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2010 Fiscal Year Final Research Report

Biomodulation by calpain

Planned Research

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Project AreaProteolysis in the Regulation of Biological Processes
Project/Area Number 18076007
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research Institution財団法人東京都医学研究機構 (2010)
Tokyo Metropolitan Organization for Medical Research (2006-2009)

Principal Investigator

SORIMACHI Hiroyuki  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 参事研究員 (10211327)

Co-Investigator(Kenkyū-buntansha) ONO Yasuko  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主席研究員 (20392376)
HATA Shoji  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主席研究員 (10392375)
OJIMA Koichi  独立行政法人農業・食品産業技術総合研究機構, 畜産草地研究所・食肉プロテオーム研究チーム, 研究員 (60415544)
Project Period (FY) 2006 – 2010
Keywords細胞内タンパク質分解 / カルパイン / カルシウム / 骨格筋 / 胃腸
Research Abstract

"Calpains", which are encoded by 15 genes in humans, constitute a family of intracellular Ca^<2+>-dependent "modulator" proteases. They function to maintain homeostasis of various living organisms, and, therefore, defects in calpain functions result in lethality or diseases like muscular dystrophy and stress-induced stomach ulcer. In this study, we focused on tissue-specific calpains, which is involved in tissue-specific functions where they are expressed. As a result, we could elucidate at least a part of molecular mechanisms how defects of calpains cause various disorders.

  • Research Products

    (61 results)

All 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article (39 results) (of which Peer Reviewed: 38 results) Presentation (19 results) Remarks (3 results)

  • [Journal Article] Chapter 453-6 and 458. μ-calpain, m-calpain, Muscle calpain, Gastrointestinal calpain, and other calpains.2012

    • Author(s)
      Sorimachi H, Ono Y, Hata S
    • Journal Title

      Handbook of Proteolytic enzymes, 3rd Edition(Rawlings ND, Salvesen G, eds)(Oxford, UK: Elsevier Academic Press.)

      Volume: in press

    • URL

      http://store.elsevier.com/product.jsp?Isbn=9780123822192&pagename=search

    • Peer Reviewed
  • [Journal Article] Calpain2012

    • Author(s)
      Sorimachi H
    • Journal Title

      Encyclopedia of Biological Chemistry 2nd Edition(Lane MD, Lennarz WJ, eds., Oxford, UK: Elsevier Academic Press)

      Volume: in press

    • URL

      http://store.elsevier.com/product.jsp?isbn=9780080547756&pagename=search

    • Peer Reviewed
  • [Journal Article] Calpains - An elaborate proteolytic system2012

    • Author(s)
      Ono Y, Sorimachi H
    • Journal Title

      Biochim Biophys Acta

      Volume: 1824 Pages: 224-236

    • DOI

      10.1016/j.bbapap.2011.08.005.

    • Peer Reviewed
  • [Journal Article] Efficient expression and purification of recombinant human m-calpain using an Escherichia coli expression system at low temperature.2012

    • Author(s)
      Hata S, Ueno M, Kitamura F, Sorimachi H
    • Journal Title

      J Biochem

      Volume: 151 Pages: 417-422

    • DOI

      10.1093/jb/mvs002.

    • Peer Reviewed
  • [Journal Article] Functional evolution of duplicated odorant-binding protein genes, Obp57d and Obp57e, in Drosophila.2012

    • Author(s)
      Harada E, Nakagawa J, Asano T, Taoka M, Sorimachi H, Ito Y, Aigaki T, Matsuo T
    • Journal Title

      PLoS One

      Volume: 7 Pages: e29710

    • DOI

      10.1371/journal.pone.0029710.

    • Peer Reviewed
  • [Journal Article] Calpain chronicle--an enzyme family under multidisciplinary characterization.2011

    • Author(s)
      Sorimachi H, HataS, Ono Y
    • Journal Title

      Proc Jpn Acad Ser B Phys Biol Sci

      Volume: 87 Pages: 287-327

    • DOI

      JST.JSTAGE/pjab/87.287[pii].

