Regulation of epigenome dynamics and regulation in germ cells

2017 Fiscal Year Final Research Report

• Project Area: Analyses and regulation of germline epigenome
• Project/Area Number: 25112001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: Shinohara Takashi 京都大学, 医学研究科, 教授 (30322770)
• Co-Investigator(Kenkyū-buntansha): 伊川 正人 大阪大学, 微生物病研究所, 教授 (20304066)
• Co-Investigator(Renkei-kenkyūsha): SAGA Yumiko 国立遺伝学研究所, 系統生物研究センター, 教授 (50221271) ; CHUMA Shinichiro 京都大学, 再生医科学研究所, 准教授 (20378889) ; SAITO Kuniaki 国立遺伝学研究所, 系統生物研究センター, 教授 (30423396) ; NAKAMURA Toshinobu 長浜バイオ大学, バイオサイエンス学部, 教授 (80403202) ; TSUKADA Yuichi 九州大学, 稲盛フロンティア研究センター, 教授 (90444801) ; OGURA Atsuo 独立行政法人理化学研究所, 遺伝工学基盤技術室, 室長 (20194524) ; KOHDA Takashi 東京医科歯科大学, 難治疾患研究所, 教授 (60211893) ; SASAKI Hiroyuki 九州大学, 生体防御医学研究所, 教授 (30183825)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: エピジェネティクス / 精子形成 / 卵子形成 / 核移植

Outline of Final Research Achievements

Our goal is to understand how the epigenetic network develops in the germline and how they are maintained thereafter. We also tried to correct or improve germline cells by epigenetic manipulation. We have conducted research for 5 years and obtained several important findings. This includes identification of sex determinant in the germline cells, derivation of pluripotent stem cells from spermatogonial stem cells, discovery of essential genes for completing spermatogenesis, analysis of the role of histone chaperone in implantation, and epigenome analysis of primordial germ cell-like cells during development from pluripotent stem cells. A total of X papers were published and Y% of them were conducted by collaboration by researchers in this research group. Four members were promoted to full professor.

Free Research Field

生殖生物学