2010 Fiscal Year Final Research Report
Mechanics of supermolecular motor proteins revealed by an advanced optical microscope designed to track three dimensional dynamics.
| Project Area | Innovative nanoscience of supermolecular motor proteins working in biomembranes |
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| Project/Area Number |
18074008
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Gakushuin University |
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Principal Investigator |
NISHIZAKA Takayuki Gakushuin University, 理学部, 教授 (40359112)
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| Co-Investigator(Kenkyū-buntansha) |
MASAIKE Tomoko 学習院大学, 理学部, 助教 (60406882)
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| Co-Investigator(Renkei-kenkyūsha) |
YAJIMA Junichiro 学習院大学
ADACHI Kengo 学習院大学
SUGAWA Mitsuhiro 学習院大学
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| Research Collaborator |
HORIBE Keiko 学習院大学
TATSUGUCHI Ayako 学習院大学
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| Project Period (FY) |
2006 – 2010
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| Keywords | 1分子生物物理学 / 光学顕微鏡 / 分子モーター / タンパク質科学 / 顕微操作 |
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| Research Abstract |
The final goal of our group is to establish the missing link between chemical reaction and mechanical event in molecular motors. To achieve this, we have developed advanced versions of conventional optical microscopes and applied them into single-molecule techniques. Our main contributions are following two studies: one is about the kinesin-microtubule system and the other F1-ATPase. These techniques are applicable to other molecular machines, hopefully in more sophisticated ways, and we hope to investigate this in future studies as a new research field 'single-molecule structural biology.'
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