Inflammation and related molecular preventive medicine in kidney diseases

2021 Fiscal Year Final Research Report

• Project Area: Preventive medicine through inflammation cellular sociology
• Project/Area Number: 17H06394
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Kanazawa University
• Principal Investigator: Wada Takashi 金沢大学, その他部局等, その他 (40334784)
• Co-Investigator(Kenkyū-buntansha): 古市 賢吾 金沢医科大学, 医学部, 教授 (50432125) ; 坂井 宣彦 金沢大学, 附属病院, 准教授 (60377421) ; 岩田 恭宜 金沢大学, 附属病院, 特任教授 (90432137)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Keywords: 腎臓病 / 慢性炎症 / 感染症 / 細菌 / ゲノム / シングルセル

Outline of Final Research Achievements

Recent studies indicated the mortality in patients with acute kidney injury (AKI) is high in infectious disease. We performed single-cell transcriptome analysis and identified a novel cell population in infection related AKI model. Moreover, we explored the association between bacterial gene mutation and clinical manifestation of infectious diseases. Attachment and biofilm related genes were associated with clinical manifestation and could be novel targets for anti-microbiotics. In addition, D-Serine and D-Alanine, those are metabolites of gut microbiota, have reno-protecive roles in AKI. These findings suggested that bacteria and related metabolites are novel therapeutic target in AKI.

Free Research Field

腎臓内科学

Academic Significance and Societal Importance of the Research Achievements

腎障害の進展機序に、腸内細菌およびその代謝産物が関わることは新たな腎障害の機序を明らかにするだけでなく、将来的な治療標的になる可能性を示しており重要な知見であると考えられた。進行性腎障害に対する治療は限られており、今後、この分野を進展させることで、新たな治療手段の開発につなげたい。