2010 Fiscal Year Final Research Report
Conversion of touch sensation to pain by the modal shift of sensor function
| Project Area | Molecular interaction and modal shift of cellular sensors |
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| Project/Area Number |
18077002
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TANABE Tsutomu Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (70183069)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 分子センサー / 触覚 / 神経因性疼痛 / アロディニア / 痛覚過敏 / 細胞感覚 |
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| Research Abstract |
We searched for the molecules which induce conversion of touch sensation to pain by the modal shift of their sensor functions. We identified μ-opioid, peripheral-type benzodiazepine receptor, and casein kinase 1ε as effectors which are functionally located downstream of N-type calcium channel activation. We also clarified how the modal shift of these molecules affect the excitability of neurons and their intracellular calcium transient [Ca^<2+>]i , and how the inhibitor of each molecule affects the observed changes caused by the modal shift of these molecules.
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[Journal Article] Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice.2009
Author(s)
Kondo, D., Saegusa, H., Yabe, R., Takasaki, I., Kurihara, T., Zong, S., Tanabe, T.
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Journal Title
J.Pharmacol.Sci. 110
Pages: 55-63
Peer Reviewed
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[Journal Article] Upregulation of casein kinase 1 epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain.2009
Author(s)
Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S., Tanabe, T.
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Journal Title
Molecular Pain 5
Pages: 74
Peer Reviewed
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[Journal Article] Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells.2007
Author(s)
Saegusa, H., Wakamori, M., Matsuda, Y., Wang, J., Mori, Y., Zong, S., Tanabe, T.
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Journal Title
Molec.Cell.Neurosci. 34
Pages: 261-270
Peer Reviewed
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[Journal Article] Progesterone receptor antagonist is effective for relieving neuropathic pain.2006
Author(s)
Kondo, D., Yabe, R., Kurihara, T., Saegusa, H., Zong, S., Tanabe, T.
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Journal Title
Eur.J.Pharm. 541
Pages: 44-48
Peer Reviewed
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[Journal Article] Altered cerebellar function in mice lacking Cav2.3 Ca^<2+> channel.2006
Author(s)
Osanai, M.., Saegusa, H., Kazuno, A., Nagayama, S., Hu, Q., Zong, S., Murakoshi, T., Tanabe, T.
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Journal Title
Biochem.Biophys.Res.Commun. 344
Pages: 920-925
Peer Reviewed
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