生殖細胞のエピゲノムダイナミクスとその制御

2015 Fiscal Year Annual Research Report

• Project Area: Analyses and regulation of germline epigenome
• Project/Area Number: 25112001
• Research Institution: Kyoto University
• Principal Investigator: 篠原 隆司 京都大学, 医学(系)研究科(研究院), 教授 (30322770)
• Co-Investigator(Kenkyū-buntansha): 伊川 正人 大阪大学, 微生物病研究所, 教授 (20304066)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: 生殖細胞 / エピゲノム

Outline of Annual Research Achievements

本年度は主な活動として研究室へのサイトビジット、若手勉強会、中間評価、国際シンポジウムを行った。以下にそれぞれについて説明する。研究室へのサイトビジットは一昨年より開始し、本年度に全て終了した。個々の研究室の実験進捗状況の確認と研究目的の再確認を行い、若手研究者については論文執筆や研究遂行についての助言をするとともに、共同研究支援についての説明も行った。若手勉強会は2015年7月22-23日にかけて伊豆の修善寺で行われた。2014年度のベストプレゼンテイター賞を受賞した慶応大学の大学院生が主催し、各研究室の若手メンバーを中心として合計50名の参加があった。中間評価には10月16日にヒアリングが行われ、本領域は「A]判定と判定された。概ね計画通り、あるいは計画以上の成果が得られているとの評価があった一方で、改善点もいくつか指摘されており、翌年度以降への課題となった。国際シンポジウムは2016年2月17日～19日に京大で開かれ、海外7カ国の参加者を含めて合計255名の参加があった。このシンポジウムでは生殖細胞とエピゲノム研究の最先端の研究者を国内外から招聘し、生殖細胞を専門とする研究者とエピゲノムを研究する研究者の融合による、既存のコミュニティーの枠を超えた共同研究や議論を行った。特に我が国の若手研究者が多く参加したことにより、両分野を開拓してきたパイオニアと直接ふれあうことは人材育成の観点からも有意義であったと考えている。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

本領域では領域設定時に設置した技術支援グループによる班員の支援が功を奏し、計画班員の平均では２９．２％、公募班では２５．９％が領域内連携による共著論文を作成している。また現在進行中の領域内共同研究は５９件にのぼり、２２班のうち１７班が領域内で共同研究を行っている。これは当初予測したよりも高い数字であり、このために当初の計画以上に進展しているとした。

Strategy for Future Research Activity

本年度行われた中間評価において、本領域は「A]判定と判定された。しかしながら、研究分野が近い他の新学術領域との連携を期待されると共に、以前からの研究の延長ではなく、新学術領域研究として研究体制を組んだことで初めて可能となる他の学問分野にも普遍的に波及するオリジナルでインパクトの高い研究が求められた。この点について鋭意取り組む予定である。具体的には「研究分野が近い他の新学術領域との連携」については「幹細胞老化と疾患」、「配偶子形成」班と連携を図る予定であり、それぞれの領域代表者と接触し計画を立ててきたプランを実施する。またこれに加えて、融合研究を促進するために若手勉強会や公開シンポジウムででの研究者間の情報交換をより緊密に行う予定である。

Research Products

• [Int'l Joint Research] カナダ・ブリティッシュコロンビア大学(カナダ)
  • Country Name: CANADA
  • Counterpart Institution: カナダ・ブリティッシュコロンビア大学
• [Int'l Joint Research] EMBL(France)
  • Country Name: France
  • Counterpart Institution: EMBL
• [Int'l Joint Research] University of Delaware(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: University of Delaware
• [Int'l Joint Research] ベイラー医科大学(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: ベイラー医科大学
• [Int'l Joint Research] マレーシア科学大学(マレーシア)
  • Country Name: MALAYSIA
  • Counterpart Institution: マレーシア科学大学
• [Int'l Joint Research]
  • # of Other Countries: 12
• [Journal Article] Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells. (2016)
  • Author(s): Taguchi A, Koga K, Kawana K, Makabe T, Sue F, Miyashita M, Yoshida M, Urata Y, Izumi G, Tkamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
  • Journal Title: Am J Reprod Immunol. Volume: 75(4) Pages: 486-92
  • DOI: 10.1111/aji.12489.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Characterization of gene expression in mouse embryos at the 1-cell stage. (2016)
  • Author(s): Yamamoto R, Abe K, Suzuki Y, Suzuki MG, Aoki F.
  • Journal Title: J Reprod Dev. Volume: 62(1) Pages: 87-92
  • DOI: 10.1262/jrd.2015-131.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enrichment of mouse spermatogonial stem cells by the stem cell dye CDy1. (2016)
  • Author(s): Kanatsu-Shinohara M, Morimoto H, Shinohara T.
  • Journal Title: Biol. Reprod. Volume: 94(1) Pages: 13
  • DOI: 10.1095/biolreprod.115.135707.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] De novo DNA methylation drives 5hmC accumulation in mouse zygotes. (2016)
  • Author(s): Amouroux R, Nashun B, Shirane K, Nakagawa S, Hill PW, D'Souza Z, Nakayama M, Matsuda M, Turp A, Ndjetehe E, Encheva V, Kudo NR, Koseki H, Sasaki H, Hajkova P.
  • Journal Title: Nat. Cell Biol. Volume: 18 Pages: 225-233
  • DOI: 10.1038/ncb3296
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Lentiviral Vector Mediated Complementation Restored Fetal Viability but Not Placental hyperplasia in Plac1-Deficient Mice. (2016)
  • Author(s): Muto M, Fujihara Y, Tobita T, Kiyozumi D, Ikawa M.
  • Journal Title: Biol Reprod. Volume: 94(1) Pages: 6
  • DOI: 10.1095/biolreprod.115.133454.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development. (2016)
  • Author(s): Suzuki A, Niimi Y, Shinmyozu K, Zhou Z, Kiso M, Saga Y.
  • Journal Title: EMBO Rep. Volume: 17(1) Pages: 37-46
  • DOI: 10.15252/embr.201540828.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Long-term ex vivo maintenance of testis tissues producing fertile sperm in a microfluidic device. (2016)
  • Author(s): Komeya M, Kimura H, Nakamura H, Yokonishi T, Sato T, Kojima K, Hayashi K, Katagiri K, Yamanaka H, Sanjo H, Yao M, Kamimura S, Inoue K, Ogonuki N, Ogura A , Fujii T, Ogawa T.
  • Journal Title: Sci Rep. Volume: 6 Pages: 21472
  • DOI: 10.1038/srep21472.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] High-yield superovulation in adult mice by anti-inhibin serum treatment combined with estrous cycle synchronization. (2016)
  • Author(s): Hasegawa A, Mochida K, Inoue H, Noda Y, Endo T, Watanabe G, Ogura A.
  • Journal Title: Biol Reprod. Volume: 94(1) Pages: 21
  • DOI: 10.1095/biolreprod.115.134023.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Analysis of chromatin structure in mouse preimplantation embryos by fluorescent recovery after photobleaching. (2016)
  • Author(s): Ooga M, Fulka1 H, Hashimoto S, Suzuki MG ,Aoki F.
  • Journal Title: Epigenetics Volume: 11(1) Pages: 85-94
  • DOI: 10.1080/155922942015.1136774
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells. (2016)
  • Author(s): Suzuki A, Hirasaki M, Hishida T, Okamura D, Wu J, Ueda A, Nishimoto M, Nakachi Y, Mizuno Y, Okazaki Y, Matsui Y, *Izpisua Belmonte JC, Okuda A.
  • Journal Title: Nat Commun Volume: 7 Pages: 11056
  • DOI: 0.1038/ncomms11056.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Combined overexpression of Jarid2, Prdm14, Esrrb, and Sall4A dramatically improves efficiency and kinetics of reporgramming to induced pluripotent stem cells. (2016)
  • Author(s): Iseki H, Nakachi Y, Hishida T, Yamashita-Sugawara Y, Hirasaki M, Ueda A, Tanimoto Y, Iijima S, Yagami K, Takahashi S, Okuda A, Okazaki Y.
  • Journal Title: Stem Cells Volume: 34(2) Pages: 322-33
  • DOI: 10.1002/stem.2243.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain deficiency. (2016)
  • Author(s): Kohda M, Mizuno Y, Hirata T, Yatsuka Y, Yamashita, Okuda A, Borna NN, Banshoya K, Ohnuma K, Suzuki T, Nagao A, Maehata H, Matsuda F, Higasa K, Nagasaki M, Yasuda J, Yamamoto M, Fushimi T, Shimura M, Kaiho-Ichimoto K, Harashima H, Yamazaki T, Mori M, Murayama K, Ohtake A, Okazaki Y.
  • Journal Title: PLoS Genetics: Volume: 12(1) Pages: e1005679
  • DOI: 10.1371/journal.pgen.1005679
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epigenetics of Sex Determination in Mammals Tachibana M. (2016)
  • Author(s): Tachibana M.
  • Journal Title: Reproductive Medicine and Biology Volume: 15 Pages: 59-67
  • DOI: 10.1007/s12522-015-0223-7
  • Peer Reviewed
• [Journal Article] カルシニューリンは精子中片部の屈曲能とオスの生殖能に必須である (2016)
  • Author(s): 宮田治彦，伊川正人.
  • Journal Title: 細胞工学 Volume: 35(3) Pages: 230-231
• [Journal Article] マウスの生殖能力に必須な精子カルシニューリンは男性避妊薬の標的となりうる (2016)
  • Author(s): 宮田治彦，伊川正人.
  • Journal Title: 実験医学 Volume: 3月号 Pages: 596-599
• [Journal Article] Pluripotent cell derivation from male germline cells by suppression of Dmrt1 and Trp53. (2015)
  • Author(s): Tanaka T, Kanatsu-Shinohara M, Hirose M, Ogura A, Shinohara T.
  • Journal Title: J. Reprod. Dev. Volume: 61(5) Pages: 473-84
  • DOI: 10.1262/jrd.2015-059.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage. (2015)
  • Author(s): Tanaka T, Kanatsu-Shinohara M, Shinohara T.
  • Journal Title: J. Reprod. Dev. Volume: 61(4) Pages: 305-16
  • DOI: 10.1262/jrd.2015-027.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ROS-generating oxidase Nox3 regulates the self-renewal of mouse spermatogonial stem cells. (2015)
  • Author(s): Morimoto H, Kanatsu-Shinohara M, Shinohara T.
  • Journal Title: Biol. Reprod. Volume: 92(6) Pages: 147.
  • DOI: 10.1095/biolreprod.114.127647.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis. (2015)
  • Author(s): Kubo N, Toh H, Shirane K, Shirakawa T, Kobayashi H, Sato T, Sone H, Sato Y, Tomizawa S, Tsurusaki Y, Shibata H, Saitsu H, Suzuki Y, Matumoto N, Suyama M, Kono T, Ohbo K ,Sasaki H.
  • Journal Title: BMC Genomics Volume: 16 Pages: 624
  • DOI: 10.1186/s12864-015-1833-5.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A role of TMEM16E carrying a scrambling domain in sperm motility. (2015)
  • Author(s): Gyobu S, Miyata H, Ikawa M, Yamazaki D, Takeshima H, Suzuki J, Nagata S.
