Automated synthesis and Functional Evaluation of Oligosaccharides as Biologically Active Middle Molecules

2019 Fiscal Year Final Research Report

• Project Area: Middle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis.
• Project/Area Number: 15H05844
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tottori University
• Principal Investigator: NOKAMI Toshiki 鳥取大学, 工学研究科, 教授 (60402963)
• Co-Investigator(Kenkyū-buntansha): 伊藤 敏幸 鳥取大学, 工学研究科, その他 (50193503)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Keywords: オリゴ糖 / グリコシル化反応 / 立体制御 / イオン液体タグ / 生物活性

Outline of Final Research Achievements

We have developed methods for synthesis of oligosaccharides as biologically active middle molecules and analyzed their biological functions during the period of research project. Automated electrochemical assembly has been utilized to synthesize chitooligosaccharides and unnatural cyclic oligosaccharides efficiently. Biological function of these oligosaccharides is under investigation.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究で合成が効率化されたキトオリゴ糖類縁体の機能解明は学術的に重要であり、その有効利用は社会的に意義深い。すなわち、これまで未解明であったオリゴ糖の生物学的意義についても、精密合成によって高純度のオリゴ糖が供給出来れば、機能解明につながると期待される。また、オリゴ糖が医薬品や食品として有効利用出来れば、オリゴ糖をベースにした新たな製品ひいては産業の創出につながると期待される。