    • Peer Reviewed
  • [Journal Article] Calpain cleavage prediction using multiple kernel learning.2011

    • Author(s)
      duVerle DA, Ono Y, Sorimachi H, Mamitsuka H
    • Journal Title

      PLoS One

      Volume: 6 Pages: 6:e19035

    • DOI

      10.1371/journal.pone.0019035.

    • Peer Reviewed
  • [Journal Article] Does the severity of the LGMD2A phenotype in compound heterozygotes depend on the combination of mutations?2011

    • Author(s)
      Saenz A, Ono Y, Sorimachi H, Goicoechea M, Leturcq F, Blazquez L, Garcia-Bragado F, Marina A, Poza JJ, Azpitarte M, Doi N, Urtasun M, Kaplan JC, Lopez de Munain A
    • Journal Title

      Muscle and Nerve

      Volume: 44 Pages: 710-714

    • DOI

      10.1002/mus.22194.

    • Peer Reviewed
  • [Journal Article] Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles.2011

    • Author(s)
      Ojima K, Ono Y, Ottenheijm C, HataS, Suzuki H, Granzier H, Sorimachi H
    • Journal Title

      J Mol Biol

      Volume: 407 Pages: 439-449

    • DOI

      10.1016/j.jmb.2011.01.057.

    • Peer Reviewed
  • [Journal Article] Impact of genetic insights into calpain biology2011

    • Author(s)
      Sorimachi H, Hata S, Ono Y
    • Journal Title

      J Biochem

      Volume: 150 Pages: 23-37

    • DOI

      10.1093/jb/mvr070.

    • Peer Reviewed
  • [Journal Article] Calpain-6, a microtubule-stabilizing protein, regulates Racl activity and cell motility through interaction with GEF-Hl.2011

    • Author(s)
      Tonami K, Kurihara Y, Arima S, Nishiyama K, Uchijima Y, Asano T, Sorimachi H, Kurihara H
    • Journal Title

      J Cell Sci

      Volume: 124 Pages: 1214-1223

    • DOI

      10.1242/jcs.072561.

    • Peer Reviewed
  • [Journal Article] Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.2010

    • Author(s)
      Ojima K, Kawabata Y, Nakao H, Nakao K, Doi N, Kitamura F, Ono Y, HataS, Suzuki H, Kawahara H, Bogomolovas J,Will C, Ottenheijm C, LabeitS, Granzier H, Toyama-Sorimachi N, Sorimachi M, Suzuki K, Maeda T, Abe K, Aiba A, Sorimachi H
    • Journal Title

      J Clin Invest

      Volume: 120 Pages: 2672-2683

    • DOI

      10.1172/JCI40658.

    • Peer Reviewed
  • [Journal Article] Skeletal muscle-specific calpain, p94/calpain-3, dynamically distributes in skeletal muscle cells to adapt to physical stress, defects of which cause muscular dystrophy.2010

    • Author(s)
      Ojima K, Ono Y, Doi N, Kitamura F, Kawabata Y, Suzuki K, Maeda T, Abe K, Nakao H, Aiba A, Suzuki H, Kawahara H, Witt C,Ottenheijm C, Labeit S, Ottenheijm C, Granzier H, Toyama-Sorimachi N, Sorimachi M, Sorimachi H
    • Journal Title

      Neuromuscul Disord

      Volume: 20 Pages: 598-599

    • URL

      http://www.elsevier.com/wps/find/journaldescription.cws_home/973/description

    • Peer Reviewed
  • [Journal Article] Redundant and non-redundant effects of Ca^<2+> and Na^+ on the activation of p94/calpain-3.2010

    • Author(s)
      Ono Y, Ojima K, Torii F, Takaya E, Doi N, Nakagawa K, Hata S, Abe K, Sorimachi H
    • Journal Title

