、中村 肇伸、柴田 克己
  • Organizer: 第13回日本栄養改善学会近畿支部学術総会
  • Place of Presentation: 京都府京都市
  • Year and Date: 2014-12-07
• [Presentation] プロゲステロンによる子宮内膜の機能調節と着床 (2014)
  • Author(s): 廣田泰
  • Organizer: 第59回日本生殖医学会学術講演会
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2014-12-05
  • Invited
• [Presentation] エピゲノム調節によるほ乳類の性決定機構 (2014)
  • Author(s): 立花誠
  • Organizer: 第59回日本生殖医学会学術講演会・総会 教育講演
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2014-12-04
  • Invited
• [Presentation] CRISPR/Casを用いたマウスゲノム編集 (2014)
  • Author(s): 伊川正人
  • Organizer: 国立大学法人動物実験施設協議会平成26年度（第20回）高度技術研修会
  • Place of Presentation: 新潟県新潟市
  • Year and Date: 2014-12-04
  • Invited
• [Presentation] DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis. (2014)
  • Author(s): Sasaki, H.
  • Organizer: The 2014 Max Planck Freiburg Epigenetics Meeting, MPI of Immunobiology and Epigenetics,
  • Place of Presentation: Freiburg, Germany,
  • Year and Date: 2014-12-03 – 2014-12-05
  • Invited
• [Presentation] Piwi-piRISC regulates binding of linker histone H1 at transposon loci (2014)
  • Author(s): Saito K.
  • Organizer: The 16th Tokyo RNA Club
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2014-11-28
  • Invited
• [Presentation] MBLR-PRC1ポリコーム複合体による減数分裂遺伝子のエピジェネティック制御 (2014)
  • Author(s): 遠藤充浩、信賀順、遠藤高帆、古関明彦
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、神奈川県横浜市
  • Year and Date: 2014-11-27
• [Presentation] Asymmetry in histone H2B O-GlcNAcylation between paternal and maternal chromatin of mouse zygotes (2014)
  • Author(s): 中村 肇伸、鈴木 健士;、後藤 悠比、中谷庸寿、関田洋一、仲野 徹
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-26
• [Presentation] 初期胚のクロマチン再構成におけるヒストンシャペロンの役割 ～DNA脱メチル化制御因子Stellaの欠損胚をモデルとして～ (2014)
  • Author(s): 荒川 達彦、中谷 庸寿、関田 洋一、木村 透、中村 肇伸、小田 昌朗、仲野徹
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-26
• [Presentation] Epigenetic abnormalities associated with somatic cell nuclear transfer in mice (2014)
  • Author(s): Ogura A
  • Organizer: Symposium "Programming/Reprogramming Stem Cell Fate",第37回分子生物学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-26
  • Invited
• [Presentation] マウス受精卵における能動的DNA脱メチル化機構の解明 (2014)
  • Author(s): 畑中勇輝，清水なつみ，守田昂太郎，井上貴美子，本多新，廣瀬美智子，松本和也，小倉淳郎
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-26
• [Presentation] β-グロビン・ノックインマウスを用いた染色体間相互作用（transvection）の遺伝学的検証 (2014)
  • Author(s): 谷本啓司、後藤義人、J.D.Engel
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] Igf2/H19刷り込み遺伝子座における受精後アリル特異的DNAメチル化活性の解析 (2014)
  • Author(s): 松崎仁美、岡村永一、牛木亜季、高橋拓也、谷本啓司
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] 腸炎モデルマウスに対する腸管ＩｇＡ抗体の作用機序の解明 (2014)
  • Author(s): 岡井 晋作、臼井 文人、野村 慎太郎、中村 肇伸、山本 和也、西山 依里、森 宙史、山田 拓司、黒川 顕、加藤 保、大野 博司、新蔵 礼子
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-25
• [Presentation] Xist/Tsix発現から見るマウス着床期におけるX不活性化ダイナミクス (2014)
  • Author(s): 志浦寛相、阿部訓也
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-25
• [Presentation] マウスES細胞においてNucleosteminノックアウトによる未分化性の消失はNanogもしくはEsrrbタンパク質強制発現により回避される (2014)
  • Author(s): 片野 幸、水野洋介、仲地 豊、平崎正孝、鈴木 歩、西本正純、岡崎康司、奥田晶彦
  • Organizer: 第37回日本分子生物学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-25
• [Presentation] 真獣類の発生過程におけるPer2とCKIεの発現は概日リズム形成に重要である (2014)
  • Author(s): 西本正純、奥田晶彦、大西芳秋
  • Organizer: 第37回日本分子生物学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-25
• [Presentation] ミトコンドリア呼吸鎖異常症の原因遺伝子の包括的大規模解析 (2014)
  • Author(s): 木下善仁、徳澤佳美、神田将和、森山陽介、水野洋介、菅原（山下）泉、 田丸俊輔、栃木秀乃、上原奈津美、仲地 豊、八塚由紀子、入月浩美、鈴木聡美、Nurun Nahar Borna、平田智子、的場奈々、加藤英政、奥田晶彦、森 雅人、安嶋まさみ、原嶋宏子、山崎太郎、村山 圭、大竹 明、岡﨑康司
  • Organizer: 第37回日本分子生物学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-25