  • Journal Title: Mol Cell Biol. Volume: 36(4) Pages: 645-59
  • DOI: 10.1128/MCB.00919-15.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. (2015)
  • Author(s): Latos PA, Sienerth AR, Murray A, Senner CE, Muto M, Ikawa M, Oxley D, Burge S, Cox BJ, Hemberger M.
  • Journal Title: Genes Dev. Volume: 29(23) Pages: 2435-48
  • DOI: 10.1101/gad.268821.115.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive. (2015)
  • Author(s): Miyata H, Satouh Y, Mashiko D, Muto M, Nozawa K, Shiba K, Fujihara Y, Isotani A, Inaba K, Ikawa M.
  • Journal Title: Science. Volume: 350(6259) Pages: 442-5
  • DOI: 10.1126/science.aad0836.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis. (2015)
  • Author(s): Young SA, Miyata H, Satouh Y, Kato H, Nozawa K, Isotani A, Aitken RJ, Baker MA, Ikawa M.
  • Journal Title: Int J Mol Sci. Volume: 16(10) Pages: 24732-24750
  • DOI: 10.3390/ijms161024732.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Sperm Postacrosomal WW Domain-Binding Protein Is Not Required for Mouse Egg Activation. (2015)
  • Author(s): Satouh Y, Nozawa K, Ikawa M.
  • Journal Title: Biol Reprod. Volume: 93(4) Pages: 94
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Calreticulin is required for development of the cumulus oocyte complex and female fertility. (2015)
  • Author(s): Tokuhiro K, Satouh Y, Nozawa K, Isotani A, Fujihara Y, Hirashima Y, Matsumura H, Takumi K, Miyano T, Okabe M, Benham AM, Ikawa M.
  • Journal Title: Sci Rep. Volume: 5 Pages: 14254.
  • DOI: 10.1038/srep14254.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes. (2015)
  • Author(s): Ono R, Ishii M, Fujihara Y, Kitazawa M, Usami T, Kaneko-Ishino T, Kanno J, Ikawa M, Ishino F.
  • Journal Title: Sci Rep. Volume: 5 Pages: 12281
  • DOI: 10.1038/srep12281.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A novel transcriptional factor nkapl is a germ cell-specific suppressor of notch signaling and is indispensable for spermatogenesis. (2015)
  • Author(s): Okuda H, Kiuchi H, Takao T, Miyagawa Y, Tsujimura A, Nonomura N, Miyata H, Okabe M, Ikawa M, Kawakami Y, Goshima N, Wada M, Tanaka H.
  • Journal Title: PLoS One. Volume: 10(4) Pages: e0124293
  • DOI: 10.1371/journal.pone.0124293. eCollection
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] One-step generation of multiple transgenic mouse lines using an improved Pronuclear Injection-based Targeted Transgenesis (i-PITT). (2015)
  • Author(s): Ohtsuka M, Miura H, Mochida K, Hirose M, Hasegawa A, Ogura A, Mizutani R, Kimura M, Isotani A, Ikawa M, Sato M, Gurumurthy CB.
  • Journal Title: BMC Genomics. Volume: 16 Pages: 274
  • DOI: 10.1186/s12864-015-1432-5.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Global DNA hypomethylation coupled to cellular transformation and metastatic ability. (2015)
  • Author(s): Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, Oboki K, Matsumoto K, Saito H, Nakano T.
  • Journal Title: FEBS lett. Volume: 589 Pages: 4053-60
  • DOI: 10.1016/j.febslet.2015.11.020.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] De novo DNA methylation through the 5'-segment of the H19 ICR maintains its imprint during early embryogenesis. (2015)
  • Author(s): Matsuzaki H, Okamura E, Takahashi T, Ushiki A, Nakamura T, Nakano T, Hata K, Fukamizu A, Tanimoto K.
  • Journal Title: Development. Volume: 142(22) Pages: 3833-44
  • DOI: 10.1242/dev.126003.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Stella controls chromocenter formation through regulation of Daxx expression in 2-cell embryos. (2015)
  • Author(s): Arakawa T, Nakatani T, Oda M, Kimura Y, Sekita Y, Kimura T, Nakamura T, Nakano T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 466(1) Pages: 60-5
  • DOI: 10.1016/j.bbrc.2015.08.106.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Human Dynactin-Associated Protein Transforms NIH3T3 Cells to Generate Highly Vascularized Tumors with Weak Cell-Cell Interaction. (2015)
  • Author(s): Kunoh T, Wang W, Kobayashi H, Matsuzaki D, Togo Y, Tokuyama M, Hosoi M, Koseki K, Wada S, Nagai N, Nakamura T, Nomura S, Hasegawa M, Sasaki R, Mizukami T.
  • Journal Title: PLoS One. Volume: 10(8) Pages: e0135836
  • DOI: 10.1371/journal.pone.0135836.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. (2015)
  • Author(s): Inoue K, Oikawa M, Kamimura S, Ogonuki N, Nakamura T, Nakano T, Abe K, Ogura A.
  • Journal Title: Sci Rep. Volume: 5 Pages: 10127
  • DOI: 10.1038/srep10127.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation. (2015)
  • Author(s): Nakatani T, Yamagata K, Kimura T, Oda M, Nakashima H, Hori M, Sekita Y, Arakawa T, Nakamura T, Nakano T.
  • Journal Title: EMBO Rep. Volume: 16(5) Pages: 582-9
  • DOI: 10.15252/embr.201439427.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells. (2015)
  • Author(s): Zhou Z, Shirakawa T, Ohbo K, Sada A, Wu Q, Hasegawa K, Saba R, Saga Y.
  • Journal Title: Dev Cell. Volume: 34(1) Pages: 96-107
  • DOI: 10.1016/j.devcel.2015.05.014.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposon. (2015)
  • Author(s): Hatanaka Y, Inoue K, Oikawa M, Kamimura S, Ogonuki N, Kodam E, Ohkawa Y, Tsukada Y, Ogura A.（
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 112(47) Pages: 14641-6
  • DOI: 10.1073/pnas.1512775112.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In quest of genomic treasure. (2015)
  • Author(s): Inoue K, Ogura A.
  • Journal Title: J Reprod Dev. Volume: 61(6) Pages: 489-93
  • DOI: 10.1262/jrd.2015-098.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genome Editing in Mouse Spermatogonial Stem Cell Lines Using TALEN and Double-Nicking CRISPR/Cas9. (2015)
  • Author(s): Sato T, Sakuma T, Yokonishi T, Katagiri K, Kamimura S, Ogonuki N, Ogura A, Yamamoto T, Ogawa T.
  • Journal Title: Stem Cell Reports. Volume: 5(1) Pages: 75-82
  • DOI: 10.1016/j.stemcr.2015.05.011.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of a general-purpose method for cell purification using Cre/loxP-mediated recombination. (2015)
  • Author(s): Kuroki S, Akiyoshi M, Ideguchi K, Kitano S, Miyachi H, Hirose M, Mise N, Abe K, Ogura A, Tachibana M.
  • Journal Title: Genesis. Volume: 53(6) Pages: 387-93
  • DOI: 10.1002/dvg.22863.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Induction of DNA methylation by artificial piRNA production in male germ cells. (2015)
  • Author(s): Itou D, Shiromoto Y, Shin-Ya Y, Ishii C, Nishimura T, Ogonuki N, Ogura A, Hasuwa H, Fujihara Y, Kuramochi-Miyagawa S, Nakano T.
  • Journal Title: Curr Biol. Volume: 25(7) Pages: 901-6
  • DOI: 10.1016/j.cub.2015.01.060.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impaired active DNA demethylation in zygotes generated by round spermatid injection. (2015)
  • Author(s): Kurotaki YK, Hatanaka Y, Kamimura S, Oikawa M, Inoue H, Ogonuki N, Inoue K, Ogura A.
  • Journal Title: Hum Reprod. Volume: 30(5) Pages: 1178-87
  • DOI: 10.1093/humrep/dev039.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Generation of cloned mice from adult neurons by direct nuclear transfer. (2015)
  • Author(s): Mizutani E, Oikawa M, Kassai H, Inoue K, Shiura H, Hirasawa R, Kamimura S, Matoba S, Ogonuki N, Nagatomo H, Abe K, Wakayama T, Aiba A, Ogura A.
  • Journal Title: Biol Reprod. Volume: 92(3) Pages: 81
  • DOI: 10.1095/biolreprod.114.123455.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A simple and robust method for establishing homogeneous mouse epiblast stem cell lines by Wnt inhibition. (2015)
  • Author(s): Sugimoto M, Kondo M, Koga Y, Shiura H, Ikeda R, Hirose M, Ogura A, Murakami A, Yoshiki a, Chuva de Sousa Lopes SM, Abe K.
  • Journal Title: Stem Cell Rep. Volume: 4(4) Pages: 744-57
  • DOI: 10.1016/j.stemcr.2015.02.014.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Naive-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells. (2015)
  • Author(s): Honsho K, Hirose M, Hatori, Yasmin L, Izu H, Matoba S, Togayachi S, Miyoshi H, Sankai T, Ogura A, Honda A.
  • Journal Title: J Reprod Dev. Volume: 61(1): Pages: 13-9
  • DOI: 10.1262/jrd.2014-098.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Maternal TET3 is dispensable for embryonic development but is required for neonatal growth. (2015)
  • Author(s): Tsukada Y, Akiyama T, and Nakayama K I.
  • Journal Title: Sci. Rep. Volume: 5 Pages: 15876
  • DOI: 10.1038/srep15876.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Selective Targeting of the KRAS Codon 12 Mutation Sequence by Pyrrole–Imidazole Polyamide seco-CBI Conjugates. (2015)
  • Author(s): Taylor RD, Chandran A, Kashiwazaki G, Hashiya K, Bando T, Nagase H and Sugiyama H. Chemistry.
  • Journal Title: Chemistry. Volume: 21(42) Pages: 14996-5003
  • DOI: 10.1002/chem.201501870.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The oncogenic role of GASC1 in chemically induced mouse skin cancer. (2015)
  • Author(s): Ozaki Y, Fujiwara K, Ikeda M, Ozaki T, Terui T, Soma M, Inazawa J, Nagase H.
  • Journal Title: Mammalian Genome. Volume: 26(11-12) Pages: 591-7
  • DOI: 10.1007/s00335-015-9592-9.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death. (2015)
  • Author(s): Ozaki T, Sugimoto H, Nakamura M, Yoda H, Hiraoka K, Shinohara K, Sang M, Fujiwara K, Shimozato O and Nagase H.
  • Journal Title: Cell Death Dis. Volume: 6 Pages: e1914
  • DOI: 10.1038/cddis.2015.242.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model. (2015)
  • Author(s): Igarashi J, Fukuda N, Inoue T, Nakai S, Saito K, Fujiwara K, Matsuda H, Ueno T, Matsumoto Y, Watanabe T, Nagase H, Bando T Sugiyama H Itoh T Soma M.
