2021 Fiscal Year Final Research Report
Dynamic regulation of brain function by Scrap & Build system
| Project Area | Dynamic regulation of brain function by Scrap & Build system |
|---|
| Project/Area Number |
16H06462
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Fujita Health University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-06-30 – 2021-03-31
|
| Keywords | 海馬歯状回 / 未成熟歯状回 / 脱成熟 / 行動解析 / インフォマティクス解析 / in vivo神経活動イメージング |
|---|
| Outline of Final Research Achievements |
In neurons of the brain, various stimuli induce a phenomenon called “dematuration,” in which neurons return to a pseudo-immature state, and a similar phenomenon has been observed in the brains of various animal models of neuropsychiatric and neurodegenerative disorders. In such immature neurons, the morphology of synapses is altered, as revealed by analysis using super-resolution microscopy and electron microscopy. We also found that induction of dematuration leads to large-scale and long-term changes in gene expression patterns and three-dimensional genome structure. Furthermore, in vivo neuronal activity measurements revealed that the information processing is disrupted in the neuronal population of the brain with dematured neurons, suggesting that neuronal network abnormalities associated with dematuration are involved in abnormalities in higher brain functions and brain-related diseases.
|
| Free Research Field |
神経科学
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究により、マウスの脳において炎症や神経過活動によって生じる神経細胞の脱成熟に関わる分子機序ならびに脱成熟に伴う神経回路・行動レベルでの機能的変化の一部を明らかにした。このような脳での変化は、ヒト精神疾患患者脳においても起きている可能性があり、疾患の病態や機序の解明につながることが期待される。
|