      Neuromuscul Disord

      Volume: 20 Pages: 608

    • URL

      http://www.elsevier.com/wps/find/journaldescription.cws_home/973/description

    • Peer Reviewed
  • [Journal Article] Expanding members and roles of the calpain superfamily and their genetically modified animals.2010

    • Author(s)
      Sorimachi H, Hata S, Ono Y
    • Journal Title

      Exp Anim

      Volume: 59 Pages: 549-566

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/21030783

    • Peer Reviewed
  • [Journal Article] Une contribution a l'histoire de la decouverte des calpainopathies.(in French).2010

    • Author(s)
      Fardeau M, Beckmann JS, Sorimachi H, Urtizberea JA
    • Journal Title

      Les Cahiers de Myologie

      Volume: 2 Pages: 5-10

  • [Journal Article] CaMPDB: a resource for calpain and modulatory proteolysis.2010

    • Author(s)
      duVerle DA, Takigawa I, Ono Y, Sorimachi H, Mamitsuka H
    • Journal Title

      Genome Inform

      Volume: 22 Pages: 202-213

    • DOI

      9781848165786_0017[pii]

    • Peer Reviewed
  • [Journal Article] Skeletal muscle-specific calpain is an intracellular Na^+-dependent protease.2010

    • Author(s)
      Ono Y, Ojima K, Torii F, Takaya E, Doi N, Nakagawa K, Hata S, Abe K, Sorimachi H
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 22986-22998

    • DOI

      10.1074/jbc.M110.126946.

    • Peer Reviewed
  • [Journal Article] Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.2010

    • Author(s)
      Hata S, Abe M, Suzuki H, Kitamura F, Toyama-Sorimachi N, Abe K, Sakimura K, Sorimachi H
    • Journal Title

      PLoS Genet

      Volume: 6 Pages: e1001040

    • DOI

      10.1371/journal.pgen.1001040.

    • Peer Reviewed
  • [Journal Article] Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.2009

    • Author(s)
      Yamada M, Yoshida Y, Mori D, Takitoh T, Kengaku M, Umeshima H, Takao K, Miyakawa T, Sato M, Sorimachi H, Wynshaw-Boris A, Hirotsune S
    • Journal Title

      Nat Med

      Volume: 15 Pages: 1202-1207

    • DOI

      10.1038/nm.2023

    • Peer Reviewed
  • [Journal Article] Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.2008

    • Author(s)
      Koyama S, HataS, Witt CC, Ono Y, Lerche S, Ojima K, Chiba T, Doi N, Kitamura F, Tanaka K, Abe K, Witt SH, Rybin V, Gasch A, Franz T, Labeit S, Sorimachi H
    • Journal Title

      J Mol Biol

      Volume: 376 Pages: 1224-1236

    • DOI

      10.1016/j.jmb.2007.11.049.

    • Peer Reviewed
  • [Journal Article] Single-cell chemical lysis method for analyses of intracellular molecules using an array of picoliter-scale microwells.2008

    • Author(s)
      Sasuga Y, Iwasawa T, Terada K, Oe Y, Sorimachi H, Ohara O, Harada Y
    • Journal Title

      Anal Chem

      Volume: 80 Pages: 9141-9149

    • DOI

      10.1021/ac8016423.

    • Peer Reviewed
  • [Journal Article] The importance of conserved amino acid residues in p94 protease sub-domain IIb and the IS2 region for constitutive autolysis.2008

    • Author(s)
      Ono Y, Hayashi C, Doi N, Tagami M, Sorimachi H
    • Journal Title

      FEBS Lett

      Volume: 582 Pages: 691-698

    • URL

      10.1016/j.febslet.2008.01.044.

    • Peer Reviewed
  • [Journal Article] Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle.2008

    • Author(s)
      Hayashi C, Ono Y, Doi N, Kitamura F, Tagami M, Mineki R, Arai T, Taguchi H, Yanagida M, Hirner S, Labeit D, Labeit S, Sorimachi H
    • Journal Title

      J Biol Chem

      Volume: 283 Pages: 14801-14

    • URL

      10.1074/jbc.M708262200.

