Regulation of epigenome dynamics and regulation in germ cells

2017 Fiscal Year Annual Research Report

• Project Area: Analyses and regulation of germline epigenome
• Project/Area Number: 25112001
• Research Institution: Kyoto University
• Principal Investigator: 篠原 隆司 京都大学, 医学研究科, 教授 (30322770)
• Co-Investigator(Kenkyū-buntansha): 伊川 正人 大阪大学, 微生物病研究所, 教授 (20304066)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: エピゲノム / 生殖細胞

Outline of Annual Research Achievements

一昨年度に行われた中間評価において研究分野が近い他の新学術領域研究との連携を期待したいとのコメントを受け、本年度は「ステムセルエイジングから解明する疾患原理」（幹細胞エイジング班）班に加えて、「動的クロマチン構造と機能」（クロマチン動構造班）班も合わせた3つの新学術領域合同の若手勉強会を開催した。2017年6月7日から9日まで和歌山県白浜温泉にて行われた。若手合宿には3領域の代表が全員参加し、合計93名の参加があった。2領域だけの合同班会議だった昨年よりもさらにトピックが幅広い会議であったが、関連している領域であるため非常に活発な議論が行われた。参加者全員による投票で選ばれるベストプレゼン賞は例年より1名多い3名に授与された。合宿での会議に加えて、国際支援班の支援のもと海外からも7名の研究者が訪れた。中でもDirk de Rooij博士（オランダUtrecht大）は、研究内容が近い「動物における配偶子生産システムの制御」（配偶子産生制御班）班の中の特に精子形成を研究対象とするメンバーとも研究打ち合わせを行い、領域間の交流に貢献した。さらに同じく国際支援班の支援により来日した柳町隆造博士（米Hawaii大）と共に公開シンポジウムにも参加され、両博士から領域に対するアドバイスも多く頂いた。公開シンポジウムの際に開かれた総括班会議では、これまでの研究成果についての反省や今後の展望について関連分野との連携の可能性など外部評価者からのアドバイスを加えて取りまとめについての意見交換が行われた。また分担研究者の伊川の所属する大阪大学とMartin Matzukの所属する米ベイラー医科大の間には部局間学術交流協定書が交わされた。

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] University of Texas/University of Hawaii/University of Pittsuburgh(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: University of Texas/University of Hawaii/University of Pittsuburgh
  • # of Other Institutions: 3
• [Int'l Joint Research] Utrecht University/ライデン大学 医学センター(オランダ)
  • Country Name: NETHERLANDS
  • Counterpart Institution: Utrecht University/ライデン大学 医学センター
• [Int'l Joint Research] McGill University/カナダ・ブリティッシュコロンビア大学(カナダ)
  • Country Name: CANADA
  • Counterpart Institution: McGill University/カナダ・ブリティッシュコロンビア大学
• [Int'l Joint Research] Teramo University(イタリア)
  • Country Name: ITALY
  • Counterpart Institution: Teramo University
• [Int'l Joint Research] Institute of Moleculer Genetics/チェコ科学アカデミー(チェコ)
  • Country Name: CZECH
  • Counterpart Institution: Institute of Moleculer Genetics/チェコ科学アカデミー
• [Int'l Joint Research]
  • # of Other Countries: 5
• [Journal Article] NANOS2 acts as an intrinsic regulator of gonocytes-to-spermatogonia transition in the murine testes. (2018)
  • Author(s): Pui HP, Saga Y.
  • Journal Title: Mech Dev Volume: 149 Pages: 27-40
  • DOI: 10.1016/j.mod.2018.01.001. Epub 2018 Jan 12.
  • Peer Reviewed
• [Journal Article] In vivo genetic manipulation of male germline stem cells and their microenvironment by adeno-associated viruses. (2018)
  • Author(s): Watanabe S, Kanatsu-Shinohara M, Ogonuki N, Matoba S, Ogura A, Shinohara T.
  • Journal Title: Stem Cell Reports Volume: - Pages: -
  • Peer Reviewed / Open Access
• [Journal Article] Nonrandom contribution of left and right testes to gremline transmission from mouse spermatogonial stem cells. (2018)
  • Author(s): Kanatsu-Shinohara M, Naoki H, Shinohara T..
  • Journal Title: Biol Reprod Volume: 97(6) Pages: 902-910
  • Peer Reviewed / Open Access
• [Journal Article] Mouse GTSF1 is an essential factor for secondary piRNA biogenesis. (2018)
  • Author(s): Yoshimura T, Watanabe T, Kuramochi-Miyagawa S, Takemoto N, Shiromoto Y, Kudo A, Kanai-Azuma M, Tashiro F, Miyazaki S, Katanaya A, Chuma S, Miyazaki JI.
  • Journal Title: EMBO Rep Volume: - Pages: -
  • DOI: 10.15252/embr.201642054.
  • Peer Reviewed
• [Journal Article] Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice (2018)
  • Author(s): Nozawa K, Satouh Y, Fujimoto T, Oji A, Ikawa M.
  • Journal Title: Sci. Rep Volume: 8 Pages: 1315
  • Peer Reviewed / Open Access
• [Journal Article] Oocyte-activating capacity of fresh and frozen-thawed spermatids in the common marmoset (Callithrix jacchus). (2018)
  • Author(s): Ogonuki N, Inoue H, Matoba S, Kurotaki YK, Kassai H, Abe Y, Sasaki E, Aiba A, Ogura A
  • Journal Title: Mol Reprod Dev Volume: - Pages: -
  • DOI: 10.1002/mrd.22971.
  • Peer Reviewed / Open Access
• [Journal Article] Identification of quantitative trait loci associated with the susceptibility of mouse spermatozoa to cryopreservation. (2018)
  • Author(s): Liu J, Mochida K, Hasegawa A, Inoue K, Ogura A.
  • Journal Title: J Reprod Dev Volume: - Pages: -
  • DOI: 10.1262/jrd.2017-148.
  • Peer Reviewed / Open Access
• [Journal Article] Parental age and gene expression profiles in individual human blastocysts. (2018)
  • Author(s): Kawai K, Harada T, Ishikawa T, Sugiyama R, Kawamura T, Yoshida A, Tsutsumi O, Ishino F, Kubota T, Kohda T.
  • Journal Title: Sci Rep Volume: 8(1) Pages: 2380
  • DOI: 10.1038/s41598-018-20614-8.
  • Peer Reviewed / Open Access
• [Journal Article] Combined loss of Jmjd1a and Jmjd1b reveals critical roles for H3K9 demethylation in the maintenance of embryonic stem cells and early embryogenesis. (2018)
  • Author(s): Kuroki S, Nakai Y, Maeda R, Okashita N, Akiyoshi M, Yamaguchi Y, Kitano S, Miyachi S, Nakato R, Ichiyanagi K, Shirahige K, Kimura H, Shinkai Y, Tachibana M.
  • Journal Title: Stem Cell Reports Volume: 18 Pages: S2213-6711
  • Peer Reviewed / Open Access
• [Journal Article] Cell Type-Specific Survey of Epigenetic Modifications by Tandem Chromatin Immunoprecipitation Sequencing (2018)
  • Author(s): Mito M, Kadota M, Tanaka K, Furuta Y, Abe K, Iwasaki S, Nakagawa S.
  • Journal Title: Sci Rep Volume: 8(1) Pages: 1143
  • Peer Reviewed / Open Access
• [Journal Article] SCPortalen: human and mouse single-cell centric database (2018)
  • Author(s): Abugessaisa I, Noguchi S, Bottcher M, Hasegawa A, Kouno T, Kato S, Tada Y, Ura H, Abe K, Shin JW, Plessy C, Carninci P, Kasukawa T.
  • Journal Title: Nucleic Acids Res Volume: 46(D1) Pages: D781-D787
  • Peer Reviewed / Open Access
• [Journal Article] “A simplified and efficient protocol for derivation and maintenance of high-quality mouse primed pluripotent stem cells using Wnt inhibition” Current Protocols in Stem (2018)
  • Author(s): Kondo M, Sugimoto M, Abe K.
  • Journal Title: Cell Biology in press Volume: - Pages: -
  • Peer Reviewed
• [Journal Article] Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs. (2018)
  • Author(s): Ikeda T, Hikichi T, Miura H, Shibata H, Mitsunaga K, Yamada Y, Woltjen K, Miyamoto K, Watanabe A, Hiratani I, Yamada Y, Yamamoto T, Hotta A, Okita K, Masui S.