  • Journal Title: PlosOne. Volume: 10(5) Pages: e0125295
  • DOI: 10.1371/journal.pone.0125295.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pyrrole-Imidazole (PI) polyamide-mediated silencing of KCNQ1OT1 expression induces cell death in Wilms tumor cells. (2015)
  • Author(s): Yoshizawa S, Fujiwara K, Sugito K, Uekusa S, Kawashima H, Hoshi R, Watanabe Y, Hirano T, Furuya T, Masuko T, Ueno T, Fukuda N, Soma M, Ozaki T, Koshinaga T, Nagase H.
  • Journal Title: Int J Oncol. Volume: 47(1) Pages: 115-21
  • DOI: 10.3892/ijo.2015.3018.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole–imidazole polyamide conjugate. (2015)
  • Author(s): Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Hiroyuki Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H.
  • Journal Title: Nat Commun. Volume: 6 Pages: 6706
  • DOI: 10.1038/ncomms7706.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Functional analysis of sex-determination genes by gene silencing with LNA-DNA gapmers in the silkworm, Bombyx mori. (2015)
  • Author(s): Sakai, H., Sakaguchi, H., Aoki, F. and Suzuki, M.G.
  • Journal Title: Mech. Dev. Volume: 137 Pages: 45-52
  • DOI: 10.1016/j.mod.2015.03.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing. (2015)
  • Author(s): Abe K, Yamamoto R, Franke V, Cao M, Suzuki Y, Suzuki MG, Vlahovicek K, Svoboda P, Schultz RM Aoki, F.
  • Journal Title: EMBO J. Volume: 34 Pages: 1523-1537
  • DOI: 10.15252/embj.201490648
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Identification of a transformer homolog in the acorn worm, Saccoglossus kowalevskii, and analysis of its activity in insect cells. (2015)
  • Author(s): Suzuki MG, Tochigi M, Sakaguchi H, Aoki F Miyamoto N.
  • Journal Title: Dev. Genes. Evol. Volume: 225 Pages: 161-169
  • DOI: 10.1007/s00427-015-0498-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Involvement of histone H2B mono-ubiquitination in the regulation of mouse preimplantation development. (2015)
  • Author(s): Ooga M, Suzuki MG , Aoki F.
  • Journal Title: J. Reprod. Dev. Volume: 61 Pages: 179-184
  • DOI: 10.1262/jrd.2014-137
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of a general-purpose method for cell purification using Cre/loxP-mediated recombination (2015)
  • Author(s): Kuroki S, Akiyoshi M, Ideguchi K, Kitano S, Miyachi H, Hirose M, Mise N, Abe K, Ogura A, Tachibana M.
  • Journal Title: Genesis. Volume: 53(6) Pages: 387-93
  • DOI: 10.1002/dvg.22863.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] H3K9MTase G9a is essential for the differentiation and growth of tenocytes in vitro. (2015)
  • Author(s): Wada S, Ideno H, Shimada A, Kamiunten T, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M , Nifuji A.
  • Journal Title: Histochem Cell Biol. Volume: 144(1) Pages: 13-20
  • DOI: 10.1007/s00418-015-1318-2.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Lhx8 regulates primordial follicle activation and postnatal folliculogenesis. (2015)
  • Author(s): Ren Y, Suzuki H, Jagarlamudi K, Golnoski K, McGuire M, Lopes R, Pachnis V, Rajkovic A.*
  • Journal Title: BMC Biol. Volume: 13(1) Pages: 39
  • DOI: 10.1186/s12915-015-0151-3
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A Niche for GFRα1-positive spermatogonia in the Terminal Segments of the Seminiferous Tubules in Hamster Testes. (2015)
  • Author(s): Aiyama Y, Tsunekawa N, Kishi K, Kawasumi M, Suzuki H, Kanai-Azuma M, Kurohmaru M, Kanai Y.
  • Journal Title: Stem Cells. Volume: 3(9) Pages: 2811-24
  • DOI: 10.1002/stem.2065.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation., Okashita, N., Saka (2015)
  • Author(s): Okashita N,Sakashita N , Ito K, Mitsuya A, Suwa Y, Seki Y.
  • Journal Title: Biochem. Biophys.Res. Commun. Volume: 466(1) Pages: 138-45
  • DOI: 10.1016/j.bbrc.2015.08.122.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation. (2015)
  • Author(s): Inoue D, Aihara H, Sato T, Mizusaki H, Doiguchi M, Higashi M, Imamura Y, Yoneda M, Miyanishi T, Fujii S, Okuda A, Nakagawa T, Ito T.
  • Journal Title: Sci Rep. Volume: 5 Pages: 16567
  • DOI: 10.1038/srep16567.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression. (2015)
  • Author(s): Katano M, Ema M, Nakachi Y, Mizuno Y, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Takahashi S, Okazaki Y, Okuda A.
  • Journal Title: Stem Cells Volume: 33(4) Pages: 1089-101
  • DOI: 10.1002/stem.1918.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Functional crosstalk between Myc and PI3K signaling for supporting unlimited self-renewal of embryonic stem cells. (2015)
  • Author(s): Hishida T, Nakachi Y, Mizuno Y, Katano M, Okazaki Y, Ema M, Takahashi S, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Hishida-Nozaki Y, Vazquez-Ferrer E, Sancho-Martinez I, Izpisua Belmonte JC Okuda A.
  • Journal Title: Stem Cells Volume: 33(3) Pages: 713-25
  • DOI: 10.1002/stem.1893.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reply to Shoji and Katsuma. (2015)
  • Author(s): Kuramochi-Miyagawa S, Nakano T.
  • Journal Title: Curr Biol. Volume: 25(16) Pages: R710
  • DOI: 10.1016/j.cub.2015.07.020.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis. (2015)
  • Author(s): Takamura M, Koga K, Izumi G, Hirata T, Harada M, Hirota Y, Hiraike O, Fujii T, Osuga Y.
  • Journal Title: Am J Reprod Immunol. Volume: 74(6) Pages: 480-6
  • DOI: 10.1111/aji.12426.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evidence of the activation of unfolded protein response in granulosa and cumulus cells during follicular growth and maturation. (2015)
  • Author(s): Harada M, Nose E, Takahashi N, Hirota Y, Hirata T, Yoshino O, Koga K, Fujii T, Osuga Y.
  • Journal Title: Gynecol Endocrinol. Volume: 31(10) Pages: 783-7
  • DOI: 10.3109/09513590.2015.1062862.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells. (2015)
  • Author(s): Miyashita M, Koga K, Izumi G, Makabe T, Hasegawa A, Hirota Y, Hirata T, Harada M, Fujii T, Osuga Y.
  • Journal Title: Fertil Steril. Volume: 104(1) Pages: 217-24.e2
  • DOI: 10.1016/j.fertnstert.2015.03.023.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus. (2015)
  • Author(s): Cha J, Burnum-Johnson KE, Bartos A, Li Y, Baker ES, Tilton SC, Webb-Robertson BJ, Piehowski PD, Monroe ME, Jegga AG, Murata S, Hirota Y, Dey SK.
  • Journal Title: J Biol Chem. Volume: 290(24) Pages: 15337-49
  • DOI: 10.1074/jbc.M115.655001.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cyclic stretch augments production of neutrophil chemokines, matrix metalloproteinases, and activin A in human endometrial stromal cells. (2015)
  • Author(s): Izumi G, Koga K, Nagai M, Urata Y, Takamura M, Harada M, Hirata T, Hirota Y, Ogawa K, Inoue S, Fujii T, Osuga Y.
  • Journal Title: Am J Reprod Immunol Volume: 73(6) Pages: 501-6.
  • DOI: 10.1111/aji.12359.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome. (2015)
  • Author(s): Hurst LD, Ghanbarian AT, Forrest AR; FANTOM consortium, Huminiecki L.
  • Journal Title: PLoS Biol. Volume: 13(12) Pages: e1002315
  • DOI: 10.1371/journal.pbio.1002315. eCollection 2015 Dec.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage. (2015)
  • Author(s): Carbajo D, Magi S, Itoh M, Kawaji H, Lassmann T, Arner E, Forrest AR, Carninci P, Hayashizaki Y, Daub CO; FANTOM consortium, Okada-Hatakeyama M, Mar JC.
  • Journal Title: PLoS One. Volume: 10(12) Pages: e0144176
  • DOI: 10.1371/journal.pone.0144176. eCollection 2015.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] From Sex Determination to Initial Folliculogenesis in Mammalian Ovaries: Morphogenetic Waves along the Anteroposterior and Dorsoventral Axes. (2015)
  • Author(s): Suzuki H, Kanai-Azuma M, Kanai Y.
  • Journal Title: Sex Dev. Volume: 9(4) Pages: 190-204
  • DOI: 10.1159/000440689
  • Peer Reviewed
• [Journal Article] Epigenetic regulation of mammalian sex determination (2015)
  • Author(s): Tachibana M.
  • Journal Title: Journal of Medical Investigation Volume: 62 Pages: 19-23
  • DOI: 10.2152/jmi.62.19.
  • Peer Reviewed
• [Journal Article] 小分子RNAを介したエピゲノム制御 (2015)
  • Author(s): 山中総一郎、塩見春彦
  • Journal Title: 細胞工学 Volume: 34(9) Pages: 862-867
• [Journal Article] 分裂酵母siRNAを介したTGS (2015)
  • Author(s): 山中総一郎
  • Journal Title: 実験医学 Volume: 33(20) Pages: 38-39
• [Journal Article] 着床前胚と始原生殖細胞におけるDNAメチル化リプログラミング (2015)
  • Author(s): 中村 肇伸
  • Journal Title: 生体の科学 Volume: 66(6) Pages: 604-610
• [Journal Article] 母性因子を用いたiPS細胞の樹立効率と質の改善 (2015)
  • Author(s): 中村 肇伸
  • Journal Title: 細胞工学 Volume: 34(7) Pages: 696-700
• [Journal Article] Advantages of using the CRISPR/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models. (2015)
  • Author(s): Young SA, Aitken RJ, Ikawa M. Asian J Androl.
  • Journal Title: Lipid Res. Volume: 17(4) Pages: 623-7
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Epigenetic alterations in sperm associated with male infertility. (2015)
  • Author(s): Kitamura A, Miyauchi N, Hamada H, Hiura H, Chiba H, Okae H, Sato A, John RM, Arima T.
  • Journal Title: Congenital Anomalies. Volume: 55(3) Pages: 133-44
  • DOI: 10.1111/cga.12113.
  • Peer Reviewed
• [Journal Article] How does Progesterone Support Embryo Implantation? (2015)
  • Author(s): Hiraoka T, Saito-Fujita T, Hirota Y.
  • Journal Title: J Mamm Ova Res Volume: 32 Pages: 87-94
  • Peer Reviewed
• [Journal Article] 着床における黄体ホルモンの作用 (2015)
  • Author(s): 平岡毅大, 廣田泰.
  • Journal Title: 産科と婦人科 Volume: 82(7) Pages: 740-745
• [Journal Article] 子宮内膜における着床制御因子 プロゲステロン・シグナルを中心に (2015)
  • Author(s): 藤田知子, 廣田泰.