• [Presentation] Zygotic gene activationと顕微授精によって誘導される遺伝子発現変化 (2014)
  • Author(s): 幸田 尚、高木 清考、及川 真実、越後貫 成美、井上 貴美子、金児-石野 知子、小倉 淳郎、石野 史敏
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2014-11-25
• [Presentation] DNMT1を用いたヒドロキシメチルシトシンの定量的検出法 (2014)
  • Author(s): 黒田 友紀子、川崎 佑季、幸田 尚、石野 史敏
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2014-11-25
• [Presentation] 始原生殖細胞におけるゲノムインプリント記憶の消去には能動的DNA脱メチル化経路が関与する (2014)
  • Author(s): 川崎 佑季、李 知英、松沢 歩、幸田 尚、金児-石野 知子、石野 史敏
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2014-11-25
• [Presentation] LTRレトロトランスポゾンに由来する真獣類特異的遺伝子Sirh11の機能解析 (2014)
  • Author(s): 入江 将仁、幸田 尚、小野 竜一、古瀬 民生、若菜 茂晴、吉川 正信、石野 史敏、金児-石野 知子
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2014-11-25
• [Presentation] 組換えDNMT1を用いたヒドロキシメチルシトシンの一塩基解像度の検出方法の開発 (2014)
  • Author(s): 高橋 沙央里、末武 勲、Jan Engelhardt、幸田 尚、田嶋 正二
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2014-11-25
• [Presentation] CRISPR/Casシステムが開く遺伝子改変マウスの未来 (2014)
  • Author(s): 伊川正人
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-25
  • Invited
• [Presentation] 生殖系列の成立に必要な因子PRDM14の動作原理解析 (2014)
  • Author(s): 関由行
  • Organizer: 第１回北陸エピジェネティクス研究会
  • Place of Presentation: 石川県金沢市
  • Year and Date: 2014-11-19
  • Invited
• [Presentation] CRISPR/CAS mediated genome editing in mice (2014)
  • Author(s): 伊川正人
  • Organizer: The 27th Annual Meeting of Japanese Association for Animal Cell Technology, JAACT2014 Kitakyushu
  • Place of Presentation: 福岡県北九州市
  • Year and Date: 2014-11-14
  • Invited
• [Presentation] CRISPR/Casシステムを用いたマウスゲノム編集 (2014)
  • Author(s): 伊川正人
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-11-12
  • Invited
• [Presentation] Recent technical advancements of somatic cell nuclear transfer in mice. (2014)
  • Author(s): Ogura A
  • Organizer: The 6th congress of The Asian Federation of Laboratory Animal Science
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2014-11-12
  • Invited
• [Presentation] Dynamic changes in DNA methylation and gene expression in spermatogonial stem cell generation and differentiation in neonatal mouse testis (2014)
  • Author(s): Sasaki, H.
  • Organizer: International symposium on Tumor Biology in Kanazawa
  • Place of Presentation: 石川県金沢市
  • Year and Date: 2014-11-04
  • Invited
• [Presentation] Regulation of Major Satellite Transcripts in Mouse Zygotes. (2014)
  • Author(s): Tsukada, Y.
  • Organizer: The 1st International Symposium of Chemistry and Biology of RNA Interference,
  • Place of Presentation: Fukuoka, Japan.
  • Year and Date: 2014-11-04
  • Invited
• [Presentation] 受精卵における能動的DNA脱メチル化の制御機構の解明 (2014)
  • Author(s): 中村 肇伸
  • Organizer: 大阪大学蛋白質研究所セミナー「DNAメチル化の制御機構-メチル化模様形成、維持と消去」
  • Place of Presentation: 大阪府吹田市
  • Year and Date: 2014-11-02
  • Invited
• [Presentation] CRISPR/Casシステムを用いたマウスゲノム編集 (2014)
  • Author(s): 伊川正人
  • Organizer: 第4回ゲノム編集研究会
  • Place of Presentation: 広島県広島市
  • Year and Date: 2014-11-01
• [Presentation] Targeting specific DNA sequences by N-methylpyrrole and N-methylimidazole polyamides provides insights for the development of novel diagnostic and therapeutic drugs. (2014)
  • Author(s): Takatori A, Yoda H, Hiraoka K, Shinohara K, Watanabe T, Koshikawa N and Nagase H.
  • Organizer: The 28th International Mammalian Genome Conference.
  • Place of Presentation: Bar Harbor, ME.
  • Year and Date: 2014-10-26 – 2014-10-29
• [Presentation] Allele-specific knock-down of KRAS mutations in cancers by using a novel alkylating Pyrrole-Imidazole Polyamide (KR12). (2014)
  • Author(s): Takatori A, Hiraoka K, Inoue T, Watanabe T, Shinohara K, Koshikawa N, Ozaki T and Nagase H.
