2010 Fiscal Year Final Research Report
Study of replication, life cycle, and pathogenesis of retrovirus (HIV)
| Project Area | Matrix of Infection Phenomena |
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| Project/Area Number |
18073008
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
KOYANAGI Yoshio Kyoto University, ウイルス研究所, 教授 (80215417)
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| Co-Investigator(Kenkyū-buntansha) |
MATANO Tetsuro 国立感染症研究所, エイズ研究センター, センター長 (00270653)
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| Project Period (FY) |
2006 – 2010
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| Keywords | HIV / 動物モデル / テトラスパニン / テザリン / 中和抗体 / SIV / CTL |
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| Research Abstract |
It has been extensively investigated on HIV and SIV replication, life cycle and pathogenesis. We show how tetraspanin and tetherin inhibit HIV infection and virus possesses accessary machinery to escapes from the inhibition. Furthermore, we show that neutralizing antibody has a role on anti-viral response of CD4+ T cells in acute phase and number of anti-viral CTL epitopes increases in chronic phase in SIV infected macaques. These data indicates the insight of HIV/SIV life cycle and pathogenesis and opens the road for its therapy.
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[Presentation] エイズ2008
Author(s)
俣野哲朗
Organizer
第34回日本医学会シンポジウム
Place of Presentation
東京都
Year and Date
2008-07-17
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