  • Journal Title: Nat Commun Volume: - Pages: -
  • Peer Reviewed
• [Journal Article] Combinational treatment of Trichostatin A and vitamin C improves the efficiency of cloning mice by somatic cell nuclear transfer. (2018)
  • Author(s): Azuma R, Miyamoto K, Oikawa M, Yamada M, Anzai M.
  • Journal Title: J Vis Exp Volume: - Pages: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Peroxiredoxin as a functional endogenous antioxidant enzyme in pronuclei of mouse zygotes. (2018)
  • Author(s): Morita K, Tokoro M, Hatanaka Y, Higuchi C, Ikegami H, Nagai K, Anzai M, Kato H, Mitani T, Taguchi Y, Yamagata K, Hosoi Y, Miyamoto K, Matsumoto K.
  • Journal Title: J Reprod Dev Volume: - Pages: -
  • DOI: 10.1262/jrd.2018-005
  • Peer Reviewed
• [Journal Article] Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration. (2018)
  • Author(s): Harada A, Maehara K, Ono Y, Taguchi H, Yoshioka K, Kitajima Y, Xie Y, Sato Y, Iwasaki T, Nogami J, Okada S, Komatsu T, Semba Y, Takemoto T, Kimura H, Kurumizaka H, Ohkawa Y.
  • Journal Title: Nature Communications Volume: - Pages: -
  • DOI: 10.1038/s41467-018-03845-1
  • Peer Reviewed / Open Access
• [Journal Article] Sensitive detection of fluorescence in western blotting by merging images. (2018)
  • Author(s): Kondo Y, Higa S, Iwasaki T, Matsumoto T, Maehara K, Harada A, Baba Y, Fujita M, Ohkawa Y.
  • Journal Title: PLoS One Volume: 13(1) Pages: e0191532
  • Peer Reviewed / Open Access
• [Journal Article] Roles of histone H3.5 in human spermatogenesis and spermatogenic disorders. (2018)
  • Author(s): Shiraishi K, Shindo A, Harada A, Kurumizaka H, Kimura H, Ohkawa Y, Matsuyama H.
  • Journal Title: Andrology Volume: 6(1) Pages: 158-165
  • Peer Reviewed / Open Access
• [Journal Article] Factors controlling sperm migration through the oviduct revealed by gene-modified mouse models (2018)
  • Author(s): fujihara Y, Miyata H, Ikawa M.
  • Journal Title: experimental Animals Volume: - Pages: -
  • DOI: 10.1538/expanim.17-0153.
  • Peer Reviewed / Open Access
• [Journal Article] PRDM14 Is a Unique Epigenetic Regulator Stabilizing Transcriptional Networks for Pluripotency. (2018)
  • Author(s): Seki Y.
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 6 Pages: 12
  • DOI: 10.3389/fcell.2018.00012
  • Peer Reviewed / Open Access
• [Journal Article] Mechanisms of kinetochore-microtubule attachment errors in mammalian oocytes. (2018)
  • Author(s): Kitajima TS.
  • Journal Title: Dev Growth Differ Volume: 60(1) Pages: 33-43
  • DOI: 10.1111/dgd.12410.
  • Peer Reviewed / Open Access
• [Journal Article] NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes. (2017)
  • Author(s): Zhou Z, Kawabe H, Suzuki A, Shinmyozu K, Saga Y.
  • Journal Title: Nat Commun Volume: 8 Pages: 15662
  • DOI: 10.1038/ncomms15662.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gonocytes-to-spermatogonia transition initiates prior to birth in murine testes and it requires FGF signaling. (2017)
  • Author(s): Pui HP, Saga Y.
  • Journal Title: Mech Dev Volume: 144 Pages: 125-139
  • DOI: 10.1016/j.mod.2017.03.002. Epub 2017 Mar 22.
  • Peer Reviewed
• [Journal Article] Transfer of a mouse artificial chromosome into spermatogonial stem cells generates transchromosomic mice. (2017)
  • Author(s): Shinohara T, Kazuki K, Ogonuki N., Morimoto H, Matoba S, Hiramatsu K, Honma K, Suzuki T, Hara T, Ogura A, Oshimura M, Kanatsu-Shinohara M, Kazuki Y.
  • Journal Title: Stem Cell Reports Volume: 9(4) Pages: 1180-1191
  • Peer Reviewed / Open Access
• [Journal Article] PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. (2017)
  • Author(s): Mochizuki AL, Katanaya A, Hayashi E, Hosokawa M, Moribe E, Motegi A, Ishiai M, Takata M, Kondoh G, Watanabe H, Nakatsuji N, Chuma S.
  • Journal Title: Mol Cell Biol Volume: 37(23) Pages: e00117-17
  • DOI: 10.1128/MCB.00117-17.
  • Peer Reviewed
• [Journal Article] Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes. (2017)
  • Author(s): Kabayama Y, Toh H, Katanaya A, Sakurai T, Chuma S, Kuramochi-Miyagawa S, Saga Y, Nakano T, Sasaki H.
  • Journal Title: Nucleic Acids Res Volume: 45(9) Pages: 5387-5398
  • DOI: 10.1093/nar/gkx027.
  • Peer Reviewed / Open Access
• [Journal Article] Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes. (2017)
  • Author(s): Hatanaka Y, Tsusaka T, Shimizu N, Morita K, Suzuki T, Machida S, Satoh M, Honda A, Hirose M, Kamimura S, Ogonuki N, Nakamura T, Inoue K, Hosoi Y, Dohmae N, Nakano T, Kurumizaka H, Matsumoto K, Shinkai Y, Ogura A.
  • Journal Title: Cell Rep Volume: 20(12) Pages: 2756-2765
  • DOI: 10.1016/j.celrep.2017.08.088.
  • Peer Reviewed / Open Access
• [Journal Article] DNA hypomethylation circuit of mouse rDNA repeats in the germ cell lineage. (2017)
  • Author(s): Furuta A, Nakamura T.
  • Journal Title: Biochem Biophys Res Commun Volume: 490(2) Pages: 429-433
  • DOI: 10.1016/j.bbrc.2017.06.058.
  • Peer Reviewed
• [Journal Article] Human globozoospermia-related gene Spata16 is required for sperm formation revealed by CRISPR/Cas9-mediated mouse models (2017)
  • Author(s): Fujihara Y, Oji A, Larasati T, Kojima-Kita K, Ikawa M
  • Journal Title: Int J Mol Sci Volume: 18(10) Pages: 2208
  • DOI: 10.3309/ijms18102208
  • Peer Reviewed / Open Access
• [Journal Article] Mouse spermatozoa with higher fertilization rates have thinner nuclei. (2017)
  • Author(s): Mashiko D, Ikawa M, Fujimoto K.
  • Journal Title: PeerJ Volume: 5 Pages: e3913
  • DOI: 10.7717/peerj.3913
  • Peer Reviewed / Open Access
• [Journal Article] TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. (2017)
  • Author(s): Castaneda JM, Hua R, Miyata H, Oji A, Guo Y, Cheng Y, Zhou T, Guo X, Cui Y, Shen B, Wang Z, Hu Z, Zhou Z, Sha J, Prunskaite-Hyyrylainen R , Yu Z, Ramirez-Solis R, Ikawa M, Matzuk MM and Liu M
  • Journal Title: Proc Natl Acad Sci U S A Volume: 114(27) Pages: E5370-E5378
  • DOI: 10.1073/pnas.1621279114.
  • Open Access / Int'l Joint Research
• [Journal Article] A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats. (2017)
  • Author(s): Isotani A, Matsumura T, Ogawa M, Tanaka T, Yamagata K, Ikawa M, Okabe M.
  • Journal Title: Biology of Reproduction Volume: 97(1) Pages: 61-68
  • DOI: 10.1093/biolre/iox066.
  • Peer Reviewed
• [Journal Article] Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation. (2017)
  • Author(s): Someya K, Nakatsukasa H, Ito M, Kondo T, Tateda KI, Akanuma T, Koya I, Sanosaka T, Kohyama J, Tsukada Y, Takamura-Enya T, Yoshimura A.