  • Organizer: The 28th International Mammalian Genome Conference.
  • Place of Presentation: Bar Harbor, ME.
  • Year and Date: 2014-10-26 – 2014-10-29
• [Presentation] Parental imprinting as a response to sex differentiation (2014)
  • Author(s): Sasaki, H.
  • Organizer: 第87回日本生化学会大会シンポジウム”The Role of Epigenome in Response to Environmental Cues”
  • Place of Presentation: 京都府京都市
  • Year and Date: 2014-10-18
  • Invited
• [Presentation] ＤＮＡ結合化合物によるゲノム・エピゲノムの変更 -新たな抗がん治療薬開発へのアプローチ- (2014)
  • Author(s): 永瀬浩喜
  • Organizer: Pyrrole-Imidazole Polyamide Drug Conjugate (PDC)
  • Place of Presentation: 東京都
  • Year and Date: 2014-10-09
  • Invited
• [Presentation] Genome-wide analysis of DNA methylation dynamics during early human development (2014)
  • Author(s): Okae H, Arima T
  • Organizer: International Human Epigenome Consortium (IHEC) Annual Meeting
  • Place of Presentation: Vancouver, Canada.
  • Year and Date: 2014-10-07
• [Presentation] DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in early postnatal testis (2014)
  • Author(s): Kubo, N., Toh, H., Shirane, K., Shirakawa, T., Kobayashi, H., Sato, T., Sone, H., Sato, Y., Tomizawa, S., Tsurusaki, Y., Shibata, H., Saitsu, H., Suzuki, Y., Matsumoto, N., Suyama, M., Kono, T., Ohbo, K. & Sasaki, H.
  • Organizer: IHEC Annual Meeting and Science Day 2014,
  • Place of Presentation: Vancouver, Canada,
  • Year and Date: 2014-10-06 – 2014-10-08
• [Presentation] Maintenance of spermatogonial stem cells (SSCs) via Nanos2-mediated mechanism. (2014)
  • Author(s): Yumiko Saga.
  • Organizer: Stem cells seminar series, Cornell University
  • Place of Presentation: Ithaca, NY, USA
  • Year and Date: 2014-10-06
  • Invited
• [Presentation] CRISPR/Casシステムを用いたマウスゲノム編集 (2014)
  • Author(s): 伊川正人
  • Organizer: 第1回 KBRP ワークショップ
  • Place of Presentation: 熊本県熊本市
  • Year and Date: 2014-10-03
  • Invited
• [Presentation] 個体発生のエピゲノム制御：ゲノムインプリンティングをモデルとして (2014)
  • Author(s): 佐々木裕之
  • Organizer: 学会学術大会・シンポジウム「発生・分化・癌化を決める遺伝子スイッチ」
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2014-09-27
  • Invited
• [Presentation] 変異型KRASを標的とした塩基配列特異的アルキル化剤によるヒト大腸癌細胞移植マウスの抗腫瘍効果 (2014)
  • Author(s): 井上貴博、平岡桐子、養田裕行、丸喜明、杉本博一、篠原憲一、渡部隆義、高取敦志、越川信子、板東俊和、杉山弘、尾崎俊文、永瀬 浩喜
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 変異型 KRAS 遺伝子を標的とした新規アルキル化剤による大腸がん抗腫瘍効果の検討 (2014)
  • Author(s): 平岡桐子、井上貴博、養田裕行、杉本博一、篠原憲一、渡部隆義、越川信子、高取敦志、板東俊和、杉山弘、尾崎俊文、永瀬浩喜
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] ZEB1/E-cadherin 転写制御を標的とした新規ピロールイミダゾールポリアミドの開発 (2014)
  • Author(s): 養田裕行、高取敦志、渡部隆義、篠原憲一、井上貴博、平岡桐子、越川信子、尾崎俊文、永瀬浩喜
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 「RUNX2 によるヒト膵臓がん細胞のゲムシタビン耐性獲得機構の解析」 (2014)
  • Author(s): 杉本博一、中村瑞代、下里修、永瀬浩喜、尾崎俊文
  • Organizer: 第73回日本癌学会学術総
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] MMP-9を標的とした脂肪族/芳香族アミノ酸ペアを有するPIポリアミドによる遺伝子抑制 (2014)
  • Author(s): 渡部隆義、越川信子、尾崎俊文、板東俊和、杉山弘、永瀬浩喜
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] RUNX2 によるTAp73 の抑制を介したDNA 損傷応答機構の制御 (2014)
  • Author(s): 尾崎俊文、杉本博一、中村瑞代、下里修、永瀬浩喜
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Decidual cellular senescence contributes to preterm delivery. (2014)
  • Author(s): 廣田泰
  • Organizer: 46th International Congress on Pathophysiology of Pregnancy / 35th Japan Society for the Study of Hypertension in Pregnancy.