    • Peer Reviewed
  • [Journal Article] Comprehensive survey of p94/calpain 3 substrates by comparative proteomics--possible regulation of protein synthesis by p94.2007

    • Author(s)
      Ono Y, Hayashi C, Doi N, Kitamura F, Shindo M, Kudo K, Tsubata T, Yanagida M, Sorimachi H
    • Journal Title

      Biotech J

      Volume: 2 Pages: 565-576

    • DOI

      10.1002/biot.200700018.

    • Peer Reviewed
  • [Journal Article] Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain.2007

    • Author(s)
      Ojima K, Ono Y, Doi N, Yoshioka K, Kawabata Y, Labeit S, Sorimachi H
    • Journal Title

      J Biol Chem

      Volume: 282 Pages: 14493-14504

    • DOI

      10.1074/jbc.M610806200.

    • Peer Reviewed
  • [Journal Article] Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation.2007

    • Author(s)
      Kamei H, Saito T, Ozawa M, Fujita Y, Asada A, Bibb JA, Saido TC, Sorimachi H, Hisanaga S
    • Journal Title

      J Biol Chem

      Volume: 282 Pages: 1687-1694

    • DOI

      10.1074/jbc.M610541200

    • Peer Reviewed
  • [Journal Article] Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.2007

    • Author(s)
      Hata S, Doi N, Kitamura F, Sorimachi H
    • Journal Title

      J Biol Chem

      Volume: 282 Pages: 27847-56

    • DOI

      10.1074/jbc.M703168200.

    • Peer Reviewed
  • [Journal Article] Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the β-subunit of coatomer complex, β-COP.2006

    • Author(s)
      Hata S, Koyama S, Kawahara H, Doi N, Maeda T, Toyama-Sorimachi N, Abe K, Suzuki K, Sorimachi H
    • Journal Title

      J Biol Chem

      Volume: 281 Pages: 11214-24

    • DOI

      10.1074/jbc.M509244200.

    • Peer Reviewed
  • [Journal Article] Extracellular production of neoculin, a sweet-tasting heterodimeric protein with taste-modifying activity, by Aspergillus oryzae.2006

    • Author(s)
      Nakajima K, Asakura T, Maruyama J, Morita Y, Oike H, Shimizu-Ibuka A, Misaka T, Sorimachi H, Arai S, Kitamoto K, Abe K
    • Journal Title

      Appl Environ Microbiol

      Volume: 72 Pages: 3716-3723

    • DOI

      10.1128/AEM.72.5.3716-3723.2006.

    • Peer Reviewed
  • [Journal Article] Neoculin, a taste-modifying protein, is recognized by human sweet taste receptor.2006

    • Author(s)
      Nakajima K, Asakura T, Oike H, Morita Y, Shimizu-Ibuka A, Misaka T, Sorimachi H, Arai S, Abe K
    • Journal Title

      Neuroreport

      Volume: 17 Pages: 1241-44

    • DOI

      10.1097/01.wnr.0000230513.01339.3b.

    • Peer Reviewed
  • [Journal Article] Spatio-temporal expression of muscle-specific calpain, p94/calpain 3, during myogenesis.2006

    • Author(s)
      Ojima K, Ono Y, Doi N, Labeit S, Sorimachi H
    • Journal Title

      Neuromuscul Disord

      Volume: 16 Pages: S56

    • URL

      http://www.elsevier.com/wps/find/journaldescription.cws_home/973/description.

    • Peer Reviewed
  • [Journal Article] Calpain system regulates the differentiation of adult primitive mesenchymal ST-13 adipocytes.2006

    • Author(s)
      Yajima Y, Sato M, Sorimachi H, Inomata M, Maki M, Kawashima S
    • Journal Title

      Endocrinology

      Volume: 147 Pages: 4811-4819

    • DOI

      10.1210/en.2005-1647.