  • Journal Title: Int Immunol Volume: 29(8) Pages: 365-375
  • Peer Reviewed / Open Access
• [Journal Article] Efficient and scheduled production of pseudopregnant female mice for embryo transfer by estrous cycle synchronization. (2017)
  • Author(s): Hasegawa A, Mochida K, Ogonuki N, Hirose M, Tomishima T, Inoue K, Ogura A.
  • Journal Title: J Reprod Dev Volume: 63(6) Pages: 539-545
  • DOI: 10.1262/jrd.2017-068.
  • Peer Reviewed / Open Access
• [Journal Article] Locus-specific hypomethylation of the mouse IAP retrotransposon is associated with transcription factor-binding sites. (2017)
  • Author(s): Shimosuga K, Fukuda K, Sasaki H, Ichiyanagi K.
  • Journal Title: Mobile DNA Volume: 8 Pages: 20
  • DOI: 10.1186/s13100-017-0105-0
  • Peer Reviewed / Open Access
• [Journal Article] Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos. (2017)
  • Author(s): Maenohara S, Unoki M, Toh H, Ohishi H, Sharif, J, Koseki, H, Sasaki H.
  • Journal Title: PLoS Genet Volume: 13 Pages: e1007042
  • DOI: 10.1371/journal.pgen.1007042
  • Peer Reviewed / Open Access
• [Journal Article] Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice. (2017)
  • Author(s): Inoue K, Ichiyanagi K, Fukuda K, Glinka M, Sasaki H.
  • Journal Title: PLoS Genet Volume: 13 Pages: e1006926
  • DOI: 10.1371/journal.pgen.1006926.
  • Peer Reviewed / Open Access
• [Journal Article] Use of the CRISPR-Cas9 system for genome editing in cultured Drosophila ovarian somatic cells. (2017)
  • Author(s): Ishizu H, Sumiyoshi T, Siomi MC.
  • Journal Title: Methods Volume: 126 Pages: 186-192
  • DOI: 10.1016/j.ymeth.2017.05.021.
  • Peer Reviewed
• [Journal Article] Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1. (2017)
  • Author(s): Mitani T, Yabuta Y, Ohta H, Nakamura T, Yamashiro C, Yamamoto T, Saitou M, Kurimoto K.
  • Journal Title: Nucleic Acids Res Volume: 45(21) Pages: 12152-12169
  • DOI: 10.1093/nar/gkx798.
  • Peer Reviewed / Open Access
• [Journal Article] Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4. (2017)
  • Author(s): Azami T, Waku T, Matsumoto K, Jeon H, Muratani M, Kawashima A, Yanagisawa J, Manabe I, Nagai R, Kunath T, Nakamura T, Kurimoto K, Saitou M, Takahashi S, Ema M.
  • Journal Title: Development Volume: 144(20) Pages: 3706-3718
  • DOI: 10.1242/dev.150755.
  • Peer Reviewed / Open Access
• [Journal Article] In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. (2017)
  • Author(s): Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M.
  • Journal Title: EMBO J Volume: 36(13) Pages: 1888-1907
  • DOI: 10.15252/embj.201695862.
  • Peer Reviewed
• [Journal Article] Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficeint mice by modulating H3K9 methylation balance. (2017)
  • Author(s): Kuroki S, Okashita N, Baba S, Maeda R, Miyawaki S, Yano M, Yamaguchi M, Kitano S, Miyachi H, Itoh A, Yoshida M, Tachibana M
  • Journal Title: PLoS Genet Sep Volume: 13 Pages: e1007034
  • Peer Reviewed / Open Access
• [Journal Article] Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation. (2017)
  • Author(s): Nakatsuka T, Tateishi K, Kudo Y, Yamamoto K, Nakagawa H, Fujiwara H, Takahashi R, Miyabayashi K, Asaoka Y, Tanaka Y, Ijichi H, Hirata Y, Otsuka M, Kato M, Sakai J, Tachibana M, Aburatani H, Shinkai Y, Koike K.
  • Journal Title: Oncogene Volume: 36(45) Pages: 6262-6271
  • Peer Reviewed
• [Journal Article] Essential roles of G9a in cell proliferation and differentiation during tooth development. (2017)
  • Author(s): Kamiunten T, Ideno H, Shimada A, Arai Y, Terashima T, Tomooka Y, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M, Nifuji A.
  • Journal Title: Exp Cell Res Volume: 357(2) Pages: 202-210
  • Peer Reviewed
• [Journal Article] Link between embryonic stem cell pluripotency and homologous allelic pairing of Oct4 loci. (2017)
  • Author(s): Asaka MN, Uranishi K, Suzuki A, Hirasaki M, Nishimoto M, Okuda A.
  • Journal Title: Dev Growth Differ Volume: 59(8) Pages: 639-647
  • DOI: 10.1111/dgd.12403.
  • Peer Reviewed / Open Access
• [Journal Article] Human induced pluripotent stem cell region recognition in microscopy images using Convolutional Neural Networks (2017)
  • Author(s): Chang YH, Abe K, Yokota H, Sudo K, Nakamura Y, Lin C-Y, Tsai M-D
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: 2017 Pages: 4058-4061
  • DOI: 10.1109/EMBC.2017.8037747
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Genome-wide DNA methylation sequencing reveals miR-663a is a novel epimutation candidate in CIMP-high endometrial cancer (2017)
  • Author(s): Yanokura M, Banno K, Adachi M, Aoki D, Abe K.
  • Journal Title: Int J Oncol Volume: 50(6) Pages: 1934-1946
  • Peer Reviewed
• [Journal Article] Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes. (2017)
  • Author(s): Franke V, Ganesh S, Karlic R, Malik R, Pasulka J, Horvat F, Kuzman M, Fulka H, Cernohorska M, Urbanova J, Svobodova E, Ma J, Suzuki Y, Aoki F, Schultz RM, Vlahovicek K, Svoboda P.
  • Journal Title: Genome Res Volume: 27(8) Pages: 1384-1394
  • DOI: 10.1101/gr.216150.116.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Long non-coding RNA exchange during the oocyte-to-embryo transition in mice. (2017)
  • Author(s): Karlic R, Ganesh S, Franke V, Svobodova E, Urbanova J, Suzuki Y, Aoki F, Vlahovicek K, Svoboda P.
  • Journal Title: DNA Res Volume: 24(2) Pages: 129-141
  • DOI: 10.1093/dnares/dsw058.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ubiquitin-proteasome system modulates zygotic genome activation in early mouse embryos and influences full-term development. (2017)
  • Author(s): Higuchi C, Shimizu N, Shin SW, Morita K, Nagai K, Anzai M, Kato H, Mitani T, Yamagata K, Hosoi Y, Miyamoto K, Matsumoto K.
  • Journal Title: J Reprod Dev. Volume: 64(1) Pages: 65-74
  • DOI: 10.1262/jrd.2017-127.
  • Peer Reviewed
• [Journal Article] A transient pool of nuclear F-actin at mitotic exit controls chromatin organization. (2017)
  • Author(s): Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM,Harniman R, Alibhai D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi A, Grosse R.
  • Journal Title: Nat Cell Biol Volume: 19(12) Pages: 1389-1399
  • DOI: 10.1038/ncb3641.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Large cytoplasm is linked to the error-prone nature of oocytes. (2017)
  • Author(s): Kyogoku H, Kitajima T S.
  • Journal Title: Dev Cell Volume: 41(3) Pages: 287-298
  • DOI: 10.1016/j.devcel.2017.04.009.
  • Peer Reviewed
• [Journal Article] Temporal regulation of chromatin during myoblast differentiation. (2017)
  • Author(s): Harada A, Ohkawa Y, Imbalzano AN.
  • Journal Title: Semin Cell Dev Biol Volume: 72 Pages: 77-86
  • DOI: 10.1111/andr.12438.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation. (2017)
  • Author(s): Kudou K, Komatsu T, Nogami J, Maehara K, Harada A, Saeki H, Oki E, Maehara Y , Ohkawa Y.
  • Journal Title: Open Biol Volume: 7(9) Pages: 170119
  • DOI: 10.1098/rsob.170119.
  • Peer Reviewed / Open Access
• [Journal Article] Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells. (2017)
  • Author(s): Semba Y, Harada A, Maehara K, Oki S; Meno C, Ueda J, Yamagata K, Suzuki A, Onimaru, M, Nogami J, Okada S, Akashi K, Ohkawa Y.