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2014-09-19
  • Invited
• [Presentation] Vps52および関連遺伝子のマウス胚発生における役割 (2014)
  • Author(s): 杉本道彦、田村勝、阿部訓也
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 滋賀県長浜市
  • Year and Date: 2014-09-19
• [Presentation] マウス雄性生殖細胞におけるレトロトランスポゾンの制御機構は発生段階によって異なる (2014)
  • Author(s): 井上晃太，一柳健司，福田渓，下須賀健一，佐々木裕之
  • Organizer: 日本遺伝学会第86回大会長浜大会
  • Place of Presentation: 滋賀県長浜市
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] ZFP57による単アレル性遺伝子発現の制御機構 (2014)
  • Author(s): 大石裕晃，鵜木元香，福田渓，佐渡敬，佐々木裕之
  • Organizer: 日本遺伝学会第86回大会長浜大会
  • Place of Presentation: 滋賀県長浜市
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] 霊長類の生殖細胞エピゲノムの進化 (2014)
  • Author(s): 福田渓， 一柳健司，佐々木裕之
  • Organizer: 日本遺伝学会第86回大会長浜大会
  • Place of Presentation: 滋賀県長浜市
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] Molecular mechanisms of piRNA-mediated transposon silencing (2014)
  • Author(s): Saito K.
  • Organizer: Symposium: The 86th Annual Meeting of the Genetic Society of Japan
  • Place of Presentation: Nagahama, Japan
  • Year and Date: 2014-09-17
  • Invited
• [Presentation] Xist/Tsix発現から見るマウス着床期におけるX不活性化ダイナミクス (2014)
  • Author(s): 志浦寛相、阿部訓也
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 滋賀県長浜市
  • Year and Date: 2014-09-17
• [Presentation] SINEレトロトランスポゾンのエピジェネティック制御と機能 (2014)
  • Author(s): 一柳健司
  • Organizer: 日本遺伝学会第86回大会長浜大会ワークショップ「レトロトランスポゾンと哺乳類ホストシステムの共存」
  • Place of Presentation: 滋賀県長浜市
  • Year and Date: 2014-09-17
  • Invited
• [Presentation] Epigenetic Mechanisms of Gene Regulation. (2014)
  • Author(s): Tsukada, Y.
  • Organizer: Kyocera Professor Meeting,
  • Place of Presentation: Kagoshima, Japan.
  • Year and Date: 2014-09-11
  • Invited
• [Presentation] Asymmetry in histone H2B O-GlcNAcylation between paternal and maternal chromatin of mouse zygotes. (2014)
  • Author(s): Nakamura T, Suzuki K, Gotou Y, Nakatani T, Sekita Y, Nakano T
  • Organizer: Cold Spring Harbor Laboratory meeting EPIGENETICS & CHROMATIN
  • Place of Presentation: New York, USA
  • Year and Date: 2014-09-09
• [Presentation] Stella preserves maternal chromosome integrity by inhibiting 5hmC-dependent γH2AX accumulation. (2014)
  • Author(s): Nakatani T, Yamagata K, Kimura T, Oda M, Nakashima H, Hori M, Sekita Y, Arakawa T, Nakamura T, Nakano T
  • Organizer: Cold Spring Harbor Laboratory meeting EPIGENETICS & CHROMATIN
  • Place of Presentation: New York, USA
  • Year and Date: 2014-09-09
• [Presentation] Epigenetic Mechanisms of Gene Regulation. (2014)
  • Author(s): Tsukada, Y.
  • Organizer: 11th Inamori Frontier Research Symposium,
  • Place of Presentation: Fukuoka, Japan.
  • Year and Date: 2014-09-09
  • Invited
• [Presentation] A genetic test for interchromosomal DNA interaction (transvection) in a β-globin knock-in mouse (2014)
  • Author(s): K. Tanimoto and J.D. Engel
  • Organizer: 19th Hemoglobin Switching Conference
  • Place of Presentation: St. John’s College, Oxford, UK
  • Year and Date: 2014-09-04 – 2014-09-08
• [Presentation] The role of histone H3 variants in the alteration of chromatin structure after fertilization. (2014)
  • Author(s): Kawamura M, Aoki F
  • Organizer: World Congress of Reproductive Biology
  • Place of Presentation: Edinburgh, England
  • Year and Date: 2014-09-04
• [Presentation] Characterization of gene expression in one-cell stage embryos. (2014)
  • Author(s): Aoki F
  • Organizer: World Congress of Reproductive Biology
  • Place of Presentation: Edinburgh, England
  • Year and Date: 2014-09-03
  • Invited
• [Presentation] Roles of the untranslated regions in the translational regulation of cyclin A2 in murine oocytes and embryos. (2014)
  • Author(s): Mori Y, Aoki F
  • Organizer: World Congress of Reproductive Biology
  • Place of Presentation: Edinburgh, England
  • Year and Date: 2014-09-03
• [Presentation] Regulation of spermatogonial stem cell self-renewal. (2014)
  • Author(s): Shinohara T
  • Organizer: Society for Reproduction and Fertility annual conference 2014
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 2014-09-02
  • Invited
• [Presentation] エピジェネティクス -ゲノムインプリンティングを中心に (2014)
  • Author(s): 佐々木裕之
  • Organizer: Pfizer Endocrinology Forum 2014，2014.08.30
  • Place of Presentation: 東京都港区
  • Year and Date: 2014-08-30
  • Invited
• [Presentation] A novel anti-cancer agent of DNA-alkylating Pyrrole-Imidazole polyamide conjugate targeting KRAS Codon 12 Mutant DNA (2014)
  • Author(s): Nagase H, Hiraoka K, Inoue T, Koshikawa N and Watanabe T.
