Control of Chirality Functions at Dynamic Interfaces

2020 Fiscal Year Final Research Report

• Project Area: Coordination Asymmetry: Design of Asymmetric Coordination Sphere and Anisotropic Assembly for the Creation of Functional Molecules
• Project/Area Number: 16H06518
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: National Institute for Materials Science
• Principal Investigator: ARIGA Katsuhiko 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA主任研究者 (50193082)
• Project Period (FY): 2016-06-30 – 2021-03-31
• Keywords: 超分子化学 / 表面・界面物性 / ナノ材料

Outline of Final Research Achievements

The aim of this project was to develop interface technologies to control the asymmetry function of molecular machines, etc. Using interface technologies such as the LB method, we explored the asymmetry function of two-dimensional supramolecular nano-assemblies and the functional molecules such as molecular machines. For example, control of the fluorescent behaviors of metal-complex-type molecular machines upon changing their orientation structure at the air-water interface was demonstrated. In addition to demonstrating the initial goal, we have achieved results far beyond our expectations, such as the control of stem cell differentiation by developing interface control technology.

Free Research Field

超分子化学

Academic Significance and Societal Importance of the Research Achievements

特別な分子に対して特別な刺激にのみ反応するのではなく、分子を自分の手で自由に動かすことができるような誰でもどこでも制御しうる動作体系を確立する道筋を作ることができた。また、予期せぬ成果として、今回開発した技術では、分化因子を用いずに幹細胞の自発分化を誘導できた。これは効率的かつ安価な分化誘導技術として大きな可能性を秘めており、材料を基軸とする再生医療技術として社会的インパクトのある研究に発展することが期待される。