2021 Fiscal Year Final Research Report
Development of efficient molecular transformation system using [metal complexes/chiral Brønsted acids] hybrid catalysis
| Project Area | Hybrid Catalysis for Enabling Molecular Synthesis on Demand |
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| Project/Area Number |
17H06447
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2017-06-30 – 2022-03-31
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| Keywords | 不斉合成 / 有機分子触媒 / 遷移金属錯体 / 物質変換 / ハイブリッド触媒 / 触媒 |
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| Outline of Final Research Achievements |
In this research, we aimed to develop a two-component hybrid catalyst system that combines "selective molecular transformation using organocatalysts, especially chiral Bronsted acids", that the applicant has been involved in so far, with "a specific molecular transformation using a metal complex catalyst". In order to develop an efficient and selective method for the preparation of enantioenriched compounds that surpass conventional catalytic systems, we connected these catalytic systems in a relay manner in one-pot during the course of the substance conversion. We have successfully established several hybrid catalytic systems using chiral Bronsted acids combined not only with metal complexes but also with photoactivation system. In addition, we also achieved the development of a chiral Bronsted acid catalyst having a higher acidity than that of conventional chiral acids, which is the key to achieving a hybrid catalytic system.
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| Free Research Field |
有機合成化学
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| Academic Significance and Societal Importance of the Research Achievements |
医薬品などの複雑化、多様化に伴い、光学活性化合物の効率的かつ選択的な合成法の確立は、益々重要となってきている。これらの迅速な供給には、効率と選択性を究極まで高めた高度分子変換反応の開発が不可欠である。加えて環境問題の深刻化により廃棄物の削減など環境に配慮した合成法の開発は急務である。本研究では二成分ハイブリッド触媒系とすることで、これらの触媒による物質変換をワンポットでリレー式につなぎ、従来系を凌ぐ効率的かつ選択的な光学活性化合物の供給法を確立することを目的としている。本研究により環境への負荷軽減や多様化する有用物質を選択的かつ効率的に供給する高度分子変換反応の開発が期待される。
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