2019 Fiscal Year Final Research Report

recording and analysis of neuronal oscillation in humans

Planned Research

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Project Area	Non-linear Neuro-oscillology: Towards Integrative Understanding of Human Nature
Project/Area Number	15H05874
Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Allocation Type	Single-year Grants
Review Section	Complex systems
Research Institution	Kyoto University
Principal Investigator	Ikeda Akio 京都大学, 医学研究科, 特定教授 (90212761)
Co-Investigator(Kenkyū-buntansha)	松本理器神戸大学, 医学研究科, 教授 (00378754) 長峯隆札幌医科大学, 医学部, 教授 (10231490) 菊池隆幸京都大学, 医学研究科, 助教 (40625084) 小林勝弘岡山大学, 医歯薬学総合研究科, 教授 (60273984) 國枝武治愛媛大学, 医学系研究科, 教授 (60609931) 宇佐美清英京都大学, 医学研究科, 特定助教 (20829204)
Project Period (FY)	2015-06-29 – 2020-03-31
Keywords	Active DC shifts / Red slow
Outline of Final Research Achievements	We developed the concept of "Active DC shifts" as the Electrocorticogram(ECoG) biomarker of epileptic focus through the application of mathematical model on ECoG, multi-institutional analysis of surgical specimen, or animal model. We revealed the importance of neuron and glial cells in epileptic seizure generation. We clarified that the "red slow", the co-occurrence of slow wave and high frequency oscillation, was observed in the same areas where active DC shifts were recorded. On the other hand, we showed the versatility of these biomarker (active DC shifts and red slow) for the scalp-recorded electroencephalogram.
Free Research Field	てんかん学、神経生理学
Academic Significance and Societal Importance of the Research Achievements	本研究で明らかにされたActive ictal DC shiftsやRed slowなどの新規のてんかん焦点の生理バイオマーカーを臨床に応用することで、難治てんかん患者に対するてんかん焦点切除術に際して、術前のてんかん焦点同定に役立ち、手術成績の向上に寄与しうる。また、本研究を通じ明らかにされたグリア細胞のてんかん発作における重要性から、グリア細胞が今後の抗てんかん薬の創薬のターゲットになりうることが示された。