  • Journal Title: Nucleic Acids Res Volume: 45(15) Pages: 8758-8772
  • DOI: 10.1093/nar/gkx475.
  • Peer Reviewed / Open Access
• [Journal Article] Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8. (2017)
  • Author(s): Taguchi H, Xie Y , Horikoshi N , Maehara K , Harada A, Nogami J, Sato K, Arimura Y, Osakabe A, Kujirai T, Iwasaki T, Semba Y, Tachibana T, Kimura H, Ohkawa Y, Kurumizaka H.
  • Journal Title: Biochemistry Volume: 56(16) Pages: 2184-2196
  • DOI: 10.1021/acs.biochem.6b01098.
  • Peer Reviewed / Open Access
• [Journal Article] Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR/Cas9. (2017)
  • Author(s): Abbasi F, Miyata H, Ikawa M.
  • Journal Title: Reproductive Medicine and Biology Volume: 17(1) Pages: 3-10
  • DOI: 10.1002/rmb2.12067
  • Peer Reviewed / Open Access
• [Journal Article] Placenta-specific gene manipulation using lentiviral vector and its application. (2017)
  • Author(s): Tobita T, Kiyozumi D, Ikawa M.
  • Journal Title: Placenta Volume: 4004(17) Pages: 31126-8
  • DOI: 10.1016/j.placenta.
  • Peer Reviewed
• [Journal Article] Cloning Mice. (2017)
  • Author(s): Ogura A .
  • Journal Title: Cold Spring Harb Protoc Volume: 2017(8) Pages: prot094425
  • DOI: 10.1101/pdb.prot094425.
  • Peer Reviewed / Open Access
• [Journal Article] エピジェネティクスの基礎 (2017)
  • Author(s): 幸田尚
  • Journal Title: 産婦人科の実際 Volume: 66(8) Pages: 951
• [Journal Article] Epigenetic regulation of mammalian sex determination. (2017)
  • Author(s): Kuroki S and Tachibana M.
  • Journal Title: Mol Cell Endocrinol Volume: 7207(17) Pages: 30634-2
  • Peer Reviewed
• [Journal Article] Regulation of zygotic gene activation by chromatin structure and epigenetic factors. (2017)
  • Author(s): Funaya S, Aoki F.
  • Journal Title: J Reprod Dev Volume: 63(4) Pages: 359-363
  • DOI: 10.1262/jrd.2017-058.
  • Peer Reviewed / Open Access
• [Journal Article] 卵子の染色体数異常の細胞生物学的な原因 (2017)
  • Author(s): 北島智也
  • Journal Title: 日本卵子学会誌 2017 Volume: 2(2) Pages: 39-44
  • Peer Reviewed
• [Presentation] CRISPR/Cas9 mediated genome editing in mice and its application for the study of reproduction (2018)
  • Author(s): Ikawa M.
  • Organizer: BBW 2018
  • Int'l Joint Research / Invited
• [Presentation] CRISPR/Cas9 mediated genome editing in mice and its application for the study of reproduction (2018)
  • Author(s): Ikawa M.
  • Organizer: The 9th Takeda Science Foundation Symposium on PharmaSciences
  • Int'l Joint Research / Invited
• [Presentation] Factors affecting the outcome of sperm and spermatid injection. (2018)
  • Author(s): Ogura A, Ogonuki N.
  • Organizer: International Symposium of Japan Society for Marmoset Research
  • Int'l Joint Research / Invited
• [Presentation] Development of reproductive engineering techniques in laboratory species (2018)
  • Author(s): Ogura A.
  • Organizer: 2nd RIKEN-MOST Collaborative Meeting
  • Int'l Joint Research / Invited
• [Presentation] マウスを用いた雌雄生殖細胞老化機構 (2018)
  • Author(s): 伊川正人
  • Organizer: AMED老化メカニズムの解明・制御プロジェクト 第一回リトリート
  • Invited
• [Presentation] ゲノム編集を利用した精巣特異的遺伝子の網羅的機能解析 (2018)
  • Author(s): 伊川正人
  • Organizer: 先端酵素学研究所講演会
  • Invited
• [Presentation] エピジェネティクスと発生と疾患 (2018)
  • Author(s): 佐々木裕之
  • Organizer: 文部科学省共同利用・共同研究事業 徳島大学先端酵素学研究所シンポジウム「医学研究のインパクトと健康長寿社会への貢献」
  • Invited
• [Presentation] Strategy and Serendipity in Science（基調講演） (2018)
  • Author(s): Sasaki H.
  • Organizer: 第10回ルドウィグボルツマンフォーラム
  • Invited
• [Presentation] エピジェネティクスと細胞記憶と疾患（特別講演） (2018)
  • Author(s): 佐々木裕之
  • Organizer: 第34回大分大学眼科研究会
  • Invited
• [Presentation] piRNA経路によるレトロトランスポゾンサイレンシング機構 (2018)
  • Author(s): 石津大嗣
  • Organizer: 弘前大学農学生命科学部 第23回研究推進セミナー
  • Invited
• [Presentation] H3K9のメチル化修飾によるほ乳類の発生・分化の制御 (2018)
  • Author(s): 立花誠
  • Organizer: 熊本大学発生医学研究所学術セミナー
  • Invited
• [Presentation] Role of H3K9 methylation dynamics for mammalian reproduction (2018)
  • Author(s): Tachibana M.
  • Organizer: RIKEN Epigenetics seminar series
  • Invited
• [Presentation] マウスにおける減数分裂の開始機構 (2018)
  • Author(s): 石黒啓一郎
  • Organizer: 基礎生物学研究所セミナー
  • Invited
• [Presentation] マウスにおける減数分裂開始機構 (2018)
  • Author(s): 石黒啓一郎
  • Organizer: 平成２９年度先端モデル動物支援プラットフォーム成果発表会特別講演
  • Invited
• [Presentation] A novel nuclear factor plays a crucial role in initiation of meiosis (2018)
  • Author(s): Ishiguro K.
  • Organizer: 第762回九州大学生医研セミナー
  • Invited
• [Presentation] A novel germ-cell specific factor responsible for initiation of meiosis (2018)
  • Author(s): Ishiguro K.
  • Organizer: KEY FORUM 2018 Stem Cell Traits and Developmental Systems
  • Invited
• [Presentation] 始原生殖細胞の初期化機構を利用した高品質iPS細胞作製の試み (2018)
  • Author(s): 関由行
  • Organizer: 神戸再生医療勉強会
  • Invited
• [Presentation] 卵子に大量に存在するヒストンバリアントTH2A/TH2Bによる核のリプログラミング (2018)
  • Author(s): 品川敏恵
  • Organizer: 第5回ヒストンバリアント研究会
  • Invited
• [Presentation] 卵の Quality（成熟能・発生能）に関わる因子について． (2018)
  • Author(s): 青木不学
  • Organizer: A-PART学術講演会
  • Invited
• [Presentation] Technology and biology of spermatogonial stem cells (2018)
  • Author(s): 篠原隆司
  • Organizer: 奈良先端大
• [Presentation] CRISPR/Cas9システムを用いた遺伝子改変マウス作製の現状 (2018)
  • Author(s): 野田大地
  • Organizer: 平成29年度新学術領域研究学術研究支援基盤形成 先端モデル動物支援プラットフォーム 成果発表会
• [Presentation] A novel nuclear factor plays a crucial role in initiation of meiosis. (2018)
  • Author(s): Ishiguro K.
  • Organizer: CDB Symposium 2018 Dynamic Homeostasis: from Development to Aging
• [Presentation] Egg or sperm: how germ cell sex is determined. (2017)
  • Author(s): Saga Y.
  • Organizer: The International Research Symposium on Regulation of Germ Cell Development in vivo and in vitro
  • Int'l Joint Research / Invited
• [Presentation] Fertility and spermatogonial stem cells (2017)
  • Author(s): Shinohara T.
  • Organizer: American Society of Andrology 2017 42nd Annual Conference
  • Int'l Joint Research / Invited
• [Presentation] piRNA-mediated epigenetic control of transposable elements in Drosophila. (2017)
  • Author(s): Saito K.
  • Organizer: The International Research Symposium on Regulation of Germ Cell Development in vivo and in vitro
  • Int'l Joint Research / Invited
• [Presentation] CRISPR/Cas9 mediated genome editing and its application for the study of sperm functions (2017)
  • Author(s): Ikawa M.
