2010 Fiscal Year Final Research Report
Alteration of cell response and behavior by temporal, special, phylogenetic modal-shifts of taste cell sensors.
| Project Area | Molecular interaction and modal shift of cellular sensors |
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| Project/Area Number |
18077004
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyushu University |
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Principal Investigator |
NINOMIYA Yuzo Kyushu University, 歯学研究院, 教授 (50076048)
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| Co-Investigator(Kenkyū-buntansha) |
SHIGEMURA Noriatsu 九州大学, 大学院・歯学研究院, 准教授 (40336079)
YOSHIDA Ryusuke 九州大学, 大学院・歯学研究院, 助教 (60380705)
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| Project Period (FY) |
2006 – 2010
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| Keywords | セルセンサー / モーダルシフト / 甘味センサー / 塩味センサー |
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| Research Abstract |
Potential modal-shifts of sensitivities of taste cell sensors were studied by examining cellular and behavior responses to sweet and salty stimuli under various molecular and environmental conditions. The results suggest that as comparable with the action of central nervous system, endocannabinoids, orexigenic mediators, enhanced peripheral sweet taste sensitivities, that opposes the action of leptin, an anorexigenic mediator. Species-specific sweet-suppressing effect of gurmarin occurs its binding to the mouse extracellular domain of T1r3(partially that of T1r2). In addition, molecular based modal-shift was found in sodium-salt sensor ENaC channels where an amino acid change (R616W) in αsubunit may produce variation in amiloride-sensitivity of the channel.
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[Journal Article] Endocannabinoids selectively enhance sweet taste.2010
Author(s)
Yoshida R., Ohkuri T., Jyotaki M., Yasuo T., Horio N., Yasumatsu K., Sanematsu K., Shigemura N., Yamamoto T., Margolskee RF., Ninomiya Y.
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Journal Title
Proc.Natl.Acad.Sci.USA 107:(2)
Pages: 935-939
Peer Reviewed
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[Journal Article] Discrimi- nation of taste qualities among mouse fungiform taste bud cells.2009
Author(s)
Yoshida R., Miyauchi A., Yasuo T., Jyotaki M., Murata Y., Yasumatsu K., Shigemura N., Yanagawa Y., Obata K., Ueno H., Margolskee RF., Ninomiya Y.
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Journal Title
J Physiol 587:(18)
Pages: 4425-4439
Peer Reviewed
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[Journal Article] Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin.2008
Author(s)
Shigemura N., Nakao K., Yasuo T., Murata Y., Yasumatsu K., Nakashima A., Katsukawa H., Sako N., Ninomiya Y.
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Journal Title
Biochem Biophys Res Commun. 367:(2)
Pages: 356-363
Peer Reviewed
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