Stereodivergent Synthesis Enabled by Hybrid Catalysis

2022 Fiscal Year Final Research Report

• Project Area: Hybrid Catalysis for Enabling Molecular Synthesis on Demand
• Project/Area Number: 17H06446
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Nagoya University
• Principal Investigator: OOI Takashi 名古屋大学, 工学研究科(WPI), 教授 (80271708)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Keywords: 触媒的不斉合成 / イオン性分子触媒 / イオン対 / イオン反応 / ラジカル反応 / 光レドックス触媒

Outline of Final Research Achievements

In this project, we have realized previously difficult asymmetric transformations, such as the three-component 1,2-dicarbofunctionalization of acyclic olefins, which had remained an unsolved problem due to the difficulty of continuous stereocontrol. The other representative achievement is the development of hybrid catalytic system of chiral ionic organic molecular catalysts and photoredox catalysts, leading to the realization of precise stereocontrol of asymmetric radical reactions.
We have also developed unique hybrid catalytic system of zwitterionic catalysts and photoredox catalysts for implementing dehydrogenative cross-coupling, specifically a direct coupling between heteroatom-containing C－H donors and enamides or 1,1-diarylethenes, under visible-light irradiation without any external oxidants.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究成果のように化学反応を精密に制御するための方法論を開拓し、従来困難であった反応を実現することは、最小単位のものづくりである合成化学において普遍的に重要な価値をもつ。革新的な新薬や電子機器デバイスの機能ユニットを創出する手段となるだけはなく、既存の有用な物質を、卑近な原料からより低コストで環境負荷を低減しながらつくり出すプロセスの実現にもつながる。