  • Organizer: 11th International Congress of Andrology
  • Int'l Joint Research / Invited
• [Presentation] CRISPR/Cas9 Mediated Genome Editing and its Application for the Study of Reproduction (2017)
  • Author(s): Ikawa M.
  • Organizer: JST戦略的国際共同研究プログラム
  • Int'l Joint Research / Invited
• [Presentation] Fertilization and Oocyte Activation: New Insights Using Genome Editing (2017)
  • Author(s): Ikawa M.
  • Organizer: Fertilization & Activation of Development
  • Int'l Joint Research / Invited
• [Presentation] CRISPR/Cas9 mediated genome editing and its application for the study of reproduction (2017)
  • Author(s): Ikawa M.
  • Organizer: 4th World Congress of Reproductive Biology
  • Int'l Joint Research / Invited
• [Presentation] Global landscape and regulatory principles of DNA methylation reprogramming during germ cell specification in vitro. (2017)
  • Author(s): Shirane K, Kurimoto K, Hayashi K, Saitou M Sasaki H.
  • Organizer: The 50th Annual Meeting of the Society for the Study of Reproduction
  • Int'l Joint Research / Invited
• [Presentation] Epigenetic events in mammalian germ cell development (2017)
  • Author(s): Sasaki H.
  • Organizer: France-Japan Epigenetics Workshop-2017: Chromatin and methylation mechanisms in development and disease
  • Int'l Joint Research / Invited
• [Presentation] Physiological function of Tet1 in germ and somatic cell development (2017)
  • Author(s): Yamaguchi S.
  • Organizer: International Symposium of Oral and Craniofacial Development and Diseases 2017
  • Int'l Joint Research / Invited
• [Presentation] Nuclear actin polymerization in mouse embryonic development. (2017)
  • Author(s): Miyamoto K.
  • Organizer: ASCB/EMBO 2017 meeting
  • Int'l Joint Research / Invited
• [Presentation] Roles of nuclear actin in nuclear reprogramming and mouse embryonic development. (2017)
  • Author(s): Miyamoto K.
  • Organizer: HMGU-Japan Epigenetics and Chromatin Symposium
  • Int'l Joint Research / Invited
• [Presentation] Roles of large cytoplasmic size of eggs (2017)
  • Author(s): Kitajima TS.
  • Organizer: The 27th Hot Spring Harbor International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Cell biological causes of aneuploidy in eggs (2017)
  • Author(s): Kitajima TS.
  • Organizer: The 11th Congress of the Pacific Society for Reproductive Medicine
  • Int'l Joint Research / Invited
• [Presentation] A unique role of kinetochores in mammalian oocytes (2017)
  • Author(s): Kitajima TS.
  • Organizer: EMBO Conference on Meiosis 2017
  • Int'l Joint Research / Invited
• [Presentation] Cell Biological causes of aneuploidy in eggs (2017)
  • Author(s): Kitajima TS.
  • Organizer: The international Research Symposium on Regulation of Germ Cell Development in vivo and in vitro
  • Int'l Joint Research / Invited
• [Presentation] The causes of chromosome segregation errors in oocytes (2017)
  • Author(s): Kitajima TS.
  • Organizer: The 2nd Meeting on SMC proteins
  • Int'l Joint Research / Invited
• [Presentation] The origins of meiotic chromosome segregation errors in mammalian oocytes (2017)
  • Author(s): Kitajima TS.
  • Organizer: EMBO Workshop: Dynamic Kinetochore
  • Int'l Joint Research / Invited
• [Presentation] The causes of chromosome segregation errors in mammalian oocytes (2017)
  • Author(s): Kitajima TS.
  • Organizer: Gordon Research Conference, Chromosome Dynamics
  • Int'l Joint Research / Invited
• [Presentation] Mechanism of sexual differentiation of mouse germ cells (2017)
  • Author(s): Saga Y.
  • Organizer: Life Science Seminar in ShanghaiTech University
  • Invited
• [Presentation] 精子幹細胞の遺伝情報伝達パターン (2017)
  • Author(s): 篠原隆司
  • Organizer: 放射線影響学会
  • Invited
• [Presentation] Myc-mediated glycolysis enhances spermatogonial stem cell self-renewal. (2017)
  • Author(s): Shinohara T.
  • Organizer: 第15回 幹細胞シンポジウム
  • Invited
• [Presentation] piRNA-mediated chromatin regulation in Drosophila gonadal cells (2017)
  • Author(s): Saito K.
  • Organizer: Symposium on Epigenome Dynamics and Regulation in Germ Cells
  • Invited
• [Presentation] piRNAによるクロマチン制御の分子機構 (2017)
  • Author(s): Saito K.
  • Organizer: Hokuriku RNA Club
  • Invited
• [Presentation] 小さなRNAによるゲノム防衛システム (2017)
  • Author(s): Saito K.
  • Organizer: 第319回発生研セミナー
  • Invited
• [Presentation] Small RNA-induced epigenetic control in Drosophila (2017)
  • Author(s): Saito K.
  • Organizer: ConBio 2017 4AS14遺伝学とエピ遺伝学
  • Invited
• [Presentation] 全能性細胞で特異的に発現する遺伝子群の機能解析 (2017)
  • Author(s): 中村肇伸
  • Organizer: 2017年度生命科学系学会合同年次大会
  • Invited
• [Presentation] ゲノム編集技術を用いた精子機能の解析 (2017)
  • Author(s): 宮田治彦
  • Organizer: 安全性評価研究会
  • Invited
• [Presentation] ゲノム編集マウスを用いた生命科学研究の進歩と課題 (2017)
  • Author(s): 伊川正人
  • Organizer: 第6回 同志社大学先端医工学研究センターシンポジウム
  • Invited
• [Presentation] 阪大微研におけるCRISPR/Cas9システムを用いた遺伝子改変マウス作製の現状 (2017)
  • Author(s): 野田大地
  • Organizer: 国立大学法人動物実験施設協議会総会
  • Invited
• [Presentation] Generation of point mutant mouse model responsible for human globozoospermia by CRISPR/Cas9 system (2017)
  • Author(s): 藤原祥高
  • Organizer: 第64回日本実験動物学会総会
  • Invited
• [Presentation] ゲノム編集技術の進歩と課題 (2017)
  • Author(s): 伊川正人
  • Organizer: 第12回関西ライフサイエンスリーディングサイエンティストセミナー
  • Invited
• [Presentation] CRISPR/Cas9システムによるゲノム編集マウスの作製と受精研究への応用 (2017)
  • Author(s): 伊川正人
  • Organizer: 生化学若い研究者の会 九州支部 夏のセミナー
  • Invited
• [Presentation] ゲノム編集による遺伝子改変マウス作製とその応用 (2017)
  • Author(s): 伊川正人
  • Organizer: 第２回秋期特別日本血管生物医学会シンポジウム
  • Invited
• [Presentation] 遺伝子改変マウスを用いた雄性生殖細胞特異的な膜タンパク質の機能解析 (2017)
  • Author(s): 藤原祥高
  • Organizer: 奈良先端科学技術大学院大学セミナー
  • Invited
• [Presentation] 周期的な精子生産を制御するレチノイン酸： 未分化細胞から配偶子へ (2017)
  • Author(s): 遠藤墾
  • Organizer: 熊本大学発生研セミナー
  • Invited
• [Presentation] ゲノム編集を用いた哺乳類生殖因子の包括的解析 (2017)
  • Author(s): 佐藤裕公
  • Organizer: 第39回 関西生殖発生毒性フォーラム
  • Invited
• [Presentation] ゲノム編集を利用した精巣特異的遺伝子の網羅的機能解析 (2017)
  • Author(s): 伊川正人
  • Organizer: 第3回生体調節研究所 内分泌代謝シンポジウム
  • Invited
• [Presentation] 遺伝子改変技術を用いた雄性不妊モデルマウスの開発と機能解析 (2017)
  • Author(s): 藤原祥高
  • Organizer: 第14回熊本大学 生命資源研究・支援センターシンポジウム
  • Invited
• [Presentation] Fertilization and Oocyte Activation: New Insights Using Genome Editing (2017)
  • Author(s): 伊川正人
  • Organizer: 新学術領域研究「生殖エピゲノムダイナミクスとその制御」第5回シンポジウム
  • Invited
• [Presentation] ゲノム編集技術の進歩と課題 (2017)
  • Author(s): 伊川正人
  • Organizer: 日本動物実験代替法学会
  • Invited
• [Presentation] ゲノム編集マウス作製と受精研究 (2017)
  • Author(s): 伊川正人
  • Organizer: 第40回日本分子生物学会年会
  • Invited
• [Presentation] 最近の発生工学技術の開発とその応用研究 (2017)
  • Author(s): 小倉淳郎
  • Organizer: 千葉県がんセンター研究所集談会
  • Invited
• [Presentation] 核移植クローンとエピジェネティクス (2017)
  • Author(s): 小倉淳郎
  • Organizer: 第11回日本エピジェネティクス研究会年会
  • Invited
• [Presentation] マウス顕微授精及び核移植から見えてくる発生のエピジェネティクス (2017)
  • Author(s): 小倉淳郎
  • Organizer: 第62回日本生殖医学会学術講演会・総会
  • Invited
• [Presentation] 体外受精とエピジェネティクス (2017)
  • Author(s): 幸田尚
  • Organizer: 第35回日本受精着床学会総会・学術講演会
  • Invited
• [Presentation] エピジェネティクスと細胞記憶と疾患 (2017)
  • Author(s): 佐々木裕之
  • Organizer: ゲノム創薬・医療フォーラム第7回談話会
  • Invited
• [Presentation] ゲノムとエピゲノム～DNAに蓄えられた情報の取り出し方と使い方～ (2017)
  • Author(s): 鵜木元香
  • Organizer: ヤンマー倉敷研究所バイオイノベーションセンター倉敷ラボ
  • Invited
• [Presentation] Chromatin regulation in the mammalian germline. (2017)
  • Author(s): Sasaki H.