  • Journal Title: HORMONE FRONTIER IN GYNECOLOGY Volume: 22(3) Pages: 176-179
• [Journal Article] 種差からみた着床 ヒトとの共通点と相違点 (2015)
  • Author(s): 江頭真宏, 廣田泰.
  • Journal Title: HORMONE FRONTIER IN GYNECOLOGY Volume: 22(3) Pages: 183-189
• [Journal Article] エピジェネティック調節（DNAメチル化） (2015)
  • Author(s): 鵜木元香, 佐々木裕之
  • Journal Title: 生体の科学 66 (特集) 細胞シグナル操作法 Volume: 66 Pages: 474-475
• [Journal Article] CD133シグナルにおけるチロシンリン酸化の意義 (2015)
  • Author(s): 下里 修、永瀬浩喜、尾崎俊文
  • Journal Title: Journal of Japanese Biochemical Society Volume: 87(3) Pages: 389-392
• [Journal Article] 「哺乳動物におけるpiRNA経路を介した人為的エピゲノム制御」 (2015)
  • Author(s): 宮川さとみ
  • Journal Title: 細胞工学 Volume: 34(9) Pages: 857-861
• [Journal Article] CRISPR/Casシステムを用いた遺伝子改変マウスの作製とその応用. (2015)
  • Author(s): 野田大地，伊川正人.
  • Journal Title: 生産と技術 Volume: 67(3) Pages: 37-42
• [Journal Article] 核移植により起こるエピジェネティックなリプログラミングエラー. (2015)
  • Author(s): 井上貴美子，小倉淳郎
  • Journal Title: 細胞工学 Volume: 34(9) Pages: 873-878
• [Journal Article] 臨床ゲノム解析：Clinical Genomes (2015)
  • Author(s): 永瀬浩喜
  • Journal Title: Medical Science Digest 特集ゲノム・エピゲノム解析とがん Volume: 41(5) Pages: 21-24
• [Presentation] ヒストンのメチル化と脱メチル化による生命機能制御 (2016)
  • Author(s): 立花誠
  • Organizer: 第4回 X染色体研究会
  • Place of Presentation: 米子市
  • Year and Date: 2016-03-25
• [Presentation] Involvement of histone variants replacement in the genome remodeling after fertilization. (2016)
  • Author(s): Aoki F.
  • Organizer: Joint Symposium on Integrated Biosciences between Zhejiang University and The University of Tokyo
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2016-03-15
  • Int'l Joint Research / Invited
• [Presentation] マウス性決定のエピジェネティックな制御機構 (2016)
  • Author(s): 立花誠
  • Organizer: 広島大学大学院理学研究科 特別セミナー｢性の生物学｣
  • Place of Presentation: 東広島市
  • Year and Date: 2016-03-15
  • Invited
• [Presentation] マウス始原生殖細胞によるエピゲノムリプログラミングとその人為的制御 (2016)
  • Author(s): 関由行
  • Organizer: 第４回 応用幹細胞医科学部門セミナー
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2016-03-15
  • Invited
• [Presentation] Nuclear transfer for the study of developmental epigenetic. (2016)
  • Author(s): Ogura A
  • Organizer: International Symposium on the Future of Nuclear Transfer and Nuclear Reprogramming
  • Place of Presentation: Yamanashi, Japan
  • Year and Date: 2016-03-10
  • Int'l Joint Research / Invited
• [Presentation] ヒストンのメチル化修飾による高次生命現象の制御 (2016)
  • Author(s): 立花誠
  • Organizer: 第9回 共同利用・共同研究｢酵素学研究拠点｣シンポジウム
  • Place of Presentation: 東京都港区
  • Year and Date: 2016-03-07
• [Presentation] 遺伝子改変技術開発と生殖生物学研究への応用 (2016)
  • Author(s): 伊川正人
  • Organizer: 第４８回関西アンドロロジーカンファレンス
  • Place of Presentation: 大阪市
  • Year and Date: 2016-03-05
  • Invited
• [Presentation] Role for Polycomb group protein MBLR in repression of two-cell- and germline-specific genes in mouse ES cells. (2016)
  • Author(s): Mitsuhiro Endoh, Takaho A. Endo, Tamie Endoh, Natsumi Shimizu, Jun Shinga, Haruhiko Koseki
  • Organizer: International Symposium for RIKEN Epigenetics Program 2016
  • Place of Presentation: RIKEN, Wako, Japan
  • Year and Date: 2016-02-15 – 2016-02-16
  • Int'l Joint Research
• [Presentation] Nuclear transfer in the study of developmental epigenetic. (2016)
  • Author(s): Ogura A
  • Organizer: International Symposium for RIKEN Epigenetics Program 2016
  • Place of Presentation: Wako, Japan
  • Year and Date: 2016-02-15
  • Int'l Joint Research / Invited
• [Presentation] KRAS癌ドライバー変異アレルを標的にしたアレキル化剤の開発 (2016)
  • Author(s): 永瀬浩喜
  • Organizer: 実用化に向けたP-DIRECTアカデミア創薬シーズ発表会PART2
  • Place of Presentation: 東京都日本橋
  • Year and Date: 2016-02-09
  • Invited
• [Presentation] Endometrial regeneration in the mouse model of decellularized matrix transplantation. (2016)
  • Author(s): Takehiro Hiraoka, Yasushi Hirota.
  • Organizer: 平成２７年度「がん研究分野の特性等を踏まえた支援活動」冬期シンポジウム
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2016-02-07
  • Int'l Joint Research
• [Presentation] プロゲステロンと子宮の機能～着床から分娩まで (2016)
  • Author(s): 廣田泰
  • Organizer: 第5回プロゲスチン研究会
  • Place of Presentation: 東京都文京区
  • Year and Date: 2016-02-06
  • Invited
• [Presentation] Piwi promotes transcriptional silencing by regulating chromatin compaction (2016)
  • Author(s): Kuniaki Saito, Yuka W. Iwasaki, Kensaku Murano, Hirotsugu Ishizu, Aoi Shibuya, Yumiko Iyoda, Mikiko C. Siomi and Haruhiko Siomi
  • Organizer: Keystone Symposia. Small RNA Silencing: Little Guides, Big Biology
  • Place of Presentation: Colorado, USA
  • Year and Date: 2016-01-25
  • Int'l Joint Research / Invited
• [Presentation] マウス性決定のエピジェネティックな制御機構 (2016)
  • Author(s): 立花誠
  • Organizer: 千葉大学理学部 第10回クロマチン代謝制御セミナー
  • Place of Presentation: 千葉市
  • Year and Date: 2016-01-25
  • Invited
• [Presentation] CRISPR/Cas9 mediated genome editing in mice (2016)
  • Author(s): Ikawa M
  • Organizer: Lecture Series from Osaka University, Japan
  • Place of Presentation: Bandung, Indonesia
  • Year and Date: 2016-01-21
  • Int'l Joint Research / Invited
• [Presentation] Polycomb group protein Pcgf6 assembles an atypical PRC1 that is essential for repression of germline- and two-cell-specific genes in mouse ES cell. (2016)
  • Author(s): Mitsuhiro Endoh, Takaho A. Endo, Tamie Endoh, Jun Shinga, Haruhiko Koseki
  • Organizer: JSPS-NUS joint symposium 2016
  • Place of Presentation: National University of Singapore
  • Year and Date: 2016-01-14 – 2016-01-15
  • Int'l Joint Research
• [Presentation] Development of reproductive engineering techniques in mice. (2016)
  • Author(s): Ogura A
  • Organizer: The 3rd Symposium of Thai Society for Animal Reproduction
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2016-01-13
  • Int'l Joint Research / Invited
• [Presentation] Polycomb group protein Pcgf6 assembles an atypical PRC1 that is essential for repression of germline- and 2-cell specific genes in mouse ES cells. (2016)
  • Author(s): Mitsuhiro Endoh, Takaho A. Endo, Tamie Endoh, Jun Shinga, Haruhiko Koseki
  • Organizer: 【AMED-CRESTエピゲノム】領域会議
  • Place of Presentation: 熊本県熊本市
  • Year and Date: 2016-01-06 – 2016-01-07
  • Int'l Joint Research
• [Presentation] マウス始原生殖細胞によるエピゲノムリプログラミングとその人為的制御 (2015)
  • Author(s): 関由行
  • Organizer: 第５回 転写Clubセミナー
  • Place of Presentation: 徳島県徳島市
  • Year and Date: 2015-12-18
  • Invited
• [Presentation] 遺伝子改変技術開発と生殖生物学研究への応用 (2015)
  • Author(s): 伊川正人
  • Organizer: CVMW2015 心血管代謝週間
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-12
  • Invited
• [Presentation] ゲノムインプリンティングとDNAメチル化と小分子RNA (2015)
  • Author(s): 佐々木裕之
  • Organizer: 大阪大学蛋白質研究所セミナー エピジェネティクス－分子機構から高次機能まで－
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-12-11 – 2015-12-12
  • Invited
• [Presentation] Chemical modifications of chromatin (2015)
  • Author(s): Y. Tsukada
  • Organizer: 9th International Symposium on Nanomedicine
  • Place of Presentation: 三重県
  • Year and Date: 2015-12-10 – 2015-12-12
  • Int'l Joint Research / Invited
• [Presentation] 抗炎症・抗腫瘍化合物の実験動物モデルにおける検証 (2015)
  • Author(s): 永瀬浩喜
  • Organizer: 平成27年度金沢大学がん進展制御研究所共同利用・共同研究拠点研究成果報告会
  • Place of Presentation: 石川県金沢市
  • Year and Date: 2015-12-07
  • Invited
• [Presentation] 着床前胚においてヒストンシャペロンCAF-1 は抑制性ヒストン修飾を調節することでレトロトランスポゾン抑制に機能する (2015)
  • Author(s): 畑中勇輝，井上貴美子，及川真実，上村悟氏，越後貫成美，児玉栄一，大川恭行，束田裕一，小倉淳郎
  • Organizer: 第38回日本分子生物学会大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-05
• [Presentation] An intrinsic buffering mechanism in spermatogonial stem cells controls the timing of mouse spermatogenesis (2015)
  • Author(s): Yumiko Saga. Zhi Zhou.
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会(BMB2015)
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-03
  • Invited
• [Presentation] Functional analyses of Nanos3 in mouse spermatogenesis. (2015)
  • Author(s): Takayuki Sakurai, Yumiko Saga.
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会(BMB2015)
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-03
  • Int'l Joint Research
• [Presentation] Role of a 3’UTR-dependent suppression of Dazl in female reproduction. (2015)
  • Author(s): Kurumi Fukuda, Yuzuru Kato, Atsushi Suzuki, Yumiko Saga.
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会(BMB2015).
