Genetic analysis of neo-self

2020 Fiscal Year Final Research Report

• Project Area: Creation, function and structure of neo-self
• Project/Area Number: 16H06502
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokai University
• Principal Investigator: SHIINA Takashi 東海大学, 医学部, 教授 (00317744)
• Co-Investigator(Kenkyū-buntansha): 細道 一善 金沢大学, 医学系, 准教授 (50420948)
• Project Period (FY): 2016-06-30 – 2021-03-31
• Keywords: ネオ・セルフ / HLA / 疾患感受性 / 遺伝子多型 / NGS / オミックス

Outline of Final Research Achievements

In this study, we developed various innovative methods to comprehensively understand gene polymorphisms, gene expression, and transcriptional regulation in HLA and its related genomic regions to elucidate the neo-self phenomenon. We also collected HLA polymorphism and expression information in Japanese population. Furthermore, we identified novel molecular mechanisms involved in qualitative and quantitative abnormalities of the HLA and its related genes by elucidating the pathophysiology of HLA-related diseases, cancers, and adverse drug reactions.

Free Research Field

免疫遺伝学

Academic Significance and Societal Importance of the Research Achievements

日本人におけるHLA多型情報や転写レベル情報は臨床に直結する極めて汎用性の高い基礎データであるため、それらを有機的に結び付けた新たなHLAアレルの分類体系の構築、それに基づくHLA疾患関連解析や移植医療への応用が期待される。また、本研究により同定された疾患感受性多型情報は個々人の体質に合わせた最適な治療法を選択するPrecision Medicineの実現に寄与することが期待される。