    • Peer Reviewed
  • [Journal Article] Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.2006

    • Author(s)
      Ono Y, Torii F, Ojima K, Doi N, Yoshioka K, Kawabata Y, Labeit D, LabeitS, Suzuki K, Abe K, Maeda T, Sorimachi H
    • Journal Title

      J Biol Chem

      Volume: 281 Pages: 18519-31

    • DOI

      10.1074/jbc.M601029200

    • Peer Reviewed
  • [Journal Article] Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region.2006

    • Author(s)
      Takahara T, Hara K, Yonezawa K, Sorimachi H, Maeda T
    • Journal Title

      J Biol Chem

      Volume: 281 Pages: 28605-28614

    • URL

      10.1074/jbc.M606087200.

    • Peer Reviewed
  • [Journal Article] How do defects in proteolytic functions of skeletal muscle-specific calpain, p94/calpain 3, cause calpainopathy/LGMD2A?2006

    • Author(s)
      Sorimachi H, Ojima K, Yanagida M, Ogawa H, Hayashi C, Doi N, Ono Y
    • Journal Title

      Neuromuscul Disord

      Volume: 16 Pages: S148

    • URL

      http://www.elsevier.com/wps/find/journaldescription.cws_home/973/description.

    • Peer Reviewed
  • [Journal Article] Crystal structure of neoculin: insights into its sweetness and taste-modifying activity.2006

    • Author(s)
      Shimizu-Ibuka A, Morita Y, Terada T, Asakura T, Nakajima K, Iwata S, Misaka T, Sorimachi H, Arai S, Abe K
    • Journal Title

      J Mol Biol

      Volume: 359 Pages: 148-158

    • DOI

      10.1016/j.jmb.2006.03.030.

    • Peer Reviewed
  • [Journal Article] Effect of N2A connectin/titin on disassembly of p94/CAPN3 caused by auaolysis in IS2.2006

    • Author(s)
      Ono Y, Torii F, Ojima K, Doi N, Yoshioka K, Labeit D, Labeit S, Suzuki K, Abe K, Maeda T, Sorimachi H
    • Journal Title

      FEBS Journal

      Volume: 273 Supp1. Pages: 50

    • DOI

      10.1111/j.1742-4658.2006.05276.x/pdf.

    • Peer Reviewed
  • [Journal Article] Relationships between p94/CAPN3 and N2A connectin/titin in skeletal muscle under the normal and dystrophic conditions.2006

    • Author(s)
      Ono Y, Ojima K, Doi N, Hayashi C, Torii F, 40K, Labeit D, Labeit S, Suzuki K, Abe K, Maeda T, Sorimachi H
    • Journal Title

      Neuromuscul Disord

      Volume: 16 Pages: S72

    • URL

      http://www.elsevier.com/wps/find/journaldescription.cws_home/973/description.

    • Peer Reviewed
  • [Presentation] Unique properties of muscle-specific calpain and muscular dystrophy caused by its defect.2011

    • Author(s)
      Sorimachi, H., Ojima, K., and Ono, Y.
    • Organizer
      IPS2011 - Seventh General Meeting of the International Proteolysis Society
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      20111020(1016-20)
  • [Presentation] Skeletal muscle-specific calpain is an intracellular Ca^<2+> and Na^+-dependent protease.2011

    • Author(s)
      Sorimachi, H., Ojima, K., Takaya, E., and Ono Y.
    • Organizer
      CaBP17 - The 17th International Symposium on Ca^<2+>-binding proteins and Ca^<2+> function in health and disease.
    • Place of Presentation
      Beijing, China.
    • Year and Date
      20110718(0716-21)
  • [Presentation] Studies of titin signaling and CAPN3.2011

    • Author(s)
      Sorimachi, H., Ojima, K., and Ono, Y.
    • Organizer
      LGMD2A Workshop: Coalition to Cure Calpain 3(C3)
    • Place of Presentation
      Santa Monica, USA.
    • Year and Date
      2011-10-27
  • [Presentation] The closing lecture]In Memoriam Koichi Suzuki: Calpains in muscles and stomach XIIth Symposium on Proteases2010

