2022 Fiscal Year Final Research Report
Symbiotic Relationship between Influenza Virus and Waterfowl in Nature
| Project Area | Neo-virology: the raison d'etre of viruses |
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| Project/Area Number |
16H06434
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University (2020, 2022)
The University of Tokyo (2016-2019) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
河岡 義裕 東京大学, 医科学研究所, 教授 (70135838)
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| Project Period (FY) |
2016-06-30 – 2021-03-31
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| Keywords | インフルエンザウイルス / 共生 / バイローム解析 |
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| Outline of Final Research Achievements |
We infected mallard ducks, the natural host of influenza viruses, with avian influenza viruses and found that they were asymptomatic, but innate immune responses were induced in their intestinal tracts in the early phase of infection and acquired immune responses in the late phase of infection.
We also established new animal infection models and analyzed the pathogenicity of avian influenza viruses and SARS-CoV-2. We collected samples from domestic and foreign wild animals and metagenomically analyzed them to identify novel crane adenoviruses and bat coronaviruses.
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| Free Research Field |
ウイルス学
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| Academic Significance and Societal Importance of the Research Achievements |
インフルエンザウイルスと自然宿主である水禽との共生が、宿主の腸内環境や生命活動に及ぼす影響やその機能メカニズムを調べることは、生物や生態系におけるウイルスの役割の理解につながる。
国内外の野生動物のウイルス叢や細菌叢を網羅的に解析することは、ウイルスが宿主の微生物叢に及ぼす影響を調べる上で非常に重要である。また新規ウイルスの発見にもつながり、ウイルスの多様性を解明するという本領域の目的達成につながる。
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