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-03
  • Int'l Joint Research
• [Presentation] 生殖系列の成立に重要な因子PRDM14の複合体成分の同定と機能解析 (2015)
  • Author(s): 中島絢香、岡下修己、谷直紀、中村輝、関由行
  • Organizer: 第３８回日本分子生物学会年会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-03
• [Presentation] PRDM14の分子進化解析に基づいた機能ドメインの探索 (2015)
  • Author(s): 川口真範、橋本翔太、阪下奈穂、東田将太、河村大輔、関由行
  • Organizer: 第３８回日本分子生物学会年会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-03
• [Presentation] PIポリアミド薬物複合体のMYCN遺伝子増幅難治性神経芽腫に対する革新的治療戦略への応用 (2015)
  • Author(s): 養田裕行, 高取敦志, 井上貴博, 渡部隆義, 越川信子, 尾崎俊文, 永瀬浩喜
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-03
• [Presentation] Anticancer activities of DNA-alkylating Pyrrole-Imidazole pylyamide conjugate targeting mutant KRAS (2015)
  • Author(s): 平岡桐子, 井上貴博, 養田裕行, Sakthisri Krishnamurthy, Jason Lin, 渡部隆義, 坂東俊和, 杉山弘, 尾崎敏文, 永瀬浩喜
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-03
• [Presentation] Anti-tumor efficacy and preferential localization of KR12, KRAS mutation specific alkylating agent in KRAS mutant xenografts with little to no adverse effects (2015)
  • Author(s): 井上 貴博, 平岡桐子, 養田裕行, 渡辺隆義, 高取敦志, 越川信子, 若菜茂晴, 坂東俊和,杉山弘, 尾崎俊文, 永瀬浩喜
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-03
• [Presentation] 全能性細胞で特異的に発現するKlf17の初期発生における必要性 (2015)
  • Author(s): 後藤悠比、鈴木健士、古田明日香、幸田尚、伊川正人、中村肇伸
  • Organizer: BMB2015（第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会)
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-02
  • Invited
• [Presentation] 全能性獲得の分子機構の理解へ向けて (2015)
  • Author(s): 伊川正人
  • Organizer: 第38回日本分子生物年会学会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-02
  • Invited
• [Presentation] 全能性とは？ (2015)
  • Author(s): 青木不学
  • Organizer: 第38回分子生物学会年会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-02
  • Invited
• [Presentation] ナイーブ型とプライム型多能性幹細胞を分けるエピジェネティックバリアーにおけるDNAメチル化の役割 (2015)
  • Author(s): 浦大樹、丹羽仁史、阿部訓也
  • Organizer: 第38回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-02
• [Presentation] 哺乳類着床前初期胚でおこるメチル化DNA酸化の個体発生における役割 (2015)
  • Author(s): 中島友紀, 束田裕一
  • Organizer: 日本分子生物学会第38回年会・日本分子生化学会第88回年会合同大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-02
• [Presentation] Endometrial regeneration in the mouse model of decellularized matrix transplantation. (2015)
  • Author(s): Takehiro Hiraoka, Yasushi Hirota, Tomoko Saito-Fujita, Tomoki Tanaka, Mitsunori Matsuo, Mahiro Egashira, Leona Matsumoto, Hirofumi Haraguchi, Katsuko S. Furukawa, Yutaka Osuga, Tomoyuki Fujii.
  • Organizer: 第38回日本分子生物学会年会 (BMB 2015)
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-02
  • Int'l Joint Research
• [Presentation] マウスにおける再構築刷り込みメチル化配列の活性の検証 (2015)
  • Author(s): 松﨑 仁美、倉持 大地、谷本啓司
  • Organizer: BMB2015（第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会）
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-01 – 2015-12-04
• [Presentation] 非典型的ポリコーム群MBLR複合体による減数分裂遺伝子のエピジェネティック制御. (2015)
  • Author(s): 遠藤充浩、遠藤多美枝、遠藤高帆、信賀順、古関明彦
  • Organizer: 第38回日本分子生物学会年会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-12-01 – 2015-12-04
• [Presentation] 胚性幹細胞における単アレル性発現遺伝子の由来とその転写制御 (2015)
  • Author(s): 大石裕晃，鵜木元香，福田渓，堀恭平，前之原章司，千葉初音，佐渡敬，佐々木裕之
  • Organizer: 第38回日本分子生物学会 第88回日本生化学学会合同大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-01 – 2015-12-03
• [Presentation] マウス雄性生殖細胞の発生過程ではレトロトランスポゾン制御機構は転写後調節から転写調節に切り替わる (2015)
  • Author(s): 井上晃太， 一柳健司，福田渓，Michael Glinka，佐々木裕之
  • Organizer: 第38回日本分子生物学会 第88回日本生化学学会合同大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-01 – 2015-12-03
• [Presentation] Max known as a Myc indispensable partner protein functions as a molecular blockade of meiotic entry (2015)
  • Author(s): Akihiko Okuda, Ayumu Suzuki, Masataka Hirasaki, Atsushi Ueda
  • Organizer: 第38回日本分子生物学会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-01
  • Int'l Joint Research / Invited
• [Presentation] マウスES細胞における減数分裂抑制機構の発見 (2015)
  • Author(s): 鈴木 歩、平崎正孝、上田 篤、松居靖久、奥田晶彦
  • Organizer: 第38回日本分子生物学会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-01
• [Presentation] Casein kinaseとJmjd3の真獣類発生過程における細胞での概日リズム形成における役割 (2015)
  • Author(s): 西本正純、奥田晶彦、大西芳秋
  • Organizer: 第38回日本分子生物学会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-01
• [Presentation] ヒト胚盤胞期胚の年齢による遺伝子発現変化 (2015)
  • Author(s): 高木清考、原田竜也、久保田俊郎、石野史敏、幸田尚
  • Organizer: 第38回日本分子生物学会年会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-01
• [Presentation] ヒドロキシメチルシトシンとメチルシトシンを同時解析する新たな解析技術EnIGMA法の開発 (2015)
  • Author(s): 川崎祐季、黒田友紀子、石野史敏、幸田尚
  • Organizer: 第38回日本分子生物学会年会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-01
• [Presentation] 子宮の低酸素誘導因子HIF2αは妊娠成立に必須である (2015)
  • Author(s): 松本玲央奈、廣田泰、藤田知子、原口広史、江頭真宏、松尾光徳、平岡毅大、田中智基、武田憲彦、大須賀穣、藤井知行
  • Organizer: 第33回日本受精着床学会総会・学術講演会
  • Place of Presentation: 東京都江東区
  • Year and Date: 2015-11-27
• [Presentation] 神経芽腫に対するPIポリアミドDNAアルキル化剤複合体を用いた治療戦略 (2015)
  • Author(s): 養田裕行, 高取敦志, 井上貴博, 渡部隆義, 越川信子, 尾崎俊文, 永瀬浩喜
  • Organizer: 日本小児血液・がん学会
  • Place of Presentation: 山梨県甲府市
  • Year and Date: 2015-11-27
• [Presentation] Neuroblastoma Genomic profiling of intermediate risk type of neuroblastoma without MYCN amplification (2015)
  • Author(s): 大平美紀, 中村洋子, 辰野健二, 堤修一, 山本尚吾, 永江玄太, 巽康年, 永瀬浩喜, 上條岳彦, 谷浩幸, 中川原章
  • Organizer: 日本小児血液・がん学会
  • Place of Presentation: 山梨県甲府市
  • Year and Date: 2015-11-27
• [Presentation] 全エクソーム解析を用いた小児骨肉腫肺転移に関連する体僧坊変異の検索 (2015)
  • Author(s): 岩田慎太郎, 巽康年, 米本司, 鴨田博人, 石井猛, 永瀬浩喜, 大平美紀
  • Organizer: 日本小児血液・がん学会
  • Place of Presentation: 山梨県甲府市
  • Year and Date: 2015-11-27
• [Presentation] 着床における低酸素誘導因子HIFの意義 (2015)
  • Author(s): 松本玲央奈、廣田泰、藤田知子、原口広史、江頭真宏、松尾光徳、平岡毅大、田中智基、武田憲彦、大須賀穣、藤井知行
  • Organizer: 第30回日本生殖免疫学会
  • Place of Presentation: 熊本市
  • Year and Date: 2015-11-21
• [Presentation] Incomplete reprogramming of germline DNA methylation in the human placenta (2015)
  • Author(s): Okae H, Hamada H, Toh H, Shirane K, Sasaki H, Arima T.
  • Organizer: International Human Epigenome Consortium (IHEC) Annual Meeting
  • Place of Presentation: 東京都
  • Year and Date: 2015-11-16 – 2015-11-18
  • Int'l Joint Research
• [Presentation] Pcgf6-PRC1 complexes mediate H2A ubiquitination and recruit PRC2 at meiosis-related genes dependently of transcription factors Mga/Max. (2015)
  • Author(s): Mitsuhiro Endoh
  • Organizer: IHEC 2015
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2015-11-16 – 2015-11-18
  • Int'l Joint Research
• [Presentation] 全能性細胞で特異的に発現する遺伝子群の機能解析 (2015)
  • Author(s): 中村肇伸
  • Organizer: 第33回神戸大学農学部インターゲノミクスセミナー
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-11-13
  • Invited
• [Presentation] 黄体ホルモンが調節する子宮内膜の胚受容能 (2015)
  • Author(s): 廣田泰
  • Organizer: 第6回金沢大学学際科学実験センターシンポジウム
  • Place of Presentation: 石川県金沢市
  • Year and Date: 2015-11-13
  • Invited
• [Presentation] Chemical genomics approaches to modify biological processes and pathological state (2015)
  • Author(s): Hiroki Nagase
  • Organizer: IMPC国際シンポジウム
  • Place of Presentation: 横浜市
  • Year and Date: 2015-11-12
  • Int'l Joint Research / Invited
• [Presentation] Xist / Tsix expression dynamics during mouse peri-implantation development revealed by whole-mount 3D RNA-FISH (2015)
  • Author(s): Hirosuke Shiura, Kuniya Abe
  • Organizer: 29th International Mammalian Genome Conference
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2015-11-10
  • Int'l Joint Research
• [Presentation] WNT inhibition facilitates the establishment of stable and homogeneous EpiSCs (2015)
  • Author(s): Michihiko Sugimoto, Kuniya Abe
  • Organizer: 29th International Mammalian Genome Conference
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2015-11-10
  • Int'l Joint Research
• [Presentation] Inhibition of KRAS mutant colon cancer using a novel DNA-alkylating Pyrrole-Imidazole polyamide conjugate targeting KRAS Codon12 Mutant DNA (2015)
  • Author(s): Hiroki Nagase, Kiriko Hiraoka, Takahiro Inoue, Takayoshi Watanabe, Ken-Ichi Shinohara, Nobuko Koshikawa, Ozaki Toshinori.