    • Author(s)
      Ono, Y., Hata, S., Ojima, K., Tonami, K., Kitamura, F., Ueno, M., Takaya, E., Granzier, H., Labeit, S., and Sorimachi, H.
    • Organizer
      Inhibitors and Biological Control
    • Place of Presentation
      Portoroz, Slovenia.
    • Year and Date
      20100928(0925-0929)
  • [Presentation] (Murachi Award-winning oral presentation)Possible interacting proteins for G-calpain, a novel gastrointestinal calpain complex of calpain 8/nCL-2 and calpain 9/nCL-4.2010

    • Author(s)
      Matsushita, G, Hata, S., and Sorimachi, H.
    • Organizer
      FASEB Summer Research Conferences - The Biology of Calpains in Health & Disease
    • Place of Presentation
      Arizona, USA.
    • Year and Date
      20100730(0725-0730)
  • [Presentation] Unique functions of mammalian unconventional calpains.2010

    • Author(s)
      Sorimachi, H., Hata, S., Ojima, K., Labeit, S., and Ono, Y.
    • Organizer
      FASEB Summer Research Conferences - The Biology of Calpains in Health & Disease
    • Place of Presentation
      Arizona, USA.
    • Year and Date
      20100730(0725-0730)
  • [Presentation] Legacy: Structure-function relationships of calpain.2010

    • Author(s)
      Sorimachi, H., A Koichi Suzuki
    • Organizer
      FASEB Summer Research Conferences - The Biology of Calpains in Health & Disease
    • Place of Presentation
      Arizona, USA.
    • Year and Date
      20100729(0725-0730)
  • [Presentation] (Selected for oral presentation) Calpain 8/nCL-2 and Calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense2010

    • Author(s)
      Hata, S., Abe, M., Suzuki, H., Kitamura, F., Toyama-Sorimachi, N., Abe, K., Sakimura, K., and Sorimachi, H.
    • Organizer
      FASEB Summer Research Conferences - The Biology of Calpains in Health & Disease
    • Place of Presentation
      Arizona, USA.
    • Year and Date
      20100729(0725-0730)
  • [Presentation] (Selected for oral presentation) Characteristics of p94/calpain 3 as an intracellular Na^+-dependent protease2010

    • Author(s)
      Ono, Y., Ojima, K., Torii, F., Takaya, E., Doi, N., Nakagawa, K., Hata, S., Abe, K., and Sorimachi, H.
    • Organizer
      FASEB Summer Research Conferences - The Biology of Calpains in Health & Disease
    • Place of Presentation
      Arizona, USA.
    • Year and Date
      20100728(0725-0730)
  • [Presentation] Calpains-introduction2010

    • Author(s)
      Ono, Y., Hata, S., and Sorimachi, H.
    • Organizer
      CHUV(Le Centre Hospitalier Universitaire Vaudois) Special Seminar
    • Place of Presentation
      Lausanne, Swizerland.
    • Year and Date
      2010-10-01
  • [Presentation] Calpain-3 and molecular interactions. Calpaines et Calpainopathies.2009

    • Author(s)
      Sorimachi, H., Ojima, K., Hata, S., andOno, Y.
    • Organizer
      VIIes Journees annuelles de la SFM(Societe Francaise de Myologie)
    • Place of Presentation
      Hendaye, France.
    • Year and Date
      20091030(1029-1031)
  • [Presentation] Roles of skeletal muscle-specific calpain, p94/calpain 3, on multiple molecular interactions using connectin/titin N2A region as a modulating scaffold.2008

