2019 Fiscal Year Final Research Report
Integrated Synthesis by Designed Reaction Field
| Project Area | Middle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis. |
|---|
| Project/Area Number |
15H05848
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Science and Engineering
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
Yasuda Makoto 大阪大学, 工学研究科, 教授 (40273601)
|
|---|
| Project Period (FY) |
2015-06-29 – 2020-03-31
|
| Keywords | 合成化学 / 有機化学 / 錯体化学 / 触媒 / 選択的反応 |
|---|
| Outline of Final Research Achievements |
The metal complexes with organic framework surrounding around the metal center were synthesized. They were applied to the catalytic reactions in which the metal complexes act as a catalyst to recognize aromatic compounds. The pi-pocket around the metal center recognized the aromatic moiety of the substrate over aliphatic ones. The complex can be tuned by through-space interaction between organic frame work and metal center that are not bound in covalent bond. The aluminum-cage shaped complex with bromine atoms at ortho positions in pi-pocket moieties catalyzed beta-selective glycosylation at room temperature. The moderate Lewis acidity and appropriate steric hindrance enabled a high selectivity at rt.
Indium-catalyzed reaction gave the coupling product to give diarylethylene derivatives that led to new type of hydrocarbon compounds with anti-aromaticity and open-shell characters in one molecule. Other types of metal catalyzed reaction based on carbometallation have been developed.
|
| Free Research Field |
有機金属化学
|
| Academic Significance and Societal Importance of the Research Achievements |
金属触媒はその金属自身の反応性に依存した触媒活性を示すため、その利用に大きな制限がある。一方で有機化合物は自在に有機合成によりデザインが多様である。この有機骨格を金属に付与することで、精密に性状を制御した金属触媒を合成し、新しい反応場を与えることができる。このことは、枯渇金属種に頼らず、豊富な金属を用いて合成反応を実施することができることから、資源の有効利用に直結する。また、これらの触媒で達成さえた選択的反応は、従来法に比して、トータルのエネルギー効率がきわめて高く、効率的な合成反応として位置付けられる。社会全体がこのような反応を活用する方向を目指す端緒となる研究である。
|