  • Organizer: 3rd International Conference of Federation of Asian Clinical Oncology(FACO)
  • Place of Presentation: Kyoto,Japan
  • Year and Date: 2015-10-29
  • Int'l Joint Research / Invited
• [Presentation] 癌ドライバー遺伝子を標的としたアルキル化剤 (2015)
  • Author(s): 永瀬浩喜
  • Organizer: 東京大学公衆衛生学セミナー
  • Place of Presentation: 東京都文京区
  • Year and Date: 2015-10-26
  • Invited
• [Presentation] マウス性決定のエピジェネティックな制御機構 (2015)
  • Author(s): 立花誠
  • Organizer: 湯島性分化勉強会
  • Place of Presentation: 東京都文京区
  • Year and Date: 2015-10-22
  • Invited
• [Presentation] マウス始原生殖細胞によるエピゲノムリプログラミングとその人為的制御 (2015)
  • Author(s): 関由行
  • Organizer: 第１３２回 BRCセミナー
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2015-10-20
  • Invited
• [Presentation] 半導体次世代シークエンサーによるリスク集団特異的がん関連遺伝子多型解析 (2015)
  • Author(s): 中村洋子, 丸喜明, 巽康年, 横井左奈, 大平美紀, 中村友紀, 高山喜美子, 稲田潤子, 田中尚武, 山本尚人, 鍋谷圭宏, 滝口伸浩, 植田健, 片山稔, 永瀬浩喜, 三上春夫
  • Organizer: 日本人類遺伝学会第60回大会
  • Place of Presentation: 東京都
  • Year and Date: 2015-10-14
• [Presentation] Vitamin B1栄養が卵子の質におよぼす影響 (2015)
  • Author(s): 辻 愛、中村 肇伸、柴田 克己
  • Organizer: 第54回 日本栄養・食糧学会 近畿支部大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-10-10
• [Presentation] 進行神経芽腫に対するMYCN遺伝子標的ピロールイミダゾールポリアミドDNAアルキル化剤複合体の開発 (2015)
  • Author(s): 養田裕行, 高取敦志, 井上貴博, 渡部隆義, 越川信子, 尾崎俊文, 永瀬浩喜
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] コンピリヘンシブがんパネルとイオントレントプロトン次世代シークエンサーによる千葉県ゲノムコホート解析 (2015)
  • Author(s): 中村洋子, 丸喜明,巽康年, 横井左奈, 大平美紀, 中村友紀, 高山喜美子, 稲田潤子, 片山稔, 永瀬浩喜, 三上春夫
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] Whole evome sequencingによる小児骨肉腫肺転移関連体細胞変異の検索 (2015)
  • Author(s): 巽康年, 岩田慎太郎, 米本司, 鴨田博人, 石井猛, 永瀬浩喜, 大平美紀
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] MDM2 は神経芽腫においてCHK1 阻害剤感受性に関わる生物学的因子である (2015)
  • Author(s): 安藤清宏, 中村洋子, 槇島誠, 永瀬浩喜, 中川原章
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] 11q 欠失を伴った難治性中間リスク型神経芽腫のゲノム・エピゲノム解析 (2015)
  • Author(s): 大平美紀, 中村洋子, 辰野健二, 堤修一, 山本尚吾, 永江玄太, 巽康年, 永瀬浩喜, 上條岳彦, 油谷浩幸, 中川原章
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] CRISPR/Cas システムが開く遺伝子改変マウスの未来 (2015)
  • Author(s): 伊川正人
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-09
  • Invited
• [Presentation] 小細胞肺癌様に形質転換した肺腺癌では神経内分泌分化に関連する細胞内経路が高頻度に体細胞突然変異をおこす (2015)
  • Author(s): 末永雄介, 新行内雅斗, 加藤護, 黒坂功, 大平美紀, 飯笹俊彦, 永瀬浩喜, 横井左奈
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] Bioinformatics Finding Computational Insights into Gene Regulation by Pyrrole-Imidazole Polyamide (2015)
  • Author(s): Jason Lin, 平岡桐子, 井上貴博, 養田裕行, Sakthisri Krishnamurthy, 渡辺隆義, 高取敦志, 越川信子, 井元清哉, 宮野悟, 永瀬浩喜
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] 癌ドライバー遺伝子を標的としたアルキル化ピロールイミダゾールポリアミドの合成 (2015)
  • Author(s): 渡部隆義, 高取敦志, 越川信子, 平岡桐子, 井上貴博, 養田裕行, Sakthisri Krishnamurthy, 杉山弘, 板東俊和, 永瀬浩喜
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] 皮膚有棘細胞癌の進展におけるEphB2 の役割 (2015)
  • Author(s): 藤原恭子, 永瀬浩喜, 相馬正義
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] ＲＵＮＸ2の発現抑制を介したTＡｐ63の活性化による膵臓がん細胞のゲムシタビン感受性の向上 (2015)
  • Author(s): 中村瑞代, 杉本博一, 小形武広, 下里修, 永瀬浩喜, 尾崎俊文
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] KRAS遺伝子G12DおよびG12V 変異DNA配列を標的にした大腸がん治療薬の開発 (2015)
  • Author(s): 永瀬浩喜. 平岡桐子、井上貴博、養田裕行、Krishnamurty Sakthisri、高取敦志、篠原憲一 、渡部隆義、越川信子、尾崎俊文、
  • Organizer: 第74回 日本癌学会 腫瘍別シンポジウム 1 『大腸がんにおける標的分子と治療開発』
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-08
  • Invited
• [Presentation] KRAS遺伝子変異大腸がん細胞においてKR12は合成致死性遺伝子を標的とし殺細胞効果を示す (2015)
  • Author(s): 高取敦志, 平岡桐子, Sakthisri Krishnamurthy, 養田裕行, 渡部隆義, 越川信子, 永瀬浩喜
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-08
• [Presentation] Development of novel anticancer drugs targeting PIK3CA gene mutation for cervical cancer (2015)
  • Author(s): Sakthisri Krishnamurthy, 高取敦志, 養田裕行, 平岡桐子, 井上貴博, 渡辺隆義, 越川信子, 永瀬浩喜
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-08
• [Presentation] NLRR2 is involved in neuronal survival and differentiation through JNK pathway in neuroblastoma (2015)
  • Author(s): Afzal Sheikh, 高取敦志, Md. Shamim Hossain, Md. Kamrul Hasan, 尾崎俊文, 永瀬浩喜, 田川雅敏, 中川原章
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] KR12, KRAS mutation specific alkylating agent inhibits tumor growth by showing accumulation in KRAS mutant xenografts (2015)
  • Author(s): 井上 貴博, 平岡桐子, 養田裕行, 渡辺隆義, 高取敦志, 越川信子, 坂東俊和, 杉山弘,尾崎俊文, 永瀬浩喜
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] 新規アルキル化剤: ピロールイミダゾールポリアミド複合体による変異型 KRAS の発現抑制 (2015)
  • Author(s): 平岡 桐子, 井上貴博, 養田裕行, Sakthisri Krishnamurthy, Lin Jason, 渡辺隆義, 越川信子, 高取敦志, 尾崎俊文, 永瀬浩喜
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] HCV 陽性肝細胞癌におけるDgcr2 遺伝子発現の検討 (2015)
  • Author(s): 高木恵子, 高山忠利, 吉田直樹, 藤原恭子, 相馬正義, 永瀬浩喜
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] 千葉県がんセンターバイオバンクの取り組み (2015)
  • Author(s): 永瀬 浩喜
  • Organizer: 第1回クリニカルバイオバンク研究会
  • Place of Presentation: 岡山市
  • Year and Date: 2015-10-04
  • Invited
• [Presentation] ゲノム編集が変えた遺伝子改変動物の作製 (2015)
  • Author(s): 伊川正人
  • Organizer: 日経バイオテク プロフェッショナルセミナー
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2015-10-02
  • Invited
• [Presentation] EpiSC樹立におけるWntシグナル抑制の効果 (2015)
  • Author(s): 杉本道彦、近藤昌代、古賀裕美子、池田理恵子、Susana M. Chuva de Sousa Lopes、阿部訓也
  • Organizer: 日本遺伝学会第87回大会
  • Place of Presentation: 仙台市
  • Year and Date: 2015-09-26
• [Presentation] ナイーブ型とプライム型を分けるエピジェネティックバリアーにおけるDNAメチル化の役割 (2015)
  • Author(s): 浦大樹、阿部訓也、丹羽仁史
  • Organizer: 日本遺伝学会第87回大会
  • Place of Presentation: 仙台市
  • Year and Date: 2015-09-25
• [Presentation] 熱ショックタンパク質はマウス雄性生殖細胞においてレトロトランスポゾンを制御する (2015)
  • Author(s): 一柳健司，一柳朋子，小川阿弥子，宮川さとみ，仲野徹，中馬新一郎，佐々木裕之，鵜殿平一郎
  • Organizer: 日本遺伝学会第87回大会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2015-09-24 – 2015-09-26
• [Presentation] Danforth's short tail (Sd) 変異はトランスポゾン挿入によって引き起こされたPtf1a遺伝子の異所性発現が原因である (2015)
  • Author(s): 荒木喜美、仙波圭、中原舞、阿部訓也、荒木正健、山村研一
  • Organizer: 日本遺伝学会第87回大会
  • Place of Presentation: 仙台市
  • Year and Date: 2015-09-24
• [Presentation] Germline Stem (GS)細胞の精子形成能獲得に必要な遺伝子の探索 (2015)
  • Author(s): 鈴木伸之介、池田理恵子、浦大樹、佐藤卓也、小川毅彦、阿部訓也
  • Organizer: 第108回日本繁殖生物学会大会
  • Place of Presentation: 宮崎県
  • Year and Date: 2015-09-18
• [Presentation] 胎盤形成過程におけるSfmbt2 マイクロ（mi）RNAクラスターの役割の解明 (2015)
  • Author(s): 井上貴美子，廣瀬美智子，畑中勇輝，井上弘貴，本多新，長谷川歩未，持田慶司，小倉淳郎
  • Organizer: 第108回日本繁殖生物学会総会
  • Place of Presentation: 宮崎県宮崎市
  • Year and Date: 2015-09-18
• [Presentation] H2B-eGFP+H2B-mCherryダブルTGマウスを用いたFRET法の開発およびその初期胚クロマチン動態解析への試み (2015)
  • Author(s): 井上弘貴, 種村健太郎，小倉淳郎
  • Organizer: 第108回日本繁殖生物学会総会
  • Place of Presentation: 宮崎県宮崎市
  • Year and Date: 2015-09-18
• [Presentation] マウス着床前胚におけるレトロトランスポゾン抑制機構の解明 (2015)
  • Author(s): 畑中勇輝，井上貴美子，及川真実，上村悟氏，越後貫成美，児玉栄一，大川恭行，束田裕一，小倉淳郎
  • Organizer: 第108回日本繁殖生物学会総会
  • Place of Presentation: 宮崎県宮崎市
  • Year and Date: 2015-09-18
• [Presentation] 日本産野生由来MSM a (nonagouti) ノックアウトマウスの作出とその表現型解析 (2015)
  • Author(s): 廣瀬美智子，長谷川歩未，持田慶司，畑中勇輝，本多新，金田秀貴，山田郁子，古瀬民生，阿部訓也，若菜茂晴，小倉淳郎
  • Organizer: 第108回日本繁殖生物学会総会
  • Place of Presentation: 宮崎県宮崎市
  • Year and Date: 2015-09-18
• [Presentation] Intrinsic regulation of the timing of gonocytes-to spermatogonia transition in the murine testes by an RNA-binding Protein NANOS2. (2015)
  • Author(s): Han Pin Pui and Yumiko Saga.