  • Organizer: 52nd JSCO 2014 International Session Anti cancer agent
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-30
• [Presentation] マウス性決定のエピジェネティックな制御機構 (2014)
  • Author(s): 立花 誠
  • Organizer: 第26回高遠展分子生物学シンポジウム｢一つのゲノムが多細胞生物を産む仕組み｣
  • Place of Presentation: 長野県伊那市
  • Year and Date: 2014-08-28 – 2014-08-29
  • Invited
• [Presentation] マウス精子形成過程のトランスポゾン抑制とRNP制御 (2014)
  • Author(s): 中馬新一郎
  • Organizer: 京都大学霊長類研究所研究会
  • Place of Presentation: 犬山
  • Year and Date: 2014-08-26 – 2014-08-27
  • Invited
• [Presentation] 進化的時間スケールでの霊長類生殖細胞エピゲノムのダイナミクス (2014)
  • Author(s): 一柳健司
  • Organizer: 霊長類研究所研究会「霊長類への展開に向けた幹細胞・生殖細胞・エピゲノム研究」
  • Place of Presentation: 愛知県犬山市
  • Year and Date: 2014-08-26
  • Invited
• [Presentation] トリコスタチンA処理による体細胞核移植クローン胚の転写因子関連遺伝子発現の改善について (2014)
  • Author(s): 井上貴美子，及川真実，上村悟氏，越後貫成美，中村肇伸，仲野徹，小倉淳郎
  • Organizer: 第107回日本繁殖生物学会総会
  • Place of Presentation: 北海道帯広市
  • Year and Date: 2014-08-23
• [Presentation] マウス栄養膜幹細胞におけるコロニー形態による未分化性の検討 (2014)
  • Author(s): 本村香織，井上貴美子，廣瀬美智子，及川真実，杉本道彦，阿部訓也，田中智，小倉淳郎
  • Organizer: 第107回日本繁殖生物学会
  • Place of Presentation: 北海道帯広市
  • Year and Date: 2014-08-22
• [Presentation] ROSI前核期におけるDNA脱メチル化の異常 (2014)
  • Author(s): 黒滝陽子, 及川真実, 畑中勇輝, 越後貫成美, 井上貴美子, 小倉淳郎
  • Organizer: 第107回日本繁殖生物学会総会
  • Place of Presentation: 北海道帯広市
  • Year and Date: 2014-08-22
• [Presentation] NOD/Scidマウスへの超スピードコンジェニック技術の応用 (2014)
  • Author(s): 越後貫成美，上村悟氏，井上貴美子，毛塚芙由子，長谷川歩未，持田慶司，古関明彦，小倉淳郎
  • Organizer: 第107回日本繁殖生物学会総会
  • Place of Presentation: 北海道帯広市
  • Year and Date: 2014-08-22
• [Presentation] トリコスタチンA処理による体細胞核移植クローン胚の転写因子関連遺伝子発現の改善について (2014)
  • Author(s): 井上 貴美子、及川 真実、上村 悟氏、越後貫 成美、中村 肇伸、仲野 徹、小倉 淳郎
  • Organizer: 第107回日本繁殖生物学会大会
  • Place of Presentation: 北海道帯広市
  • Year and Date: 2014-08-21
• [Presentation] Fluorescence Recovery After Photobleaching (FRAP)法によるマウス着床前初期胚のクロマチン構造の解析 (2014)
  • Author(s): 大我正敏、橋本聖、フルコバヘレナ、青木不学
  • Organizer: 第107回日本繁殖生物学会
  • Place of Presentation: 帯広
  • Year and Date: 2014-08-21
• [Presentation] マウス初期胚発生においてCcnA2の非翻訳領域が翻訳量に及ぼす影響 (2014)
  • Author(s): 森優賀、青木不学
  • Organizer: 第107回日本繁殖生物学会
  • Place of Presentation: 帯広
  • Year and Date: 2014-08-21
• [Presentation] 受精前後におけるヒストンH3変異体の動態および機能解析 (2014)
  • Author(s): 河村真愛、青木不学
  • Organizer: 第107回日本繁殖生物学会
  • Place of Presentation: 帯広
  • Year and Date: 2014-08-21
• [Presentation] CRISPR/Casを用いたマウスゲノム編集と表現型解析 (2014)
  • Author(s): 伊川正人
  • Organizer: がん支援活動公開シンポジウム
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2014-08-21
  • Invited
• [Presentation] マウス受精卵における能動的DNA脱メチル化機構の解明 (2014)
  • Author(s): 畑中勇輝，清水なつみ，守田昂太郎，井上貴美子，本多新，廣瀬美智子，松本和也，小倉淳郎
  • Organizer: 第107回日本繁殖生物学会大会
  • Place of Presentation: 北海道帯広市
  • Year and Date: 2014-08-21
