Optical Measurement and Control of Multiareal Brain Information Dynamics in Memory and Emotional Behavior

2022 Fiscal Year Final Research Report

• Project Area: Brain information dynamics underlying multi-area interconnectivity and parallel processing
• Project/Area Number: 17H06312
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: The University of Tokyo
• Principal Investigator: Bito Haruhiko 東京大学, 大学院医学系研究科(医学部), 教授 (00291964)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Keywords: 脳情報動態 / カルシウム / 記憶 / 情動

Outline of Final Research Achievements

This research has led to the following outcomes: 1) this improved the technology for labeling and manipulating memory trace cell populations using Arc enhancer-promoter technology. 2) This helped create of the highest performance Ca2+ sensor, XCaMP, with enhanced Ca2+ responsiveness and linearity, which has dramatically advanced in vivo multicolor Ca2+ sensing technology; 3) This has elucidation of the significance of the CaMK-CREB-Arc pathway in in vivo physiology and pathology. All of these achievements were made possible by the development of first-in-kin experimental systems established in this grant, and have contributed greatly to advancing the field of brain information dynamics.

Free Research Field

神経生化学

Academic Significance and Societal Importance of the Research Achievements

本研究を通じ、記憶転送や記憶痕跡創発に寄与する脳情報動態・情報処理解明に資する研究手法の開発がなされたことは特筆されるところである。すべて申請者らが世界に先駆けて構築した実験系であり、今後、全く新たな脳情報動態学の創成の端緒となることが期待される。