  • Organizer: Mouse Molecular Genetics
  • Place of Presentation: Hinxton,Cambridge,UK
  • Year and Date: 2015-09-16 – 2015-09-19
  • Int'l Joint Research
• [Presentation] De novo DNA methylation mediated by 5’ portion of the H19 ICR is essential for maintaining its methylation imprintduring early embryogenesis in mice (2015)
  • Author(s): Tanimoto K, Matsuzaki H, Okamura E, Ushiki A, Takahashi T.
  • Organizer: 28th Mouse Molecular Genetics Conference
  • Place of Presentation: Hinxton, Cambridge, UK
  • Year and Date: 2015-09-16 – 2015-09-19
  • Int'l Joint Research
• [Presentation] 生殖細胞の性分化決定機構「精子と卵子のわかれめ」 (2015)
  • Author(s): 相賀裕美子
  • Organizer: 第9回家畜DNA西郷シンポジウム
  • Place of Presentation: 福島市
  • Year and Date: 2015-09-16
• [Presentation] Critical functions of totipotent-cell specific genes Klf17 and Btg4 in zygotic reprogramming (2015)
  • Author(s): Kenji Suzuki, Yui Goto, Asuka Furuta, Takashi Kohda, Masahito Ikawa, Toshinobu Nakamura
  • Organizer: The 40th Naito Conference EpigeneticsーFrom Histone Code to Therapeutic Strategy
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-09-16
  • Int'l Joint Research
• [Presentation] Genomic imprinting, DNA methylation and small RNA in mouse germ cells (2015)
  • Author(s): Sasaki H.
  • Organizer: The 40th Naito Conference on Epigenetics－From Histone Code to Therapeutic Strategy
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-09-15 – 2015-09-18
  • Int'l Joint Research / Invited
• [Presentation] Sex determination of mouse germ cells. (2015)
  • Author(s): Yumiko Saga.
  • Organizer: Seminar in Francis Crick Institute.
  • Place of Presentation: London
  • Year and Date: 2015-09-15
  • Int'l Joint Research / Invited
• [Presentation] CRISPR/Cas mediated genome ediAng in mice and its applicaAon for the study of reproduction (2015)
  • Author(s): Ikawa M
  • Organizer: ISCA 2015
  • Place of Presentation: Dublin, Ireland
  • Year and Date: 2015-09-08
  • Int'l Joint Research / Invited
• [Presentation] The presence of ovarian hormone-independent endometrial epithelial growth in endometrial remodeling and regeneration. (2015)
  • Author(s): Takehiro Hiraoka, Yasushi Hirota
  • Organizer: The Second International Meeting for Epithelial Tubulology
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2015-08-22
  • Int'l Joint Research / Invited
• [Presentation] CRISPR/Cas9 システムを用いたマウスゲノム編集 (2015)
  • Author(s): 伊川正人
  • Organizer: 第7回遺伝子組換え実験安全研修会 ～ゲノム編集技術の進展と課題～
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2015-08-01
  • Invited
• [Presentation] マウスの発生過程におけるエピジェネティックな遺伝子発現制御機構の役 割 (2015)
  • Author(s): 立花誠
  • Organizer: 富山県立大学生物工学科 研究セミナー
  • Place of Presentation: 射水市
  • Year and Date: 2015-07-29
  • Invited
• [Presentation] 全能性細胞で高発現するBtg4の初期発生における必要性 (2015)
  • Author(s): 鈴木 健士、後藤 悠比、古田 明日香、伊川 正人、中村 肇伸
  • Organizer: 文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第3回若手勉強会
  • Place of Presentation: 静岡県伊豆市
  • Year and Date: 2015-07-23
• [Presentation] 初期胚のクロマチン再構成におけるヒストンシャペロンの役割 ～DNA脱メチル化制御因子Stella欠損胚をモデルとして～ (2015)
  • Author(s): 荒川 達彦、中谷 庸寿、小田 昌朗、木村 康義、関田 洋一、木村 透、中村 肇伸、仲野 徹
  • Organizer: 文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第3回若手勉強会
  • Place of Presentation: 静岡県伊豆市
  • Year and Date: 2015-07-23
• [Presentation] ヒト初期発生過程におけるインプリンティング制御 (2015)
  • Author(s): 岡江寛明
  • Organizer: 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」若手勉強会
  • Place of Presentation: 静岡県
  • Year and Date: 2015-07-22 – 2015-07-24
• [Presentation] ポリコーム群MBLR複合体による減数分裂遺伝子の転写制御 (2015)
  • Author(s): 遠藤充浩
  • Organizer: 生殖エピゲノム若手勉強会2015
  • Place of Presentation: 静岡県伊豆市
  • Year and Date: 2015-07-22 – 2015-07-24
• [Presentation] Transcriptional and post-transcriptional regulation of retrotransposons in developing male germ cells in mice (2015)
  • Author(s): 井上晃太，一柳健司，福田渓，Michael Glinka，佐々木裕之
  • Organizer: 2015年度 新学術領域生殖エピゲノム若手勉強会
  • Place of Presentation: 静岡県三島市
  • Year and Date: 2015-07-22 – 2015-07-24
• [Presentation] ヒストンメチル化によるほ乳類の発生制御 (2015)
  • Author(s): 立花誠
  • Organizer: 東京工業大学大学院生命理工学研究科 研究セミナー
  • Place of Presentation: 横浜市
  • Year and Date: 2015-07-15
  • Invited
• [Presentation] 化学物質によるゲノムへの介入―疾患（がん）治療への試み (2015)
  • Author(s): 永瀬浩喜
  • Organizer: 第29回 モロシヌス研究会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-07-04
  • Invited
• [Presentation] ヒストンメチル化・脱メチル化によるほ乳類の発生・分化の制御 (2015)
  • Author(s): 立花誠
  • Organizer: 北海道大学生命科学院 生命融合科学コース 研究セミナー
  • Place of Presentation: 札幌市
  • Year and Date: 2015-06-26
  • Invited
• [Presentation] A Simple and Robust Method for Establishing Homogeneous Mouse Epiblast Stem Cell Lines by WNT Inhibition (2015)
  • Author(s): Kuniya Abe, Michihiko Sugimoto, Masayo Kondo, Yumiko Koga, Hirosuke Shiura, Susana M. Chuva de Sousa Lopes
  • Organizer: International Society for Stem Cell Research 2015 Annual Meeting
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2015-06-26
  • Int'l Joint Research
• [Presentation] バイオマーカーと遺伝子 変異型KRAS遺伝子を標的とした塩基配列特異的アルキル化剤の大腸癌細胞における抗腫瘍効果 (2015)
  • Author(s): 平岡桐子, 井上貴博, 養田裕行, Sakthisri Krishnamurthy, 高取敦志, 篠原憲一, 渡部隆義, 越川信子, 尾崎俊文, 永瀬浩喜
  • Organizer: 第24回日本癌病態治療研究会
  • Place of Presentation: 栃木県日光市
  • Year and Date: 2015-06-26
• [Presentation] 変異型KRASを標的としたピロールイミダゾールポリアミドのヒト大腸癌異種移植モデルでの効果 (2015)
  • Author(s): 井上貴博, 平岡桐子, 鈴木有性, 養田裕行, 渡部隆義, 高取敦志, 越川信子, 尾崎俊文,永瀬浩喜
  • Organizer: 第24回日本癌病態治療研究会
  • Place of Presentation: 栃木県日光市
  • Year and Date: 2015-06-25
• [Presentation] CRISPR/Cas-Mediated Genome Editing in Mice and Its Application for the Study of Reproduction (2015)
  • Author(s): Ikawa M
  • Organizer: SSR 2015 Annual Meeting
  • Place of Presentation: San Juan, Puerto Rico, USA
  • Year and Date: 2015-06-21
  • Int'l Joint Research / Invited
• [Presentation] The grant system in Japan and advice for applicants (2015)
  • Author(s): Ikawa M
  • Organizer: SSR 2015 Annual Meeting
  • Place of Presentation: San Juan, Puerto Rico, USA
  • Year and Date: 2015-06-19
  • Int'l Joint Research / Invited
• [Presentation] Crucial role of hypoxia inducible factor 2α in the pregnant uterus. (2015)
  • Author(s): Leona Matsumoto, Yasushi Hirota, Tomoko Saito-Fujita, Hirofumi Haraguchi, Mahiro Egashira, Mitsunori Matsuo, Takehiro Hiraoka, Kaori Koga, Sudhansu K. Dey, Tomoyuki Fujii, Yutaka Osuga.
  • Organizer: 31st ESHRE Annual Meeting
  • Place of Presentation: Portugal, Lisbon
  • Year and Date: 2015-06-15
  • Int'l Joint Research
• [Presentation] Transcriptional and post-transcriptional regulation of retrotransposons in developing male germ cells in mice (2015)
  • Author(s): Inoue, K., Ichiyanagi, K., Fukuda, K., Glinka M. & Sasaki, H.
  • Organizer: Federation of American Societies for Experimental Biology (FASEB) International Science Research Conferences “Mobile DNA in Mammalian Genomes”
  • Place of Presentation: Florida, USA
  • Year and Date: 2015-06-14 – 2015-06-19
  • Int'l Joint Research
• [Presentation] 卵細胞質とエピジェネティクス (2015)
  • Author(s): 佐々木裕之
  • Organizer: 第21回セント・ルカセミナー／第3回大分がん・生殖医療研究会
  • Place of Presentation: 大分県大分市
  • Year and Date: 2015-06-14
  • Invited
• [Presentation] KRASコドン12変異を標的としたDNAアルキル化 (2015)
  • Author(s): 永瀬浩喜
  • Organizer: 日本がん分子標的治療学会第19回学術集会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2015-06-11
• [Presentation] iPS細胞技術を用いたヒト免疫細胞への低線量放射線影響の研究 (2015)
  • Author(s): 遠藤充浩、遠藤多美枝、古関明彦、稲葉俊哉、神谷研二
  • Organizer: 第56回原子爆弾後障害研究会
  • Place of Presentation: 広島県広島市
  • Year and Date: 2015-06-07
  • Invited
• [Presentation] tw5遺伝子とマウス初期発生：t－コンプレックスの発生遺伝学 (2015)
  • Author(s): Kuniya Abe, Karen Artzt, Michihiko Sugimoto
  • Organizer: 日本発生生物学会第48回年会 シンポジウム
  • Place of Presentation: つくば市
  • Year and Date: 2015-06-05
  • Invited
• [Presentation] A simple and robust method for establishing homogeneous mouse EpiSC lines by Wnt inhibition (2015)
  • Author(s): Michihiko Sugimoto, Masayo Kondo, Yumiko Koga, Hirosuke Shiura, Rieko Ikeda, Susana Chuva de Sousa Lopes, Kuniya Abe
  • Organizer: 日本発生生物学会第48回年会
  • Place of Presentation: つくば市
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] Functional analyses of Nanos3 in mouse spermatogenesis. (2015)
  • Author(s): Takayuki Sakurai, Yumiko Saga.
  • Organizer: 第48回日本発生生物学会年会.
  • Place of Presentation: 筑波
  • Year and Date: 2015-06-02 – 2015-06-05
  • Int'l Joint Research
• [Presentation] piRNA in germ cell development. (2015)
  • Author(s): Shinichiro Chuma.