• [Presentation] CRISPR/Cas mediated genome editing in mice and its application for reproductive studies. (2014)
  • Author(s): Ikawa M
  • Organizer: The 12th International Symposium on Spermatology
  • Place of Presentation: Newcastle, Australia
  • Year and Date: 2014-08-14
  • Invited
• [Presentation] MicroRNA-200a confers progesterone signaling deficiency making the cervix unfavorable to embryo implantation (2014)
  • Author(s): Hirota Y
  • Organizer: Gordon Research Conference on Mammalian Reproduction
  • Place of Presentation: New London, USA
  • Year and Date: 2014-08-13
  • Invited
• [Presentation] マウス性決定のエピジェネティックな制御機構 (2014)
  • Author(s): 立花 誠
  • Organizer: 第32回日本受精着床学会総会・学術講演会、シンポジウムI｢発生生物学トピックス｣
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2014-07-31 – 2014-08-01
  • Invited
• [Presentation] 受精前後におけるエピジェネティック・リプログラミングについて (2014)
  • Author(s): 青木不学
  • Organizer: ART(Assisted Reproductive Technology)forum14
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2014-07-31
  • Invited
• [Presentation] PRDM14による能動的脱メチル化を介した多能性獲得機構の解明 (2014)
  • Author(s): 関由行
  • Organizer: 第32回日本受精着床学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2014-07-31
  • Invited
• [Presentation] マウス受精卵における能動的DNA脱メチル化機構の解明 (2014)
  • Author(s): 畑中勇輝，清水なつみ，守田昂太郎，井上貴美子，本多新，廣瀬美智子，松本和也, 小倉淳郎
  • Organizer: 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第1回若手勉強会
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2014-07-17
• [Presentation] CRISPR/CASシステムを用いたマウスゲノム編集 (2014)
  • Author(s): 伊川正人
  • Organizer: 第41回日本毒性学会学術年会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2014-07-04
  • Invited
• [Presentation] がんドライバーミューテーション特異的アルキル化剤の開発 (2014)
  • Author(s): 永瀬浩喜、平岡桐子、井上貴博、越川信子、渡部隆義
  • Organizer: 第28回モロシヌス研究会
  • Place of Presentation: 修善寺
  • Year and Date: 2014-06-28
• [Presentation] KRASコドン12変異を標的とした分子標的アルキル化剤 (2014)
  • Author(s): 永瀬浩喜、平岡桐子、井上貴博、越川信子、渡部隆義
  • Organizer: 第18回日本癌分子標的治療学会
  • Place of Presentation: 仙台
  • Year and Date: 2014-06-26
• [Presentation] Dynamic changes in DNA methylation and gene expression in spermatogonial stem cell differentiation in neonatal mouse testis. (2014)
  • Author(s): Sasaki, H.
  • Organizer: 2nd Canadian Conference on Epigenetics: Epigenetics, Eh!,
  • Place of Presentation: Ontario, Canada,
  • Year and Date: 2014-06-24 – 2014-06-26
  • Invited
• [Presentation] 哺乳類発生過程におけるエピゲノム動態解析」 (2014)
  • Author(s): 阿部訓也
  • Organizer: 第28回環境ホルモン学会
  • Place of Presentation: 東京都
  • Year and Date: 2014-06-19
  • Invited
• [Presentation] 最近の実験動物における発生工学研究 (2014)
  • Author(s): 小倉淳郎
  • Organizer: 染色体工学研究センターセミナー
  • Place of Presentation: 鳥取県米子市
  • Year and Date: 2014-06-19
• [Presentation] DNA methylation and gene expression profiles in mouse germ cell development. (2014)
  • Author(s): Sasaki, H.