    • Author(s)
      Sorimachi, H., Hayashi, C., Hata, S., Ojima, K., Koyama, S., Doi, N., Kitamura, F., Takaya, E., Ueno, M., Kaneko, N., and Ono, Y.
    • Organizer
      11th International Symposium on PROTEINASE INHIBITORS AND BIOLOGICAL CONTROL
    • Place of Presentation
      Portoroz, Slovenia.
    • Year and Date
      20080902(0830-0903)
  • [Presentation] Lacalpaina como "proteina moduladora" en la enfermedad y la salud.(Calpain as a "modulator protease" in health and muscle disease.)2008

    • Author(s)
      Sorimachi, H.
    • Organizer
      UPV/EHU(Universidad del Pais Vasco/Euskal Herriko Unibertsitatea) Summer Course Symposium: Distrofias por Deficit de Calpaina-3: Una Vision General
    • Place of Presentation
      San Sebastian, Spain.
    • Year and Date
      20080714(0714-15)
  • [Presentation] Unconventional calpains.2007

    • Author(s)
      Ono, Y., Ojima, K., Hayashi, C., Doi, N., Kitamura, F., Koyama, S., Hata, S., Labeit, S., Yanagida, M., Maeda, T., and Sorimachi, H.
    • Organizer
      FASEB Summer Research Conferences - The Biology of Calpains in Health & Disease
    • Place of Presentation
      Colorado, USA.
    • Year and Date
      20070715(0714-0719)
  • [Presentation] Novel approaches for analysis of proteolytic activity of muscle-specific calpain p94/calpain 32007

    • Author(s)
      Ono, Y., Ojima, K., Hayashi, C., Doi, N., Kitamura, F., Koyama, S., Hata, S., Labeit, S., Yanagida, M., Maeda, T., and Sorimachi, H.
    • Organizer
      Xth International Symposium on PROTEINASE INHIBITORS AND BIOLOGICAL CONTROL: From single molecules to degradomics
    • Place of Presentation
      Portoroz, Slovenia.
    • Year and Date
      20070624(0623-0627)
  • [Presentation] Toward Understanding Relationships between Proteolytic Activity of Skeletal Muscle-Specific Calpain and Calpainopathy.2007

    • Author(s)
      Ono, Y., Ojima, K., Hata, S., and Sorimachi, H.
    • Organizer
      2007 Korea-Japan Joint Symposium "Protein Modification and Degradation in Human Diseases"
    • Place of Presentation
      Seoul, South Korea.
    • Year and Date
      2007-09-05
  • [Presentation] A novel genetic assay system for a rapidly autolyzing muscle-specific calpain p94/calpain 32006

    • Author(s)
      Ono, Y., Torii, F., Ojima, K., Doi, N., Yoshioka, K., Kawabata, Y., Labeit, D., Labeit, S., Suzuki, K., Abe, K., Maeda, T., Hata, S., Koyama, S., and Sorimachi, H.
    • Organizer
      5^<th> Internationla Conference on Cysteine Proteinases and Their Inhitbitors: From Structure to Regulation and Biology
    • Place of Presentation
      Portoroz, Slovenia.
    • Year and Date
      20060904(0902-0906)
  • [Presentation] How do defects in proteolytic functions of skeletal muscle-specific calpain, p94/calpain 3, cause calpainopathy/LGMD2A?2006

    • Author(s)
      Sorimachi, H., Ojima, K., Yanagida, M., Ogawa, H., Hayashi, C., Doi, N., and Ono, Y.
    • Organizer
      XIth International Congress on Neuromuscular Diseases
    • Place of Presentation
      Istanbul, Turkey.
    • Year and Date
      20060706(0702-0707)
  • [Presentation] Novel function of calpain at the membranes.2006

    • Author(s)
      Sorimachi, H., Maeda, T., Suzuki, K.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11^<th> FAOBMB Congress.
    • Place of Presentation
      Kyoto, Japan.
    • Year and Date
      20060622(0618-0623)
  • [Remarks] ウェッブサイト

    • URL

      http://www.igakuken.or.jp/calpain/

  • [Remarks]

    • URL

      http://calpain.org/viewer.rb

  • [Remarks]

    • URL

      http://calpain.net/

URL: 

Published: 2013-07-31  

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