Integration of reactive species-cooperative reaction system

2019 Fiscal Year Final Research Report

• Project Area: Middle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis.
• Project/Area Number: 15H05850
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Osaka Prefecture University
• Principal Investigator: FUKUYAMA Takahide 大阪府立大学, 理学(系)研究科(研究院), 准教授 (60332962)
• Co-Investigator(Kenkyū-buntansha): 植田 光洋 大阪府立大学, 理学(系)研究科(研究院), 講師 (60566298) ; 柳 日馨 大阪府立大学, 研究推進機構, 特認教授 (80210821)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Keywords: 活性種共同系 / マイクロリアクター / フロー合成 / 混合触媒リアクター

Outline of Final Research Achievements

This study focused on the development of the integrated flow synthesis, in which plural reaction species act co-operatively. One flow synthesis of pristane was achieved by consecutive acid-catalyzed dehydration of allylic alcohols and Pd-catalyzed hydrogenation of alkenes. Single step synthesis of pristane and tranexamic acid were successfully carried out using the mixed column system, in which plural catalysts were packed in a one-column. A variety of reactions, such as, chlorination, radical reactions, photo-redox catalytic reactions, and so one, were effectively carried out using flow microreactors.

Free Research Field

有機化学

Academic Significance and Societal Importance of the Research Achievements

本研究ではフローマイクロリアクターを活用した活性種協同型反応プロセスの効率的集積化法を開拓し、生物活性物質や機能性物質創製に適用できる力量ある方法論として確立せんとするものであり、必然的にオリジナルな新方法論の開発を伴う。活性種協同型反応を集積化の観点から積極的にとらえ、種々の反応の集積化を実証しており、様々な生物活性化合物や機能性物質合成への波及効果が予想される。