2010 Fiscal Year Final Research Report
Infection and pathogenesis of negative strand RNA viruses
| Project Area | Matrix of Infection Phenomena |
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| Project/Area Number |
18073014
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyushu University |
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Principal Investigator |
YANAGI Yuusuke Kyushu University, 医学研究院, 教授 (40182365)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 麻疹ウイルス / 受容体 / SLAM |
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| Research Abstract |
We have determined crystal structures of the measles virus attachment protein in complex with the receptor SLAM, thereby shedding a new light on the mechanism of the measles virus-induced membrane fusion and entry. We have also shown that measles virus can infect polarized epithelial cells independently of SLAM. Furthermore, we have revealed how measles virus interacts, via its C and V proteins, with the host interferon system.
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