Modal shifts in cellular and network oscillations

2019 Fiscal Year Final Research Report

• Project Area: Non-linear Neuro-oscillology: Towards Integrative Understanding of Human Nature
• Project/Area Number: 15H05872
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: FUKUDA Atsuo 浜松医科大学, 医学部, 教授 (50254272)
• Co-Investigator(Kenkyū-buntansha): 柳川 右千夫 群馬大学, 大学院医学系研究科, 教授 (90202366) ; 江川 潔 北海道大学, 医学研究院, 助教 (40450829)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Keywords: GABA / Cl- / Ca2+振動 / γ振動 / てんかん

Outline of Final Research Achievements

A multi-dimensional and multi-level modal shift and its mechanism including oscillation modalities such as transition from membrane potential oscillation to Ca2+ oscillation, nerve cell oscillation becoming cell population oscillation and generating a rhythm component of EEG via neural circuit synchronization, and of which mechanisms were studied by means of animal experiments based on GABA-Cl- homeodynamics theory. We tried and elucidated some of the underlying mechanism of such as: functions of molecules that induce certain types of epilepsy, excitatory GABA that influences cycles of hormone secretion, genes responsible for excessive nerve binding to dopamine neurons, changes in oscillatory phenomena due to phosphorylation of Cl- transporter, GABA synapses related to γ oscillation, effects of static magnetic field stimulation on cerebrocortical neural circuit function, and modeling of the modal shift mechanism by which neuronal oscillation cause a network pathology.

Free Research Field

神経生理学

Academic Significance and Societal Importance of the Research Achievements

てんかん症例の遺伝子変異と脳波の関連性、興奮性GABAがもたらすCRHやGnRHの周期変動、MHCI異常によるドーパミン細胞でのネットワーク異常が薬物依存や発振を誘発する可能性、KCC2持続リン酸化によるGABA作用減弱により感覚刺激誘発性のけいれん重積などの発振や呼吸運動、歩行運動のリズム異常が起こること、パルブアルブミンGABA細胞が関わるシナプスによるγ振動発生機構と行動の維持／更新との関連性、ヒトでも利用される静磁場刺激がCl-チャネルを介し脳波に影響すること等を明らかにした。いずれも学術的意義や社会的意義が高く、一流誌の表紙とeditorによる紹介記事、新聞報道など客観的評価も得た。