  • Organizer: International Society for Stem Cell Research 12th Annual Meeting Vancouver,
  • Place of Presentation: Canada,
  • Year and Date: 2014-06-18 – 2014-06-21
  • Invited
• [Presentation] Precision Medicineを目指したオンコジェニックドライバーを標的とした治療 (2014)
  • Author(s): 永瀬浩喜、平岡桐子、井上隆博、渡部隆義、越川信子、尾崎俊文
  • Organizer: 第23回癌病態治療研究会
  • Place of Presentation: 岐阜県
  • Year and Date: 2014-06-12 – 2014-06-13
  • Invited
• [Presentation] CRISPR/CAS mediated genome editing in mice (2014)
  • Author(s): 伊川正人
  • Organizer: 第66回日本細胞生物学会大会
  • Place of Presentation: 奈良県奈良市
  • Year and Date: 2014-06-11
  • Invited
• [Presentation] piRNA in germ cell development. "germinal stem cell biology" (2014)
  • Author(s): Chuma, S
  • Organizer: Gordon Research Conference 2015.5.31-6.5,
  • Place of Presentation: Hong Kong
  • Year and Date: 2014-05-31 – 2014-06-30
  • Invited
• [Presentation] Role of an atypical Polycomb Repressive Complex 1 (PRC1) involving MBLR and Mga/Max in repressing meiosis-related genes in mouse ES cells (2014)
  • Author(s): 遠藤充浩、信賀順、遠藤高帆、古関明彦
  • Organizer: 第12回幹細胞シンポジウム
  • Place of Presentation: 九州大学医学部百年講堂、福岡県福岡市
  • Year and Date: 2014-05-30 – 2014-05-31
• [Presentation] PRDM14 promotes active DNA demethylation through the TET-BER-mediated base excision repair pathway in embryonic stem cells (2014)
  • Author(s): 関由行
  • Organizer: 第47回日本発生生物学会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2014-05-29
• [Presentation] 受精卵におけるヒストンH2BのN-アセチルグルコサミン修飾 (2014)
  • Author(s): 中村 肇伸、鈴木 健士、後藤悠比、中谷 庸寿、関田 洋一、仲野 徹
  • Organizer: 第8回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都
  • Year and Date: 2014-05-27
• [Presentation] Whole-mount MeFISH：特定DNA配列メチル化と遺伝子／タンパク発現の同時イメージング (2014)
  • Author(s): 志浦寛相、 岡本晃充、佐々木裕之、阿部訓也
  • Organizer: 第8回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都
  • Year and Date: 2014-05-26
• [Presentation] マウス生殖細胞の性分化制御機構Mechanism of sexual differentiation of mouse germ cells (2014)
  • Author(s): 相賀裕美子
  • Organizer: エピジェネティックス研究会
  • Place of Presentation: 東京大学
  • Year and Date: 2014-05-26
  • Invited
• [Presentation] UHRF1相互作用タンパク質を介したエピジェネティック制御機構の解明を目指して (2014)
  • Author(s): 鵜木元香，益田晶子，堂前直，新田洋久，前之原章司，福井宣規，白川昌宏，中村祐輔，佐々木裕之
  • Organizer: 第8回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都文京区
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] マウスH19 ICRにおける受精後アリル特異的DNAメチル化活性の解析 (2014)
  • Author(s): 松﨑仁美、岡村永一、牛木亜季、高橋拓也、谷本啓司
  • Organizer: 第8回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京大学伊藤国際学術研究センター
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] MBLR-assembled atypical Polycomb Repressive Complex 1 (PRC1) is directed to meiosis-related genes by Max/Mga and drives PRC2 recruitment (2014)
  • Author(s): 遠藤充浩、信賀順、遠藤高帆、古関明彦
  • Organizer: 第8回日本エピジェネティクス研究会年会
  • Place of Presentation: 伊藤国際学術研究センター、東京都文京区
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] DNMT1を用いた新しいヒドロキシメチルシトシンの同定法－EnIGMA法の開発 (2014)
  • Author(s): 幸田 尚
  • Organizer: 第8回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京大学、東京
  • Year and Date: 2014-05-25
• [Presentation] CRISPR/Cas人工制限酵素システムを用いたマウスゲノム編集 (2014)
  • Author(s): 伊川正人
  • Organizer: ワークショップ「ゲノム編集の現状と可能性」
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2014-05-23
  • Invited
• [Presentation] トランスポゾン制御破綻が引き起こす精子形成不全症 (2014)
  • Author(s): 中馬新一郎
  • Organizer: 第61回日本実験動物学会シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2014-05-15 – 2014-05-17
  • Invited
• [Presentation] The regulation mechanism for dormancy and activation of primordial follicles in mouse ovary. (2014)
  • Author(s): Hitomi Suzuki Aleksandar Rajkovic, Masami Kanai-Azuma
  • Organizer: aoanese Association for Laboratory Animal Science, 61th Annual meeting
  • Place of Presentation: Hokkaido, Japan
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] Investigation of Sox17 function for implantation (2014)
  • Author(s): Miyuri Kawasumi, Hitomi Suzuki, Yoshiakira Kanai, Masami Kanai-Azuma
  • Organizer: Jaoanese Association for Laboratory Animal Science, 61th Annual meeting（
  • Place of Presentation: Hokkaido, Japan
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] 若齢雄マウスのfirst wave精子を用いた体外受精の試み (2014)
  • Author(s): 持田慶司，長谷川歩未， 廣瀬美智子，小倉淳郎
  • Organizer: 第61回日本実験動物学会総会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2014-05-15
• [Presentation] Dynamic changes in DNA methylation and gene expression in spermatogonial stem cell differentiation in neonatal mouse festis (2014)
  • Author(s): Sasaki, H.
