Development of novel reactions through organo/metal hybrid catalysis

2021 Fiscal Year Final Research Report

• Project Area: Hybrid Catalysis for Enabling Molecular Synthesis on Demand
• Project/Area Number: 17H06449
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kanazawa University
• Principal Investigator: Ohmiya Hirohisa 金沢大学, 薬学系, 教授 (40508876)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Keywords: 触媒・化学反応プロセス

Outline of Final Research Achievements

Benzylation and allylation of aldehyde acyl anions were enabled by the merger of a thiazolium N-heterocyclic carbene catalyst and a palladium/bisphosphine catalyst in a synergistic manner. Owing to the mildness of the reaction conditions, various functional groups were tolerated in the substrates. The reaction between aromatic aldehydes and aryl or allyl electrophiles with a silylboronate utilizing a chiral copper/N-heterocyclic carbene catalyst and a palladium/bisphosphine catalyst in a synergistic manner occurred with high enantioselectivities to deliver the three-component coupling products, chiral silyl-protected secondary alcohol derivatives.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究では、高選択的炭素－炭素結合形成反応を最適な触媒を複数の触媒を同時に用い、その機能を協働的に生かすことで実現できた。本研究で開発された高選択的炭素－炭素結合形成反応は、環境調和、省資源、省エネルギー、低炭素社会の実現に資することができる有機合成技術である。