2010 Fiscal Year Final Research Report
Infection with parasites and landlord response
| Project Area | Matrix of Infection Phenomena |
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| Project/Area Number |
18073016
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
NAKANISHI Kenji Hyogo College of Medicine, 医学部, 教授 (60172350)
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| Project Period (FY) |
2006 – 2010
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| Keywords | Th2応答 / 好塩基球 / APC / 蠕虫感染 / アジュバント / キチン / IL-33 |
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| Research Abstract |
Although intestinal helinth is expelled mainly by the action of Th2 cells, the mechanism how helminth infection induces Th2/IgE response remains uncertain. To our surprise, basophils express MHC class II and CD80/86. They have the capacity to take-up and process protein antigen (Ag), particularly Ag-IgE complex, and to present peptide with MHC class II and produce IL-4. Thus, basophils are APC, which selectively induce Th2 cells. Furthermore Basophil-lacking mice showed diminished capacity to expel Strongyloides venezuelensis (Sv), although they developed Th2 response in response to infection with Sv. Since helminth infection induces Th2 response, we wished to determine the molecules responsible for inducing Th2 response. Here, we demonstrated that chtin is adjuvant. Furthermore, ip injection of chitin promptly induces IL-33, which in turn stimulates ST2-expressing innate type cells (e. g., natural helper cell) to produce IL-5 and IL-13.
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Research Products
(19 results)
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[Journal Article] The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.2010
Author(s)
Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S.
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Journal Title
Nat Immunol 11
Pages: 936-944
Peer Reviewed
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[Journal Article] Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system.2008
Author(s)
Kondo, Y., Yoshimoto, T., Yasuda, K., Futatsugi-Yumikura, S., Morimoto, M., Hayashi, N., Hoshino, T., Fujimoto, J., Nakanishi, K.
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Journal Title
Int.Immunol. 20
Pages: 791-800
Peer Reviewed
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[Journal Article] T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-γ and IL-13 production.2007
Author(s)
Hayashi, N., Yoshimoto, T., Izuhara, K., Matsui, K., Tanaka, T., Nakanishi, K.
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Journal Title
Proc.Natl.Acad.Sci.USA. 104
Pages: 14765-14770
Peer Reviewed
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[Journal Article] Contribution of IL-18 to atopic dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice.2006
Author(s)
Terada, M., Tsutsui, H., Imai, Y., Yasuda, K., Mizutani, H., Yamanishi, K., Kubo, M., Matsui, K., Sano, H., Nakanishi, K.
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Journal Title
Proc.Natl.Acad.Sci.U.S.A. 103
Pages: 8816-8821
Peer Reviewed
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