Role of dendritic cells in bridging innate and adaptive immune responses during bacterial infection

2010 Fiscal Year Final Research Report

• Project Area: Matrix of Infection Phenomena
• Project/Area Number: 18073015
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Keio University
• Principal Investigator: KOYASU Shigeo Keio University, 医学部, 教授 (90153684)
• Project Period (FY): 2006 – 2010
• Keywords: 消化管関連リンパ組織 / 上皮細胞 / 樹状細胞 / リステリア / ヘリコバクター

Research Abstract

We examined in this study how immune responses are induced against bacterial infection in the gastrointestinal tract. Immune response against Helicobacter pylori results in gastritis. We showed that H. pylori is captured by dendritic cells in Peyer's patches in the intestine but not in the stomach. Listeria monocytogenes invades our body through intestine and causes food poisoning. We showed that the major site of L. monocytogenes invasion is Peyer's patches with the aid of a Lieterial protein named internalin B.

Research Products

• [Journal Article] Listerial invasion protein intemalin B promotes the entry into ileal Peyer's patches in vivo (2011)
  • Author(s): Chiba, S., Nagai, T., Hayashi, T., Baba, Y., Nagai, S., Koyasu, S.
  • Journal Title: Microbiol Immunol. 55 Pages: 123-129
• [Journal Article] Type 2 innate immune responses and the natural helper cell. (2011)
  • Author(s): Koyasu, S., Moro, K.
  • Journal Title: Immunology 132 Pages: 475-481
• [Journal Article] Innate Th2-type immune responses and the Natural Helper Cell, a newly identified lymphocyte population. (2011)
  • Author(s): Koyasu, S., Moro, K.
  • Journal Title: Curr.Opin.Allergy Clin.Immunol. 11 Pages: 109-114
• [Journal Article] Innate production of Th2 cytokines by adipose tissue-associated c-Kit^<+>Sca-1^<+> lymphoid cells. (2010)
  • Author(s): Moro, K., Yamada, T., Tanabe, M., Takeuchi, T., Ikawa, T., Kawamoto, H., Furusawa, J.-I., Ohtani, M., Fujii, H. Koyasu, S.
  • Journal Title: Nature 463 Pages: 540-544
• [Journal Article] Natural Helper Cells: a new player in the innate immune response against helminth infection. (2010)
  • Author(s): Koyasu, S., Moro, K., Tanabe, M., Takeuchi, T.
  • Journal Title: Adv.Immunol. 108 Pages: 21-44
• [Journal Article] Critical roles of NK and CD8^<+> T cells in distinct phases of CNS listeriosis. (2009)
  • Author(s): Hayashi, T., Nagai, S., Baba, Y., Ikeda, E., Kawase, T., Koyasu, S.
  • Journal Title: J. Immunol. 182 Pages: 6360-6368
• [Journal Article] The non-phosphorylated status of CagA is pivotal for Helicobacter pylori pathogenesis. (2009)
  • Author(s): Suzuki, M., Mimuro, H., Kiga, K., Fukumatsu, M., Ishijima, N., Morikawa, H., Nagai, H., Koyasu, S., Gilman, R.H., Kersulyte, D., Berg, D.E., Sasakawa, C.
  • Journal Title: Cell Host Microb. 5 Pages: 23-34
• [Journal Article] Critical role of dendritic cells in determining the Th1/Th2 balance and the disease outcome upon Leishmania major infection. (2008)
  • Author(s): Suzue, K., Kobayashi, S., Takeuchi, T., Suzuki, M., Koyasu, S.
  • Journal Title: Int.Immunol. 20 Pages: 337-343
• [Journal Article] Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach. (2007)
  • Author(s): Mimuro, H., Suzuki, T., Nagai, S., Rieder, G., Suzuki, M., Nagai, T., Fujita, Y., Nagamatsu, K., Ishijima, N., Koyasu, S., Haas, R., Sasakawa, C.
  • Journal Title: Cell Host Microbe 2 Pages: 250-263
• [Journal Article] Role of Peyer's patches in Helicobacter pylori-induced gastritis. (2007)
  • Author(s): Nagai, S., Mimuro, H., Yamada, T., Baba, Y., Moro, K., Nochi, T., Kiyono, H., Suzuki, T., Sasakawa, C., Koyasu, S.
  • Journal Title: Proc.Natl.Acad.Sci.USA 104 Pages: 8971-8976
