Brain Protein Aging and Dementia Control

2018 Fiscal Year Final Research Report

• Project Area: Prevention of brain protein aging and dementia
• Project/Area Number: 26117001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Nagoya University
• Principal Investigator: Sobue Gen 名古屋大学, 医学系研究科, 特任教授 (20148315)
• Research Collaborator: WATANABE hirohisa
• Project Period (FY): 2014-07-10 – 2019-03-31
• Keywords: 蛋白質 / 痴呆 / 脳・神経 / 老化 / 神経科学 / 神経変性疾患 / タウ / 脳タンパク質

Outline of Final Research Achievements

Our general manager section coordinated the progress of the whole area and formulated the activity policy. The section made support and evaluation and advice on individual research activities while promoting exchange and cooperation among members necessary for achieving the purpose. We effectively promoted the exchange of information and joint research within our group and developed an external public relations activity of domain research including the promotion of internationalization and outreach activity. Specifically, we held a total of nine members' meetings and four retreats. Information and our activity were regularly sent on the website to support various domestic symposia. We held summer school and winter school for young researchers three to six times a year, and also held educational activities for high school students, and held one to two public lectures once a year. We proceeded with the management and transportation of PET probes.

Free Research Field

神経内科学

Academic Significance and Societal Importance of the Research Achievements

総括班は、新学術領域研究（研究領域提案型）「脳タンパク質老化と認知症制御」に参画した国内外の多くの研究者が円滑に研究を推進しできるように包括的な支援をするとともに、若手の教育機会の提供や、市民へのアウトリーチ活動などを精力的に行った。結果として、別の報告書にあるように、当領域からの多くの国際的研究成果発信に繋がるとともに、今後の発展的な連携へ向けた多くの協力研究体制基盤や、大規模イメージング・ゲノム・オミックスコホートが構築された。これらは、将来的な認知症の克服に繋がると期待され、その社会的意義は極めて大きい。さらに、成果の社会・国民への発信も強力にサポートした。