  • Organizer: Epigenetics, chromatine & transcription, Cold Spring Harbor Conferences Asia,
  • Place of Presentation: Suzhou, China,
  • Year and Date: 2014-05-05 – 2014-05-09
  • Invited
• [Presentation] 妊娠成立に関わるプロゲステロン・シグナルの意義とその調節機構 (2014)
  • Author(s): 廣田泰
  • Organizer: 第87回日本内分泌学会学術総会
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2014-04-24
  • Invited
• [Presentation] KRAS G12D and G12V Specific Alkylating Agent (KR12) inhibits growth of colon cancer with those KRA mutations in vitro as well as in vivo. (2014)
  • Author(s): Nagase H, Hiraoka K, Inoue T, Watanabe T, Shinohara K, Koshikawa N, Toshinori O.
  • Organizer: AACR American Association for Cancer Research ANUAL MEETING 2014
  • Place of Presentation: サンディエゴ 米国
  • Year and Date: 2014-04-05 – 2014-04-09
• [Book] Epigenetic Mechanisms in Cellular Reprogramming (2015)
  • Author(s): Nakamura T and Nakano T.
  • Total Pages: 31-42
  • Publisher: Springer
• [Book] Epigenetics 2nd edition, (2015)
  • Author(s): Shi, Y., Tsukada, Y.
  • Total Pages: 13-15
  • Publisher: Cold Spring Harbor Laboratory Press,
• [Book] HORMONE FRONTIER IN GYNECOLOGY 22巻 (2015)
  • Author(s): 松尾光徳，廣田泰.
  • Total Pages: 11-17
  • Publisher: メディカルレビュー社
• [Book] 脳21 (2015)
  • Author(s): 野田大地，伊川正人
  • Total Pages: 104-109
  • Publisher: 株式会社金芳堂
• [Book] 医学のあゆみ (2015)
  • Author(s): 藤原祥高, 伊川正人
  • Total Pages: 165-169
  • Publisher: 医歯薬出版株式会社
• [Book] 実験医学 32 (2014)
  • Author(s): 白根健次郎, 佐々木裕之
  • Total Pages: 847-852
  • Publisher: 株式会社羊土社
• [Book] エピジェネティクスの産業応用 (畑田出穂, 久保田健夫監修), (2014)
  • Author(s): 鵜木元香, 佐々木裕之
  • Total Pages: 78-89
  • Publisher: シーエムシー出版,
• [Book] Reprod Med Biol. (2014)
  • Author(s): Hiura H, Okae H, Chiba H, Miyauchi N, Sato F, Sato A, Arima T.
  • Total Pages: 193-202
  • Publisher: Springer
• [Book] 化学と生物 (2014)
  • Author(s): 立花誠
  • Total Pages: 216-217
  • Publisher: 公益社団法人 日本農芸化学会
• [Book] 実感医学vol41 (2014)
  • Author(s): 丸 喜明，佐々木泰史，中村友紀，横井左奈，大平美紀，時野隆至，永瀬浩喜2
  • Total Pages: 1781-1788
  • Publisher: 羊土社
• [Book] Methods in Molecular Biology (2014)
  • Author(s): Saito K.
  • Total Pages: 25-33
  • Publisher: Springer
• [Book] 生体の科学 (2014)
  • Author(s): 束田裕一
  • Total Pages: 349-356
  • Publisher: 医学書院
• [Book] 実験医学別冊 次世代シークエンス解析スタンダード 二階堂愛・編集 (2014)
  • Author(s): 池田理恵子、阿部訓也
  • Total Pages: 165-172
  • Publisher: 羊土社
• [Book] 実験医学別冊 次世代シークエンス解析スタンダード 二階堂愛・編集 (2014)
  • Author(s): 鈴木雅子、阿部訓也
  • Total Pages: 173-181
  • Publisher: 羊土社
• [Book] 実験医学 vol 32 (2014)
  • Author(s): 中馬新一郎
  • Total Pages: 853-858
  • Publisher: 羊土社
• [Book] Targeted Genome Editing Using Site-Specific Nucleases (2014)
  • Author(s): Young S, Baker M, Ikawa M.
  • Total Pages: 151-166
  • Publisher: Springer
• [Book] Methods Enzymol. (2014)
  • Author(s): Fujihara Y, Ikawa M.
  • Total Pages: 319-336
  • Publisher: Plasmid Injection.
• [Book] 実験医学vol32No11 (2014)
  • Author(s): 藤原祥高, 伊川正人
  • Total Pages: 1709-1714
  • Publisher: 株式会社羊土社
• [Book] 実験医学 vol.32 (2014)
  • Author(s): 中村 肇伸
  • Total Pages: 2588
  • Publisher: 株式会社羊土社
• [Book] Mobile DNA. (2014)
  • Author(s): Yamanaka S, Siomi MC, Siomi H
  • Total Pages: 22
  • Publisher: Springer
• [Patent(Industrial Property Rights)] 細胞の分化状態を非侵襲的に評価するためのバイオマーカーおよび方法 (2014)
  • Inventor(s): 中辻憲夫、末盛博文、中馬新一郎、鈴木崇
  • Industrial Property Rights Holder: 島津製作所、京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2014-094507
  • Filing Date: 2014-05-01