• [Presentation] Natural helper cell : innate lymphocyte producing Th2 cytokines. Annual Meeting of the Austrian Society for Allergology and Immunology in co-operation with the national societies of Croatia (2010)
  • Author(s): Shigeo Koyasu.
  • Organizer: Czech Republic, Hungary, Slovakia and Slovenia
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2010-12-05
• [Presentation] Role of phosphoinositide 3-kinase on helper T cell differentiation in Hlicobacter pylori-induced gastritis. (2010)
  • Author(s): Shigenori Nagai, Yutaka Kurebayashi, Yukiko Baba, Shigeo Koyasu.
  • Organizer: The 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-25
• [Presentation] Role of intemalin B in the gastrointestinal infection of and host immune response to Listeria monocytogenes. (2010)
  • Author(s): Sayuri Chiba Takeshi Nagai, Shigeo Koyasu.
  • Organizer: The 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-25
• [Presentation] Natural helper cell : a newly identified innate lymphocyte producing Th2 cytokines. (2010)
  • Author(s): Shigeo Koyasu.
  • Organizer: The 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-24
• [Presentation] リステリア腸管感染における病原因子Internalin Bの役割 (2009)
  • Author(s): 千葉紗由利, 永井重徳, 永井武, 小安重夫
  • Organizer: 第39回日本免疫学会総会・学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Role of dendritic cells in infectious immunity. (2009)
  • Author(s): Shigeo Koyasu.
  • Organizer: The 7^<th> Conference of the Federation of African Immunology Societies, Sharm El-Sheick
  • Place of Presentation: Egypt
  • Year and Date: 2009-11-04
• [Presentation] Critical role of IL-17A in helicobacter pylori-induced gastritis. (2009)
  • Author(s): Shigenori Nagai, T.Yamada, Y.Baba, Y.Iwakura, Shigeo Koyasu.
  • Organizer: The 9^<th> World Congress of Inflammation
  • Place of Presentation: 東京
  • Year and Date: 2009-07-08
• [Presentation] Host immune response against Helicobacter pylori infection. (2008)
  • Author(s): Shigeo Koyasu.
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] 中枢神経系リステリア感染症におけるIFNγとIL-17の役割 (2008)
  • Author(s): 林俊行, 永井重徳, 馬場夕紀子, 小安重夫
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] ヘリコバクタービロリ感染による胃炎発症におけるIL-17Aの役割 (2008)
  • Author(s): 永井重徳, 山田健人, 馬場夕紀子, 岩倉洋一郎, 小安重夫
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] The role of PI3K for the function of gastrointestinal mast cells. (2008)
  • Author(s): Shigeo Koyasu, Akiko Minowa, Satoshi Matsuda.
  • Organizer: The 27^<th> Symposium of the Collegium Internationale Allergologicum
  • Place of Presentation: Curacao, the Netherlands
  • Year and Date: 2008-05-02
• [Presentation] Role of PI3K in immune receptor signaling (2007)
  • Author(s): Shigeo Koyasu
  • Organizer: The 13^<th> International Congress of Immunology
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2007-08-25
• [Presentation] 胃炎発症における球状ヘリコバクターピロリの重要性 (2007)
  • Author(s): 永井重徳, 三室仁美, 山田健人, 馬場夕紀子, 茂呂和世, 鈴木敏彦, 笹川千尋, 小安重夫
  • Organizer: 第13回日本ヘリコバクター学会
  • Place of Presentation: 滋賀
  • Year and Date: 2007-06-22
• [Presentation] The role of coccoid form of Helicobacter pylori on the induction of gastritis. (2006)
  • Author(s): Shigenori Nagai, Hitomi Mimuro, Taketo Yamada, Yukiko Baba, Kazuyo Moro, Toshihiko Suzuki, Chihiro Sasakawa, Shigeo Koyasu.
  • Organizer: 第36回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2006-12-13
• [Presentation] The role of acquirec immunity on CNS listeriosis. (2006)
  • Author(s): Toshiyuki Hayashi, Shigenori Nagai, Yukikc Baba, Shigeo Kovasu.
  • Organizer: 第36回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2006-12-13
• [Remarks] ホームページ
  • URL: http://www.koyasu.umin.ne.jp/
• [Remarks]
  • URL: http://www.med.keio.ac.jp/rdb/gcoe-stemcell/view.php?i=13