  • Organizer: IGMM Three Special Seminars
  • Invited
• [Presentation] 哺乳類の個体発生を支える卵子エピ遺伝学因子へのトランスオミクスアプローチ (2017)
  • Author(s): 佐々木裕之
  • Organizer: 第40回日本分子生物学会年会2017年度生命科学系学会合同年次大会
  • Invited
• [Presentation] エピジェネティクスと個体発生と疾患： 予測と偶然の科学 (2017)
  • Author(s): 佐々木裕之
  • Organizer: 第2回 生体調節研究所 内分泌代謝学 共同利用共同研究拠点 若手研究者育成プログラムセミナー
  • Invited
• [Presentation] ほ乳類性決定におけるエピゲノム制御の役割 (2017)
  • Author(s): 立花誠
  • Organizer: New Insights of Molecular Genetics on Growth Disorders
  • Invited
• [Presentation] エピジェネティック制御によるほ乳類のオス化の仕組み (2017)
  • Author(s): 立花誠
  • Organizer: 第7回ゲノム創薬・医療フォーラム
  • Invited
• [Presentation] A novel STRA8 interacting factor plays a crucial role in initiation of meiosis. (2017)
  • Author(s): Ishiguro K.
  • Organizer: The 1965th NIG Biological seminar
  • Invited
• [Presentation] A novel germ cell-specific factor responsible for initiation of mammalian meiosis. (2017)
  • Author(s): Ishiguro K.
  • Organizer: The International Research Symposium on Regulation of Germ Cell Development in vivo and in vitro
  • Invited
• [Presentation] NGSで眺め、ウェットでひたすら掘って見えてくる もの ～相関関係から因果関係へ～ (2017)
  • Author(s): 関由行
  • Organizer: KOBE NGS DAY
  • Invited
• [Presentation] 始原生殖細胞の初期化原理に基づいた新規初期化技術の開発と抗がん剤スクリーニングへの応用 (2017)
  • Author(s): 関由行
  • Organizer: 神戸医療産業都市 クラスター交流会
  • Invited
• [Presentation] Evolutionary and functional analysis of PRDM14 in pluripotent cells and primordial germ cells. (2017)
  • Author(s): Seki Y.
  • Organizer: 熊本大学 博士課程リーディングプログラム 最先端セミナー
  • Invited
• [Presentation] CRISPR/Cas9システムを利用した複数遺伝子発現制御システムの開発 (2017)
  • Author(s): 鈴木伸之介、阿部訓也
  • Organizer: Epigenome Editing Study Workshop
  • Invited
• [Presentation] １細胞期胚の雌雄前核におけるヒストンH3変異体の非対称的局在について (2017)
  • Author(s): 青木不学
  • Organizer: 第40回分子生物学会年会
  • Invited
• [Presentation] Roles of nuclear actin in mouse embryonic development (2017)
  • Author(s): 宮本圭
  • Organizer: 2017年度生命科学系学会合同年次大会
  • Invited
• [Presentation] 核の初期化とマウス初期胚発生における核アクチンの役割 (2017)
  • Author(s): 宮本圭
  • Organizer: 新学術領域研究・第5回公開シンポジウム
  • Invited
• [Presentation] クローン動物から再生医療へ～細胞の初期化がもたらす未来～ (2017)
  • Author(s): 宮本圭
  • Organizer: 平成29年度中央区民カレッジ
  • Invited
• [Presentation] クローン動物がもたらした可能性 (2017)
  • Author(s): 宮本圭
  • Organizer: 平成29年度大阪府高等学校生物教育研究会
  • Invited
• [Presentation] Efficient nuclear reprogramming of somatic cells towards totipotency is supported by synergistic effects of small molecules. (2017)
  • Author(s): Miyamoto K, Tajima Y, Yoshida K, Oikawa M, Azuma R, Mori M, Imasato Y, Allen GE, Tsujikawa T, Tsukaguchi T, Bradshaw CR, Jullien J, Yamagata K, Matsumoto K, Anzai M, Imai H, Gurdon JB, Yamada M.
  • Organizer: 第50回 日本発生生物学会
  • Invited
• [Presentation] 卵子の巨大な細胞質サイズの役割 (2017)
  • Author(s): 北島智也
  • Organizer: Symposium on Epigenome Dynamics and Regulation in Germ Cells
  • Invited
• [Presentation] 卵子の染色体数異常の細胞生物学的な原因 (2017)
  • Author(s): 北島智也
  • Organizer: 日本人類遺伝学会第62回大会
  • Invited
• [Presentation] 卵母細胞における染色体分配エラーの原因 (2017)
  • Author(s): 北島智也
  • Organizer: 第２回eurofin学術セミナー
  • Invited
• [Presentation] 卵子の染色体数異常の原因 (2017)
  • Author(s): 北島智也
  • Organizer: 京都大学生物物理学セミナー
  • Invited
• [Presentation] ライブイメージングで探る卵子の染色体数異常の原因 (2017)
  • Author(s): 北島智也
  • Organizer: 第35回日本受精着床学会総会・学術講演会
  • Invited
• [Presentation] 卵子の染色体異常の原因 (2017)
  • Author(s): 北島智也
  • Organizer: 東京大学大学院薬学系研究科主催講演会
  • Invited
• [Presentation] トランスクリプトミクス研究における新しい展開 (2017)
  • Author(s): 原田哲仁
  • Organizer: タカラバイオ主催TGCAセミナー"【特別企画】次世代シーケンスで開く新たな世界 NGSプレミアムセミナー
  • Invited
• [Presentation] Technology and biology of spermatogonial stem cells (2017)
  • Author(s): 篠原隆司
  • Organizer: 産総研
  • Invited
• [Presentation] 生殖系列細胞の発生サイクルにおける減数分裂プログラムの獲得メカニズム (2017)
  • Author(s): 細川美穂子、刀谷在美、林瑛理、望月綾子、沼田興治、 阿部訓也、末盛博文、中辻憲夫、中馬新一郎
  • Organizer: 日本遺伝学会第89回大会
• [Presentation] PARI regulates stalled replication fork processing to maintain genome stability upon replication stress in mice (2017)
  • Author(s): 望月綾子、刀谷在美、林瑛理、細川美穂子、 森部江美子、茂木章、石合正道、高田穰、近藤玄、 渡辺仁美、中辻憲夫、中馬新一郎
  • Organizer: 日本遺伝学会第89回大会
• [Presentation] Developmental control of genome stability and diversification in the germline cell cycle in mice. (2017)
  • Author(s): Katanaya A, Hosokawa M, Mochizuki A,Hayashi E, Moribe E, Nakatsuji N, Chuma S.