  • Organizer: "germinal stem cell biology" Gordon Research Conference
  • Place of Presentation: Hong Kong
  • Year and Date: 2015-05-31 – 2015-06-05
  • Int'l Joint Research / Invited
• [Presentation] Sp1/3 sustain self-renewal of embryonic stem cell through regulating core Klf circuitry (2015)
  • Author(s): Hiroki Ura
  • Organizer: 第13回 幹細胞シンポジウム
  • Place of Presentation: 東京都
  • Year and Date: 2015-05-29
  • Int'l Joint Research
• [Presentation] 卵胞成熟過程におけるエピジェネティックな転写調節機構の解析 (2015)
  • Author(s): 鈴木仁美、Aleksandar Rajkovic、金井正美
  • Organizer: 第62回日本実験動物学会総会、
  • Place of Presentation: 京都市
  • Year and Date: 2015-05-28 – 2015-05-30
• [Presentation] Comparison of ovary- and testis-derived piRNAs reveals gender-specific piRNA clusters in Syrian hamster (2015)
  • Author(s): Kuniaki Saito, Naomi Seki, Marie Tsuchiya, Takamasa Hirano, Yuka W. Iwasaki, Mikiko C. Siomi and Haruhiko Siomi
  • Organizer: The Twentieth Annual Meeting of the RNA Society
  • Place of Presentation: Madison, USA
  • Year and Date: 2015-05-28
  • Int'l Joint Research
• [Presentation] Analysis of the effect of low-dose radiation on anti-tumor immune responses using human iPS cell technology. (2015)
  • Author(s): Mitsuhiro Endoh, Tamie Endoh, Haruhiko Koseki, Toshiya Inaba, Kenji Kamiya
  • Organizer: 15th International Congress of Radiation Research (ICRR2015)
  • Place of Presentation: Kyoto
  • Year and Date: 2015-05-25 – 2015-05-29
  • Int'l Joint Research
• [Presentation] Reconstitution of a differentially methylated region (2015)
  • Author(s): 松﨑仁美、谷本啓司
  • Organizer: 第９回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都
  • Year and Date: 2015-05-25 – 2015-05-26
  • Int'l Joint Research
• [Presentation] マウス性決定のエピジェネティックな制御機構 (2015)
  • Author(s): 立花誠
  • Organizer: 日本エピジェネティクス研究会第9回年会
  • Place of Presentation: 東京都
  • Year and Date: 2015-05-25
• [Presentation] PRDM14による能動的脱メチル化を介した多能性獲得機構の解明 (2015)
  • Author(s): 関由行
  • Organizer: 第９回 日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都
  • Year and Date: 2015-05-25
  • Invited
• [Presentation] ショウジョウバエPiwi-piRNA複合体によるクロマチン制御機構 (2015)
  • Author(s): 齋藤都暁
  • Organizer: 第9回日本エピジェネティクス研究会
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2015-05-25
  • Invited
• [Presentation] ホールマウントRNA-FISHによるマウス着床期におけるXist/Tsix発現動態解析 (2015)
  • Author(s): 志浦寛相、阿部訓也
  • Organizer: 第9回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都
  • Year and Date: 2015-05-25
• [Presentation] 分化能の異なる２つの多能性状態における転写因子とDNAメチル化の関係について (2015)
  • Author(s): 浦大樹、阿部訓也
  • Organizer: 第9回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都
  • Year and Date: 2015-05-25
• [Presentation] マウス受精卵におけるStellaの雌性ゲノム保護とその初期胚発生への重要性 (2015)
  • Author(s): 中谷 庸寿、山縣 一夫、木村 透、小田 昌朗、中島 啓行、堀 真由子、関田 洋一、荒川 達彦、中村 肇伸、仲野 徹
  • Organizer: 第9回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都
  • Year and Date: 2015-05-25
• [Presentation] 黄体ホルモンによる妊娠成立・維持のしくみ (2015)
  • Author(s): 廣田泰
  • Organizer: 第38回東京成長ホルモン成長因子セミナー
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2015-05-22
  • Invited
• [Presentation] ヒドロキシメチルシトシンとメチルシトシンを同時解析する新たな解析技術EnIGMA法の開発 (2015)
  • Author(s): 川崎祐季、黒田友紀子、石野史敏、幸田尚
  • Organizer: 第９回日本エピジェネティクス研究会年会
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2015-05-15
• [Presentation] Biotin-deficient diet induces abnormal oocyte in mouse (2015)
  • Author(s): Ai Tsuji, Toshinobu Nakamura, Katsumi Shibata
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] DNA methylation dynamics and regulation of genomic imprinting during human development (2015)
  • Author(s): Okae H, Hamada H, Chiba H, Arima T.
  • Organizer: EMBO Workshop Embryonic Extraembryonic Interfaces
  • Place of Presentation: Germany
  • Year and Date: 2015-05-06 – 2015-05-09
  • Int'l Joint Research
• [Presentation] 遺伝子改変動物が導く受精メカニズムの新論争 (2015)
  • Author(s): 伊川正人
  • Organizer: 第60回日本生殖医学会学術講演会
  • Place of Presentation: 横浜市
  • Year and Date: 2015-04-27
  • Invited
• [Presentation] 子宮におけるプロゲステロン受容体シグナルと着床 (2015)
  • Author(s): 廣田泰
  • Organizer: 第60回日本生殖医学会学術講演会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2015-04-27
  • Invited
• [Presentation] The presence of cellular senescence and its possible roles in the postpartum uterus. (2015)
  • Author(s): Mahiro Egashira, Yasushi Hirota, Tomoko Saito-Fujita, Hirofumi Haraguchi, Leona Matsumoto, Mitsunori Matsuo, Takehiro Hiraoka, Yutaka Osuga, Tomoyuki Fujii.
  • Organizer: IFFS/JSRM International Meeting 2015
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2015-04-26
  • Int'l Joint Research
• [Presentation] MicroRNA controls receptivity to the embryo by regulating progesterone signaling in the cervix and uterus. (2015)
  • Author(s): Hirofumi Haraguchi, Yasushi Hirota, Tomoko Saito-Fujita, Mahiro Egashira, Leona Matsumoto, Mitsunori Matsuo, Takehiro Hiraoka, Kaori Koga, Sudhansu K. Dey, Yutaka Osuga, Tomoyuki Fujii.
  • Organizer: IFFS/JSRM International Meeting 2015
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2015-04-26
  • Int'l Joint Research
• [Presentation] Tumor accumulation of a novel alkylating pyrrole-imidazole polyamide (KR12) targeting KRAS codon 12 mutations in murine xenograft models of human colon cancer (2015)
  • Author(s): Takahiro Inoue, Kiriko Hiraoka, Yusei Suzuki, Hiroyuki Yoda, Takayoshi Watanabe, Atsushi Takatori, Nobuko Koshikawa, Toshinori Ozaki, Hiroki Nagase
  • Organizer: AACR American Association for Cancer Research ANUAL MEETING 2015 ミニシンポジウム“Exploiting the MAPK pathway in cancer”
  • Place of Presentation: Philadelphia , USA
  • Year and Date: 2015-04-18 – 2015-04-22
  • Int'l Joint Research / Invited
• [Presentation] A novel alkylating pyrrole-imidazole polyamide, KR12, specifically recognizes mutant KRAS genes and potently induces cell death (2015)
  • Author(s): Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Atsushi Takatori, Takayoshi Watanabe, Nobuko Koshikawa, Toshinori Ozaki, Hiroki Nagase.
  • Organizer: AACR American Association for Cancer Research ANUAL MEETING 2015 ミニシンポジウム“Exploiting the MAPK pathway in cancer”
  • Place of Presentation: Philadelphia , USA
  • Year and Date: 2015-04-18 – 2015-04-22
  • Int'l Joint Research / Invited
• [Presentation] The mechanism of sex determination of mouse germ cells. (2015)
  • Author(s): Yumiko Saga.
  • Organizer: Seventh international symposium on the biology of vertebrate sex determination.
  • Place of Presentation: Hawaii
  • Year and Date: 2015-04-13 – 2015-04-17
  • Int'l Joint Research / Invited
• [Book] 図書バイオテクノロジー入門 (2016)
  • Author(s): 高畑京也・蔡晃植・齊藤修 編著 今村綾・宇佐美昭二・尾山廣・数岡孝幸・河内浩行・佐々壽浩・髙村岳樹・田中直子・永井信夫・仲亀誠司・中村肇伸・徳田宏晴・殿山泰弘・濱田博喜・室伏誠・若生豊 共著
  • Total Pages: 168
  • Publisher: 建帛社
• [Book] Stella and zygotic reprogramming. (2015)
  • Author(s): Nakamura T ,Nakano T.
  • Total Pages: 230
  • Publisher: Springer
• [Book] 進化するゲノム編集技術 (2015)
  • Author(s): 宮田治彦, 伊川正人.
  • Total Pages: 386
  • Publisher: 株式会社エヌ・ティー・エス
• [Patent(Industrial Property Rights)] 化合物またはその塩および医薬組成物 (2016)
  • Inventor(s): 森下 和広、兼田 加珠子、齋藤 祐介、永瀬 浩喜
  • Industrial Property Rights Holder: 森下 和広、兼田 加珠子、齋藤 祐介、永瀬 浩喜
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2015-58868
  • Filing Date: 2016-03-23
• [Patent(Industrial Property Rights)] ピロールイミダゾール含有ポリアミドを用いた標的二本鎖核酸分子の濃縮方法およびキット (2015)
  • Inventor(s): 永瀬 浩喜、塚本 圭、北野 史朗
  • Industrial Property Rights Holder: 永瀬 浩喜、塚本 圭、北野 史朗
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2015-20059
  • Filing Date: 2015-10-08
• [Funded Workshop] Joint Symposium on Integrated Biosciences between Zhejiang University and The University of Tokyo (2016)
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2016-03-15 – 2016-03-16
• [Funded Workshop] International symposium on epigenome dynamics and regulation in germ cells (2016)
  • Place of Presentation: 京都大学
  • Year and Date: 2016-02-17 – 2016-02-19
• [Funded Workshop] 第106回生命機能研究科コロキウム (2016)
  • Place of Presentation: 大阪府
  • Year and Date: 2016-02-03 – 2016-02-03
• [Funded Workshop] 大阪大学蛋白質研究所セミナー「エピジェネティクス―分子機構から高次機能まで－」 (2015)
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-12-11 – 2015-12-12
• [Funded Workshop] BMB2015（第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会） (2015)
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-02 – 2015-12-03
• [Funded Workshop] BMB2015『Nuclear non-coding RNA architecture for physiological functions』 (2015)
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-12-02 – 2015-12-03
• [Funded Workshop] Mouse Molecular Genetics 2015 (2015)
  • Place of Presentation: Hinxton, UK
  • Year and Date: 2015-09-16 – 2015-09-19
• [Funded Workshop] 第40回内藤カンファレンス「Epigenetics－From Histone Code to Therapeutic Strategy」 (2015)
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2015-09-15 – 2015-09-18
• [Funded Workshop] 生殖エピゲノム若手勉強会2015 (2015)
  • Place of Presentation: 静岡県伊豆市
  • Year and Date: 2015-07-22 – 2015-07-24