Development of Highly Selective Domino Reactions using High-Performance Hybrid Catalyst System

2022 Fiscal Year Final Research Report

• Project Area: Hybrid Catalysis for Enabling Molecular Synthesis on Demand
• Project/Area Number: 17H06450
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kyoto University
• Principal Investigator: Maruoka Keiji 京都大学, 薬学研究科, 研究員(特任教授) (20135304)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Keywords: ハイブリッド触媒 / ドミノ反応 / 精密有機合成 / 有機分子触媒 / 金属錯体触媒 / ペプチド

Outline of Final Research Achievements

In recent years, there has been a strong demand for molecular design of catalysts and development of organic synthesis that are environmentally friendly. For this reason, incorporation of the advantages of in vivo systems into organic synthesis seems to be a powerful strategy. For example, in biological systems, activation of organic molecules and synthesis of complex natural products are easily carried out by multi-catalytic reactions involving multiple enzymes (biocatalysts), but it is extremely difficult to realize the similar transformations in an artificial manner. In this research, we extract functions such as the recognition and activation of substrates without using macromolecules such as the enzymes. Aiming to construct a "high-performance hybrid catalyst system", a series of new and precise domino-type synthetic transformations have been successfully developed.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

幾つかの高性能ハイブリッド触媒系を創製できれば、従来の「生体触媒」や「金属錯体触媒」では及びもつかないような反応性や選択性の獲得が可能になる。それによって新規なドミノ型有機合成反応を開拓でき、従来、合成が難しいと思われていた有機化合物の新たな創製へとつながり、関連研究の諸分野の発展に大きな波及効果をもたらすものと思われる。また、新たな研究開発手法のパラダイムが創出でき、また、それによりイノベーションを創出することも可能になり、新たな科学技術への展開や波及効果が期待されるであろう。