  • Organizer: 新学術領域「生殖細胞のエピゲノムダイナミクスとその制御」公開シンポジウム
• [Presentation] Meiosis priming in the germline stem cell cycle in mice. (2017)
  • Author(s): Hosokawa M, Katanaya A, Hayashi E, Mochizuki A, Numata K, Abe K, Suemori H, Nakatsuji N , Chuma S.
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] piRNAによるエピゲノム制御の分子機構 (2017)
  • Author(s): Saito K.
  • Organizer: 3領域合同若手勉強会
• [Presentation] マウスES細胞由来胚様体の金属メッシュデバイスによるサイズ分画と心筋分化の検討 (2017)
  • Author(s): 木村七海、井上有香、水上民夫、細井美穂、土田美江、中村肇伸、神波誠治、近藤孝志、長谷川慎
  • Organizer: 第17回日本再生医療学会総会
• [Presentation] 全能性細胞特異的遺伝子を用いた高品質iPS細胞の作製 (2017)
  • Author(s): 原口大生、中村肇伸
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] ES細胞に含まれる全能性細胞のエネルギー代謝経路 (2017)
  • Author(s): 古田明日香、中村肇伸
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] ES細胞に含まれる全能性細胞の誘導と解析 (2017)
  • Author(s): 中村肇伸
  • Organizer: 文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」第4回公開シンポジウム
• [Presentation] Induction and characterization of totipotent fraction in ES culture. (2017)
  • Author(s): Furuta A, Nakamura T.
  • Organizer: World Congress of Reproductive Biology 2017
• [Presentation] Effects of Akt signaling on totipotent cells within ES cell culture. (2017)
  • Author(s): Kakihara A, Furuta A, Mori A, Nakamura T.
  • Organizer: World Congress of Reproductive Biology 2017
• [Presentation] Induction of totipotent fraction in ES cell culture. (2017)
  • Author(s): Furuta A, Nakamura T.
  • Organizer: International Society for Stem Cell Research
• [Presentation] ES細胞に含まれる全能性細胞の可視化とその制御 (2017)
  • Author(s): 古田明日香、中村肇伸
  • Organizer: 文部科学省科学研究費補助金 新学術領域研究「生殖細胞のエピゲノムダイナミクスとその制御」「ステムセルエイジングから解明する疾患原理」「動的クロマチン構造と機能」合同若手勉強会2017
• [Presentation] Screening for extracellular matrix factors that may concern in mouse male fertility (2017)
  • Author(s): Kiyozumi D, Tobita T, Yamaguchi R, Okabe M, Ikawa M.
  • Organizer: 第64回日本実験動物学会総会
• [Presentation] IZUMO1の細胞内領域はマウスの生殖能力に必須ではない (2017)
  • Author(s): 宮田治彦、Samantha AM Young、佐藤裕公、武藤真長、Martin R Larsen、R John Aitken、Mark A Baker、伊川 正人
  • Organizer: 第64回日本実験動物学会総会
• [Presentation] RSPH6A is essential for sperm flagellum formation and male fertility in mice (2017)
  • Author(s): Ferheen Abbasi
  • Organizer: 3領域合同若手勉強会
• [Presentation] Low-invasive Imaging of Ca2+ Oscillations and Quantitative Analysis of the Cortical Reaction in Mammalian Eggs (2017)
  • Author(s): 佐藤裕公、野澤香織、伊川正人
  • Organizer: 50th Annual Meeting of the Society for the Study of Reproduction
• [Presentation] Sperm motility and its competency for mammalian fertilization (2017)
  • Author(s): 宮田治彦、伊川正人
  • Organizer: 50th Annual Meeting of the Society for the Study of Reproduction
• [Presentation] Gk2 knockout mice show impaired sperm motility and male infertility (2017)
  • Author(s): 嶋田圭祐、宮田治彦、佐藤裕公、伊川正人
  • Organizer: 50th Annual Meeting of the Society for the Study of Reproduction
• [Presentation] Functional Analysis of Spermatogenesis in the Y Chromosome Azoospermia Factor Region in Mice (2017)
  • Author(s): 松村貴史、小川昌樹、磯谷綾子、伊川正人
  • Organizer: 50th Annual Meeting of the Society for the Study of Reproduction
• [Presentation] TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa (2017)
  • Author(s): Julio Castaneda、宮田治彦、伊川正人、大字亜沙美
  • Organizer: 50th Annual Meeting of the Society for the Study of Reproduction
• [Presentation] CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa (2017)
  • Author(s): 宮田治彦
  • Organizer: Fertilization & Activation of Development
• [Presentation] Low-invasive Imaging of Ca2+ Oscillations and Quantitative Analysis of the Cortical Reaction in Mammalian Eggs (2017)
  • Author(s): 佐藤裕公
  • Organizer: 大阪大学医学系研究科若手研究フォーラム
• [Presentation] Human globozoospermia-related gene Spata16 is essential for spermiogenesis in mice (2017)
  • Author(s): 藤原祥高
  • Organizer: 4th World Congress of Reproductive Biology
• [Presentation] Screening for extracellular matrix factors that may concern in male fertility (2017)
  • Author(s): 淨住大慈
  • Organizer: 4th World Congress of Reproductive Biology
• [Presentation] Functional analysis of the Y chromosome gene (2017)
  • Author(s): 松村貴史
  • Organizer: 4th World Congress of Reproductive Biology
• [Presentation] The involvement of linker histone variant H1foo in the chromatin remodeling during the 1 and 2-cell stages in mouse embryos. (2017)
  • Author(s): Funaya S, Aoki F.
  • Organizer: 4th World Congress of Reproductive Biology
• [Presentation] Human globozoospermia-related gene Spata16 is essential for spermiogenesis in mice (2017)
  • Author(s): 藤原祥高
  • Organizer: 第40回日本分子生物学会年会
• [Presentation] マウス着床前初期胚に存在する全能性細胞の評価 (2017)
  • Author(s): 束田裕一
  • Organizer: さきがけ「エピジェネティクスの制御と生命機能」第2回終了領域研究会
• [Presentation] マウス着床前初期胚を構成する割球がもつ全能性の評価 (2017)
  • Author(s): 前村万里野、中島友紀、大川恭行、束田裕一
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Developmental potential of single mouse blastomere (2017)
  • Author(s): Nakajima Y, Gotoh M, Tsukada Y.
  • Organizer: World Congress of Reproductive Biology 2017
• [Presentation] Mouse D1Pas1, a DEAD-box RNA helicase, is required for the completion of first meiotic prophase in male germ cells (2017)
  • Author(s): Inoue H, Ogonuki N, Hirose M, Hatanaka Y, Matoba S, Koga Y, Suzuki S, Abe K, Chuma S, Kobayashi K, Wakana S, Noguchi J, Inoue K, Tanemura K, Ogura A.
  • Organizer: 4th World Congress for Reproductive Biology
• [Presentation] Conservation of the Piwi-piRNA patway in mammals (2017)
  • Author(s): Fulka H, Hirose M, Kabayama Y, Sasaki H, Makalowski W, Svoboda P, Ogura A
  • Organizer: 4th World Congress for Reproductive Biology
• [Presentation] Rapid production of next generations by in vitro fertilization using spermatozoa from prepubertal male mice. (2017)
  • Author(s): Mochida K, Hasegawa A, Ogonuki N, Liu J, Inoue K, Ogura A.
  • Organizer: 4th World Congress for Reproductive Biology
• [Presentation] Shortening the marmoset intergeneration time using immature spermatozoa. (2017)
  • Author(s): Ogonuki N, Kassai H, Inoue H, Aiba A, Ogura A.
  • Organizer: 4th World Congress for Reproductive Biology
• [Presentation] Slc38a4/SNAT4, a system A amino acid transporter, plays critical roles for mouse placental development. (2017)
  • Author(s): Matoba S, Ogura A.
  • Organizer: 4th World Congress for Reproductive Biology
• [Presentation] The rodent-specific microRNA cluster within the Sfmbt2 gene is imprinted and essential for placental development. (2017)
  • Author(s): Inoue K, Hirose M, Inoue H, Hatanaka Y, Honda A, Hasegawa A, Mochida K, Ogura A.
