Redesign of biosynthetic machineries based on molecular and genome evolution of plant specialized metabolisms

2020 Fiscal Year Final Research Report

• Project Area: Creation of Complex Functional Molecules by Rational Redesign of Biosynthetic Machineries
• Project/Area Number: 16H06454
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Chiba University
• Principal Investigator: Yamazaki Mami 千葉大学, 大学院薬学研究院, 教授 (70222370)
• Project Period (FY): 2016-06-30 – 2021-03-31
• Keywords: アルカロイド / ゲノム / トランスクリプトーム / メタボローム / 分子進化 / 二次代謝

Outline of Final Research Achievements

Plant metabolites are important resource with in chemical diversity and biological activity. In this study, molecular evolution of chemodiversity in plants is main theme and following subjects were studied. (1) Molecular mechanism of bifunctional lysine/ornithine decarboxylase that is the key enzyme in biosynthesis of lysine derived alkaloids. (2)Integral omics aproaches to reveal the whole biossynthetic pathway of camptothecin.

Free Research Field

薬用資源学

Academic Significance and Societal Importance of the Research Achievements

植物による物質生産は地球上のバイオマスの大半を占めておりこれを有効利用することは、持続可能な文明社会のに維持のために不可欠な技術である。本研究で明らかにされた植物性アルカロイド生産の分子メカニズム並びに分子進化に関する知見は将来の合成生物学、代謝工学による医薬品原料化合物の合理的な物質生産に応用展開が可能である。