2010 Fiscal Year Final Research Report
Replication and pathogenesis of plus strand RNA viruses and double strand RNA viruses
| Project Area | Matrix of Infection Phenomena |
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| Project/Area Number |
18073002
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo (2006-2008, 2010)
Microbial Chemistry Research Foundation (2009) |
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Principal Investigator |
NOMOTO Akio The University of Tokyo, 微生物化学研究所, 所長 (70112670)
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| Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Kouki 藤田保健衛生大学, 医学部, 教授 (40094213)
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| Co-Investigator(Renkei-kenkyūsha) |
OHKA Seii 独立行政法人国立がん研究センター研究所, がん幹細胞研究分野, 研究員 (80313097)
MUNAKATA Tsubasa 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主席研究員 (50420237)
TANAKA Yoshikazu 北海道大学, 創成研究機構, 特任助教 (20374225)
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| Project Period (FY) |
2006 – 2010
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| Keywords | ウイルス / 感染症 / リバースジェネティックス / プラス鎖RNA / マイナス鎖 / RNA |
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| Research Abstract |
Reverse genetics systems for poliovirus, Aichivirus, and hepatitis C virus were established. For these viruses, interaction between viral and host molecules were investigated to give an insight into molecular mechanisms of viral replication and pathogenesis. As for rotavirus whose reverse genetics is not completely established, mainly antigenic structure and cleavage region of viral VP4 were studied. At the same time, we made an effort to establish better reverse genetics system for rotavirus.
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