  • Organizer: 4th World Congress for Reproductive Biology
• [Presentation] CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene (2017)
  • Author(s): Hirose M, Hasegawa A, Mochida K, Matoba S, Hatanaka Y, Inoue K, Goto T, Kaneda H, Yamada I, Furuse T, Abe K, Uenoyama Y, Tsukamura H, Wakana S, Honda A,Ogura A.
  • Organizer: 4th World Congress for Reproductive Biology
• [Presentation] Efficient and scheduled production of pseudopregnant female mice by progesterone injections. (2017)
  • Author(s): Hasegawa A, Mochida K, Tomishima T, Hirose M, Ogonuki N, Inoue K,Ogura A.
  • Organizer: 4th World Congress for Reproductive Biology
• [Presentation] 体外受精胚の遺伝子発現制御 (2017)
  • Author(s): 幸田尚、川井清考、石川智則、久保田俊郎、宮坂尚幸、石野史敏
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] 部分的機能欠損XistによるX染色体不活性化の異常 (2017)
  • Author(s): 中島達郎、保木裕子、佐々木裕之、佐渡敬
  • Organizer: 新学術領域合同若手勉強会2017
• [Presentation] ヒストン修飾の機能解明-conditional knock-in mouseをもちいて (2017)
  • Author(s): 阿部周策、石内崇士、佐々木裕之
  • Organizer: 新学術領域合同若手勉強会2017
• [Presentation] マウスの発生におけるDnmt3a PWWPドメインの機能解析 (2017)
  • Author(s): 木部加奈子、白根健次郎、大石裕晃、佐々木裕之
  • Organizer: 新学術領域合同若手勉強会2017
• [Presentation] primary piRNA生合成におけるRNAヘリカーゼ Armitageの機能解析 (2017)
  • Author(s): 木下達貴、石津大嗣、塩見美喜子
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] ミトコンドリア外膜に局在するpiRNA生合成因子GasZの機能解析 (2017)
  • Author(s): 山城はるな、石津大嗣、塩見美喜子
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway (2017)
  • Author(s): Ishizu H, Kinoshita T, Siomi MC.
  • Organizer: The 43rd Naito Conference on "NoncodingRNA: Biology, Chemistry, & Diseases", CHATERAISE Gaueaux Kingdom
• [Presentation] 始原生殖細胞形成過程におけるエピゲノムリモデリングの動態 (2017)
  • Author(s): 栗本一基、薮田幸宏、大田浩、白根健次郎、林克彦、三谷忠宏、木村宏、山本拓也、白髭克彦、佐々木裕之、斎藤通紀
  • Organizer: 2017年度生命科学系学会合同年次大会 ConBio2017
• [Presentation] 転写制御因子BLIMP1の細胞系譜横断的解析 (2017)
  • Author(s): 三谷忠宏、栗本一基、斎藤通紀
  • Organizer: 2017年度生命科学系学会合同年次大会 ConBio2017
• [Presentation] 新規の減数分裂開始因子の同定 (2017)
  • Author(s): 石黒啓一郎
  • Organizer: 第35回染色体ワークショップ・第16回核ダイナミクス研究会合同開催
• [Presentation] マウス生殖細胞における減数分裂の開始機構. (2017)
  • Author(s): 石黒啓一郎
  • Organizer: 性と生殖の懇談会
• [Presentation] 新規の減数分裂誘導因子の同定 (2017)
  • Author(s): 石黒啓一郎
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] 新規の減数分裂開始因子の同定 (2017)
  • Author(s): 石黒啓一郎
  • Organizer: モロシヌス研究会
• [Presentation] REC8 and RAD21L plays distinct roles in chromosome dynamics in mouse meiosis I. (2017)
  • Author(s): Ishiguro K.
  • Organizer: SMC proteins Meeting
• [Presentation] 後口動物における多能性ネットワークの起源と変容 (2017)
  • Author(s): 関由行
  • Organizer: 第４回北陸エピジェネティクス研究会
• [Presentation] 後口動物における多能性ネットワークの起源と変容 (2017)
  • Author(s): 関由行
  • Organizer: 第89回日本遺伝学会年会
• [Book] アレルギーの臨床 Vol.38 No.4 (2018)
  • Author(s): 神沼修、形山和史、井上貴美子、小倉淳郎、廣井隆親、森晶夫
  • Total Pages: 94
  • Publisher: 北隆館
• [Book] 和光純薬時報 Vol.86 No.1 (2018)
  • Author(s): 石津大嗣
  • Total Pages: 32
  • Publisher: 和光純薬工業株式会社
• [Book] DNA and Histone Methylation as Cancer Targets. (2017)
  • Author(s): Kaneda A, Tsukada Y.
  • Total Pages: 624
  • Publisher: Springer Nature
  • ISBN: 978-3319597843
• [Book] 日本薬理学雑誌 Vol.150 No.2 (2017)
  • Author(s): 神沼修、井上貴美子、佐伯真弓、片山和史、森晶夫、小倉淳郎
  • Total Pages: 49
  • Publisher: 公益法人 日本薬理学会
• [Book] 実験医学 別冊「エピジェネティクス実験スタンダード」 (2017)
  • Author(s): 石津大嗣
  • Total Pages: 398
  • Publisher: 羊土社
  • ISBN: 978-4-7581-0199-8
• [Book] 実験医学 別冊「エピジェネティクス実験スタンダード」 (2017)
  • Author(s): 立花誠
  • Total Pages: 398
  • Publisher: 羊土社
• [Book] 実験医学別冊 エピジェネティクス実験スタンダード (2017)
  • Author(s): 前之原章司、鵜木元香
  • Total Pages: 398
  • Publisher: 羊土社
• [Patent(Industrial Property Rights)] 産業財産権の名称： 雄性生殖細胞またはセルトリ細胞にポリヌクレオチドを導入する方法 (2017)
  • Inventor(s): 篠原隆司,渡邉哲史
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2017-092384
• [Patent(Industrial Property Rights)] iPS細胞の白色光観察＋機械学習判定 (2017)
  • Inventor(s): 張元翔,横田秀夫,阿部訓也,蔡明達
  • Industrial Property Rights Holder: 国立研究開発法人理化学研究所, 中原大學
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2017-026477
• [Patent(Industrial Property Rights)] 産業財産権の名称： DNA結合タンパク質の結合領域の近傍に所望のDNA断片を挿入する方法 (2017)
  • Inventor(s): 大川恭行,原田哲仁,胡桃坂仁志,木村宏,半田哲也,佐藤優子
  • Industrial Property Rights Holder: 国立大学法人九州大学、国立大学法人東京工業大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願PCT/JP2017/019309
  • Overseas
• [Patent(Industrial Property Rights)] Method and apparatus for detecting cell reprogramming (2017)
  • Inventor(s): 張元翔,横田秀夫,阿部訓也,蔡明達
  • Industrial Property Rights Holder: 国立研究開発法人理化学研究所, 中原大學
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2017-026477
  • Overseas
• [Patent(Industrial Property Rights)] 産業財産権の名称： DNA脱メチル化誘導法及びその用途 (2014)
  • Inventor(s): 関由行
  • Industrial Property Rights Holder: 学校法人関西学院
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 第61611261
• [Funded Workshop] "エピゲノム解析（DNAのシトシンメチル化、ヒドロキシメチル化解析技術の紹介） (2018)
• [Funded Workshop] トランスオミクス医学研究拠点ネットワーク形成事業技術講習会 (2018)
• [Funded Workshop] 生命系学会合同年次大会（第40回日本分子生物学会年会、第90回日本生化学会大会）ワークショップ「全能性獲得と消失の分子機構の理解に向けて」 (2017)
• [Funded Workshop] 第5回領域シンポジウム「生殖細胞のエピゲノムダイナミクスとその制御」 (2017)
• [Funded Workshop] マウス顕微授精研修 (2017)
• [Funded Workshop] France-Japan Epigenetics Workshop-2017: Chromatin and methylation mechanisms in development and disease (2017)
• [Funded Workshop] Zhejiang University- The University of Tokyo Joint Symposium 2017 (2017)
• [Funded Workshop] 第40回分子生物学会年会『全能性獲得と消失の分子機構の理解に向けて』 (2017)
• [Funded Workshop] 核内アクチンとラミンから細胞核アーキテクチャーを解く (2017)