2019 Fiscal Year Final Research Report
Acute Effects of Space Radiation with Different Radiation Qualities and Dose-rates
| Project Area | "LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE" |
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| Project/Area Number |
15H05945
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
日出間 純 東北大学, 生命科学研究科, 准教授 (20250855)
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| Project Period (FY) |
2015-06-29 – 2020-03-31
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| Keywords | 宇宙放射線 / 太陽紫外線 / 微小重力 / 複合影響 / がんの進行 |
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| Outline of Final Research Achievements |
We developed the system of simultaneous irradiation (ultraviolet-light, X-rays, C-ions, and neutron) in simulated-microgravity and partial gravity using a clinostat. Using these simulator, we reported reduced expression of cell-cycle-suppressing genes and enhanced expression of cell-cycle promoting ones in human fibroblast cells after C ion irradiation under simulated-microgravity. Supporting this result, we have also reported a higher rate of chromosomal aberrations and abnormalities in the same combined conditions. Furthermore, we clarified that autophagy is important for overcoming ultraviolet-light and microgravity obstacles. We also reported that hindlimb suspension significantly increased tumor growth and metastasis to the lung, and caused greater thymic and splenocyte atrophy compared with mice in constant orthostatic suspension or unmanipulated mice under standard housing conditions.
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| Free Research Field |
放射線生物
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| Academic Significance and Societal Importance of the Research Achievements |
これらの成果をもとに，①植物を用いた宇宙での紫外線と微小重力による障害と修復，②マウスを用いた宇宙での微小重力によるガンの進行について，2018年の国際宇宙ステーション「きぼう」日本実験棟の船内環境を利用する実験テーマに採択され，その実現に向けて準備をすすめている．さらに，我々の開発した装置をプラットフォームとして利用し，その次のISS，人工衛星，Gateway，月や火星での宇宙実験に向けた研究の基盤が構築され，本領域のさらなる発展につながった．安全・安心に「宇宙に生きる」ため，放射線リスク評価に，従来の放射線の質と量のみならず，重力変化との複合影響の重要性を提示したことは社会的意義が大きい．
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